SLD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLD5_HUMAN
• UniProt AC: Q9BRT9
• Protein Name: DNA replication complex GINS protein SLD5
• Gene Name: GINS4
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA..
• Protein Sequence: MTEEVDFLGQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEHMEENLRRAKREDLKVSIHQMEMERIRYVLSSYLRCRLMKIEKFFPHVLEKEKTRPEGEPSSLSPEELAFAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQENILVEPDTDEQRDYVIDLEKGSQHLIRYKTIAPLVASGAVQLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTEEVDFL -------CCCCCCCC	10.84	20068231
2	Acetylation	------MTEEVDFLG ------CCCCCCCCE	40.63	21406692
2	Phosphorylation	------MTEEVDFLG ------CCCCCCCCE	40.63	22115753
12	Phosphorylation	VDFLGQDSDGGSEEV CCCCEECCCCCCEEE	30.21	25159151
16	Phosphorylation	GQDSDGGSEEVVLTP EECCCCCCEEEEECH	35.79	25159151
22	Phosphorylation	GSEEVVLTPAELIER CCEEEEECHHHHHHH	14.62	22115753
47	Sumoylation	APELLESKPEIVECV CHHHHHCCHHHHHHH	36.98	-
87	Phosphorylation	MEMERIRYVLSSYLR HHHHHHHHHHHHHHH	11.90	23911959
90	Phosphorylation	ERIRYVLSSYLRCRL HHHHHHHHHHHHHHH	13.59	24719451
92	Phosphorylation	IRYVLSSYLRCRLMK HHHHHHHHHHHHHHH	8.52	23911959
94	Methylation	YVLSSYLRCRLMKIE HHHHHHHHHHHHHHH	8.69	-
102	Ubiquitination	CRLMKIEKFFPHVLE HHHHHHHHHHHHHHH	56.64	29967540
110	Ubiquitination	FFPHVLEKEKTRPEG HHHHHHHHCCCCCCC	61.42	-
112	Acetylation	PHVLEKEKTRPEGEP HHHHHHCCCCCCCCC	61.98	25953088
112	Ubiquitination	PHVLEKEKTRPEGEP HHHHHHCCCCCCCCC	61.98	29967540
121	Phosphorylation	RPEGEPSSLSPEELA CCCCCCCCCCHHHHH	43.51	29214152
123	Phosphorylation	EGEPSSLSPEELAFA CCCCCCCCHHHHHHH	32.01	25159151
142	Ubiquitination	ANTESYLKNVALKHM HCCHHHHHHHHHHCC	40.94	29967540
164 (in isoform 1)	Ubiquitination	-	44.56	21890473
164	Ubiquitination	DLFRAVPKPDLDSYV CEEECCCCCCCCCEE	44.56	22817900
194	Phosphorylation	DTDEQRDYVIDLEKG CCHHHCCEEEECCCC	11.07	27642862
200	Ubiquitination	DYVIDLEKGSQHLIR CEEEECCCCCEEEEE	71.77	33845483
209	Ubiquitination	SQHLIRYKTIAPLVA CEEEEEHHHHHHHHH	24.49	-
210	Phosphorylation	QHLIRYKTIAPLVAS EEEEEHHHHHHHHHC	17.28	-
217	Phosphorylation	TIAPLVASGAVQLI- HHHHHHHCCCEECC-	21.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSF3_HUMAN	GINS3	physical	21705323
PSF1_HUMAN	GINS1	physical	21705323
PSF2_HUMAN	GINS2	physical	21705323
ARLY_HUMAN	ASL	physical	22863883
LDHB_HUMAN	LDHB	physical	22863883
1433Z_HUMAN	YWHAZ	physical	22863883
WDHD1_HUMAN	WDHD1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.