| UniProt ID | FACD2_MOUSE | |
|---|---|---|
| UniProt AC | Q80V62 | |
| Protein Name | Fanconi anemia group D2 protein homolog | |
| Gene Name | Fancd2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1450 | |
| Subcellular Localization | Nucleus. Concentrates in nuclear foci during S phase and upon genotoxic stress.. | |
| Protein Description | Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.. | |
| Protein Sequence | MISKRRRLDSEDKENLTEDASKTMPLSKLAKKSHNSHEVEENGSVFVKLLKASGLTLKTGENQNQLGVDQVIFQRKLFQALRKHPAYPKVIEEFVNGLESYTEDSESLRNCLLSCERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESENRDGINMARLIINQLKWLDRIVDGKDLTAQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELGELLVQNTSLTVPILDVFSSLRLDPNFLSKIRQLVMGKLSSVRLEDFPVIVKFLLHSVTDTTSLEVIAELRENLNVQQFILPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLVFDVIKSAIRYEKTISEAWFKAIERIESAAEHKALDVVMLLIIYSTSTQTKKGVEKLLRNKIQSDCIQEQLLDSAFSTHYLVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGALVTHVCSGTEAEVDTALDVLLELIVLNASAMRLNAAFVKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRSVPSNSSQRSANVSSEQRTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIFNDFQDAFVVDFCAAPEGDFPFPVKALYGLEEYSTQDGIVINLLPLFYQECAKDASRATSQESSQRSMSSLCLASHFRLLRLCVARQHDGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQGILEKYLAVIPDYVPPFASVDLDTLDMMPRSSSAVAAKNRNKGKTGGKKQKADSNKASCSDTLLTEDTSECDMAPSGRSHVDKESTGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENMLTAPFAKRICCFKNKGRQNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAEHLSADDKARATAQEQHTMACCYQKLLQVLHALFAWKGFTHQSKHRLLHSALEVLSNRLKQMEQDQPLEELVSQSFSYLQNFHHSVPSFQCGLYLLRLLMALLEKSAVPNQKKEKLASLAKQLLCRAWPHGEKEKNPTFNDHLHDVLYIYLEHTDNVLKAIEEITGVGVPELVSAPKDAASSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTAADSQQVHEEKLLYWNMAVRDFSILLNLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHREDVLSLLQTLQLNTRLLHHLCGHSKIRQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQDPSSSESNAEDSEDGVTSHVSRNRATEDGEDEASDEQKDQDSDESDDSSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | SKRRRLDSEDKENLT CCCCCCCHHHHHCCC | 52.89 | 26824392 | |
| 17 | Phosphorylation | SEDKENLTEDASKTM HHHHHCCCHHHHHHC | 43.32 | 25619855 | |
| 21 | Phosphorylation | ENLTEDASKTMPLSK HCCCHHHHHHCCHHH | 40.77 | 25619855 | |
| 100 | Phosphorylation | EFVNGLESYTEDSES HHHHHHHHCCCCHHH | 42.26 | - | |
| 101 | Phosphorylation | FVNGLESYTEDSESL HHHHHHHCCCCHHHH | 12.55 | - | |
| 102 | Phosphorylation | VNGLESYTEDSESLR HHHHHHCCCCHHHHH | 42.46 | - | |
| 220 | Phosphorylation | LPEILGDSQHANVGK HHHHHCCCCCCCHHH | 23.28 | - | |
| 359 | Phosphorylation | IRYEKTISEAWFKAI HHHHHHHCHHHHHHH | 26.88 | 22802335 | |
| 481 | Phosphorylation | ALVTHVCSGTEAEVD HHHHHHHCCCHHHHH | 47.89 | - | |
| 559 | Ubiquitination | DMHLVIRKQLSSTVF CHHHHHHHHHHHHHH | 44.46 | - | |
| 714 | Phosphorylation | KDASRATSQESSQRS HHHHHHCCHHHHHHH | 30.85 | - | |
| 777 | Phosphorylation | SMSAKDRSLMCSLTF HCCHHHHHHHHHHHH | 30.50 | 25777480 | |
| 781 | Phosphorylation | KDRSLMCSLTFLTFN HHHHHHHHHHHHHHH | 19.24 | 25777480 | |
| 783 | Phosphorylation | RSLMCSLTFLTFNWF HHHHHHHHHHHHHHH | 10.58 | 25777480 | |
| 786 | Phosphorylation | MCSLTFLTFNWFREV HHHHHHHHHHHHHHH | 15.67 | 25777480 | |
| 888 | Phosphorylation | DTLLTEDTSECDMAP CCEECCCCCCCCCCC | 21.86 | 21149613 | |
| 889 | Phosphorylation | TLLTEDTSECDMAPS CEECCCCCCCCCCCC | 48.85 | 21149613 | |
| 896 | Phosphorylation | SECDMAPSGRSHVDK CCCCCCCCCCCCCCH | 36.98 | 21149613 | |
| 979 | Phosphorylation | QKLENMLTAPFAKRI HHHHHHHHHHHHHHH | 22.86 | - | |
| 1000 | Phosphorylation | GRQNIGFSHLHQRSV CCCCCCCCCCCHHCH | 21.67 | 28066266 | |
| 1251 | Phosphorylation | VKGLQAGTAADSQQV HHHHHCCCCCCCHHH | 22.99 | 28066266 | |
| 1255 | Phosphorylation | QAGTAADSQQVHEEK HCCCCCCCHHHHHHH | 20.13 | 28066266 | |
| 1399 | Phosphorylation | LQGEEIISQDPSSSE CCCCCCCCCCCCCCC | 33.90 | 25293948 | |
| 1403 | Phosphorylation | EIISQDPSSSESNAE CCCCCCCCCCCCCCC | 55.58 | 22817900 | |
| 1404 | Phosphorylation | IISQDPSSSESNAED CCCCCCCCCCCCCCC | 43.44 | 22817900 | |
| 1405 | Phosphorylation | ISQDPSSSESNAEDS CCCCCCCCCCCCCCC | 49.75 | 22817900 | |
| 1407 | Phosphorylation | QDPSSSESNAEDSED CCCCCCCCCCCCCCC | 43.20 | 19060867 | |
| 1412 | Phosphorylation | SESNAEDSEDGVTSH CCCCCCCCCCCCCHH | 29.14 | 22817900 | |
| 1417 | Phosphorylation | EDSEDGVTSHVSRNR CCCCCCCCHHHHHCC | 20.74 | 25293948 | |
| 1418 | Phosphorylation | DSEDGVTSHVSRNRA CCCCCCCHHHHHCCC | 21.34 | 25293948 | |
| 1421 | Phosphorylation | DGVTSHVSRNRATED CCCCHHHHHCCCCCC | 20.58 | 25293948 | |
| 1426 | Phosphorylation | HVSRNRATEDGEDEA HHHHCCCCCCCCCCC | 31.22 | - | |
| 1434 | Phosphorylation | EDGEDEASDEQKDQD CCCCCCCCHHHHCCC | 39.36 | 21149613 |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 220 | S | Phosphorylation |
| - |
| 559 | K | ubiquitylation |
| - |
| 1399 | S | Phosphorylation |
| - |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FACD2_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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