ACAD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACAD8_HUMAN
• UniProt AC: Q9UKU7
• Protein Name: Isobutyryl-CoA dehydrogenase, mitochondrial
• Gene Name: ACAD8
• Organism: Homo sapiens (Human).
• Sequence Length: 415
• Subcellular Localization: Mitochondrion .
• Protein Description: Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex..
• Protein Sequence: MLWSGCRRFGARLGCLPGGLRVLVQTGHRSLTSCIDPSMGLNEEQKEFQKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLSRLDTSVIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQGDHYILNGSKAFISGAGESDIYVVMCRTGGPGPKGISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIASCSLGAAHASVILTRDHLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLFATDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRILISRSLLQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	GLRVLVQTGHRSLTS CEEEEEECCCCCHHH	27.72	23312004
50	Succinylation	EEQKEFQKVAFDFAA HHHHHHHHHHHHHHH	40.63	-
50	Succinylation	EEQKEFQKVAFDFAA HHHHHHHHHHHHHHH	40.63	-
50	Acetylation	EEQKEFQKVAFDFAA HHHHHHHHHHHHHHH	40.63	-
50	Ubiquitination	EEQKEFQKVAFDFAA HHHHHHHHHHHHHHH	40.63	29967540
67	Ubiquitination	MAPNMAEWDQKELFP HCCCHHHCCHHHCCC	12.09	-
70	Acetylation	NMAEWDQKELFPVDV CHHHCCHHHCCCHHH	54.64	25038526
100	Ubiquitination	TDVGGSGLSRLDTSV CCCCCCCHHHCCHHH	2.63	-
101	Ubiquitination	DVGGSGLSRLDTSVI CCCCCCHHHCCHHHH	34.03	-
136	Ubiquitination	CAWMIDSFGNEEQRH HHHHHHCCCCHHHHH	12.35	-
144	Ubiquitination	GNEEQRHKFCPPLCT CCHHHHHCCCCCCHH	51.34	-
154	Acetylation	PPLCTMEKFASYCLT CCCHHHHHHHHHHCC	35.09	25038526
155	Ubiquitination	PLCTMEKFASYCLTE CCHHHHHHHHHHCCC	3.30	-
158	Ubiquitination	TMEKFASYCLTEPGS HHHHHHHHHCCCCCC	6.50	-
177	Ubiquitination	ASLLTSAKKQGDHYI HHHHHHHHHHCCEEE	45.45	29967540
177	Acetylation	ASLLTSAKKQGDHYI HHHHHHHHHHCCEEE	45.45	25953088
178	Acetylation	SLLTSAKKQGDHYIL HHHHHHHHHCCEEEE	60.26	30585331
178	Ubiquitination	SLLTSAKKQGDHYIL HHHHHHHHHCCEEEE	60.26	29967540
213	Acetylation	RTGGPGPKGISCIVV CCCCCCCCCEEEEEE	74.84	30585319
213	Malonylation	RTGGPGPKGISCIVV CCCCCCCCCEEEEEE	74.84	26320211
213	Succinylation	RTGGPGPKGISCIVV CCCCCCCCCEEEEEE	74.84	-
213	Ubiquitination	RTGGPGPKGISCIVV CCCCCCCCCEEEEEE	74.84	-
213	Succinylation	RTGGPGPKGISCIVV CCCCCCCCCEEEEEE	74.84	-
216	Phosphorylation	GPGPKGISCIVVEKG CCCCCCEEEEEEECC	13.37	45666025
222	Acetylation	ISCIVVEKGTPGLSF EEEEEEECCCCCCCC	57.38	30585325
226	Ubiquitination	VVEKGTPGLSFGKKE EEECCCCCCCCCCCC	33.52	-
231	Acetylation	TPGLSFGKKEKKVGW CCCCCCCCCCCCCCC	56.61	2418809
232	Ubiquitination	PGLSFGKKEKKVGWN CCCCCCCCCCCCCCC	75.13	-
235	Ubiquitination	SFGKKEKKVGWNSQP CCCCCCCCCCCCCCC	47.25	-
261	Phosphorylation	PVANRIGSEGQGFLI EEHHHCCCCCCCEEE	35.86	46157365
268	Ubiquitination	SEGQGFLIAVRGLNG CCCCCEEEEEECCCC	2.88	-
303	Ubiquitination	RDHLNVRKQFGEPLA CCCHHHHHHHCCCCC	45.77	-
345	Ubiquitination	VALQEERKDAVALCS HHHHHHHHHHHHHHH	54.01	-
352	Phosphorylation	KDAVALCSMAKLFAT HHHHHHHHHHHHHCC	23.71	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACAD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACAD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACAD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACDSB_HUMAN	ACADSB	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.