| UniProt ID | IFT88_MOUSE | |
|---|---|---|
| UniProt AC | Q61371 | |
| Protein Name | Intraflagellar transport protein 88 homolog | |
| Gene Name | Ift88 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 824 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Cell projection, cilium . | |
| Protein Description | Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.. | |
| Protein Sequence | MENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANIYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSSGGSRSKREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Phosphorylation | VTAKIPSTAVSRPIA CCCCCCCCCCCCCCC | 26.23 | 29514104 | |
| 66 | Phosphorylation | AVSRPIATGYGSKTS CCCCCCCCCCCCCCC | 31.49 | 29514104 | |
| 443 | Acetylation | DTLKMFEKKDSRVKS HHHHHHHHCCHHHHH | 51.09 | 23864654 | |
| 490 | Ubiquitination | NPSALTNKGNTVFAN CHHHHCCCCCEEEEC | 48.58 | - | |
| 515 | Phosphorylation | KEALRNDSSCTEALY HHHHHCCCHHHHHHH | 30.75 | - | |
| 744 | Phosphorylation | SRSKREGSAGSDSGQ CCCCCCCCCCCCCCC | 25.38 | 23684622 | |
| 749 | Phosphorylation | EGSAGSDSGQNNSAS CCCCCCCCCCCCCCC | 43.93 | - | |
| 756 | Phosphorylation | SGQNNSASSKSERLS CCCCCCCCCHHHHHH | 37.81 | - | |
| 757 | Phosphorylation | GQNNSASSKSERLSA CCCCCCCCHHHHHHH | 39.66 | - | |
| 801 | Phosphorylation | PQIERPKTAAKKRID CCCCCCCCHHHHCCC | 34.23 | 25338131 | |
| 805 | Acetylation | RPKTAAKKRIDEDDF CCCCHHHHCCCCCCC | 50.27 | 22902405 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IFT88_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IFT88_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IFT88_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of IFT88_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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