CUX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUX1_MOUSE
• UniProt AC: P53564
• Protein Name: Homeobox protein cut-like 1
• Gene Name: Cux1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1515
• Subcellular Localization: Nucleus .
• Protein Description: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator..
• Protein Sequence: MLCVAGAKLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDVGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEEVKKELNTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGSARRKGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDVNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNRSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQTSSTSSSGNSDDAIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILTPKHLSASPMSTVSTYPPLAISLKKTPAAPETSTAALPSAPALKKEAQDVPTLDPPGSADAAQGVLRPMKSELVRGSTWKDPWWSPIQPERRNLTSSEETKADETTASGKERAGSSQPRAERSQLQGPSASAEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVASLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPAIETSKEGKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVEATDAEEPGGNIVATKSQGGLAEVAAAPADREEATQPAEKAKAQPLCSGTPGQDDGEDASRPRPLPEGLADAPAPVPSLAAPAAGEDAATSATAPATATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQSLFGLPEAAGARDNPVRKKKAANLNSIIHRLEKAASREEPIEWEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	RKRLIEQSREFKKNT HHHHHHHHHHHHHCC	22.46	21743459
59	Phosphorylation	QVAPLLKSFQGEIDA HHHHHHHHHHHHHHH	23.83	28059163
349	Phosphorylation	KLKGQADYEEVKKEL HHCCCCCHHHHHHHH	19.60	25159016
386	Ubiquitination	LEVLLLEKNRSLQSE HHHEEECCCCCCCCC	58.59	-
405	Phosphorylation	RISNSDLSGSARRKG EEECCCCCCCCCCCC	35.37	28066266
407	Phosphorylation	SNSDLSGSARRKGRD ECCCCCCCCCCCCCC	18.41	28066266
427	Phosphorylation	RPGPLPASPPPQLPR CCCCCCCCCCCCCCC	35.68	26824392
583	Phosphorylation	VLGLSQGSVSEILAR HHCCCCCCHHHHHCC	18.16	9446557
661	Phosphorylation	ITTRIRASETGSDEA CCCEEECCCCCCHHH	26.33	30635358
663	Phosphorylation	TRIRASETGSDEAIK CEEECCCCCCHHHHH	39.22	30635358
665	Phosphorylation	IRASETGSDEAIKSI EECCCCCCHHHHHHH	39.43	30635358
740	Phosphorylation	QPDLTILTPKHLSAS CCCCEEECCCCCCCC	26.83	26643407
747	Phosphorylation	TPKHLSASPMSTVST CCCCCCCCCCCCCCC	20.12	26643407
761	Phosphorylation	TYPPLAISLKKTPAA CCCCEEEEECCCCCC	28.64	-
765	Phosphorylation	LAISLKKTPAAPETS EEEEECCCCCCCCCC	19.30	28066266
771	Phosphorylation	KTPAAPETSTAALPS CCCCCCCCCCCCCCC	30.25	-
772	Phosphorylation	TPAAPETSTAALPSA CCCCCCCCCCCCCCC	17.87	-
773	Phosphorylation	PAAPETSTAALPSAP CCCCCCCCCCCCCCH	24.30	28059163
797	Phosphorylation	PTLDPPGSADAAQGV CCCCCCCCHHHHHHH	28.84	25338131
824	Phosphorylation	TWKDPWWSPIQPERR CCCCCCCCCCCHHHC	14.30	28066266
879	Phosphorylation	EYWKEWPSAESPYSQ HHHHHCCCCCCCCCC	45.82	26643407
882	Phosphorylation	KEWPSAESPYSQSSE HHCCCCCCCCCCCCC	28.93	26643407
884	Phosphorylation	WPSAESPYSQSSELS CCCCCCCCCCCCCCC	28.73	26643407
885	Phosphorylation	PSAESPYSQSSELSL CCCCCCCCCCCCCCC	27.28	26643407
887	Phosphorylation	AESPYSQSSELSLTG CCCCCCCCCCCCCCC	21.60	26643407
888	Phosphorylation	ESPYSQSSELSLTGA CCCCCCCCCCCCCCC	34.61	26643407
891	Phosphorylation	YSQSSELSLTGASRS CCCCCCCCCCCCCCC	21.60	26643407
893	Phosphorylation	QSSELSLTGASRSET CCCCCCCCCCCCCCC	27.59	26643407
896	Phosphorylation	ELSLTGASRSETPQN CCCCCCCCCCCCCCC	37.37	26643407
898	Phosphorylation	SLTGASRSETPQNSP CCCCCCCCCCCCCCC	43.24	26643407
900	Phosphorylation	TGASRSETPQNSPLP CCCCCCCCCCCCCCC	31.27	26643407
904	Phosphorylation	RSETPQNSPLPSSPI CCCCCCCCCCCCCCC	23.67	26643407
908	Phosphorylation	PQNSPLPSSPIVPMA CCCCCCCCCCCCCCC	57.33	25266776
909	Phosphorylation	QNSPLPSSPIVPMAK CCCCCCCCCCCCCCC	19.39	25266776
972	Phosphorylation	VLGLSQGSVSDMLSR HHCCCCCCHHHHHCC	15.71	9446557
1044	Phosphorylation	SSESTPKTSASCSPA CCCCCCCCCCCCCCC	30.63	25619855
1045	Phosphorylation	SESTPKTSASCSPAP CCCCCCCCCCCCCCC	25.06	22668510
1047	Phosphorylation	STPKTSASCSPAPES CCCCCCCCCCCCCCC	18.20	25619855
1049	Phosphorylation	PKTSASCSPAPESPM CCCCCCCCCCCCCCC	22.92	22668510
1054	Phosphorylation	SCSPAPESPMSSSES CCCCCCCCCCCCCHH	25.50	25619855
1057	Phosphorylation	PAPESPMSSSESVKS CCCCCCCCCCHHHHH	33.81	25619855
1058	Phosphorylation	APESPMSSSESVKSL CCCCCCCCCHHHHHH	31.69	25619855
1059	Phosphorylation	PESPMSSSESVKSLT CCCCCCCCHHHHHHH	26.95	25293948
1061	Phosphorylation	SPMSSSESVKSLTEL CCCCCCHHHHHHHHH	36.47	25293948
1064	Phosphorylation	SSSESVKSLTELVQQ CCCHHHHHHHHHHHC	38.07	25521595
1066	Phosphorylation	SESVKSLTELVQQPC CHHHHHHHHHHHCCC	34.07	26239621
1155	Phosphorylation	ILGLTQGSVSDLLAR HHCCCCCCHHHHHCC	14.50	9446557
1170	Phosphorylation	PKPWHKLSLKGREPF CCCCHHCCCCCCCCE	32.60	17682059
1201	Acetylation	MDMKRMEKKAYMKRR HCHHHHHHHHHHHHH	33.10	24062335
1206	Acetylation	MEKKAYMKRRHSSVS HHHHHHHHHHCCCCC	33.34	15607471
1210	Phosphorylation	AYMKRRHSSVSDSQP HHHHHHCCCCCCCCC	30.53	29514104
1211	Phosphorylation	YMKRRHSSVSDSQPC HHHHHCCCCCCCCCC	21.37	21659605
1213	Phosphorylation	KRRHSSVSDSQPCEP HHHCCCCCCCCCCCC	33.23	25293948
1215	Phosphorylation	RHSSVSDSQPCEPPS HCCCCCCCCCCCCCC	28.63	26643407
1227	Phosphorylation	PPSVGIDYSQGASPQ CCCCCCCCCCCCCCC	10.85	26643407
1228	Phosphorylation	PSVGIDYSQGASPQP CCCCCCCCCCCCCCC	20.56	26643407
1232	Phosphorylation	IDYSQGASPQPQHQL CCCCCCCCCCCHHHC	30.78	16081423
1261	Acetylation	LKRAYQQKPYPSPKT HHHHHHCCCCCCHHH	30.87	6569179
1263	Phosphorylation	RAYQQKPYPSPKTIE HHHHCCCCCCHHHHH	24.31	25777480
1265	Phosphorylation	YQQKPYPSPKTIEEL HHCCCCCCHHHHHHH	32.93	22942356
1268	Phosphorylation	KPYPSPKTIEELATQ CCCCCHHHHHHHHHH	36.68	26643407
1274	Phosphorylation	KTIEELATQLNLKTS HHHHHHHHHHCCCHH	46.33	26643407
1290	Phosphorylation	VINWFHNYRSRIRRE HHHHHHHHHHHHHHH	11.03	-
1307	Phosphorylation	IEEIQAGSQGQAGAS HHHHHCCCCCCCCCC	33.87	25619855
1314	Phosphorylation	SQGQAGASDSPSARS CCCCCCCCCCCCHHH	37.39	25619855
1316	Phosphorylation	GQAGASDSPSARSSR CCCCCCCCCCHHHCC	20.47	25619855
1318	Phosphorylation	AGASDSPSARSSRAA CCCCCCCCHHHCCCC	40.02	25619855
1327	Phosphorylation	RSSRAAPSSEGDSCD HHCCCCCCCCCCCCC	35.97	24453211
1328	Phosphorylation	SSRAAPSSEGDSCDG HCCCCCCCCCCCCCC	44.53	21082442
1332	Phosphorylation	APSSEGDSCDGVEAT CCCCCCCCCCCCCCC	25.60	27087446
1339	Phosphorylation	SCDGVEATDAEEPGG CCCCCCCCCCCCCCC	23.41	21659605
1378	Phosphorylation	TQPAEKAKAQPLCSG CCHHHHHHCCCCCCC	59.63	24719451
1386	Phosphorylation	AQPLCSGTPGQDDGE CCCCCCCCCCCCCCC	14.14	28576409
1450	Phosphorylation	AGPAERSSALPSTSA CCCCCCCCCCCCCCC	39.79	24453211
1454	Phosphorylation	ERSSALPSTSAPANA CCCCCCCCCCCCCCC	35.53	25521595
1455	Phosphorylation	RSSALPSTSAPANAP CCCCCCCCCCCCCCC	27.28	27600695
1456	Phosphorylation	SSALPSTSAPANAPA CCCCCCCCCCCCCCC	36.27	27600695
1467	Phosphorylation	NAPARRPSSLQSLFG CCCCCCCCHHHHHHC	41.70	25521595
1468	Phosphorylation	APARRPSSLQSLFGL CCCCCCCHHHHHHCC	32.86	21082442
1471	Phosphorylation	RRPSSLQSLFGLPEA CCCCHHHHHHCCHHH	30.84	26239621
1496	Phosphorylation	KKAANLNSIIHRLEK HHHHHHHHHHHHHHH	26.53	29176673
1506	Phosphorylation	HRLEKAASREEPIEW HHHHHHHCCCCCCCC	45.12	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
583	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS
882	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
972	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS
1155	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS
1232	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUX1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CUX1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.