SYT16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT16_HUMAN
• UniProt AC: Q17RD7
• Protein Name: Synaptotagmin-16
• Gene Name: SYT16
• Organism: Homo sapiens (Human).
• Sequence Length: 645
• Protein Description: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent..
• Protein Sequence: MVLAMASQDVQNFFQPFSSWISRVYEALQQAGDMLSASLVNISKQDSKLSDKLDQDLDNIQIQETYFEDEEQDNDWSQEDANSLFLEVDHFSCCNSDLQDSAQNSSPSLSQHAKDSCSTMSQWPNWASDDRKLPHVLSSIAEEEHHLEKQRSGLQHGFDSQLPGTLETVNGKKQVNSFGDDEELSTSSDSDEEVIKQFEISVSRSQSFRSVTSEKGKQTGLEQKPKFSRSLLTHGEDGTEVSACEDLDGASQRRYSENLSYGEDDHIPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQSTEGSLEMETAFNSRGFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTLLES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	SSWISRVYEALQQAG HHHHHHHHHHHHHHH	8.38	23532336
36	Phosphorylation	QQAGDMLSASLVNIS HHHHHHHHHHHEEHH	14.80	23532336
43	Phosphorylation	SASLVNISKQDSKLS HHHHEEHHHCCHHHH	21.04	-
47	Phosphorylation	VNISKQDSKLSDKLD EEHHHCCHHHHHHHH	32.76	-
50	Phosphorylation	SKQDSKLSDKLDQDL HHCCHHHHHHHHHHH	36.11	18212344
116	Phosphorylation	LSQHAKDSCSTMSQW HHHHHHHHHHHHHHC	14.84	24114839
118	Phosphorylation	QHAKDSCSTMSQWPN HHHHHHHHHHHHCCC	30.97	24114839
121	Phosphorylation	KDSCSTMSQWPNWAS HHHHHHHHHCCCCCC	29.22	24114839
128	Phosphorylation	SQWPNWASDDRKLPH HHCCCCCCCCCCHHH	31.49	24114839
201	Phosphorylation	VIKQFEISVSRSQSF HHHHHEEEEECCCCC	13.57	24719451
256	Phosphorylation	GASQRRYSENLSYGE CHHHHHHHCCCCCCC	20.42	-
260	Phosphorylation	RRYSENLSYGEDDHI HHHHCCCCCCCCCCC	42.55	-
261	Phosphorylation	RYSENLSYGEDDHIP HHHCCCCCCCCCCCC	27.92	-
295	Phosphorylation	QESSVVQSLRRQSTE HHHHHHHHHHHHCCC	16.54	20068231
300	Phosphorylation	VQSLRRQSTEGSLEM HHHHHHHCCCCCEEE	26.98	22210691
300 (in isoform 2)	Phosphorylation	-	26.98	26471730
301	Phosphorylation	QSLRRQSTEGSLEME HHHHHHCCCCCEEEE	35.71	22210691
301 (in isoform 2)	Phosphorylation	-	35.71	26471730
304	Phosphorylation	RRQSTEGSLEMETAF HHHCCCCCEEEEHHC	18.22	22210691
304 (in isoform 2)	Phosphorylation	-	18.22	26471730
336	Phosphorylation	SPEEQDRTNLQVPSG CHHHHCCCCCCCCCC	48.87	-
349	Phosphorylation	SGVSEPISKCGDLDV CCCCCCHHHCCCCEE	32.39	-
387	Phosphorylation	KDRSGVNSWQVHVVL CCCCCCCCEEEEEEE	19.24	24719451
563	Phosphorylation	EMSRCKTSIRRGQPN HHHHHHCHHHCCCCC	10.29	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYT16_HUMAN	SYT16	physical	12801916
SYT14_HUMAN	SYT14	physical	12801916
SEMG2_HUMAN	SEMG2	physical	28514442
SEMG1_HUMAN	SEMG1	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
H15_HUMAN	HIST1H1B	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.