TDRD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TDRD1_MOUSE
• UniProt AC: Q99MV1
• Protein Name: Tudor domain-containing protein 1
• Gene Name: Tdrd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1172
• Subcellular Localization: Cytoplasm . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:20439430). DDX4 is required for meiotic nuage localization. Also present in chromatoid bod
• Protein Description: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins..
• Protein Sequence: MMPRNNLEASTCKMAEPFNFEKKESKPPPQDPLRSPVAQHNHPTFRLKSPENGNTKNNFLLCEQNKQYLASQEDSSVVSSNPAVVNGEVGGSKGDRKPPPTGNPVSPLSLGNSSPPNQVKTKPSSNVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLNKLEDNKSPFETKAIEVKSEVDCPPGVTKEITAGAERVMFSDLRSLQLKKTMEIKGTVTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFCSVKVMDILEEEVLTCAVDLVLQSSGKQLDHVLVEMGYGVKPGEQSSTEQSVDHSALEDVGRVTVESKIVTDRNALIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAVCVMKEMVQNRMVTVRVVGMLGTRALVELIDKSVAPHVSASKALIDSGFAIKEKDVADKGSSMHTASVPLAIEGPAEALEWTWVEFTVDETVDVVVCMMYSPGEFYCHFLKDDALEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEATARFQACVVGLKLQARVVEITANGVGVELTDLSTPYPKIISDVLIREQLVLRCGSPQDSLMSRPANQHKQIDSHRVQASPSAEQWKTMELPVNKTIAANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQLVMELLRNAMLNQSVVLSVKAISKNVHAVSVEKCSENGMINIAENLVMCGLAENLTSKRKSASTKEIPHSRDCCCTELQKQIEKHEQILLFLLNNPTNQSKFTEMKKLLRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	HPTFRLKSPENGNTK CCCEECCCCCCCCCC	41.88	22817900
101	Phosphorylation	GDRKPPPTGNPVSPL CCCCCCCCCCCCCCC	56.20	25293948
106	Phosphorylation	PPTGNPVSPLSLGNS CCCCCCCCCCCCCCC	22.75	22817900
109	Phosphorylation	GNPVSPLSLGNSSPP CCCCCCCCCCCCCCC	37.30	25293948
113	Phosphorylation	SPLSLGNSSPPNQVK CCCCCCCCCCCCCCC	42.28	19060867
114	Phosphorylation	PLSLGNSSPPNQVKT CCCCCCCCCCCCCCC	48.66	22817900
128	Phosphorylation	TKPSSNVTPEKSKKS CCCCCCCCCCHHHHH	29.95	22817900
346	Phosphorylation	AHVLYIDYGNEEMIP CCEEEEECCCCEEEE	16.58	22871156
361	Phosphorylation	IDSVHPLSRGLDLFP CCCCCCCCCCCCCCC	28.84	22871156
893	Phosphorylation	QLVLRCGSPQDSLMS HHHHHCCCCCHHHHC	24.02	21082442
1096	Phosphorylation	AVSVEKCSENGMINI EEEEEECCCCCCEEH	45.20	26643407
1117	Phosphorylation	CGLAENLTSKRKSAS HHHHHHHCCCCCCCC	43.73	26643407
1118	Phosphorylation	GLAENLTSKRKSAST HHHHHHCCCCCCCCC	33.36	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TDRD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TDRD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TDRD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TDRD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.