F16P1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F16P1_HUMAN
• UniProt AC: P09467
• Protein Name: Fructose-1,6-bisphosphatase 1
• Gene Name: FBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 338
• Protein Description: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain..
• Protein Sequence: MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADQAPFDT ------CCCCCCCCC	20.02	-
28	Phosphorylation	EGRKARGTGELTQLL CHHHCCCHHHHHHHH	23.17	28258704
32	Phosphorylation	ARGTGELTQLLNSLC CCCHHHHHHHHHHHH	16.93	28857561
58	Phosphorylation	KAGIAHLYGIAGSTN HHCCCHHHCCCCCCC	9.16	27642862
63	Phosphorylation	HLYGIAGSTNVTGDQ HHHCCCCCCCCCCHH	14.05	-
72	Acetylation	NVTGDQVKKLDVLSN CCCCHHHHHHHHCCC	41.82	7744611
88	Phosphorylation	LVMNMLKSSFATCVL HHHHHHHHHCCEEEE	27.08	-
144	Phosphorylation	FGIYRKKSTDEPSEK HEEEECCCCCCCCHH	44.09	24719451
151	Succinylation	STDEPSEKDALQPGR CCCCCCHHHCCCCCC	53.27	-
151	Succinylation	STDEPSEKDALQPGR CCCCCCHHHCCCCCC	53.27	-
210	Phosphorylation	IKKKGKIYSLNEGYA EEECCEEEECCCCCC	15.59	-
216	Phosphorylation	IYSLNEGYARDFDPA EEECCCCCCCCCCHH	7.71	21253578
227	Phosphorylation	FDPAVTEYIQRKKFP CCHHHHHHHHHCCCC	7.93	-
232	Acetylation	TEYIQRKKFPPDNSA HHHHHHCCCCCCCCC	66.35	19813147
241	Phosphorylation	PPDNSAPYGARYVGS CCCCCCCCCHHHHHH	24.12	21712546
245	Phosphorylation	SAPYGARYVGSMVAD CCCCCHHHHHHHHHC	14.50	24275569
256	Phosphorylation	MVADVHRTLVYGGIF HHHCHHHHHEECEEE	13.00	28152594
259	Phosphorylation	DVHRTLVYGGIFLYP CHHHHHEECEEEEEE	16.85	28152594
265	Phosphorylation	VYGGIFLYPANKKSP EECEEEEEECCCCCC	6.91	28348404
269	Acetylation	IFLYPANKKSPNGKL EEEEECCCCCCCCCE	57.65	7744623
271	Phosphorylation	LYPANKKSPNGKLRL EEECCCCCCCCCEEE	25.80	29457462
280	Phosphorylation	NGKLRLLYECNPMAY CCCEEEEEEECCHHH	24.03	28258704
297	Phosphorylation	EKAGGMATTGKEAVL HHCCCCCCCCCCHHH	27.47	-
298	Phosphorylation	KAGGMATTGKEAVLD HCCCCCCCCCCHHHH	36.40	-
321	Phosphorylation	RAPVILGSPDDVLEF CCCEEECCHHHHHHH	23.01	24719451
330	Acetylation	DDVLEFLKVYEKHSA HHHHHHHHHHHHHCC	48.36	20167786
334	Acetylation	EFLKVYEKHSAQ--- HHHHHHHHHCCC---	25.77	27178108

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
63	S	Phosphorylation	Kinase	ULK1	O75385	PSP
88	S	Phosphorylation	Kinase	ULK1	O75385	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM28	Q13263	PMID:28394358

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F16P1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F16P1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCX4_HUMAN	PCNXL4	physical	16189514
FXR2_HUMAN	FXR2	physical	16189514
RN183_HUMAN	RNF183	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
F16P1_HUMAN	FBP1	physical	16189514
F16P1_HUMAN	FBP1	physical	16169070
F16P1_HUMAN	FBP1	physical	2164670
NKG2C_HUMAN	KLRC2	physical	21988832
BIN1_HUMAN	BIN1	physical	16275660
F16P1_HUMAN	FBP1	physical	25416956
F16P2_HUMAN	FBP2	physical	25416956
F16P1_HUMAN	FBP1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 229700: Fructose-1,6-bisphosphatase deficiency (FBPD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00131: Adenosine monophosphate