YTHD1_HUMAN - dbPTM
YTHD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YTHD1_HUMAN
UniProt AC Q9BYJ9
Protein Name YTH domain-containing family protein 1 {ECO:0000305}
Gene Name YTHDF1 {ECO:0000312|HGNC:HGNC:15867}
Organism Homo sapiens (Human).
Sequence Length 559
Subcellular Localization Cytoplasm .
Protein Description Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency. [PubMed: 24284625]
Protein Sequence MSATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGQSNQSNSYPSMSDPYLSSYYPPSIGFPYSLNEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIYQHRFNFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQPGFHSDTLSKAPGMNSLEQGMVGLKIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVESHPVLEKLKAAHSYNPKEFEWNLKSGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMSSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEEEVVRKERQSRNKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSATSVDTQ
------CCCCCCCCC		40.0125849741
2Acetylation------MSATSVDTQ
------CCCCCCCCC		40.0122814378
4Phosphorylation----MSATSVDTQRT
----CCCCCCCCCCC		23.2125849741
5Phosphorylation---MSATSVDTQRTK
---CCCCCCCCCCCC		20.0825849741
8PhosphorylationMSATSVDTQRTKGQD
CCCCCCCCCCCCCCC		20.1424043423
11PhosphorylationTSVDTQRTKGQDNKV
CCCCCCCCCCCCCCC		29.7024043423
12UbiquitinationSVDTQRTKGQDNKVQ
CCCCCCCCCCCCCCC		57.6829967540
28 (in isoform 2)Phosphorylation-27.1220068231
39 (in isoform 2)Phosphorylation-27.6020068231
50 (in isoform 2)Phosphorylation-23.7624043423
52 (in isoform 2)Phosphorylation-39.5124043423
65 (in isoform 2)Phosphorylation-23.0924043423
69 (in isoform 2)Phosphorylation-25.5924043423
71 (in isoform 2)Phosphorylation-37.1324043423
73 (in isoform 2)Phosphorylation-15.1324043423
116PhosphorylationGGLGNNIYQHRFNFF
CCCCCCCHHCCCCCC		10.61-
130O-linked_GlycosylationFPENPAFSAWGTSGS
CCCCCCCCCCCCCCC		25.8130059200
152O-linked_GlycosylationSAYGSSYTYPPSSLG
CCCCCCCCCCHHHHC		31.3430059200
156O-linked_GlycosylationSSYTYPPSSLGGTVV
CCCCCCHHHHCCEEE		33.4230059200
157O-linked_GlycosylationSYTYPPSSLGGTVVD
CCCCCHHHHCCEEEC		36.4930059200
161O-linked_GlycosylationPPSSLGGTVVDGQPG
CHHHHCCEEECCCCC		18.6330059200
173O-linked_GlycosylationQPGFHSDTLSKAPGM
CCCCCCCCCCCCCCC		35.6330059200
182PhosphorylationSKAPGMNSLEQGMVG
CCCCCCCHHHCCCCC		25.1325159151
186 (in isoform 2)Ubiquitination-11.9021906983
191UbiquitinationEQGMVGLKIGDVSSS
HCCCCCEEECCCCHH		38.4232015554
196O-linked_GlycosylationGLKIGDVSSSAVKTV
CEEECCCCHHHHHHH		24.2630059200
196PhosphorylationGLKIGDVSSSAVKTV
CEEECCCCHHHHHHH		24.2622210691
196O-linked_GlycosylationGLKIGDVSSSAVKTV
CEEECCCCHHHHHHH		24.2620068230
197PhosphorylationLKIGDVSSSAVKTVG
EEECCCCHHHHHHHH		23.3625159151
197O-linked_GlycosylationLKIGDVSSSAVKTVG
EEECCCCHHHHHHHH		23.3630059200
198PhosphorylationKIGDVSSSAVKTVGS
EECCCCHHHHHHHHH		29.5821815630
198O-linked_GlycosylationKIGDVSSSAVKTVGS
EECCCCHHHHHHHHH		29.5830059200
202O-linked_GlycosylationVSSSAVKTVGSVVSS
CCHHHHHHHHHHHHH		24.4130059200
205O-linked_GlycosylationSAVKTVGSVVSSVAL
HHHHHHHHHHHHHHH		18.2730059200
208O-linked_GlycosylationKTVGSVVSSVALTGV
HHHHHHHHHHHHCCE		19.5530059200
208PhosphorylationKTVGSVVSSVALTGV
HHHHHHHHHHHHCCE		19.5527174698
209PhosphorylationTVGSVVSSVALTGVL
HHHHHHHHHHHCCEE		10.3727174698
209O-linked_GlycosylationTVGSVVSSVALTGVL
HHHHHHHHHHHCCEE		10.3730059200
213PhosphorylationVVSSVALTGVLSGNG
HHHHHHHCCEECCCC		18.5927174698
213O-linked_GlycosylationVVSSVALTGVLSGNG
HHHHHHHCCEECCCC		18.5930059200
217PhosphorylationVALTGVLSGNGGTNV
HHHCCEECCCCCCCE		28.0127174698
222PhosphorylationVLSGNGGTNVNMPVS
EECCCCCCCEECCCC		37.0727174698
229PhosphorylationTNVNMPVSKPTSWAA
CCEECCCCCCCCHHH		27.3527174698
232O-linked_GlycosylationNMPVSKPTSWAAIAS
ECCCCCCCCHHHHHC		40.4130059200
240UbiquitinationSWAAIASKPAKPQPK
CHHHHHCCCCCCCCC		39.7225015289
252PhosphorylationQPKMKTKSGPVMGGG
CCCCCCCCCCCCCCC		54.2725159151
256SulfoxidationKTKSGPVMGGGLPPP
CCCCCCCCCCCCCCC		4.6721406390
266UbiquitinationGLPPPPIKHNMDIGT
CCCCCCCCCCCCCCC		34.4029967540
273PhosphorylationKHNMDIGTWDNKGPV
CCCCCCCCCCCCCCC		29.9430576142
291PhosphorylationPVPQQAPSPQAAPQP
CCCCCCCCCCCCCCC		32.4321945579
317PhosphorylationPALAQPQYQSPQQPP
CHHCCCCCCCCCCCC		20.0321945579
319PhosphorylationLAQPQYQSPQQPPQT
HCCCCCCCCCCCCCC		21.5321945579
326PhosphorylationSPQQPPQTRWVAPRN
CCCCCCCCCEECCCC		32.0721945579
327MethylationPQQPPQTRWVAPRNR
CCCCCCCCEECCCCC		22.1897812453
341PhosphorylationRNAAFGQSGGAGSDS
CCCCCCCCCCCCCCC		39.3023401153
346PhosphorylationGQSGGAGSDSNSPGN
CCCCCCCCCCCCCCC		37.0123401153
348PhosphorylationSGGAGSDSNSPGNVQ
CCCCCCCCCCCCCCC		40.6930278072
350PhosphorylationGAGSDSNSPGNVQPN
CCCCCCCCCCCCCCC		37.8330278072
358PhosphorylationPGNVQPNSAPSVESH
CCCCCCCCCCCCCCC		48.5224732914
361PhosphorylationVQPNSAPSVESHPVL
CCCCCCCCCCCCHHH		37.9324732914
364PhosphorylationNSAPSVESHPVLEKL
CCCCCCCCCHHHHHH		30.8224732914
370 (in isoform 1)Ubiquitination-51.6421906983
370AcetylationESHPVLEKLKAAHSY
CCCHHHHHHHHHHCC		51.6426051181
370UbiquitinationESHPVLEKLKAAHSY
CCCHHHHHHHHHHCC		51.642190698
372UbiquitinationHPVLEKLKAAHSYNP
CHHHHHHHHHHCCCH		55.3729967540
380UbiquitinationAAHSYNPKEFEWNLK
HHHCCCHHHEEEEEC		71.9829967540
387UbiquitinationKEFEWNLKSGRVFII
HHEEEEECCCCEEEE		47.8829967540
395UbiquitinationSGRVFIIKSYSEDDI
CCCEEEEEECCHHHH		38.23-
396PhosphorylationGRVFIIKSYSEDDIH
CCEEEEEECCHHHHH		24.3928152594
397PhosphorylationRVFIIKSYSEDDIHR
CEEEEEECCHHHHHH		15.8628152594
398PhosphorylationVFIIKSYSEDDIHRS
EEEEEECCHHHHHHH		41.4625159151
409PhosphorylationIHRSIKYSIWCSTEH
HHHHHEEEEEEECCC		12.47-
413PhosphorylationIKYSIWCSTEHGNKR
HEEEEEEECCCCCEE		23.10-
419UbiquitinationCSTEHGNKRLDSAFR
EECCCCCEEEHHHHH		59.95-
469UbiquitinationAGVWSQDKWKGKFDV
CCCCCCCCCCCCEEE		43.0729967540
473UbiquitinationSQDKWKGKFDVQWIF
CCCCCCCCEEEEEEE		34.36-
493MethylationNNQLRHIRLENNDNK
CCCEEEEEEECCCCC		29.80-
500UbiquitinationRLENNDNKPVTNSRD
EEECCCCCCCCCCCC		43.6729967540
503PhosphorylationNNDNKPVTNSRDTQE
CCCCCCCCCCCCCCC		35.6824732914
505PhosphorylationDNKPVTNSRDTQEVP
CCCCCCCCCCCCCCC		23.3624732914
515UbiquitinationTQEVPLEKAKQVLKI
CCCCCHHHHHHHHHH		69.4433845483
517UbiquitinationEVPLEKAKQVLKIIS
CCCHHHHHHHHHHHH		52.5930230243
527UbiquitinationLKIISSYKHTTSIFD
HHHHHHCCCCCCHHH		36.1029967540
529PhosphorylationIISSYKHTTSIFDDF
HHHHCCCCCCHHHHH		20.3424247654
531PhosphorylationSSYKHTTSIFDDFAH
HHCCCCCCHHHHHHH		23.5528857561
539PhosphorylationIFDDFAHYEKRQEEE
HHHHHHHHHHHHHHH		21.5128796482
541UbiquitinationDDFAHYEKRQEEEEV
HHHHHHHHHHHHHHH		52.8229967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YTHD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YTHD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YTHD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FAF1_HUMANFAF1physical
26389662
STPAP_HUMANTUT1physical
28514442
FAF1_HUMANFAF1physical
28514442
MEPCE_HUMANMEPCEphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YTHD1_HUMAN

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Related Literatures of Post-Translational Modification

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