| UniProt ID | PRAF1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UI14 | |
| Protein Name | Prenylated Rab acceptor protein 1 | |
| Gene Name | RABAC1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 185 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cytoplasm . Golgi apparatus . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membr |
|
| Protein Description | General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.. | |
| Protein Sequence | MAAQKDQQKDAEAEGLSGTTLLPKLIPSGAGREWLERRRATIRPWSTFVDQQRFSRPRNLGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLESKLVLFGREVSPAHQYALAGGISFPFFWLAGAGSAVFWVLGATLVVIGSHAAFHQIEAVDGEELQMEPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Ubiquitination | ---MAAQKDQQKDAE ---CCCCHHHHHHHH | 53.42 | 33845483 | |
| 9 | Ubiquitination | AAQKDQQKDAEAEGL CCCHHHHHHHHHCCC | 53.96 | 21906983 | |
| 17 | Phosphorylation | DAEAEGLSGTTLLPK HHHHCCCCCCCHHHH | 44.97 | 25159151 | |
| 19 | Phosphorylation | EAEGLSGTTLLPKLI HHCCCCCCCHHHHHC | 15.76 | 28555341 | |
| 20 | Phosphorylation | AEGLSGTTLLPKLIP HCCCCCCCHHHHHCC | 29.80 | 25693802 | |
| 24 | Ubiquitination | SGTTLLPKLIPSGAG CCCCHHHHHCCCCCC | 60.04 | 23000965 | |
| 28 | Phosphorylation | LLPKLIPSGAGREWL HHHHHCCCCCCHHHH | 33.99 | 28348404 | |
| 32 | Methylation | LIPSGAGREWLERRR HCCCCCCHHHHHHHH | 31.23 | 115489993 | |
| 41 | Phosphorylation | WLERRRATIRPWSTF HHHHHHCCCCCCHHH | 18.73 | - | |
| 46 | Phosphorylation | RATIRPWSTFVDQQR HCCCCCCHHHHCHHH | 18.04 | 21712546 | |
| 47 | Phosphorylation | ATIRPWSTFVDQQRF CCCCCCHHHHCHHHH | 24.65 | 27134283 | |
| 114 | Phosphorylation | CYILYLRTLESKLVL HHHHHHHHHHHCHHH | 32.08 | - | |
| 118 | Ubiquitination | YLRTLESKLVLFGRE HHHHHHHCHHHCCCC | 32.99 | 23000965 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRAF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRAF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRAF1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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