dbPTM

FAF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FAF1_HUMAN
UniProt AC	Q9UNN5
Protein Name	FAS-associated factor 1
Gene Name	FAF1
Organism	Homo sapiens (Human).
Sequence Length	650
Subcellular Localization	Nucleus .
Protein Description	Ubiquitin-binding protein. [PubMed: 19722279 Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation]
Protein Sequence	MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLEAKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Ubiquitination	IDEAITLLEQNNWDL HHHHHHHHHHCCHHH	4.81	23000965
34	Ubiquitination	ITLLEQNNWDLVAAI HHHHHHCCHHHHHHH	33.08	21890473
37	Ubiquitination	LEQNNWDLVAAINGV HHHCCHHHHHHHCCC	1.82	23000965
48	Ubiquitination	INGVIPQENGILQSE HCCCCCCCCCCEEEC	52.66	23000965
54	Ubiquitination	QENGILQSEYGGETI CCCCCEEECCCCCCC	29.37	23000965
70	O-linked_Glycosylation	GPAFNPASHPASAPT CCCCCCCCCCCCCCC	31.12	23301498
80	O-linked_Glycosylation	ASAPTSSSSSAFRPV CCCCCCCCCCCCCCC	28.25	23301498
112	Ubiquitination	VEYRDRNVDVVLEDT EEECCCCCCEEEECC	6.52	21890473
120	Glutathionylation	DVVLEDTCTVGEIKQ CEEEECCCCHHHHHH	4.49	22555962
138	Phosphorylation	NELQIPVSKMLLKGW CCCCCCHHHHHHCCC	13.64	30622161
139 (in isoform 1)	Ubiquitination	-	33.53	21890473
139 (in isoform 2)	Ubiquitination	-	33.53	21890473
139	Ubiquitination	ELQIPVSKMLLKGWK CCCCCHHHHHHCCCC	33.53	21890473
139	Ubiquitination	ELQIPVSKMLLKGWK CCCCCHHHHHHCCCC	33.53	23000965
143 (in isoform 1)	Ubiquitination	-	59.78	21890473
143 (in isoform 2)	Ubiquitination	-	59.78	21890473
143	Ubiquitination	PVSKMLLKGWKTGDV CHHHHHHCCCCCCCC	59.78	23000965
143	Ubiquitination	PVSKMLLKGWKTGDV CHHHHHHCCCCCCCC	59.78	21890473
143	Acetylation	PVSKMLLKGWKTGDV CHHHHHHCCCCCCCC	59.78	25953088
146	Ubiquitination	KMLLKGWKTGDVEDS HHHHCCCCCCCCCCC	51.83	21890473
146	Ubiquitination	KMLLKGWKTGDVEDS HHHHCCCCCCCCCCC	51.83	23000965
146	Acetylation	KMLLKGWKTGDVEDS HHHHCCCCCCCCCCC	51.83	19819239
146 (in isoform 1)	Ubiquitination	-	51.83	21890473
146 (in isoform 2)	Ubiquitination	-	51.83	21890473
147	Phosphorylation	MLLKGWKTGDVEDST HHHCCCCCCCCCCCC	31.91	20068231
153	Phosphorylation	KTGDVEDSTVLKSLH CCCCCCCCCCCEEEE	13.60	20068231
154	Phosphorylation	TGDVEDSTVLKSLHL CCCCCCCCCCEEEEC	42.03	20068231
157 (in isoform 1)	Ubiquitination	-	46.78	21890473
157	Malonylation	VEDSTVLKSLHLPKN CCCCCCCEEEECCCC	46.78	26320211
157	Acetylation	VEDSTVLKSLHLPKN CCCCCCCEEEECCCC	46.78	25953088
157	Ubiquitination	VEDSTVLKSLHLPKN CCCCCCCEEEECCCC	46.78	23000965
157	Ubiquitination	VEDSTVLKSLHLPKN CCCCCCCEEEECCCC	46.78	21890473
157 (in isoform 2)	Ubiquitination	-	46.78	21890473
163	Ubiquitination	LKSLHLPKNNSLYVL CEEEECCCCCEEEEE	75.11	23000965
207	Phosphorylation	HREVQREYNLNFSGS EHHHHHHHCCCCCCC	27.43	29083192
212	Phosphorylation	REYNLNFSGSSTIQE HHHCCCCCCCHHHHH	36.37	25693802
214	Phosphorylation	YNLNFSGSSTIQEVK HCCCCCCCHHHHHHH	24.10	25693802
215	Phosphorylation	NLNFSGSSTIQEVKR CCCCCCCHHHHHHHH	32.81	25693802
216	Phosphorylation	LNFSGSSTIQEVKRN CCCCCCHHHHHHHHH	28.51	25693802
221 (in isoform 1)	Ubiquitination	-	37.19	21890473
221	Ubiquitination	SSTIQEVKRNVYDLT CHHHHHHHHHHCCCC	37.19	21890473
221	Ubiquitination	SSTIQEVKRNVYDLT CHHHHHHHHHHCCCC	37.19	21963094
225	Phosphorylation	QEVKRNVYDLTSIPV HHHHHHHCCCCCCCC	14.58	28152594
264	Phosphorylation	SYPCHRLTVGRRSSP CCCCEEECCCCCCCC	22.37	21712546
269	Phosphorylation	RLTVGRRSSPAQTRE EECCCCCCCCCHHHH	39.03	20068231
270	Phosphorylation	LTVGRRSSPAQTREQ ECCCCCCCCCHHHHC	23.57	28176443
274	Phosphorylation	RRSSPAQTREQSEEQ CCCCCCHHHHCCHHH	37.98	20068231
289	Phosphorylation	ITDVHMVSDSDGDDF CCEEEEEECCCCCCH	24.67	11713579
291	Phosphorylation	DVHMVSDSDGDDFED EEEEEECCCCCCHHH	35.67	11713579
292 (in isoform 2)	Ubiquitination	-	70.32	21890473
305 (in isoform 2)	Ubiquitination	-	59.59	21890473
314	Phosphorylation	GEVFGMASSALRKSP HHHEEECCHHHHCCC	13.78	26074081
315	Phosphorylation	EVFGMASSALRKSPM HHEEECCHHHHCCCC	23.06	26074081
319	Ubiquitination	MASSALRKSPMMPEN ECCHHHHCCCCCCCC	60.81	-
320	Phosphorylation	ASSALRKSPMMPENA CCHHHHCCCCCCCCC	16.17	30278072
335	Ubiquitination	ENEGDALLQFTAEFS CCCCCHHHHHHHHHH	4.16	22817900
342	Phosphorylation	LQFTAEFSSRYGDCH HHHHHHHHHHHCCCE	12.86	-
343	Phosphorylation	QFTAEFSSRYGDCHP HHHHHHHHHHCCCEE	34.54	-
348	Ubiquitination	FSSRYGDCHPVFFIG HHHHHCCCEEEEEEE	3.20	22053931
434	Phosphorylation	MCNRHFGSVVAQTIR HHHHHHHHHHHHHHH	16.69	24043423
439	Phosphorylation	FGSVVAQTIRTQKTD HHHHHHHHHHCCCCC	11.59	24043423
442	Phosphorylation	VVAQTIRTQKTDQFP HHHHHHHCCCCCCCC	30.48	24043423
444 (in isoform 1)	Ubiquitination	-	54.15	21890473
444	Ubiquitination	AQTIRTQKTDQFPLF HHHHHCCCCCCCCEE	54.15	21906983
445	Phosphorylation	QTIRTQKTDQFPLFL HHHHCCCCCCCCEEE	25.80	24043423
457	Ubiquitination	LFLIIMGKRSSNEVL EEEEEEECCCHHHHH	31.55	20639865
457 (in isoform 1)	Ubiquitination	-	31.55	21890473
496	Ubiquitination	AQQQEDIKDEDEREA HHHHHHCCCHHHHHH	68.34	29901268
508	Sumoylation	REARENVKREQDEAY HHHHHHHHHHHHHHH	62.90	-
518	Phosphorylation	QDEAYRLSLEADRAK HHHHHHHHHHHHHHH	18.37	28555341
544	Ubiquitination	FRLEQIRKEQEEERE HCHHHHHHHHHHHHH	66.43	-
556	Phosphorylation	EREAIRLSLEQALPP HHHHHHHHHHHHCCC	21.73	25159151
566	Ubiquitination	QALPPEPKEENAEPV HHCCCCCCCCCCCCC	75.81	24816145
575	Ubiquitination	ENAEPVSKLRIRTPS CCCCCCCCCEEECCC	41.86	29901268
580	Phosphorylation	VSKLRIRTPSGEFLE CCCCEEECCCHHHHH	21.31	23401153
582	Phosphorylation	KLRIRTPSGEFLERR CCEEECCCHHHHHHH	50.79	19664994
631	Ubiquitination	VTQLDPNKSLLEVKL CCCCCCCCCCEEEEE	48.12	29967540
637	Ubiquitination	NKSLLEVKLFPQETL CCCCEEEEECCCCCE	34.73	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
289	S	Phosphorylation	Kinase	AURKA	O14965	GPS
289	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
289	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
289	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
291	S	Phosphorylation	Kinase	AURKA	O14965	GPS
291	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
291	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
291	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
556	S	Phosphorylation	Kinase	IKKE	Q14164	PSP
582	S	Phosphorylation	Kinase	AKT1	P31749	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:23307929

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FAF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FAF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	21411632
TERA_HUMAN	VCP	physical	18775313
NPL4_HUMAN	NPLOC4	physical	18775313
UFD1_HUMAN	UFD1L	physical	18775313
CUL1_HUMAN	CUL1	physical	18775313
CUL2_HUMAN	CUL2	physical	18775313
CUL3_HUMAN	CUL3	physical	18775313
UBR1_HUMAN	UBR1	physical	18775313
HIF1A_HUMAN	HIF1A	physical	18775313
PPB1_HUMAN	ALPP	physical	18775313
VCIP1_HUMAN	VCPIP1	physical	18775313
SKP1_HUMAN	SKP1	physical	18775313
FBW1B_HUMAN	FBXW11	physical	18775313
KLH22_HUMAN	KLHL22	physical	18775313
KBTB7_HUMAN	KBTBD7	physical	18775313
WDR26_HUMAN	WDR26	physical	18775313
AMFR_HUMAN	AMFR	physical	18775313
UBR2_HUMAN	UBR2	physical	18775313
UBR4_HUMAN	UBR4	physical	18775313
PJA2_HUMAN	PJA2	physical	18775313
NPL4_HUMAN	NPLOC4	physical	21914798
TERA_HUMAN	VCP	physical	21914798
UFD1_HUMAN	UFD1L	physical	21914798
FBW1A_HUMAN	BTRC	physical	22730322
CUL1_HUMAN	CUL1	physical	22730322
SKP1_HUMAN	SKP1	physical	22730322
TNR6_HUMAN	FAS	physical	10462485
TERA_HUMAN	VCP	physical	15743842
UBC_HUMAN	UBC	physical	15743842
HSP74_HUMAN	HSPA4	physical	22876279
TERA_HUMAN	VCP	physical	21645854
UBC_HUMAN	UBC	physical	19722279
TF65_HUMAN	RELA	physical	14600157
HSP7C_HUMAN	HSPA8	physical	15596450
HSP74_HUMAN	HSPA4	physical	15596450
FADD_HUMAN	FADD	physical	12702723
IKKB_HUMAN	IKBKB	physical	17684021
NLRP3_HUMAN	NLRP3	physical	17046979
TERA_HUMAN	VCP	physical	22350894
TERA_HUMAN	VCP	physical	23293021
UBC_HUMAN	UBC	physical	23293021
HSP74_HUMAN	HSPA4	physical	23293021
NPL4_HUMAN	NPLOC4	physical	23293021
UFD1_HUMAN	UFD1L	physical	23293021
CARM1_HUMAN	CARM1	physical	22863883
SYCC_HUMAN	CARS	physical	22863883
NXP20_HUMAN	FAM114A1	physical	22863883
SYFB_HUMAN	FARSB	physical	22863883
PUR2_HUMAN	GART	physical	22863883
HIRP3_HUMAN	HIRIP3	physical	22863883
HSP74_HUMAN	HSPA4	physical	22863883
HS105_HUMAN	HSPH1	physical	22863883
ILK_HUMAN	ILK	physical	22863883
PLOD2_HUMAN	PLOD2	physical	22863883
PPM1G_HUMAN	PPM1G	physical	22863883
2A5G_HUMAN	PPP2R5C	physical	22863883
ANM3_HUMAN	PRMT3	physical	22863883
PUF60_HUMAN	PUF60	physical	22863883
RANB3_HUMAN	RANBP3	physical	22863883
RL24_HUMAN	RPL24	physical	22863883
SAMH1_HUMAN	SAMHD1	physical	22863883
SC23A_HUMAN	SEC23A	physical	22863883
SET_HUMAN	SET	physical	22863883
SF01_HUMAN	SF1	physical	22863883
SWP70_HUMAN	SWAP70	physical	22863883
TLN1_HUMAN	TLN1	physical	22863883
RO60_HUMAN	TROVE2	physical	22863883
UGPA_HUMAN	UGP2	physical	22863883
XPO7_HUMAN	XPO7	physical	22863883
VAPA_HUMAN	VAPA	physical	24885147
VAPB_HUMAN	VAPB	physical	24885147
TERA_HUMAN	VCP	physical	24885147
UBC_HUMAN	UBC	physical	24885147
UBL4A_HUMAN	UBL4A	physical	24885147
ASNA_HUMAN	ASNA1	physical	24885147
GET4_HUMAN	GET4	physical	24885147
BAG6_HUMAN	BAG6	physical	24885147
RPN2_HUMAN	RPN2	physical	24885147
OST48_HUMAN	DDOST	physical	24885147
FAF1_HUMAN	FAF1	physical	23720822
UBC_HUMAN	UBC	physical	18775313
CTNB1_HUMAN	CTNNB1	physical	22730322
UBC_HUMAN	UBC	physical	22876279
CDT1_HUMAN	CDT1	physical	26842564
TERA_HUMAN	VCP	physical	26842564
CTNB1_HUMAN	CTNNB1	physical	26456834
IPO5_HUMAN	IPO5	physical	26811330
WDR24_HUMAN	WDR24	physical	26389662
YTHD1_HUMAN	YTHDF1	physical	26389662
RAE1L_HUMAN	RAE1	physical	26389662
VAPA_HUMAN	VAPA	physical	26389662
TERA_HUMAN	VCP	physical	26389662
NPL4_HUMAN	NPLOC4	physical	26389662
UFD1_HUMAN	UFD1L	physical	26389662
BACD3_HUMAN	KCTD10	physical	26389662
VAPB_HUMAN	VAPB	physical	26389662
YTHD3_HUMAN	YTHDF3	physical	26389662
WDR59_HUMAN	WDR59	physical	26389662
MMAB_HUMAN	MMAB	physical	26389662
NUP98_HUMAN	NUP98	physical	26389662
MYCB2_HUMAN	MYCBP2	physical	26389662
UBP11_HUMAN	USP11	physical	26389662
ASPC1_HUMAN	ASPSCR1	physical	26389662
HSP72_HUMAN	HSPA2	physical	26389662
MIO_HUMAN	MIOS	physical	26389662
UBXN6_HUMAN	UBXN6	physical	26389662
BTBD9_HUMAN	BTBD9	physical	26389662
BACD1_HUMAN	KCTD13	physical	26389662
BACD2_HUMAN	TNFAIP1	physical	26389662
UBXN7_HUMAN	UBXN7	physical	26389662
CASP8_HUMAN	CASP8	physical	28414080
TF65_HUMAN	RELA	physical	28414080

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FAF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320 AND SER-582, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-225, AND MASSSPECTROMETRY.	15592455 [Abstract]