COE4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COE4_HUMAN
• UniProt AC: Q9BQW3
• Protein Name: Transcription factor COE4
• Gene Name: EBF4
• Organism: Homo sapiens (Human).
• Sequence Length: 602
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'..
• Protein Sequence: MFPAQDALPRSGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPGSNQELLLKRAADVAEALYSTPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPSPGSQQSGYGGGLGAGLGGYGAPGVAGLGVPGSPSFLNGSTATSPFAIMPSSPPLAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPVLRPPSSPPQACPRAHGEGLPDQSFEDSDKFHSPARGLQGLAYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	LLPAGLGSVRSWMQG CCCCCHHHHHHHHHC	21.28	24719451
66	Phosphorylation	PPSNLRKSNFFHFVL CCCCCCCCCCHHHHH	32.22	-
76	Phosphorylation	FHFVLAMYDRQGQPV HHHHHEEECCCCCEE	11.45	-
117	Phosphorylation	HYRLRLVYNNGLRTE EEEEEEEEECCCCCC	13.91	-
136	Phosphorylation	VRLIDSMSKQAIIYE HHHHHHHCCEEEEEE	26.10	-
348	Phosphorylation	LNEPTIDYGFQRLQK CCCCCCCHHHHHHHH	18.91	-
455	Phosphorylation	PEPGYARSCSSASPR CCCCCCCCCCCCCCC	15.35	-
561	Phosphorylation	SAFAPVLRPPSSPPQ CCCCCCCCCCCCCCC	41.12	27251275
564	Phosphorylation	APVLRPPSSPPQACP CCCCCCCCCCCCCCC	59.15	28348404
565	Phosphorylation	PVLRPPSSPPQACPR CCCCCCCCCCCCCCC	46.50	28348404
582	Phosphorylation	GEGLPDQSFEDSDKF CCCCCCCCCCCCCCC	37.67	28348404
586	Phosphorylation	PDQSFEDSDKFHSPA CCCCCCCCCCCCCCC	35.19	28348404
591	Phosphorylation	EDSDKFHSPARGLQG CCCCCCCCCCCCCCC	24.32	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COE4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COE4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COE4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.