ACDSB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACDSB_HUMAN
• UniProt AC: P45954
• Protein Name: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
• Gene Name: ACADSB
• Organism: Homo sapiens (Human).
• Sequence Length: 432
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent..
• Protein Sequence: MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	IPPHVSKSSQSEALL CCCCCCCCCCCHHHH	26.55	27251275
36	Phosphorylation	PPHVSKSSQSEALLN CCCCCCCCCCHHHHH	41.27	27251275
70	Ubiquitination	MIKSSVKKFAQEQIA HHHHHHHHHHHHHHH	43.72	21890473
70	Ubiquitination	MIKSSVKKFAQEQIA HHHHHHHHHHHHHHH	43.72	21890473
70	Ubiquitination	MIKSSVKKFAQEQIA HHHHHHHHHHHHHHH	43.72	21890473
70	Acetylation	MIKSSVKKFAQEQIA HHHHHHHHHHHHHHH	43.72	25953088
70	Succinylation	MIKSSVKKFAQEQIA HHHHHHHHHHHHHHH	43.72	21890473
70	Succinylation	MIKSSVKKFAQEQIA HHHHHHHHHHHHHHH	43.72	-
81	Phosphorylation	EQIAPLVSTMDENSK HHHHHHHHCCCCCCH	26.20	46157407
82	Phosphorylation	QIAPLVSTMDENSKM HHHHHHHCCCCCCHH	22.59	46157413
182	Ubiquitination	CLSEAGAGSDSFALK ECCCCCCCCCCEEEE	30.94	-
182	Acetylation	CLSEAGAGSDSFALK ECCCCCCCCCCEEEE	30.94	-
183	Phosphorylation	LSEAGAGSDSFALKT CCCCCCCCCCEEEEE	29.55	27251275
185	Phosphorylation	EAGAGSDSFALKTRA CCCCCCCCEEEEECC	17.70	69000345
198	Phosphorylation	RADKEGDYYVLNGSK CCCCCCCEEEECCCE	13.31	75089
199	Phosphorylation	ADKEGDYYVLNGSKM CCCCCCEEEECCCEE	11.82	22817900
226	Phosphorylation	VMANVDPTIGYKGIT EEECCCCCCCCCCHH	23.67	28258704
229	Phosphorylation	NVDPTIGYKGITSFL CCCCCCCCCCHHEEE	11.37	28258704
259	Phosphorylation	KLGLRASSTCPLTFE CCCCCCCCCCCCEEC	32.80	26503514
284	Ubiquitination	GQIGHGYKYAIGSLN EEECCHHHHEEECCC	32.57	21890473
284	Ubiquitination	GQIGHGYKYAIGSLN EEECCHHHHEEECCC	32.57	21890473
284	Ubiquitination	GQIGHGYKYAIGSLN EEECCHHHHEEECCC	32.57	21890473
284	Succinylation	GQIGHGYKYAIGSLN EEECCHHHHEEECCC	32.57	21890473
284	Acetylation	GQIGHGYKYAIGSLN EEECCHHHHEEECCC	32.57	19608861
284	Succinylation	GQIGHGYKYAIGSLN EEECCHHHHEEECCC	32.57	-
285	Phosphorylation	QIGHGYKYAIGSLNE EECCHHHHEEECCCC	8.58	28258704
289	Phosphorylation	GYKYAIGSLNEGRIG HHHHEEECCCCCCHH	23.16	69008769
365	Acetylation	EAGKPFIKEASMAKY HCCCCCHHHHHHHHH	47.83	7462021
371	Acetylation	IKEASMAKYYASEIA HHHHHHHHHHHHHHC	30.10	25038526
372	Phosphorylation	KEASMAKYYASEIAG HHHHHHHHHHHHHCC	8.50	28152594
373	Phosphorylation	EASMAKYYASEIAGQ HHHHHHHHHHHHCCC	11.71	28152594
413	Phosphorylation	DAKIGTIYEGASNIQ CCCCCCEEECCCCCC	14.24	7105053
426	Acetylation	IQLNTIAKHIDAEY- CCHHHHHHHHCCCC-	36.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACDSB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACDSB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACDSB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YTHD1_HUMAN	YTHDF1	physical	26186194
ACTZ_HUMAN	ACTR1A	physical	26344197
KDSR_HUMAN	KDSR	physical	26344197
PXDN_HUMAN	PXDN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610006: Short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00167: L-Isoleucine
• DB00313: Valproic Acid

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-284, AND MASS SPECTROMETRY.
PubMed: 19608861