DPOE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPOE1_HUMAN
• UniProt AC: Q07864
• Protein Name: DNA polymerase epsilon catalytic subunit A
• Gene Name: POLE
• Organism: Homo sapiens (Human).
• Sequence Length: 2286
• Subcellular Localization: Nucleus.
• Protein Description: Participates in DNA repair and in chromosomal DNA replication..
• Protein Sequence: MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQLGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSLRSGGRRRAD ---CCCCCCCCCCCC	51.39	22617229
20	Phosphorylation	PGADGEASRDDGATS CCCCCCCCCCCCCCC	31.75	25849741
26	Phosphorylation	ASRDDGATSSVSALK CCCCCCCCCCHHHHH	27.36	28985074
27	Phosphorylation	SRDDGATSSVSALKR CCCCCCCCCHHHHHH	28.36	29449344
28	Phosphorylation	RDDGATSSVSALKRL CCCCCCCCHHHHHHH	18.75	29449344
33	Ubiquitination	TSSVSALKRLERSQW CCCHHHHHHHHHHCC	55.44	29967540
43	Ubiquitination	ERSQWTDKMDLRFGF HHHCCCCCHHHHHCH	27.26	-
46	Ubiquitination	QWTDKMDLRFGFERL CCCCCHHHHHCHHHC	4.35	21963094
76	Ubiquitination	TEILDEDKRLGSAVD HHHCCCCCCCCCCEE	47.69	-
84	Phosphorylation	RLGSAVDYYFIQDDG CCCCCEEEEEEECCC	8.15	-
85	Phosphorylation	LGSAVDYYFIQDDGS CCCCEEEEEEECCCC	6.96	-
100	Phosphorylation	RFKVALPYKPYFYIA EEEEEEECCCEEEEE	25.99	-
118	Ubiquitination	GCEREVSSFLSKKFQ CCHHHHHHHHHHHHC	35.07	27667366
136	Ubiquitination	AKVETVPKEDLDLPN EEEEECCHHHCCCCC	60.57	29967540
149	Ubiquitination	PNHLVGLKRNYIRLS CCHHHHHCCCEEEEE	32.44	-
156	Phosphorylation	KRNYIRLSFHTVEDL CCCEEEEEEECHHHH	12.72	-
168	Ubiquitination	EDLVKVRKEISPAVK HHHHHHHHHHCHHHH	63.49	29967540
175	Ubiquitination	KEISPAVKKNREQDH HHHCHHHHHHHHCCC	46.57	24816145
197	Methylation	LLSSVLQRGGVITDE HHHHHHHHCCCCCCH	39.41	115488077
202	Phosphorylation	LQRGGVITDEEETSK HHHCCCCCCHHHHHH	34.65	22817900
209	Ubiquitination	TDEEETSKKIADQLD CCHHHHHHHHHHHHH	56.47	21906983
210	Ubiquitination	DEEETSKKIADQLDN CHHHHHHHHHHHHHH	42.78	23503661
220	Ubiquitination	DQLDNIVDMREYDVP HHHHHHCCHHHCCCC	26.99	21890473
233	Phosphorylation	VPYHIRLSIDLKIHV CCEEEEEEEEEEEEE	12.28	24961811
248	Phosphorylation	AHWYNVRYRGNAFPV EEEEEEEECCCEECE	20.70	29691806
290	Phosphorylation	LKFPDAETDQIMMIS CCCCCCCCCEEEEEE	34.62	24043423
297	Phosphorylation	TDQIMMISYMIDGQG CCEEEEEEEEECCCC	7.25	24043423
298	Phosphorylation	DQIMMISYMIDGQGY CEEEEEEEEECCCCE	6.28	24043423
305	Phosphorylation	YMIDGQGYLITNREI EEECCCCEEEECCEE	6.24	24043423
308	Phosphorylation	DGQGYLITNREIVSE CCCCEEEECCEEEEC	26.15	24043423
382	Phosphorylation	RAAVHGLSMQQEIGF HHHHHCCCHHHHCCC	21.09	28176443
391	Ubiquitination	QQEIGFQKDSQGEYK HHHCCCCCCCCCCCC	58.02	-
425	Ubiquitination	PVGSHNLKAAAKAKL CCCCCCHHHHHHHHC	41.10	27667366
431	Ubiquitination	LKAAAKAKLGYDPVE HHHHHHHHCCCCCCC	41.56	-
587	Ubiquitination	HALEEEEKVPVEQVT HHHHHHCCCCHHHCC	55.93	29967540
604	Ubiquitination	EEVCDEIKSKLASLK HHHHHHHHHHHHCCC	39.22	21963094
606	Ubiquitination	VCDEIKSKLASLKDV HHHHHHHHHHCCCCC	42.97	29967540
611	Ubiquitination	KSKLASLKDVPSRIE HHHHHCCCCCCCCCC	54.93	29967540
623	Phosphorylation	RIECPLIYHLDVGAM CCCCCEEEEECCCCC	12.19	22210691
637	Phosphorylation	MYPNIILTNRLQPSA CCCCEEEECCCCCCC	14.10	22210691
643	Phosphorylation	LTNRLQPSAMVDEAT EECCCCCCCCCCHHH	18.94	22210691
658	Ubiquitination	CAACDFNKPGANCQR HHHCCCCCCCCCCCC	44.84	-
666	Ubiquitination	PGANCQRKMAWQWRG CCCCCCCCCCCEECC	13.69	-
692	Phosphorylation	RIQHQLESEKFPPLF HHHHHHHHCCCCCCC	55.46	25159151
705	Methylation	LFPEGPARAFHELSR CCCCCHHHHHHHHCH	40.70	115386217
718	Phosphorylation	SREEQAKYEKRRLAD CHHHHHHHHHHHHHH	29.69	30576142
743	Ubiquitination	ITKVEERLTTICQRE CEEHHHHHHHHHHHC	5.84	21963094
773	Ubiquitination	YEFKGLHKVWKKKLS CCCCCHHHHHHHHHH	55.63	29967540
778	Ubiquitination	LHKVWKKKLSAAVEV HHHHHHHHHHHEEEC	43.90	29967540
792	Ubiquitination	VGDAAEVKRCKNMEV CCCHHHHHCCCCCHH	43.51	-
827	Phosphorylation	MRKGARWYSMEMAGI HHCCCCEEEEECCCE	7.81	24043423
828	Phosphorylation	RKGARWYSMEMAGIV HCCCCEEEEECCCEE	10.99	24043423
838	Phosphorylation	MAGIVCFTGANIITQ CCCEEEECCHHHHHH	30.20	24043423
844	Phosphorylation	FTGANIITQARELIE ECCHHHHHHHHHHHH	16.63	24043423
889	Phosphorylation	NVKKPKVTISYPGAM CCCCCEEEEECCCHH	15.44	22210691
891	Phosphorylation	KKPKVTISYPGAMLN CCCEEEEECCCHHHE	18.86	22210691
892	Phosphorylation	KPKVTISYPGAMLNI CCEEEEECCCHHHEE	11.22	22210691
917	Phosphorylation	YQELAEPSSLTYVTR HHHHCCCCCCEEEEC	29.50	28555341
969	Ubiquitination	DGSLAELKGFEVKRR CCCHHHHCCCEEEEC	53.73	29967540
1027	Phosphorylation	KAANMPDSELFELIS HHHCCCCHHHHHHHH	30.26	30257219
1042	Ubiquitination	ENRSMSRKLEDYGEQ CCHHHHHHHHHHCCC	49.25	29967540
1046	Phosphorylation	MSRKLEDYGEQKSTS HHHHHHHHCCCHHCH	17.12	25003641
1050	Ubiquitination	LEDYGEQKSTSISTA HHHHCCCHHCHHHHH	51.93	21906983
1051	Phosphorylation	EDYGEQKSTSISTAK HHHCCCHHCHHHHHH	27.38	25003641
1052	Phosphorylation	DYGEQKSTSISTAKR HHCCCHHCHHHHHHH	36.80	25003641
1058	Ubiquitination	STSISTAKRLAEFLG HCHHHHHHHHHHHHC	48.29	29967540
1061	Ubiquitination	ISTAKRLAEFLGDQM HHHHHHHHHHHCHHH	14.99	21890473
1068	Sulfoxidation	AEFLGDQMVKDAGLS HHHHCHHHHHHCCCC	4.87	21406390
1070	Ubiquitination	FLGDQMVKDAGLSCR HHCHHHHHHCCCCCE	36.20	-
1087	Phosphorylation	ISRKPEGSPVTERAI EECCCCCCCCCCCHH	17.97	28387310
1090	Phosphorylation	KPEGSPVTERAIPLA CCCCCCCCCCHHCCH	24.12	28387310
1106	Ubiquitination	FQAEPTVRKHFLRKW HCCCHHHHHHHHHHH	29.25	21890473
1120	Ubiquitination	WLKSSSLQDFDIRAI HHHCCCCCCCCHHHH	51.80	21890473
1155	Ubiquitination	PAALQQVKNPVPRVK HHHHHHCCCCCCCCC	51.72	-
1162	Ubiquitination	KNPVPRVKHPDWLHK CCCCCCCCCCCHHHH	51.18	29967540
1169	Ubiquitination	KHPDWLHKKLLEKND CCCCHHHHHHHHCCC	42.84	29967540
1174	Ubiquitination	LHKKLLEKNDVYKQK HHHHHHHCCCHHHHH	59.42	29967540
1182	Ubiquitination	NDVYKQKKISELFTL CCHHHHHHHHHHHEE	49.31	29967540
1184	Phosphorylation	VYKQKKISELFTLEG HHHHHHHHHHHEECC	36.81	20068231
1196	Phosphorylation	LEGRRQVTMAEASED ECCCEEEEHHCCCCC	11.43	29978859
1201	Phosphorylation	QVTMAEASEDSPRPS EEEHHCCCCCCCCCC	33.18	18691976
1204	Phosphorylation	MAEASEDSPRPSAPD HHCCCCCCCCCCCCC	20.82	25159151
1208	Phosphorylation	SEDSPRPSAPDMEDF CCCCCCCCCCCHHHC	54.43	26714015
1228	Phosphorylation	PHPAAPVTVKRKRVL CCCCCCCEECEEEEE	21.17	28555341
1297	Phosphorylation	RKRQRLESAEGVLRP HHHHHHHHCCCCCCC	35.89	28555341
1313	Phosphorylation	AIRDGPATGLGSFLR CCCCCCCCCHHHHHH	35.75	27080861
1317	Phosphorylation	GPATGLGSFLRRTAR CCCCCHHHHHHHHHH	26.59	23401153
1320	Methylation	TGLGSFLRRTARSIL CCHHHHHHHHHHHHH	31.71	115488069
1361	Phosphorylation	DLHCIRLSIPRVFYV CCEEHHHCCCEEEEE	22.24	24719451
1374	Ubiquitination	YVNQRVAKAEEGASY EECHHHHHHHCCCCH	54.17	-
1490	Phosphorylation	SIRHIYLYHHAQAHK CEEEEEEEEHHHHHH	3.74	22817900
1506	Phosphorylation	LFGIFIPSQRRASVF HHEEECCCCCCEEEE	31.35	24719451
1525	Phosphorylation	VRSNQMPSLGALYSA HHHCCCCCHHHHHHH	33.81	22210691
1550	Ubiquitination	PELLPPPKHTFEVRA HHHCCCCCCEEEEEC	62.14	29967540
1562	Ubiquitination	VRAETDLKTICRAIQ EECCCCHHHHHHHHH	38.36	-
1583	Phosphorylation	KEERRGPTLIAVQSS HHHHCCCEEEEEECH	33.35	27251275
1590	Phosphorylation	TLIAVQSSWELKRLA EEEEEECHHHHHHHH	13.89	27251275
1636	Phosphorylation	ARRMIRHYLNLDTCL HHHHHHHHCCHHHHH	6.35	22798277
1650	Phosphorylation	LSQAFEMSRYFHIPI HHHHHHHHHHHCCCC	19.34	22798277
1664	Ubiquitination	IGNLPEDISTFGSDL CCCCCCCHHHHCHHH	3.89	21890473
1678	Ubiquitination	LFFARHLQRHNHLLW HHHHHHHHHCCCEEE	38.16	21890473
1797	Phosphorylation	NTFRILKSMVVGWVK CHHHHHHHHHHHHHH	17.23	-
1803	Ubiquitination	KSMVVGWVKEITQYH HHHHHHHHHHHHHHH	3.07	21890473
1807	Phosphorylation	VGWVKEITQYHNIYA HHHHHHHHHHHCEEC	24.94	24043423
1809	Phosphorylation	WVKEITQYHNIYADN HHHHHHHHHCEECCC	6.54	24043423
1813	Phosphorylation	ITQYHNIYADNQVMH HHHHHCEECCCHHHH	17.14	24043423
1817	Ubiquitination	HNIYADNQVMHFYRW HCEECCCHHHHHHHH	34.16	21890473
1822	Phosphorylation	DNQVMHFYRWLRSPS CCHHHHHHHHHHCHH	6.03	24043423
1827	Phosphorylation	HFYRWLRSPSSLLHD HHHHHHHCHHHHHCC	27.28	24043423
1829	Phosphorylation	YRWLRSPSSLLHDPA HHHHHCHHHHHCCHH	34.56	24043423
1830	Phosphorylation	RWLRSPSSLLHDPAL HHHHCHHHHHCCHHH	38.03	24043423
1940	Phosphorylation	IHCGLQDSQKAGGAE EEECCCCHHCCCCCC	22.18	17525332
2018	Phosphorylation	MKDGLRRSAPGSTPV HHHCHHHCCCCCCCC	32.17	27794612
2022	Phosphorylation	LRRSAPGSTPVRRRG HHHCCCCCCCCHHCC	28.60	29396449
2023	Phosphorylation	RRSAPGSTPVRRRGA HHCCCCCCCCHHCCH	31.55	28985074
2031	Phosphorylation	PVRRRGASQLSQEAE CCHHCCHHHHHHHHH	34.18	24043423
2034	Phosphorylation	RRGASQLSQEAEGAV HCCHHHHHHHHHHHC	20.52	24043423
2049	Phosphorylation	GALPGMITFSQDYVA CCCCCCEEECHHHHH	14.35	24043423
2051	Phosphorylation	LPGMITFSQDYVANE CCCCEEECHHHHHHH	17.31	24043423
2054	Phosphorylation	MITFSQDYVANELTQ CEEECHHHHHHHHHH	8.20	24043423
2060	Phosphorylation	DYVANELTQSFFTIT HHHHHHHHHHHHHHH	18.91	24043423
2062	Phosphorylation	VANELTQSFFTITQK HHHHHHHHHHHHHHH	19.66	24043423
2065	Phosphorylation	ELTQSFFTITQKIQK HHHHHHHHHHHHHHH	22.54	24043423
2067	Phosphorylation	TQSFFTITQKIQKKV HHHHHHHHHHHHHHH	22.28	24043423
2075	Phosphorylation	QKIQKKVTGSRNSTE HHHHHHHHCCCCCCC	38.02	25627689
2077	Phosphorylation	IQKKVTGSRNSTELS HHHHHHCCCCCCCHH	20.94	25627689
2080	Phosphorylation	KVTGSRNSTELSEMF HHHCCCCCCCHHHHC	23.34	25627689
2081	Phosphorylation	VTGSRNSTELSEMFP HHCCCCCCCHHHHCC	44.48	25627689
2110	Ubiquitination	EFIKYVCKVLSLDTN HHHHHHHHHHCCCCC	35.85	21890473
2124	Ubiquitination	NITNQVNKLNRDLLR CHHHHHHHHCHHHHH	48.56	23000965
2135	Ubiquitination	DLLRLVDVGEFSEEA HHHHHCCCCCCCCCC	6.53	21890473
2215	Phosphorylation	QKKLMAFTLQDLVCL HHHHHCCHHHHHHHH	17.61	-
2223	Ubiquitination	LQDLVCLKCRGVKET HHHHHHHHCCCCCCC	19.43	23503661
2228	Ubiquitination	CLKCRGVKETSMPVY HHHCCCCCCCCCCEE	59.09	23503661
2235	Phosphorylation	KETSMPVYCSCAGDF CCCCCCEEEECCCCE	3.47	25599653
2248	Phosphorylation	DFALTIHTQVFMEQI CEEEEEHHHHHHHHH	23.68	25599653

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPOE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPOE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPOE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SLD5_HUMAN	GINS4	physical	21705323
DPOE3_HUMAN	POLE3	physical	22939629
DPOE2_HUMAN	POLE2	physical	22939629
PRI1_HUMAN	PRIM1	physical	22939629
DPOE2_HUMAN	POLE2	physical	26186194
MSH6_HUMAN	MSH6	physical	26344197
PABP1_HUMAN	PABPC1	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
DPOE2_HUMAN	POLE2	physical	26344197
PCNA_HUMAN	PCNA	physical	26903512
DPOE2_HUMAN	POLE2	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615083: Colorectal cancer 12 (CRCS12)
• 615139: Facial dysmorphism, immunodeficiency, livedo, and short stature (FILS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00242: Cladribine

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1940, AND MASSSPECTROMETRY.
PubMed: 17525332