| UniProt ID | PRP4_MOUSE | |
|---|---|---|
| UniProt AC | Q9DAW6 | |
| Protein Name | U4/U6 small nuclear ribonucleoprotein Prp4 | |
| Gene Name | Prpf4 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 521 | |
| Subcellular Localization | Nucleus speckle . Colocalizes with spliceosomal snRNPs.. | |
| Protein Description | Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity).. | |
| Protein Sequence | MASSRASSTTTKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Acetylation | LVAPVVKKPHIYYGS CEECCCCCCCEEECC | 30.16 | 23806337 | |
| 31 | Phosphorylation | VKKPHIYYGSLEEKE CCCCCEEECCCCHHH | 10.31 | 29899451 | |
| 33 | Phosphorylation | KPHIYYGSLEEKERE CCCEEECCCCHHHHH | 19.24 | 29899451 | |
| 145 | Ubiquitination | VVGTDALKKTKKDDE HHCHHHHHHCCCCCH | 61.18 | - | |
| 184 | Phosphorylation | RLWIANYSLPRAMKR HHHHHCCCHHHHHHH | 31.53 | 22802335 | |
| 224 | S-nitrosocysteine | LRSLNNFCSQIGDDR HHHHHHHHHHHCCCC | 2.96 | - | |
| 224 | S-nitrosylation | LRSLNNFCSQIGDDR HHHHHHHHHHHCCCC | 2.96 | 20925432 | |
| 482 | Phosphorylation | IWTHPGWSPLKTLAG EEECCCCCCCHHHCC | 26.69 | 26745281 | |
| 500 | Phosphorylation | KVMGLDISSDGQLIA EEEEEEECCCCCEEE | 23.26 | - | |
| 501 | Phosphorylation | VMGLDISSDGQLIAT EEEEEECCCCCEEEE | 46.20 | - | |
| 514 | Phosphorylation | ATCSYDRTFKLWMAE EEEECCCEEEEEEEC | 23.40 | 24759943 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP4_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP4_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP4_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PRP4_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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