IMDH2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMDH2_MOUSE
• UniProt AC: P24547
• Protein Name: Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}
• Gene Name: Impdh2
• Organism: Mus musculus (Mouse).
• Sequence Length: 514
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors..
• Protein Sequence: MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LISGGTSYVPDDGLT EECCCCCCCCCCCCC	18.81	-
19	Phosphorylation	YVPDDGLTAQQLFNC CCCCCCCCHHHHCCC	28.13	-
60	Phosphorylation	SALTKKITLKTPLVS HHHCCEEECCCCCCC	30.95	22871156
109	Acetylation	NEVRKVKKYEQGFIT HHHHHHHEECCCCCC	57.94	23806337
109	Ubiquitination	NEVRKVKKYEQGFIT HHHHHHHEECCCCCC	57.94	22790023
116	Phosphorylation	KYEQGFITDPVVLSP EECCCCCCCCEECCC	31.80	25266776
122	Phosphorylation	ITDPVVLSPKDRVRD CCCCEECCCHHHHHH	20.49	21659605
134	Ubiquitination	VRDVFEAKARHGFCG HHHHHHHHHHHCCCC	38.46	22790023
140	Glutathionylation	AKARHGFCGIPITDT HHHHHCCCCCEECCC	5.98	24333276
159	Phosphorylation	SRLVGIISSRDIDFL HHHEEEEECCCCCCC	19.87	27818261
160	Phosphorylation	RLVGIISSRDIDFLK HHEEEEECCCCCCCC	24.46	22942356
195	Ubiquitination	APAGVTLKEANEILQ ECCCCCHHHHHHHHH	45.47	22790023
206	Ubiquitination	EILQRSKKGKLPIVN HHHHHHHCCCCCCCC	63.63	22790023
208	Ubiquitination	LQRSKKGKLPIVNEN HHHHHCCCCCCCCCC	61.03	22790023
229	Acetylation	IARTDLKKNRDYPLA EEECCHHHCCCCCCC	65.59	6568891
233	Phosphorylation	DLKKNRDYPLASKDA CHHHCCCCCCCCHHH	9.26	22418434
237	Phosphorylation	NRDYPLASKDAKKQL CCCCCCCCHHHHHHH	38.46	22418434
241	Acetylation	PLASKDAKKQLLCGA CCCCHHHHHHHHCCC	51.70	6569359
242	Ubiquitination	LASKDAKKQLLCGAA CCCHHHHHHHHCCCC	48.15	22790023
257	Acetylation	IGTHEDDKYRLDLLA CCCCCCHHHHHHHHH	44.59	22826441
293	Ubiquitination	MIKYIKEKYPSLQVI EHHHHHHHCCCCEEE	58.41	22790023
296	Phosphorylation	YIKEKYPSLQVIGGN HHHHHCCCCEEECCE	28.48	28059163
306	Phosphorylation	VIGGNVVTAAQAKNL EECCEECCHHHHHHH	16.40	-
327	Phosphorylation	ALRVGMGSGSICITQ EEEECCCCCCEEEEH	22.07	26060331
329	Phosphorylation	RVGMGSGSICITQEV EECCCCCCEEEEHHH	18.91	26060331
331	Glutathionylation	GMGSGSICITQEVLA CCCCCCEEEEHHHHH	2.70	24333276
333	Phosphorylation	GSGSICITQEVLACG CCCCEEEEHHHHHCC	17.79	26060331
339	Glutathionylation	ITQEVLACGRPQATA EEHHHHHCCCCCCEE	4.09	24333276
345	Phosphorylation	ACGRPQATAVYKVSE HCCCCCCEEEEHHHH	16.06	26060331
348	Phosphorylation	RPQATAVYKVSEYAR CCCCEEEEHHHHHHH	11.83	26060331
351	Phosphorylation	ATAVYKVSEYARRFG CEEEEHHHHHHHHHC	22.27	26060331
353	Phosphorylation	AVYKVSEYARRFGVP EEEHHHHHHHHHCCC	9.63	26060331
375	Ubiquitination	QNVGHIAKALALGAS CCHHHHHHHHHHCCH	43.24	-
400	Phosphorylation	TTEAPGEYFFSDGIR CCCCCCCEECCCCCE	18.81	22817900
403	Phosphorylation	APGEYFFSDGIRLKK CCCCEECCCCCEEEE	25.65	-
416	Phosphorylation	KKYRGMGSLDAMDKH EEECCCCCHHHHHHH	17.74	25521595
425	Phosphorylation	DAMDKHLSSQNRYFS HHHHHHHHHCCCCCC	29.60	29514104
426	Phosphorylation	AMDKHLSSQNRYFSE HHHHHHHHCCCCCCH	37.52	29514104
430	Phosphorylation	HLSSQNRYFSEADKI HHHHCCCCCCHHHHH	21.00	25367039
432	Phosphorylation	SSQNRYFSEADKIKV HHCCCCCCHHHHHHE	23.96	25367039
444	Phosphorylation	IKVAQGVSGAVQDKG HHEECCCCCCCCCCC	28.05	27841257
450	Ubiquitination	VSGAVQDKGSIHKFV CCCCCCCCCCHHHHH	37.15	22790023
459	Phosphorylation	SIHKFVPYLIAGIQH CHHHHHHHHHHHHHH	12.87	-
474	Ubiquitination	SCQDIGAKSLTQVRA HHHHCCCCCHHHHHH	40.56	22790023
485	Phosphorylation	QVRAMMYSGELKFEK HHHHHHHCCCCEEEE	14.11	-
495	Phosphorylation	LKFEKRTSSAQVEGG CEEEECCCCCEEECC	27.92	28507225
496	Phosphorylation	KFEKRTSSAQVEGGV EEEECCCCCEEECCC	23.31	25338131
511	Acetylation	HSLHSYEKRLF---- CCCCCHHHCCC----	46.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMDH2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMDH2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMDH2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IMDH2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.