PSF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSF1_HUMAN
• UniProt AC: Q14691
• Protein Name: DNA replication complex GINS protein PSF1
• Gene Name: GINS1
• Organism: Homo sapiens (Human).
• Sequence Length: 196
• Subcellular Localization: Nucleus.
• Protein Description: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function..
• Protein Sequence: MFCEKAMELIRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSGGRSDLIPTIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNALRFHMAAEEMEWFNNYKRSLATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVDDGTSVLLKKNSQHFLPRWKCEQLIRQGVLEHILS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MFCEKAMELIRE ---CHHHHHHHHHHH	54.97	24816145
16	Ubiquitination	LIRELHRAPEGQLPA HHHHHHCCCCCCCCC	8.85	27667366
28	Ubiquitination	LPAFNEDGLRQVLEE CCCCCHHHHHHHHHH	19.31	21890473
37	Ubiquitination	RQVLEEMKALYEQNQ HHHHHHHHHHHHHCH	38.22	21906983
40	Phosphorylation	LEEMKALYEQNQSDV HHHHHHHHHHCHHHH	21.96	-
45	Phosphorylation	ALYEQNQSDVNEAKS HHHHHCHHHHHHHHC	51.59	-
51	Acetylation	QSDVNEAKSGGRSDL HHHHHHHHCCCCCCC	43.38	25953088
51	Ubiquitination	QSDVNEAKSGGRSDL HHHHHHHHCCCCCCC	43.38	21906983
52	Phosphorylation	SDVNEAKSGGRSDLI HHHHHHHCCCCCCCC	54.23	-
56	Phosphorylation	EAKSGGRSDLIPTIK HHHCCCCCCCCCEEC	39.79	-
63	Ubiquitination	SDLIPTIKFRHCSLL CCCCCEECHHCHHHH	38.53	21906983
63	Acetylation	SDLIPTIKFRHCSLL CCCCCEECHHCHHHH	38.53	23749302
123	Phosphorylation	NYKRSLATYMRSLGG HHHHHHHHHHHHCCC	24.12	25262027
124	Phosphorylation	YKRSLATYMRSLGGD HHHHHHHHHHHCCCC	5.73	25262027
141	Ubiquitination	LDITQDMKPPKSLYI CCCCCCCCCCCEEEE	67.47	-
156	Phosphorylation	EVRCLKDYGEFEVDD EEEEECCCCCEEECC	19.57	-
165	Phosphorylation	EFEVDDGTSVLLKKN CEEECCCCEEEEECC	23.74	-
166	Phosphorylation	FEVDDGTSVLLKKNS EEECCCCEEEEECCC	19.12	-
170	Ubiquitination	DGTSVLLKKNSQHFL CCCEEEEECCCCCCC	45.83	29967540
171	Ubiquitination	GTSVLLKKNSQHFLP CCEEEEECCCCCCCC	62.90	29967540
181	Ubiquitination	QHFLPRWKCEQLIRQ CCCCCHHHHHHHHHH	29.22	29967540
196	Phosphorylation	GVLEHILS------- HHHHHHHC-------	37.26	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSF3_HUMAN	GINS3	physical	21705323
SLD5_HUMAN	GINS4	physical	21705323
PSF2_HUMAN	GINS2	physical	22939629
SLD5_HUMAN	GINS4	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.