DUS14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS14_HUMAN
• UniProt AC: O95147
• Protein Name: Dual specificity protein phosphatase 14
• Gene Name: DUSP14
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Protein Description: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases..
• Protein Sequence: MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	O-linked_Glycosylation	------MSSRGHSTL ------CCCCCCCCC	28.83	30379171
3	Phosphorylation	-----MSSRGHSTLP -----CCCCCCCCCC	40.77	23532336
4	Methylation	----MSSRGHSTLPR ----CCCCCCCCCCC	39.27	-
7	Phosphorylation	-MSSRGHSTLPRTLM -CCCCCCCCCCCCCC	34.17	19369195
8	Phosphorylation	MSSRGHSTLPRTLMA CCCCCCCCCCCCCCC	34.80	23532336
11	Methylation	RGHSTLPRTLMAPRM CCCCCCCCCCCCCCC	43.54	-
17	Methylation	PRTLMAPRMISEGDI CCCCCCCCCCCCCCC	26.06	-
96	Ubiquitination	YFDTVADKIHSVSRK EEHHHHHHHHHHHHH	32.36	-
99	Phosphorylation	TVADKIHSVSRKHGA HHHHHHHHHHHHHCC	25.84	27732954
101	Phosphorylation	ADKIHSVSRKHGATL HHHHHHHHHHHCCEE	38.33	27732954
103	Ubiquitination	KIHSVSRKHGATLVH HHHHHHHHHCCEEEH	38.59	-
161	Phosphorylation	FWRQLIDYERQLFGK HHHHHHHHHHHHHCC	13.15	-
168	Ubiquitination	YERQLFGKSTVKMVQ HHHHHHCCHHHEEEE	35.30	-
169	Phosphorylation	ERQLFGKSTVKMVQT HHHHHCCHHHEEEEC	38.52	18669648
172	Ubiquitination	LFGKSTVKMVQTPYG HHCCHHHEEEECCCC	33.18	21906983
176	Phosphorylation	STVKMVQTPYGIVPD HHHEEEECCCCCCCC	13.68	18669648
178	Phosphorylation	VKMVQTPYGIVPDVY HEEEECCCCCCCCHH	23.91	20090780
185	Phosphorylation	YGIVPDVYEKESRHL CCCCCCHHCHHHHCC	28.76	20068231
187	Ubiquitination	IVPDVYEKESRHLMP CCCCHHCHHHHCCCC	43.21	21890473
195	Phosphorylation	ESRHLMPYWGI---- HHHCCCCCCCC----	11.42	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TANK	Q92844	PMID:26521044

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INO1_HUMAN	ISYNA1	physical	21988832
SPERT_HUMAN	SPERT	physical	25416956
TRAF2_HUMAN	TRAF2	physical	26521044
AP3B1_HUMAN	AP3B1	physical	27880917
NUDT5_HUMAN	NUDT5	physical	27880917
P5CR1_HUMAN	PYCR1	physical	27880917
P5CR2_HUMAN	PYCR2	physical	27880917
ACOX1_HUMAN	ACOX1	physical	28514442
TFG_HUMAN	TFG	physical	28514442
F136A_HUMAN	FAM136A	physical	28514442
ACAD8_HUMAN	ACAD8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND THR-8, AND MASSSPECTROMETRY.
PubMed: 19369195