IFT57_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFT57_MOUSE
• UniProt AC: Q8BXG3
• Protein Name: Intraflagellar transport protein 57 homolog
• Gene Name: Ift57
• Organism: Mus musculus (Mouse).
• Sequence Length: 429
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Concentrates within the inner segment of cilia.
• Protein Description: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear..
• Protein Sequence: MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVMEDLVEKLKLLRYEEELLRKSNLKPPSRHYFALPTNPGEQFYMFCTLAAWLINKTGRAFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEQVCYVLDCLAEEALKYIGFTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEETDNEENFIDLNVLKAQTYRLDTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQGNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	KSNLKPPSRHYFALP HCCCCCCCCCEEECC	39.97	-
199	Phosphorylation	EEFVEEETDNEENFI HHHHHHHCCCCCCEE	47.61	25619855
347	Phosphorylation	TERTRLLSEVTEELE HHHHHHHHHHHHHHH	34.31	26745281
350	Phosphorylation	TRLLSEVTEELEKVK HHHHHHHHHHHHHHH	21.49	26745281
410	S-nitrosocysteine	QSKLKEKCNMTRDMH HHHHHHHCCCCHHHH	4.40	-
410	S-nitrosylation	QSKLKEKCNMTRDMH HHHHHHHCCCCHHHH	4.40	21278135
421	Phosphorylation	RDMHAAVTPESAIGF HHHHCCCCHHHHCCC	19.33	26160508
424	Phosphorylation	HAAVTPESAIGFY-- HCCCCHHHHCCCC--	26.79	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFT57_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFT57_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFT57_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFT88_MOUSE	Ift88	physical	19253336

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.