dbPTM

WDHD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDHD1_HUMAN
UniProt AC	O75717
Protein Name	WD repeat and HMG-box DNA-binding protein 1
Gene Name	WDHD1
Organism	Homo sapiens (Human).
Sequence Length	1129
Subcellular Localization	Nucleus, nucleoplasm.
Protein Description	Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication..
Protein Sequence	MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPATRKPMRYG ----CCCCCCCCCCC	50.37	-
7	Ubiquitination	-MPATRKPMRYGHTE -CCCCCCCCCCCCCC	14.81	22817900
10	Phosphorylation	ATRKPMRYGHTEGHT CCCCCCCCCCCCCCC	13.65	22210691
13	Phosphorylation	KPMRYGHTEGHTEVC CCCCCCCCCCCCEEE	39.02	22210691
30	Phosphorylation	DSGSFIVTCGSDGDV CCCCEEEEECCCCCE	13.31	-
33	Phosphorylation	SFIVTCGSDGDVRIW CEEEEECCCCCEEEE	40.33	22210691
49	Ubiquitination	DLDDDDPKFINVGEK CCCCCCCCCCCHHHH	66.91	29967540
56	Acetylation	KFINVGEKAYSCALK CCCCHHHHHHHHHHH	46.85	26051181
56	Ubiquitination	KFINVGEKAYSCALK CCCCHHHHHHHHHHH	46.85	29967540
63	Ubiquitination	KAYSCALKSGKLVTA HHHHHHHHCCCEEEE	38.34	29967540
64	Ubiquitination	AYSCALKSGKLVTAV HHHHHHHCCCEEEEE	41.85	-
64	Ubiquitination	AYSCALKSGKLVTAV HHHHHHHCCCEEEEE	41.85	29967540
66	Acetylation	SCALKSGKLVTAVSN HHHHHCCCEEEEEEC	47.04	26051181
66	Ubiquitination	SCALKSGKLVTAVSN HHHHHCCCEEEEEEC	47.04	29967540
74	Ubiquitination	LVTAVSNNTIQVHTF EEEEEECCEEEEEEC	30.93	-
74	Ubiquitination	LVTAVSNNTIQVHTF EEEEEECCEEEEEEC	30.93	29967540
77	Ubiquitination	AVSNNTIQVHTFPEG EEECCEEEEEECCCC	20.92	33845483
85	Ubiquitination	VHTFPEGVPDGILTR EEECCCCCCCCEEEE	3.58	-
85	Ubiquitination	VHTFPEGVPDGILTR EEECCCCCCCCEEEE	3.58	32015554
88	Ubiquitination	FPEGVPDGILTRFTT CCCCCCCCEEEEEEC	15.67	-
108	Ubiquitination	VFNGDGTKIAAGSSD EECCCCCEECCCCCC	35.56	29967540
119	Ubiquitination	GSSDFLVKIVDVMDS CCCCEEEEEEEECCH	38.88	29967540
124	Sulfoxidation	LVKIVDVMDSSQQKT EEEEEEECCHHCCCE	3.42	21406390
126	Phosphorylation	KIVDVMDSSQQKTFR EEEEECCHHCCCEEC	16.38	30576142
127	Phosphorylation	IVDVMDSSQQKTFRG EEEECCHHCCCEECC	32.16	-
130	Ubiquitination	VMDSSQQKTFRGHDA ECCHHCCCEECCCCC	41.83	21906983
131	Phosphorylation	MDSSQQKTFRGHDAP CCHHCCCEECCCCCC	17.77	-
141	Phosphorylation	GHDAPVLSLSFDPKD CCCCCEEEEEECHHH	23.38	25599653
149	Ubiquitination	LSFDPKDIFLASASC EEECHHHEEEEEEEC	3.68	29967540
186	Ubiquitination	KCNDVINAKSICRLA HCCCCCCHHHHHHHH	8.89	-
186	Ubiquitination	KCNDVINAKSICRLA HCCCCCCHHHHHHHH	8.89	29967540
187	Ubiquitination	CNDVINAKSICRLAW CCCCCCHHHHHHHHC	35.55	29967540
191	Ubiquitination	INAKSICRLAWQPKS CCHHHHHHHHCCCCC	26.27	29967540
197	Ubiquitination	CRLAWQPKSGKLLAI HHHHCCCCCCCEEEE	57.66	29967540
200	Acetylation	AWQPKSGKLLAIPVE HCCCCCCCEEEEECH	47.63	25953088
200	Sumoylation	AWQPKSGKLLAIPVE HCCCCCCCEEEEECH	47.63	-
200	Ubiquitination	AWQPKSGKLLAIPVE HCCCCCCCEEEEECH	47.63	33845483
208	Ubiquitination	LLAIPVEKSVKLYRR EEEEECHHHHHHHCC	61.86	32015554
211	Ubiquitination	IPVEKSVKLYRRESW EECHHHHHHHCCCCC	47.06	-
267	Ubiquitination	ETKDCMERVKHEKGY CCHHHHHHHHHCCCE	18.85	32015554
272	Ubiquitination	MERVKHEKGYAICGL HHHHHHCCCEEEEEE	57.87	29967540
307	Phosphorylation	LENVCDPSGKTSSSK HHCEECCCCCCCCHH	39.40	21712546
309	Acetylation	NVCDPSGKTSSSKVS CEECCCCCCCCHHHH	49.96	25953088
309	Ubiquitination	NVCDPSGKTSSSKVS CEECCCCCCCCHHHH	49.96	29967540
310	Phosphorylation	VCDPSGKTSSSKVSS EECCCCCCCCHHHHH	37.05	25159151
311	Phosphorylation	CDPSGKTSSSKVSSR ECCCCCCCCHHHHHH	35.78	21712546
313	Phosphorylation	PSGKTSSSKVSSRVE CCCCCCCHHHHHHHC	36.52	25627689
314	Ubiquitination	SGKTSSSKVSSRVEK CCCCCCHHHHHHHCC	48.35	29967540
323	Phosphorylation	SSRVEKDYNDLFDGD HHHHCCCCCCCCCCC	22.95	17081983
333	Phosphorylation	LFDGDDMSNAGDFLN CCCCCCCCCCHHHHC	30.44	28731282
348	Phosphorylation	DNAVEIPSFSKGIIN CCCEECCCCCCCCCC	48.06	22199227
350	Phosphorylation	AVEIPSFSKGIINDD CEECCCCCCCCCCCC	34.02	22199227
364	Sulfoxidation	DEDDEDLMMASGRPR CCCHHHHHHHCCCCC	3.05	21406390
367	Phosphorylation	DEDLMMASGRPRQRS HHHHHHHCCCCCCCC	19.89	25159151
374	Phosphorylation	SGRPRQRSHILEDDE CCCCCCCCCCCCCCC	13.41	23927012
383	Phosphorylation	ILEDDENSVDISMLK CCCCCCCCEEHHHHH	21.08	29255136
387	Phosphorylation	DENSVDISMLKTGSS CCCCEEHHHHHCCCH	17.38	22167270
390	Ubiquitination	SVDISMLKTGSSLLK CEEHHHHHCCCHHHH	42.05	32015554
391	Phosphorylation	VDISMLKTGSSLLKE EEHHHHHCCCHHHHH	38.03	20873877
393	Phosphorylation	ISMLKTGSSLLKEEE HHHHHCCCHHHHHHH	24.04	23898821
394	Phosphorylation	SMLKTGSSLLKEEEE HHHHCCCHHHHHHHC	38.78	28102081
397	Sumoylation	KTGSSLLKEEEEDGQ HCCCHHHHHHHCCCC	69.26	28112733
407	Phosphorylation	EEDGQEGSIHNLPLV HCCCCCCCCCCCCEE	21.66	23401153
415	Phosphorylation	IHNLPLVTSQRPFYD CCCCCEECCCCCCCC	27.16	30576142
416	Phosphorylation	HNLPLVTSQRPFYDG CCCCEECCCCCCCCC	19.40	30576142
421	Phosphorylation	VTSQRPFYDGPMPTP ECCCCCCCCCCCCCC	23.75	30576142
427	Phosphorylation	FYDGPMPTPRQKPFQ CCCCCCCCCCCCCCC	25.50	26074081
442	Ubiquitination	SGSTPLHLTHRFMVW CCCCCCEEEECCEEC	5.94	23000965
448	Ubiquitination	HLTHRFMVWNSIGII EEEECCEECCEEEEE	3.93	21890473
487	Ubiquitination	HLSNTLNYTIADLSH HHHHHCCEEHHHCCH	11.57	29967540
488	Ubiquitination	LSNTLNYTIADLSHE HHHHCCEEHHHCCHH	14.49	29967540
548	Ubiquitination	GQGWAAAATSALLLR CCHHHHHHHHHHHHH	9.43	32015554
556	Ubiquitination	TSALLLRLFTIGGVQ HHHHHHHHHHHCCCC	4.47	24816145
558	Ubiquitination	ALLLRLFTIGGVQKE HHHHHHHHHCCCCHH	24.25	24816145
580	Ubiquitination	VVSMAGHGEQLFIVY EEEECCCCCEEEEEE	24.35	24816145
582	Ubiquitination	SMAGHGEQLFIVYHR EECCCCCEEEEEEEC	46.39	24816145
591	Phosphorylation	FIVYHRGTGFDGDQC EEEEECCCCCCHHHH	34.33	-
597	Ubiquitination	GTGFDGDQCLGVQLL CCCCCHHHHHHHHHH	29.84	27667366
599	Ubiquitination	GFDGDQCLGVQLLEL CCCHHHHHHHHHHHC	6.64	27667366
610	Ubiquitination	LLELGKKKKQILHGD HHHCCCCCCHHHCCC	54.09	29967540
611	Ubiquitination	LELGKKKKQILHGDP HHCCCCCCHHHCCCC	51.99	29967540
621	Ubiquitination	LHGDPLPLTRKSYLA HCCCCCCCCCCEEEE	10.75	-
625	Phosphorylation	PLPLTRKSYLAWIGF CCCCCCCEEEEEEEE	23.30	25907765
626	Phosphorylation	LPLTRKSYLAWIGFS CCCCCCEEEEEEEEC	11.95	25907765
631	Ubiquitination	KSYLAWIGFSAEGTP CEEEEEEEECCCCCC	10.35	-
633	Phosphorylation	YLAWIGFSAEGTPCY EEEEEEECCCCCCCE	21.87	25907765
636	Ubiquitination	WIGFSAEGTPCYVDS EEEECCCCCCCEECC	34.37	-
636	Ubiquitination	WIGFSAEGTPCYVDS EEEECCCCCCCEECC	34.37	29967540
637	Phosphorylation	IGFSAEGTPCYVDSE EEECCCCCCCEECCH	11.16	25907765
640	Phosphorylation	SAEGTPCYVDSEGIV CCCCCCCEECCHHHH	14.43	25907765
643	Phosphorylation	GTPCYVDSEGIVRML CCCCEECCHHHHHHH	27.90	25907765
644	Ubiquitination	TPCYVDSEGIVRMLN CCCEECCHHHHHHHH	48.77	32015554
651	Ubiquitination	EGIVRMLNRGLGNTW HHHHHHHHCCCCCCE	26.99	-
651	Ubiquitination	EGIVRMLNRGLGNTW HHHHHHHHCCCCCCE	26.99	33845483
671	Acetylation	TREHCKGKSDHYWVV CCHHHCCCCCCEEEE	37.90	30583533
671	Ubiquitination	TREHCKGKSDHYWVV CCHHHCCCCCCEEEE	37.90	32015554
682	Ubiquitination	YWVVGIHENPQQLRC EEEEEECCCCCCEEE	69.55	-
682	Ubiquitination	YWVVGIHENPQQLRC EEEEEECCCCCCEEE	69.55	23000965
683	Ubiquitination	WVVGIHENPQQLRCI EEEEECCCCCCEEEE	26.05	24816145
685	Ubiquitination	VGIHENPQQLRCIPC EEECCCCCCEEEEEC	67.53	24816145
688	Ubiquitination	HENPQQLRCIPCKGS CCCCCCEEEEECCCC	16.39	21890473
688	Ubiquitination	HENPQQLRCIPCKGS CCCCCCEEEEECCCC	16.39	23000965
696	Ubiquitination	CIPCKGSRFPPTLPR EEECCCCCCCCCCCC	57.68	29967540
710	Phosphorylation	RPAVAILSFKLPYCQ CCCEEEEEEECCCCE	17.77	24719451
717	Ubiquitination	SFKLPYCQIATEKGQ EEECCCCEEECCCCC	23.62	-
717	Ubiquitination	SFKLPYCQIATEKGQ EEECCCCEEECCCCC	23.62	29967540
744	Ubiquitination	NHLDYLAKNGYEYEE HHHHHHHHCCCCCHH	48.59	-
745	Phosphorylation	HLDYLAKNGYEYEES HHHHHHHCCCCCHHH	53.31	32645325
754	Ubiquitination	YEYEESTKNQATKEQ CCCHHHHCCCCCHHH	57.23	-
759	Ubiquitination	STKNQATKEQQELLM HHCCCCCHHHHHHHH	57.45	29967540
767	Ubiquitination	EQQELLMKMLALSCK HHHHHHHHHHHHHCH	30.63	32015554
774	Acetylation	KMLALSCKLEREFRC HHHHHHCHHHHHHHH	50.43	25953088
774	Ubiquitination	KMLALSCKLEREFRC HHHHHHCHHHHHHHH	50.43	33845483
776	Ubiquitination	LALSCKLEREFRCVE HHHHCHHHHHHHHHH	35.34	32015554
792	Ubiquitination	ADLMTQNAVNLAIKY HHHHHHHHHHHHHHH	5.03	29967540
796	Ubiquitination	TQNAVNLAIKYASRS HHHHHHHHHHHHHHC	7.33	24816145
798	Ubiquitination	NAVNLAIKYASRSRK HHHHHHHHHHHHCHH	29.20	24816145
799	Phosphorylation	AVNLAIKYASRSRKL HHHHHHHHHHHCHHH	12.05	20363803
801	Phosphorylation	NLAIKYASRSRKLIL HHHHHHHHHCHHHHH	27.91	20363803
803	Phosphorylation	AIKYASRSRKLILAQ HHHHHHHCHHHHHHH	31.13	20363803
805	Ubiquitination	KYASRSRKLILAQKL HHHHHCHHHHHHHHH	40.92	23000965
811	Ubiquitination	RKLILAQKLSELAVE HHHHHHHHHHHHHHH	48.66	23000965
813	Phosphorylation	LILAQKLSELAVEKA HHHHHHHHHHHHHHH	37.28	-
819	Ubiquitination	LSELAVEKAAELTAT HHHHHHHHHHHCCCC	46.42	29967540
820	Ubiquitination	SELAVEKAAELTATQ HHHHHHHHHHCCCCC	7.83	24816145
822	Ubiquitination	LAVEKAAELTATQVE HHHHHHHHCCCCCCC	52.06	24816145
824	Phosphorylation	VEKAAELTATQVEEE HHHHHHCCCCCCCHH	21.11	17525332
826	Phosphorylation	KAAELTATQVEEEEE HHHHCCCCCCCHHHH	28.10	17525332
834	Ubiquitination	QVEEEEEEEDFRKKL CCCHHHHHHHHHHHH	67.17	33845483
837	Ubiquitination	EEEEEEDFRKKLNAG HHHHHHHHHHHHHCC	16.25	27667366
839	Acetylation	EEEEDFRKKLNAGYS HHHHHHHHHHHCCCC	62.70	-
839	Acetylation	EEEEDFRKKLNAGYS HHHHHHHHHHHCCCC	62.70	19608861
839	Ubiquitination	EEEEDFRKKLNAGYS HHHHHHHHHHHCCCC	62.70	27667366
840	Sumoylation	EEEDFRKKLNAGYSN HHHHHHHHHHCCCCC	42.59	-
840	Sumoylation	EEEDFRKKLNAGYSN HHHHHHHHHHCCCCC	42.59	-
840	Ubiquitination	EEEDFRKKLNAGYSN HHHHHHHHHHCCCCC	42.59	29967540
845	Phosphorylation	RKKLNAGYSNTATEW HHHHHCCCCCCCCCC	9.06	27251275
846	Phosphorylation	KKLNAGYSNTATEWS HHHHCCCCCCCCCCC	27.13	28450419
848	Phosphorylation	LNAGYSNTATEWSQP HHCCCCCCCCCCCCH	29.08	28450419
848	Ubiquitination	LNAGYSNTATEWSQP HHCCCCCCCCCCCCH	29.08	29967540
850	Phosphorylation	AGYSNTATEWSQPRF CCCCCCCCCCCCHHH	35.63	27251275
853	Phosphorylation	SNTATEWSQPRFRNQ CCCCCCCCCHHHHHH	24.87	21815630
868	Phosphorylation	VEEDAEDSGEADDEE HHHCHHHCCCCCCCC	30.00	23927012
886	Phosphorylation	IHKPGQNSFSKSTNS CCCCCCCCCCCCCCC	24.02	23401153
888	Phosphorylation	KPGQNSFSKSTNSSD CCCCCCCCCCCCCCC	26.05	23401153
893	Phosphorylation	SFSKSTNSSDVSAKS CCCCCCCCCCCCCCC	28.18	30576142
899	Acetylation	NSSDVSAKSGAVTFS CCCCCCCCCCCEEEC	41.75	25953088
899	Ubiquitination	NSSDVSAKSGAVTFS CCCCCCCCCCCEEEC	41.75	32015554
900	Phosphorylation	SSDVSAKSGAVTFSS CCCCCCCCCCEEECC	31.53	28555341
904	Phosphorylation	SAKSGAVTFSSQGRV CCCCCCEEECCCCCC	19.77	30576142
906	Phosphorylation	KSGAVTFSSQGRVNP CCCCEEECCCCCCCC	16.64	30576142
907	Phosphorylation	SGAVTFSSQGRVNPF CCCEEECCCCCCCCE	32.25	20164059
915	Methylation	QGRVNPFKVSASSKE CCCCCCEEEECCCCC	36.22	115978713
915	Ubiquitination	QGRVNPFKVSASSKE CCCCCCEEEECCCCC	36.22	29967540
917	Phosphorylation	RVNPFKVSASSKEPA CCCCEEEECCCCCCC	24.03	20068231
919	Phosphorylation	NPFKVSASSKEPAMS CCEEEECCCCCCCHH	34.14	20068231
919	Ubiquitination	NPFKVSASSKEPAMS CCEEEECCCCCCCHH	34.14	24816145
920	Phosphorylation	PFKVSASSKEPAMSM CEEEECCCCCCCHHC	40.53	20068231
921	Ubiquitination	FKVSASSKEPAMSMN EEEECCCCCCCHHCC	66.28	24816145
923	Ubiquitination	VSASSKEPAMSMNSA EECCCCCCCHHCCCH	36.68	24816145
925	Ubiquitination	ASSKEPAMSMNSARS CCCCCCCHHCCCHHH	5.97	24816145
926	Phosphorylation	SSKEPAMSMNSARST CCCCCCHHCCCHHHC	19.54	20068231
929	Phosphorylation	EPAMSMNSARSTNIL CCCHHCCCHHHCCHH	19.20	20068231
932	Phosphorylation	MSMNSARSTNILDNM HHCCCHHHCCHHHHC	26.06	28450419
933	Phosphorylation	SMNSARSTNILDNMG HCCCHHHCCHHHHCC	22.26	28450419
939	Sulfoxidation	STNILDNMGKSSKKS HCCHHHHCCCCCCHH	7.74	21406390
941	Acetylation	NILDNMGKSSKKSTA CHHHHCCCCCCHHHH	40.56	25953088
942	Phosphorylation	ILDNMGKSSKKSTAL HHHHCCCCCCHHHHC	41.48	29214152
943	Ubiquitination	LDNMGKSSKKSTALS HHHCCCCCCHHHHCC	47.81	24816145
945	Ubiquitination	NMGKSSKKSTALSRT HCCCCCCHHHHCCCC	55.79	24816145
952	Phosphorylation	KSTALSRTTNNEKSP HHHHCCCCCCCCCCC	30.42	23927012
953	Phosphorylation	STALSRTTNNEKSPI HHHCCCCCCCCCCCC	34.63	23927012
957	Ubiquitination	SRTTNNEKSPIIKPL CCCCCCCCCCCCCCC	64.75	33845483
958	Phosphorylation	RTTNNEKSPIIKPLI CCCCCCCCCCCCCCC	18.36	23927012
958	Ubiquitination	RTTNNEKSPIIKPLI CCCCCCCCCCCCCCC	18.36	33845483
960	Ubiquitination	TNNEKSPIIKPLIPK CCCCCCCCCCCCCCC	9.03	27667366
962	Acetylation	NEKSPIIKPLIPKPK CCCCCCCCCCCCCCC	34.19	19608861
962	Ubiquitination	NEKSPIIKPLIPKPK CCCCCCCCCCCCCCC	34.19	27667366
971	Ubiquitination	LIPKPKPKQASAASY CCCCCCCCCCCHHHH	65.70	29967540
974	Phosphorylation	KPKPKQASAASYFQK CCCCCCCCHHHHHHH	23.13	28555341
976	Ubiquitination	KPKQASAASYFQKRN CCCCCCHHHHHHHHC	11.41	33845483
977	Phosphorylation	PKQASAASYFQKRNS CCCCCHHHHHHHHCC	26.62	-
978	Phosphorylation	KQASAASYFQKRNSQ CCCCHHHHHHHHCCC	12.80	-
984	Phosphorylation	SYFQKRNSQTNKTEE HHHHHHCCCCCCCHH	42.27	30576142
986	Phosphorylation	FQKRNSQTNKTEEVK HHHHCCCCCCCHHHH	38.20	30576142
989	Phosphorylation	RNSQTNKTEEVKEEN HCCCCCCCHHHHHHH	39.17	26074081
997	Ubiquitination	EEVKEENLKNVLSET HHHHHHHHHHHHHCC	4.89	33845483
1004	Acetylation	LKNVLSETPAICPPQ HHHHHHCCCCCCCCC	18.04	-
1004	Acetylation	LKNVLSETPAICPPQ HHHHHHCCCCCCCCC	18.04	19608861
1004	Phosphorylation	LKNVLSETPAICPPQ HHHHHHCCCCCCCCC	18.04	28555341
1013	Phosphorylation	AICPPQNTENQRPKT CCCCCCCCCCCCCCC	30.94	25599653
1041	Phosphorylation	LSDNPDFSDEADIIK CCCCCCCCCHHHHHH	41.75	21082442
1046	Ubiquitination	DFSDEADIIKEGMIR CCCCHHHHHHHCCEE	6.63	24816145
1048	Ubiquitination	SDEADIIKEGMIRFR CCHHHHHHHCCEEEE	48.85	24816145
1058	Phosphorylation	MIRFRVLSTEERKVW CEEEEECCHHHHHHH	30.80	29396449
1059	Phosphorylation	IRFRVLSTEERKVWA EEEEECCHHHHHHHC	37.39	21815630
1063	Acetylation	VLSTEERKVWANKAK ECCHHHHHHHCHHCC	45.46	7662305
1068	Acetylation	ERKVWANKAKGETAS HHHHHCHHCCCCCCC	43.67	7662315
1070	Acetylation	KVWANKAKGETASEG HHHCHHCCCCCCCCC	59.91	7662325
1081	Ubiquitination	ASEGTEAKKRKRVVD CCCCCCHHHHHCCCC	47.05	33845483
1090	Phosphorylation	RKRVVDESDETENQE HHCCCCCCCCCCCHH	35.96	29255136
1093	Phosphorylation	VVDESDETENQEEKA CCCCCCCCCCHHHHH	45.27	29255136
1099	Ubiquitination	ETENQEEKAKENLNL CCCCHHHHHHHHCCC	65.10	33845483
1101	Acetylation	ENQEEKAKENLNLSK CCHHHHHHHHCCCCC	59.19	12431223
1107	Phosphorylation	AKENLNLSKKQKPLD HHHHCCCCCCCCCCC	36.41	21815630
1108	Acetylation	KENLNLSKKQKPLDF HHHCCCCCCCCCCCC	63.49	25953088
1116	Phosphorylation	KQKPLDFSTNQKLSA CCCCCCCCCCCCEEE	26.56	29083192
1117	Phosphorylation	QKPLDFSTNQKLSAF CCCCCCCCCCCEEEE	41.48	29083192
1120	Acetylation	LDFSTNQKLSAFAFK CCCCCCCCEEEEEEC	46.62	25953088
1120	Ubiquitination	LDFSTNQKLSAFAFK CCCCCCCCEEEEEEC	46.62	33845483
1127	Sumoylation	KLSAFAFKQE----- CEEEEEECCC-----	50.52	-
1127	Acetylation	KLSAFAFKQE----- CEEEEEECCC-----	50.52	23749302
1127	Sumoylation	KLSAFAFKQE----- CEEEEEECCC-----	50.52	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
826	T	Phosphorylation	Kinase	ATR	Q13535	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDHD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDHD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT2A_HUMAN	KAT2A	physical	21987584
H32_HUMAN	HIST2H3C	physical	21725360
KAT2A_HUMAN	KAT2A	physical	21725360
ZMYM3_HUMAN	ZMYM3	physical	22939629
MAP4_HUMAN	MAP4	physical	22863883
PSF3_HUMAN	GINS3	physical	26344197
SF3A3_HUMAN	SF3A3	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDHD1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-962 AND LYS-1127, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-374 ANDSER-383, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-868, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-383; SER-387;SER-868 AND SER-1090, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-383 ANDSER-868, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1041, AND MASSSPECTROMETRY.	15302935 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-826, AND MASSSPECTROMETRY.	17525332 [Abstract]