dbPTM

MDM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MDM2_MOUSE
UniProt AC	P23804
Protein Name	E3 ubiquitin-protein ligase Mdm2
Gene Name	Mdm2
Organism	Mus musculus (Mouse).
Sequence Length	489
Subcellular Localization	Nucleus, nucleoplasm . Cytoplasm . Nucleus, nucleolus . Colocalizes with RASSF1 isoform A in the nucleus (By similarity). Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleo
Protein Description	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. [PubMed: 15195100]
Protein Sequence	MCNTNMSVSTEGAASTSQIPASEQETLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVAVSQQDSGTSLSESRRQPEGGSDLKDPLQAPPEEKPSSSDLISRLSTSSRRRSISETEENTDELPGERHRKRRRSLSFDPSLGLCELREMCSGGSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQTGESDTDSFEGDPEISLADYWKCTSCNEMNPPLPSHCKRCWTLRENWLPDDKGKDKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELKEETQDKDESVESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Acetylation	QNDTYTMKEIIFYIG CCCCEEHHHHHHHHH	37.65	7626421
100	Phosphorylation	VKEHRKIYAMIYRNL HHHHHHHHHHHHHHH	7.98	22871156
111	Phosphorylation	YRNLVAVSQQDSGTS HHHHHHHHHCCCCCC	16.64	22871156
161	Phosphorylation	STSSRRRSISETEEN CCHHCCCCCCCCCCC	28.75	26824392
163	Phosphorylation	SSRRRSISETEENTD HHCCCCCCCCCCCCC	39.45	26824392
165	Phosphorylation	RRRSISETEENTDEL CCCCCCCCCCCCCCC	41.63	25619855
169	Phosphorylation	ISETEENTDELPGER CCCCCCCCCCCCCHH	33.84	25619855
183	Phosphorylation	RHRKRRRSLSFDPSL HHHHHHHHCCCCCCC	26.93	25521595
185	Phosphorylation	RKRRRSLSFDPSLGL HHHHHHCCCCCCCCH	28.93	22942356
189	Phosphorylation	RSLSFDPSLGLCELR HHCCCCCCCCHHHHH	36.59	25159016
216	Phosphorylation	SSSESTETPSHQDLD CCCCCCCCCCCCCCC	30.13	11359766
238	Phosphorylation	GDCLDQDSVSDQFSV CCCCCCCCCCCCEEE	20.21	15610030
240	Phosphorylation	CLDQDSVSDQFSVEF CCCCCCCCCCEEEEE	29.64	16055726
244	Phosphorylation	DSVSDQFSVEFEVES CCCCCCEEEEEEEEE	18.33	15610030
254	Phosphorylation	FEVESLDSEDYSLSD EEEEECCCCCCCCCC	37.35	16055726
258	Phosphorylation	SLDSEDYSLSDEGHE ECCCCCCCCCCCCCC	33.45	19833129
260	Phosphorylation	DSEDYSLSDEGHELS CCCCCCCCCCCCCCC	27.89	-
274	Phosphorylation	SDEDDEVYRVTVYQT CCCCCCEEEEEEEEC	9.41	22817900
277	Phosphorylation	DDEVYRVTVYQTGES CCCEEEEEEEECCCC	12.42	25293948
279	Phosphorylation	EVYRVTVYQTGESDT CEEEEEEEECCCCCC	7.32	22817900
281	Phosphorylation	YRVTVYQTGESDTDS EEEEEEECCCCCCCC	25.81	25293948
284	Phosphorylation	TVYQTGESDTDSFEG EEEECCCCCCCCCCC	47.34	25293948
286	Phosphorylation	YQTGESDTDSFEGDP EECCCCCCCCCCCCC	42.70	25293948
288	Phosphorylation	TGESDTDSFEGDPEI CCCCCCCCCCCCCCC	27.56	25293948
361	Ubiquitination	GLDVPDGKKLTENDA CCCCCCCCCCCCCCC	52.57	-
362	Ubiquitination	LDVPDGKKLTENDAK CCCCCCCCCCCCCCC	67.19	-
394	Phosphorylation	SQESDDYSQPSTSSS CCCCCCCCCCCCCCC	42.48	-
406	Phosphorylation	SSSIVYSSQESVKEL CCCEEECCHHHHHHH	21.93	-
417	Phosphorylation	VKELKEETQDKDESV HHHHHHHHCCCCHHH	43.06	-
423	Phosphorylation	ETQDKDESVESSFSL HHCCCCHHHHHHHCC	41.12	-
427	Phosphorylation	KDESVESSFSLNAIE CCHHHHHHHCCCCCC	12.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
163	S	Phosphorylation	Kinase	SGK1	Q9WVC6	Uniprot
163	S	Phosphorylation	Kinase	PIK3CA	P42337	PSP
163	S	Phosphorylation	Kinase	P70S6K	Q8BSK8	PSP
163	S	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
163	S	Phosphorylation	Kinase	AKT1	P31750	PSP
216	T	Phosphorylation	Kinase	CDK2	P24941	PSP
216	T	Phosphorylation	Kinase	CDK2	P97377	PSP
238	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
238	S	Phosphorylation	Kinase	KC1D	Q9DC28	PhosphoELM
240	S	Phosphorylation	Kinase	GSK-3_GROUP	-	PhosphoELM
240	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
240	S	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP
240	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
240	S	Phosphorylation	Kinase	KC1D	Q9DC28	PhosphoELM
244	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
244	S	Phosphorylation	Kinase	KC1D	Q9DC28	PhosphoELM
254	S	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP
258	S	Phosphorylation	Kinase	PLK1	P53350	PSP
267	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
394	S	Phosphorylation	Kinase	ATM	Q62388	Uniprot
406	S	Phosphorylation	Kinase	ATM	Q62388	Uniprot
417	T	Phosphorylation	Kinase	ATM	Q62388	Uniprot
423	S	Phosphorylation	Kinase	ATM	Q62388	Uniprot
427	S	Phosphorylation	Kinase	ATM	Q62388	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Btrc	Q3ULA2	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Mdm2	P23804	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
163	S	Phosphorylation	-
Phosphorylation on Ser-163 by SGK1 activates ubiquitination of p53/TP53.
163	S	ubiquitylation	-
Phosphorylation on Ser-163 by SGK1 activates ubiquitination of p53/TP53.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MDM2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RASF1_MOUSE	Rassf1	physical	18566590
P53_MOUSE	Trp53	physical	18566590
MDM2_MOUSE	Mdm2	physical	18566590
P53_MOUSE	Trp53	physical	17936560
MDM2_MOUSE	Mdm2	physical	17086174
P53_MOUSE	Trp53	physical	17086174
ARRB2_HUMAN	ARRB2	physical	19372219
P53_MOUSE	Trp53	physical	22216266
PAX3_MOUSE	Pax3	physical	22216266
UBP7_MOUSE	Usp7	physical	18566590
DAXX_MOUSE	Daxx	physical	18566590
SENP2_MOUSE	Senp2	physical	21183956
P53_MOUSE	Trp53	physical	21183956
IGF1R_MOUSE	Igf1r	physical	15878855
MDM4_MOUSE	Mdm4	physical	22666487
NBN_MOUSE	Nbn	physical	15734743
MRE11_MOUSE	Mre11a	physical	15734743
CDN2A_MOUSE	Cdkn2a	physical	10713175
ARF_MOUSE	Cdkn2a	physical	10713175
ELAV1_MOUSE	Elavl1	physical	22095636
MDM4_MOUSE	Mdm4	physical	17616658
NUMB_HUMAN	NUMB	physical	9632782
DPOE1_HUMAN	POLE	physical	10982879
P53_MOUSE	Trp53	physical	10982879
DPOE1_MOUSE	Pole	physical	10982879
CCNG1_MOUSE	Ccng1	physical	11983168
P53_MOUSE	Trp53	physical	10205143
GSK3B_MOUSE	Gsk3b	physical	21738215
P53_MOUSE	Trp53	physical	21738215
P53_MOUSE	Trp53	physical	23580573
RL11_MOUSE	Rpl11	physical	15989966
NECD_MOUSE	Ndn	physical	22905258
CCAR1_MOUSE	Ccar1	physical	22905258
ARRB2_MOUSE	Arrb2	physical	11588219
P53_MOUSE	Trp53	physical	20832751
RL11_MOUSE	Rpl11	physical	20832751
CDN2A_MOUSE	Cdkn2a	physical	20832751
ARF_MOUSE	Cdkn2a	physical	20832751
UB2D3_MOUSE	Ube2d3	physical	22216266
UB2D1_MOUSE	Ube2d1	physical	21183956
CEBPB_MOUSE	Cebpb	physical	25720496
DDX24_HUMAN	DDX24	physical	24980433
P53_HUMAN	TP53	physical	24980433
HMGB1_HUMAN	HMGB1	physical	24980433
HMGB2_HUMAN	HMGB2	physical	24980433
XRCC5_HUMAN	XRCC5	physical	24980433
RL11_HUMAN	RPL11	physical	24980433
RL3_HUMAN	RPL3	physical	24980433
RL9_HUMAN	RPL9	physical	24980433
RS10_HUMAN	RPS10	physical	24980433
RS14_HUMAN	RPS14	physical	24980433
RS19_HUMAN	RPS19	physical	24980433
RS2_HUMAN	RPS2	physical	24980433
RS25_HUMAN	RPS25	physical	24980433
RS3A_HUMAN	RPS3A	physical	24980433
RS6_HUMAN	RPS6	physical	24980433
RS7_HUMAN	RPS7	physical	24980433
RS9_HUMAN	RPS9	physical	24980433
MEP50_HUMAN	WDR77	physical	24980433
HNRPF_HUMAN	HNRNPF	physical	24980433
HNRH1_HUMAN	HNRNPH1	physical	24980433
HNRPK_HUMAN	HNRNPK	physical	24980433
RBM10_HUMAN	RBM10	physical	24980433
U520_HUMAN	SNRNP200	physical	24980433
GRWD1_HUMAN	GRWD1	physical	24980433
NUCL_HUMAN	NCL	physical	24980433
MRRP1_HUMAN	TRMT10C	physical	24980433
TCPB_HUMAN	CCT2	physical	24980433
TCPD_HUMAN	CCT4	physical	24980433
TCPE_HUMAN	CCT5	physical	24980433
PRS7_HUMAN	PSMC2	physical	24980433
TCPA_HUMAN	TCP1	physical	24980433
ECHA_HUMAN	HADHA	physical	24980433
NPM_HUMAN	NPM1	physical	24980433
1433B_HUMAN	YWHAB	physical	24980433
1433T_HUMAN	YWHAQ	physical	24980433
CDK9_HUMAN	CDK9	physical	24980433
STK38_HUMAN	STK38	physical	24980433
ST38L_HUMAN	STK38L	physical	24980433
PI42C_HUMAN	PIP4K2C	physical	24980433
RO52_HUMAN	TRIM21	physical	24980433
TR150_HUMAN	THRAP3	physical	24980433
EZRI_HUMAN	EZR	physical	24980433
SP1_MOUSE	Sp1	physical	22378045
PTC1_MOUSE	Ptch1	genetic	21437245
P53_HUMAN	TP53	physical	10202144

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MDM2_MOUSE

Related Literatures of Post-Translational Modification

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