PSF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSF3_HUMAN
• UniProt AC: Q9BRX5
• Protein Name: DNA replication complex GINS protein PSF3
• Gene Name: GINS3
• Organism: Homo sapiens (Human).
• Sequence Length: 216
• Subcellular Localization: Nucleus.
• Protein Description: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA..
• Protein Sequence: MSEAYFRVESGALGPEENFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDSPENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQKGLNDFQCWEKGQASQITASNLVQNYKKRKFTDMED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	DILMSHEKLPVRTET HHHHCCCCCCCCCCC	53.30	-
63 (in isoform 2)	Phosphorylation	-	22.22	27174698
65	Ubiquitination	NAVPQGSKLELPLWL CCCCCCCCCCHHHHH	53.45	-
74	Ubiquitination	ELPLWLAKGLFDNKR CHHHHHHHCCCCCCC	54.71	-
74 (in isoform 2)	Phosphorylation	-	54.71	27174698
75 (in isoform 2)	Phosphorylation	-	26.43	27174698
79 (in isoform 2)	Phosphorylation	-	32.19	27174698
80	Ubiquitination	AKGLFDNKRRILSVE HHCCCCCCCEEEEEE	44.92	-
80	Acetylation	AKGLFDNKRRILSVE HHCCCCCCCEEEEEE	44.92	25953088
80	2-Hydroxyisobutyrylation	AKGLFDNKRRILSVE HHCCCCCCCEEEEEE	44.92	-
83 (in isoform 2)	Phosphorylation	-	3.79	27174698
84 (in isoform 2)	Phosphorylation	-	4.44	27174698
90 (in isoform 1)	Ubiquitination	-	67.67	21890473
90	Ubiquitination	ILSVELPKIYQEGWR EEEEECCHHHHCCHH	67.67	21890473
90	Acetylation	ILSVELPKIYQEGWR EEEEECCHHHHCCHH	67.67	23954790
117	Phosphorylation	HKMGPHFYGFGSQLL HHCCCCCCCCCCCCC	14.44	26074081
121	Phosphorylation	PHFYGFGSQLLHFDS CCCCCCCCCCCCCCC	18.52	26074081
128	Phosphorylation	SQLLHFDSPENADIS CCCCCCCCCCCCCCC	32.92	26074081
181	Ubiquitination	GLFQTGQKGLNDFQC HHHHCCCCCCCCCCH	67.71	-
191	Ubiquitination	NDFQCWEKGQASQIT CCCCHHHCCCCHHCC	31.64	-
195	Phosphorylation	CWEKGQASQITASNL HHHCCCCHHCCHHHH	17.77	25159151
207	Ubiquitination	SNLVQNYKKRKFTDM HHHHHHHHHCCCCCC	54.36	-
207	Acetylation	SNLVQNYKKRKFTDM HHHHHHHHHCCCCCC	54.36	24469663
212	Phosphorylation	NYKKRKFTDMED--- HHHHCCCCCCCC---	37.15	24719451
251 (in isoform 3)	Phosphorylation	-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SLD5_HUMAN	GINS4	physical	22939629
PSF2_HUMAN	GINS2	physical	26186194
MCM7_HUMAN	MCM7	physical	26186194
TIM_HUMAN	TIMELESS	physical	26186194
PSF1_HUMAN	GINS1	physical	26186194
MCM2_HUMAN	MCM2	physical	26186194
SLD5_HUMAN	GINS4	physical	26186194
CLSPN_HUMAN	CLSPN	physical	26186194
TIPIN_HUMAN	TIPIN	physical	26186194
PSF1_HUMAN	GINS1	physical	26344197
PSF2_HUMAN	GINS2	physical	26344197
SLD5_HUMAN	GINS4	physical	26344197
PSF2_HUMAN	GINS2	physical	28514442
SLD5_HUMAN	GINS4	physical	28514442
PSF1_HUMAN	GINS1	physical	28514442
CLSPN_HUMAN	CLSPN	physical	28514442
TIM_HUMAN	TIMELESS	physical	28514442
TIPIN_HUMAN	TIPIN	physical	28514442
MCM7_HUMAN	MCM7	physical	28514442
SSRP1_HUMAN	SSRP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.