dbPTM

ARLY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARLY_HUMAN
UniProt AC	P04424
Protein Name	Argininosuccinate lyase
Gene Name	ASL
Organism	Homo sapiens (Human).
Sequence Length	464
Subcellular Localization
Protein Description
Protein Sequence	MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASESGKLW ------CCCCCCCCC	23.23	-
3	Phosphorylation	-----MASESGKLWG -----CCCCCCCCCC	30.88	28857561
5	Phosphorylation	---MASESGKLWGGR ---CCCCCCCCCCCC	38.44	24719451
7	Acetylation	-MASESGKLWGGRFV -CCCCCCCCCCCCCC	50.80	25953088
7	Ubiquitination	-MASESGKLWGGRFV -CCCCCCCCCCCCCC	50.80	-
23	Ubiquitination	AVDPIMEKFNASIAY CCHHHHHHHCHHHCC	26.91	21906983
43	Ubiquitination	EVDVQGSKAYSRGLE EEECCCCHHHHCHHH	59.16	21906983
51	Ubiquitination	AYSRGLEKAGLLTKA HHHCHHHHCCCCCHH	53.44	21906983
57	Ubiquitination	EKAGLLTKAEMDQIL HHCCCCCHHHHHHHH	42.17	21906983
69	Acetylation	QILHGLDKVAEEWAQ HHHHHHHHHHHHHHH	48.68	20167786
80	Ubiquitination	EWAQGTFKLNSNDED HHHHCCEECCCCCCC	46.74	21906983
83	Phosphorylation	QGTFKLNSNDEDIHT HCCEECCCCCCCHHH	56.97	23312004
90	Phosphorylation	SNDEDIHTANERRLK CCCCCHHHHHHHHHH	31.35	24275569
97	Malonylation	TANERRLKELIGATA HHHHHHHHHHHHCCC	48.97	26320211
97	Ubiquitination	TANERRLKELIGATA HHHHHHHHHHHHCCC	48.97	21906983
103	Phosphorylation	LKELIGATAGKLHTG HHHHHHCCCCCCCCC	30.63	22210691
106	Ubiquitination	LIGATAGKLHTGRSR HHHCCCCCCCCCCCC	34.33	21906983
106	Methylation	LIGATAGKLHTGRSR HHHCCCCCCCCCCCC	34.33	-
142	Phosphorylation	LLWELIRTMVDRAEA HHHHHHHHHHHHHHH	17.98	24043423
287	Ubiquitination	GSSLMPQKKNPDSLE CCCCCCCCCCCCHHH	48.96	21906983
288	Acetylation	SSLMPQKKNPDSLEL CCCCCCCCCCCHHHH	69.35	20167786
288	Ubiquitination	SSLMPQKKNPDSLEL CCCCCCCCCCCHHHH	69.35	20167786
323	Ubiquitination	GLPSTYNKDLQEDKE CCCCCCCCCHHHCHH	49.77	21906983
376	Phosphorylation	LATDLAYYLVRKGMP HHHHHHHHHHHCCCC	7.97	-
397	Sulfoxidation	ASGKAVFMAETKGVA HCCCEEEEEECHHHH	2.37	30846556
446	Phosphorylation	ALGGTARSSVDWQIR CCCCCCHHCHHHHHH	32.05	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARLY_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
288	K	Acetylation		20167786
Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARLY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYQ_HUMAN	QARS	physical	16189514
ARLY_HUMAN	ASL	physical	9256435
F16P1_HUMAN	FBP1	physical	21988832
HMOX1_HUMAN	HMOX1	physical	21988832
ARLY_HUMAN	ASL	physical	21988832
CSK22_HUMAN	CSNK2A2	physical	21988832
OVGP1_HUMAN	OVGP1	physical	21988832
EFTU_HUMAN	TUFM	physical	22863883
ARLY_HUMAN	ASL	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
207900	Argininosuccinic aciduria (ARGINSA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00125	L-Arginine

Regulatory Network of ARLY_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Regulation of cellular metabolism by protein lysine acetylation."; Zhao S., Xu W., Jiang W., Yu W., Lin Y., Zhang T., Yao J., Zhou L.,Zeng Y., Li H., Li Y., Shi J., An W., Hancock S.M., He F., Qin L.,Chin J., Yang P., Chen X., Lei Q., Xiong Y., Guan K.L.; Science 327:1000-1004(2010). Cited for: ACETYLATION AT LYS-69 AND LYS-288, ENZYME REGULATION, MASSSPECTROMETRY, AND MUTAGENESIS OF LYS-288.	20167786 [Abstract]

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