MAGD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGD1_MOUSE
• UniProt AC: Q9QYH6
• Protein Name: Melanoma-associated antigen D1
• Gene Name: Maged1
• Organism: Mus musculus (Mouse).
• Sequence Length: 775
• Subcellular Localization: Nucleus . Cytoplasm. Cell membrane; Peripheral membrane protein. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF..
• Protein Description: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed..
• Protein Sequence: MAQKPDGGAGLRGFQAEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNATTKGPNDYSQARNAKEMPKNQSKAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKTAKAWNDTTKVPGADAQTQNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQNVESRTIIRGKRTRKVNNLNVEENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	TTKGPNDYSQARNAK CCCCCCHHHHHHHHH	14.88	30635358
97	Phosphorylation	TKGPNDYSQARNAKE CCCCCHHHHHHHHHH	21.89	30635358
120	Phosphorylation	AFKSQNGTPKGPHAA HHHCCCCCCCCCCCC	29.40	29514104
152	Phosphorylation	MAFKGQNSTKAGPGT CCCCCCCCCCCCCCC	24.32	24759943
159	Phosphorylation	STKAGPGTTYNFPQS CCCCCCCCCCCCCCC	29.28	28066266
160	Phosphorylation	TKAGPGTTYNFPQSP CCCCCCCCCCCCCCC	23.53	28066266
161	Phosphorylation	KAGPGTTYNFPQSPS CCCCCCCCCCCCCCC	18.04	28066266
166	Phosphorylation	TTYNFPQSPSANEMT CCCCCCCCCCHHHHC	22.51	25263469
168	Phosphorylation	YNFPQSPSANEMTNN CCCCCCCCHHHHCCC	49.31	24453211
173	Phosphorylation	SPSANEMTNNQPKTA CCCHHHHCCCCCCCC	25.49	28066266
188	Ubiquitination	KAWNDTTKVPGADAQ HHHCCCCCCCCCCHH	48.83	-
196	Phosphorylation	VPGADAQTQNVNQAK CCCCCHHCCCCCHHH	24.67	-
246	Ubiquitination	IRGKRTRKVNNLNVE ECCCCEEEECCCCCC	49.02	27667366
264	Phosphorylation	SGDQRRASLASGNWR CHHHHHHHHHCCCCC	23.74	26824392
267	Phosphorylation	QRRASLASGNWRSAP HHHHHHHCCCCCCCC	37.64	23984901
302	Phosphorylation	PLAWQNPSGWQNQTA CCCCCCCCCCCCCCC	61.28	25338131
308	Phosphorylation	PSGWQNQTARQTPPA CCCCCCCCCCCCCCH	31.21	25338131
312	Phosphorylation	QNQTARQTPPAARQS CCCCCCCCCCHHHCC	26.20	25777480
319	Phosphorylation	TPPAARQSPPARQTP CCCHHHCCCCCCCCC	27.57	26824392
477	Ubiquitination	ERANKLVKYLMLKDY HHHHHHHHHHHCCCC	43.00	-
482	Ubiquitination	LVKYLMLKDYTKVPI HHHHHHCCCCCCCCC	34.42	27667366
486	Ubiquitination	LMLKDYTKVPIKRSE HHCCCCCCCCCCHHH	39.52	27667366
519	Ubiquitination	RACFVLEKKFGIQLK HHHHHHHHHHCCEEE	49.60	-
520	Ubiquitination	ACFVLEKKFGIQLKE HHHHHHHHHCCEEEE	39.17	-
602	Ubiquitination	PLLGDLRKLLTYEFV CCHHHHHHHHHHHHH	55.96	-
610	Ubiquitination	LLTYEFVKQKYLDYR HHHHHHHHHHHHCCC	46.52	27667366
612	Ubiquitination	TYEFVKQKYLDYRRV HHHHHHHHHHCCCCC	41.90	-
641	Ubiquitination	RSYHETSKMKVLRFI CCCCHHCHHHHHHHH	50.59	-
653	Ubiquitination	RFIAEVQKRDPRDWT HHHHHHHHCCCCHHH	65.04	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Pja1	O55176	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIAS1_MOUSE	Pias1	physical	24911587

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.