NECD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NECD_MOUSE
• UniProt AC: P25233
• Protein Name: Necdin
• Gene Name: Ndn
• Organism: Mus musculus (Mouse).
• Sequence Length: 325
• Subcellular Localization: Cytoplasm . Nucleus, nucleoplasm . Nucleus matrix . Mainly cytoplasmic. Translocates to the nucleus where it is found associated with the nuclear matrix.
• Protein Description: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences..
• Protein Sequence: MSEQSKDLSDPNFAAEVPDCEMQDSDAVPVGIPPPASLAANLAGPPCAPEGPMAAQQASPPPEERIEDVDPKILQQAAEEGRAHQPQSPARPIPAPPAPAQLVQKAHELMWYVLVKDQKRMVLWFPDMVKEVMGSYKKWCRSILRRTSVILARVFGLHLRLTNLHTMEFALVKALSPEELDRVALNNRMPMTGLLLMILSLIYVKGRGAREGAVWNVLRILGLRPWKKHSTFGDVRKIITEEFVQQNYLKYQRVPHIEPPEYEFFWGSRANREITKMQIMEFLARVFKKDPQAWPSRYREALEQARALREANLAAQAPRSSVSED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Ubiquitination	RIEDVDPKILQQAAE HHCCCCHHHHHHHHH	52.14	22790023
88	Phosphorylation	GRAHQPQSPARPIPA CCCCCCCCCCCCCCC	27.49	26824392
142	Phosphorylation	SYKKWCRSILRRTSV HHHHHHHHHHHHHHH	23.88	30387612
148	Phosphorylation	RSILRRTSVILARVF HHHHHHHHHHHHHHH	12.83	21454597
200	Phosphorylation	GLLLMILSLIYVKGR HHHHHHHHHHHHHCC	11.20	29895711
203	Phosphorylation	LMILSLIYVKGRGAR HHHHHHHHHHCCCHH	11.03	29895711
237	Ubiquitination	STFGDVRKIITEEFV CCHHHHHHHHCHHHH	38.01	22790023
250	Ubiquitination	FVQQNYLKYQRVPHI HHHHCCHHHCCCCCC	29.04	22790023
288	Ubiquitination	EFLARVFKKDPQAWP HHHHHHHHHCCCCCH	54.10	-
320	Phosphorylation	LAAQAPRSSVSED-- HHHHCCCCCCCCC--	33.75	26824392
321	Phosphorylation	AAQAPRSSVSED--- HHHCCCCCCCCC---	30.83	27357545
323	Phosphorylation	QAPRSSVSED----- HCCCCCCCCC-----	37.69	23527152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NECD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NECD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NECD_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F4_HUMAN	E2F4	physical	12198120
E2F1_MOUSE	E2f1	physical	12198120
E2F1_MOUSE	E2f1	genetic	12198120
EID1_MOUSE	Eid1	physical	22442722
TADA3_MOUSE	Tada3	physical	22442722
WWTR1_MOUSE	Wwtr1	physical	22442722
POGZ_MOUSE	Pogz	physical	22442722
NFX1_MOUSE	Nfx1	physical	22442722
CTBP2_MOUSE	Ctbp2	physical	22442722
DAZP2_MOUSE	Dazap2	physical	22442722
NUCB1_MOUSE	Nucb1	physical	22442722
CYBP_MOUSE	Cacybp	physical	22442722
HCFC1_MOUSE	Hcfc1	physical	22442722
CABP1_MOUSE	Cabp1	physical	22442722
RUFY2_MOUSE	Rufy2	physical	22442722
MED22_MOUSE	Med22	physical	22442722
CADH4_MOUSE	Cdh4	physical	22442722
LAMB1_MOUSE	Lamb1	physical	22442722
CADH5_MOUSE	Cdh5	physical	22442722
CADH2_MOUSE	Cdh2	physical	22442722
PCD18_MOUSE	Pcdh18	physical	22442722
ITB5_MOUSE	Itgb5	physical	22442722
LIPA3_MOUSE	Ppfia3	physical	22442722
DCBD2_MOUSE	Dcbld2	physical	22442722
NIN_MOUSE	Nin	physical	22442722
NFL_MOUSE	Nefl	physical	22442722
TBA1A_MOUSE	Tuba1a	physical	22442722
MYL9_MOUSE	Myl9	physical	22442722
STRN4_MOUSE	Strn4	physical	22442722
THOC5_MOUSE	Thoc5	physical	22442722
TBRG1_MOUSE	Tbrg1	physical	22442722
TYDP2_MOUSE	Tdp2	physical	22442722
DNER_MOUSE	Dner	physical	22442722
CCM2_MOUSE	Ccm2	physical	22442722
QCR1_MOUSE	Uqcrc1	physical	22442722
HUWE1_MOUSE	Huwe1	physical	22442722
OTUB1_MOUSE	Otub1	physical	22442722
KI21B_MOUSE	Kif21b	physical	22442722
COPB2_MOUSE	Copb2	physical	22442722
DCTN1_MOUSE	Dctn1	physical	22442722
MCM10_MOUSE	Mcm10	physical	22442722
CND2_MOUSE	Ncaph	physical	22442722
RL28_MOUSE	Rpl28	physical	22442722
NECD_MOUSE	Ndn	physical	22442722
IFT57_MOUSE	Ift57	physical	22442722
HAP1_MOUSE	Hap1	physical	22442722
TTC4_MOUSE	Ttc4	physical	22442722
ANGL2_MOUSE	Angptl2	physical	22442722
RN114_MOUSE	Rnf114	physical	22442722
PEX19_MOUSE	Pex19	physical	22442722
KCC1A_MOUSE	Camk1	physical	22442722
RCBT2_MOUSE	Rcbtb2	physical	22442722
CHM4B_MOUSE	Chmp4b	physical	22442722
CHMP5_MOUSE	Chmp5	physical	22442722
DDX24_MOUSE	Ddx24	physical	22442722
TYW1_MOUSE	Tyw1	physical	22442722
IFFO2_MOUSE	Iffo2	physical	22442722
MIER2_MOUSE	Mier2	physical	22442722
IFFO1_MOUSE	Iffo1	physical	22442722
SOBP_MOUSE	Sobp	physical	22442722
TBCD9_MOUSE	Tbc1d9	physical	22442722
MPND_MOUSE	Mpnd	physical	22442722
CH037_MOUSE	2610301B20Rik	physical	22442722
FEZ1_MOUSE	Fez1	physical	15649943
FEZ2_MOUSE	Fez2	physical	15649943
NTRK1_MOUSE	Ntrk1	physical	16049186
CCAR1_MOUSE	Ccar1	physical	22905258
MDM2_MOUSE	Mdm2	physical	22905258
RTN4_MOUSE	Rtn4	physical	19386232
EPAS1_MOUSE	Epas1	physical	23785149
PIAS1_MOUSE	Pias1	physical	24911587
P53_MOUSE	Trp53	physical	24911587
CYS1_MOUSE	Cys1	physical	24349431
FOXO1_MOUSE	Foxo1	physical	22514318
SIR1_MOUSE	Sirt1	physical	22514318
DTBP1_HUMAN	DTNBP1	physical	21502952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.