| UniProt ID | LNX1_HUMAN | |
|---|---|---|
| UniProt AC | Q8TBB1 | |
| Protein Name | E3 ubiquitin-protein ligase LNX | |
| Gene Name | LNX1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 728 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.. | |
| Protein Sequence | MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 88 (in isoform 2) | Phosphorylation | - | 54.27 | - | |
| 132 | Phosphorylation | QTSCKGASHYGLTKD CCCCCCHHHCCCCCC | 26.38 | 21406692 | |
| 134 | Phosphorylation | SCKGASHYGLTKDRK CCCCHHHCCCCCCCC | 16.01 | 21406692 | |
| 137 | Phosphorylation | GASHYGLTKDRKRRS CHHHCCCCCCCCCCC | 26.91 | 21406692 | |
| 184 | Phosphorylation | PGLDNPAYVSSAEDG CCCCCCCEECCCCCC | 11.34 | 9535908 | |
| 229 | Phosphorylation | KKINRALSVLRRTKS HHHHHHHHHHHHCCC | 20.37 | 24719451 | |
| 234 | Phosphorylation | ALSVLRRTKSGSAVA HHHHHHHCCCCCHHH | 24.11 | 26657352 | |
| 236 | Phosphorylation | SVLRRTKSGSAVANH HHHHHCCCCCHHHCC | 37.05 | 25849741 | |
| 238 | Phosphorylation | LRRTKSGSAVANHAD HHHCCCCCHHHCCCH | 27.02 | 26657352 | |
| 264 | Phosphorylation | PEVFPRLYHLIPDGE CCHHHHHHHHCCCCC | 8.89 | 27642862 | |
| 285 | Phosphorylation | NRVDPSESLSIRLVG EEECCCCCEEEEEEC | 31.58 | 24719451 | |
| 287 | Phosphorylation | VDPSESLSIRLVGGS ECCCCCEEEEEECCC | 18.23 | 24719451 | |
| 354 | Phosphorylation | PCQVLWLTVMREQKF HHHHHHHHHHHHHHH | 10.73 | - | |
| 379 | Phosphorylation | AYRPRDDSFHVILNK CCCCCCCCEEEEECC | 22.88 | 23312004 | |
| 418 | Phosphorylation | VLDGGVAYRHGQLEE ECCCCCEECCCCCCC | 10.75 | 22210691 | |
| 439 | Phosphorylation | INGHDLRYGSPESAA ECCEECCCCCHHHHH | 29.29 | 23186163 | |
| 441 | Phosphorylation | GHDLRYGSPESAAHL CEECCCCCHHHHHHH | 19.29 | 29496963 | |
| 444 | Phosphorylation | LRYGSPESAAHLIQA CCCCCHHHHHHHHHH | 33.85 | 23186163 | |
| 461 | Phosphorylation | RRVHLVVSRQVRQRS CCEEEEEEHHHHHHC | 14.98 | 24719451 | |
| 468 | Phosphorylation | SRQVRQRSPDIFQEA EHHHHHHCCHHHHHC | 20.70 | 22617229 | |
| 479 | Phosphorylation | FQEAGWNSNGSWSPG HHHCCCCCCCCCCCC | 35.74 | 28348404 | |
| 482 | Phosphorylation | AGWNSNGSWSPGPGE CCCCCCCCCCCCCCC | 28.73 | 22617229 | |
| 484 | Phosphorylation | WNSNGSWSPGPGERS CCCCCCCCCCCCCCC | 22.98 | 28348404 | |
| 491 | Phosphorylation | SPGPGERSNTPKPLH CCCCCCCCCCCCCCC | 40.53 | 28857561 | |
| 493 | Phosphorylation | GPGERSNTPKPLHPT CCCCCCCCCCCCCCC | 33.66 | 28857561 | |
| 500 | Phosphorylation | TPKPLHPTITCHEKV CCCCCCCCEECEEEE | 20.40 | 23312004 | |
| 502 | Phosphorylation | KPLHPTITCHEKVVN CCCCCCEECEEEEEE | 15.41 | 23312004 | |
| 547 | Phosphorylation | VEPGGVISRDGRIKT ECCCCEECCCCCEEC | 23.16 | 24719451 | |
| 554 | Phosphorylation | SRDGRIKTGDILLNV CCCCCEECCCEEEEC | 37.40 | - | |
| 567 | Phosphorylation | NVDGVELTEVSRSEA ECCCEEEEEECHHHH | 22.34 | - | |
| 570 | Phosphorylation | GVELTEVSRSEAVAL CEEEEEECHHHHHHH | 24.69 | - | |
| 572 | Phosphorylation | ELTEVSRSEAVALLK EEEEECHHHHHHHHH | 23.54 | - | |
| 581 | Phosphorylation | AVALLKRTSSSIVLK HHHHHHHCCCCCEEE | 31.23 | 23312004 | |
| 582 | Phosphorylation | VALLKRTSSSIVLKA HHHHHHCCCCCEEEE | 26.56 | 25954137 | |
| 583 | Phosphorylation | ALLKRTSSSIVLKAL HHHHHCCCCCEEEEE | 24.38 | 24719451 | |
| 584 | Phosphorylation | LLKRTSSSIVLKALE HHHHCCCCCEEEEEE | 19.24 | 25954137 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LNX1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LNX1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LNX1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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