CCAR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCAR1_MOUSE
• UniProt AC: Q8CH18
• Protein Name: Cell division cycle and apoptosis regulator protein 1
• Gene Name: Ccar1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1146
• Subcellular Localization: Cytoplasm, perinuclear region.
• Protein Description: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (By similarity). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. [PubMed: 24245781 Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells]
• Protein Sequence: MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAVLQQQYSQPQQALYSVQQQLQQPQQTILTQPAVALPTSLSLSTPQPAAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLGAVKGKTPQVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERDRERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAVLDPPDADHLYSAKVMLMASPSMEDLYHKSCALAEDPQDLRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEETHKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKKADGEQDEEEKDDGEVKEIATPTHWSKLDPKAMKVNDLRKELESRALSSKGLKSQLIARLTKQLKIEEQKEEQKELEKSEKEEEDEDDKKSEDDKEEEERKRQEEVERQRQERRYILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKDKEKKSKKEERKDKKEEREDDIDEPKPKRRKSGDDKDKKEDRDERKKEEKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEDDDREEEEVKRDDKRDVSRYCKDRPAKDKEKEKPQMVTVNRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLRESCFYRKLTDTSKDDENHEESEALQEDMLGNRLLLPTPTIKQESKDGEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREVKKDLGQLQENLEVSENMNLQFENQLNKTLRNLSTVMDDIHTVLKKDNVKSEDRDEKSKENGSGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
139	Phosphorylation	PRSSQQQTQPQKQRV CCCCCCCCCCCHHHH	37.57	22345495
189	Phosphorylation	RVLVEATYNPNMPFK EEEEEEECCCCCCCC	35.35	22817900
284	Phosphorylation	QPPVRIVSQPQPARR CCCEEEECCCCCCCC	33.50	29514104
296	Phosphorylation	ARRLDPPSRFSGRND CCCCCCCCCCCCCCC	51.88	29176673
299	Phosphorylation	LDPPSRFSGRNDRGD CCCCCCCCCCCCCCC	35.41	29176673
316	Phosphorylation	PNRKDDRSRERDRER CCCCCHHHHHHHHHH	45.55	29899451
326	Phosphorylation	RDRERRRSRERSPQR HHHHHHHHHHHCHHH	36.36	23737553
330	Phosphorylation	RRRSRERSPQRKRSR HHHHHHHCHHHHHHH	22.19	23737553
336	Phosphorylation	RSPQRKRSRERSPRR HCHHHHHHHHCCHHH	41.34	27717184
340	Phosphorylation	RKRSRERSPRRERER HHHHHHCCHHHHHHC	20.29	23384938
451	Phosphorylation	AKVMLMASPSMEDLY HEEEHHCCCCHHHHH	11.98	27600695
453	Phosphorylation	VMLMASPSMEDLYHK EEHHCCCCHHHHHHH	32.10	25338131
458	Phosphorylation	SPSMEDLYHKSCALA CCCHHHHHHHHHHHC	21.37	29550500
624	Phosphorylation	GEVKEIATPTHWSKL CCEEECCCCCCHHHC	34.09	23684622
626	Phosphorylation	VKEIATPTHWSKLDP EEECCCCCCHHHCCH	31.46	26745281
664	Phosphorylation	SQLIARLTKQLKIEE HHHHHHHHHHHHHHH	15.93	-
682	Phosphorylation	EQKELEKSEKEEEDE HHHHHHHHHHHHCCC	44.52	23684622
684	Acetylation	KELEKSEKEEEDEDD HHHHHHHHHHCCCCC	77.00	6566565
692	Acetylation	EEEDEDDKKSEDDKE HHCCCCCCCCCCHHH	71.20	6566235
694	Phosphorylation	EDEDDKKSEDDKEEE CCCCCCCCCCHHHHH	52.58	23684622
829	Phosphorylation	PKPKRRKSGDDKDKK CCCCCCCCCCCCCCC	45.72	-
852	Phosphorylation	EEKRKDDSKDDDETE HHHCCCCCCCCCCCC	48.39	23684622
858	Phosphorylation	DSKDDDETEEDNNQD CCCCCCCCCCCCCCC	52.23	25521595
946	Ubiquitination	KDLEEILYTLGLHLS HHHHHHHHHHCCCCC	12.94	27667366
988	Phosphorylation	DDENHEESEALQEDM CCCCCHHHHHHHHHH	25.78	26370283
1004	Phosphorylation	GNRLLLPTPTIKQES CCCEECCCCCCEECC	32.79	28285833
1008	Sumoylation	LLPTPTIKQESKDGE ECCCCCCEECCCCCC	50.95	28289178
1008	Ubiquitination	LLPTPTIKQESKDGE ECCCCCCEECCCCCC	50.95	27667366
1011	Phosphorylation	TPTIKQESKDGEENV CCCCEECCCCCCCCE	33.29	27600695
1071	Phosphorylation	TILNLENSNKSLSGE EEEECCCCCCCCCHH	35.94	29472430
1076	Phosphorylation	ENSNKSLSGELREVK CCCCCCCCHHHHHHH	36.99	-
1132	Phosphorylation	LKKDNVKSEDRDEKS HHHCCCCCCCCCHHH	40.21	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCAR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCAR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCAR1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NECD_MOUSE	Ndn	physical	22905258
MDM2_MOUSE	Mdm2	physical	22905258

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.