dbPTM

TERA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TERA_HUMAN
UniProt AC	P55072
Protein Name	Transitional endoplasmic reticulum ATPase
Gene Name	VCP
Organism	Homo sapiens (Human).
Sequence Length	806
Subcellular Localization	Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787). Present in the Lewy bodies specifically found i
Protein Description	Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. [PubMed: 26565908 Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites]
Protein Sequence	MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDNDDDLYG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGADSKG ------CCCCCCCCC	19.37	21406692
3	Phosphorylation	-----MASGADSKGD -----CCCCCCCCCC	32.96	23401153
7	Phosphorylation	-MASGADSKGDDLST -CCCCCCCCCCCHHH	37.69	25159151
8	Sumoylation	MASGADSKGDDLSTA CCCCCCCCCCCHHHH	67.89	-
8	Acetylation	MASGADSKGDDLSTA CCCCCCCCCCCHHHH	67.89	19335618
8	Sumoylation	MASGADSKGDDLSTA CCCCCCCCCCCHHHH	67.89	28112733
8	Ubiquitination	MASGADSKGDDLSTA CCCCCCCCCCCHHHH	67.89	21890473
13	Phosphorylation	DSKGDDLSTAILKQK CCCCCCHHHHHHHCC	23.84	29255136
14	Phosphorylation	SKGDDLSTAILKQKN CCCCCHHHHHHHCCC	25.64	29255136
18	Acetylation	DLSTAILKQKNRPNR CHHHHHHHCCCCCCC	53.78	19335618
18	Sumoylation	DLSTAILKQKNRPNR CHHHHHHHCCCCCCC	53.78	28112733
18	Ubiquitination	DLSTAILKQKNRPNR CHHHHHHHCCCCCCC	53.78	21906983
20	Ubiquitination	STAILKQKNRPNRLI HHHHHHCCCCCCCEE	54.02	-
37	Phosphorylation	EAINEDNSVVSLSQP ECCCCCCCEEECCCC	35.90	22817900
40	Phosphorylation	NEDNSVVSLSQPKMD CCCCCEEECCCCCCC	21.83	21712546
45	Ubiquitination	VVSLSQPKMDELQLF EEECCCCCCCCCHHH	51.88	21906983
46	Sulfoxidation	VSLSQPKMDELQLFR EECCCCCCCCCHHHC	6.52	21406390
56	Phosphorylation	LQLFRGDTVLLKGKK CHHHCCCEEEECCCC	18.84	22817900
60	Sumoylation	RGDTVLLKGKKRREA CCCEEEECCCCCCEE	65.60	-
60	Acetylation	RGDTVLLKGKKRREA CCCEEEECCCCCCEE	65.60	19335618
60	Sumoylation	RGDTVLLKGKKRREA CCCEEEECCCCCCEE	65.60	-
60	Ubiquitination	RGDTVLLKGKKRREA CCCEEEECCCCCCEE	65.60	-
62	Sumoylation	DTVLLKGKKRREAVC CEEEECCCCCCEEEE	41.33	-
62	Acetylation	DTVLLKGKKRREAVC CEEEECCCCCCEEEE	41.33	19335618
62	Sumoylation	DTVLLKGKKRREAVC CEEEECCCCCCEEEE	41.33	-
63	Sumoylation	TVLLKGKKRREAVCI EEEECCCCCCEEEEE	66.41	-
63	Sumoylation	TVLLKGKKRREAVCI EEEECCCCCCEEEEE	66.41	-
63	Ubiquitination	TVLLKGKKRREAVCI EEEECCCCCCEEEEE	66.41	-
73	Phosphorylation	EAVCIVLSDDTCSDE EEEEEEEECCCCCHH	23.65	22817900
76	Phosphorylation	CIVLSDDTCSDEKIR EEEEECCCCCHHHHC	20.92	28270605
78	Phosphorylation	VLSDDTCSDEKIRMN EEECCCCCHHHHCHH	51.39	28270605
81	Acetylation	DDTCSDEKIRMNRVV CCCCCHHHHCHHHHH	40.37	19335618
81	Ubiquitination	DDTCSDEKIRMNRVV CCCCCHHHHCHHHHH	40.37	21906983
101	Phosphorylation	VRLGDVISIQPCPDV EECCCEEEEEECCCC	18.28	22817900
105	S-nitrosocysteine	DVISIQPCPDVKYGK CEEEEEECCCCCCCC	2.29	-
105	Glutathionylation	DVISIQPCPDVKYGK CEEEEEECCCCCCCC	2.29	22555962
105	S-nitrosylation	DVISIQPCPDVKYGK CEEEEEECCCCCCCC	2.29	22178444
109	2-Hydroxyisobutyrylation	IQPCPDVKYGKRIHV EEECCCCCCCCEEEE	56.52	-
109	Acetylation	IQPCPDVKYGKRIHV EEECCCCCCCCEEEE	56.52	25953088
109	Ubiquitination	IQPCPDVKYGKRIHV EEECCCCCCCCEEEE	56.52	21890473
110	Phosphorylation	QPCPDVKYGKRIHVL EECCCCCCCCEEEEE	27.94	22817900
112	Acetylation	CPDVKYGKRIHVLPI CCCCCCCCEEEEEEC	45.12	25953088
112	Ubiquitination	CPDVKYGKRIHVLPI CCCCCCCCEEEEEEC	45.12	-
136	Sumoylation	NLFEVYLKPYFLEAY CEEEEEECHHHHHHH	21.71	-
136	Sumoylation	NLFEVYLKPYFLEAY CEEEEEECHHHHHHH	21.71	-
138	Phosphorylation	FEVYLKPYFLEAYRP EEEEECHHHHHHHCC	21.14	22817900
143	Phosphorylation	KPYFLEAYRPIRKGD CHHHHHHHCCCCCCC	13.93	22817900
148	Malonylation	EAYRPIRKGDIFLVR HHHCCCCCCCEEEEE	62.75	26320211
148	Ubiquitination	EAYRPIRKGDIFLVR HHHCCCCCCCEEEEE	62.75	-
155	Methylation	KGDIFLVRGGMRAVE CCCEEEEECCCCEEE	37.79	115919777
164	Sumoylation	GMRAVEFKVVETDPS CCCEEEEEEEECCCC	31.68	-
164	Acetylation	GMRAVEFKVVETDPS CCCEEEEEEEECCCC	31.68	19335618
164	Sumoylation	GMRAVEFKVVETDPS CCCEEEEEEEECCCC	31.68	-
164	Ubiquitination	GMRAVEFKVVETDPS CCCEEEEEEEECCCC	31.68	21890473
168	Phosphorylation	VEFKVVETDPSPYCI EEEEEEECCCCCCEE	41.42	28152594
171	Phosphorylation	KVVETDPSPYCIVAP EEEECCCCCCEEECC	31.17	28152594
173	Phosphorylation	VETDPSPYCIVAPDT EECCCCCCEEECCCE	10.11	28152594
180	Phosphorylation	YCIVAPDTVIHCEGE CEEECCCEEEEECCC	21.94	28152594
190	2-Hydroxyisobutyrylation	HCEGEPIKREDEEES EECCCCCCCCCCHHH	61.52	-
190	Acetylation	HCEGEPIKREDEEES EECCCCCCCCCCHHH	61.52	26051181
190	Ubiquitination	HCEGEPIKREDEEES EECCCCCCCCCCHHH	61.52	-
197	Phosphorylation	KREDEEESLNEVGYD CCCCCHHHHHHCCCC	39.51	25159151
203	Phosphorylation	ESLNEVGYDDIGGCR HHHHHCCCCCCCHHH	18.67	21406692
211	2-Hydroxyisobutyrylation	DDIGGCRKQLAQIKE CCCCHHHHHHHHHHH	54.46	-
211	Ubiquitination	DDIGGCRKQLAQIKE CCCCHHHHHHHHHHH	54.46	21890473
217	Ubiquitination	RKQLAQIKEMVELPL HHHHHHHHHHHHCCC	27.90	21906983
219	Sulfoxidation	QLAQIKEMVELPLRH HHHHHHHHHHCCCCC	2.11	30846556
231	Acetylation	LRHPALFKAIGVKPP CCCHHHHHHCCCCCC	39.69	26051181
231	Methylation	LRHPALFKAIGVKPP CCCHHHHHHCCCCCC	39.69	24604063
231	Ubiquitination	LRHPALFKAIGVKPP CCCHHHHHHCCCCCC	39.69	21890473
236	Ubiquitination	LFKAIGVKPPRGILL HHHHCCCCCCCEEEE	44.05	21906983
244	Phosphorylation	PPRGILLYGPPGTGK CCCEEEEECCCCCCH	24.92	25147952
249	Phosphorylation	LLYGPPGTGKTLIAR EEECCCCCCHHHHHH	41.08	22817900
251	2-Hydroxyisobutyrylation	YGPPGTGKTLIARAV ECCCCCCHHHHHHHH	39.74	-
251	Acetylation	YGPPGTGKTLIARAV ECCCCCCHHHHHHHH	39.74	19335618
251	Ubiquitination	YGPPGTGKTLIARAV ECCCCCCHHHHHHHH	39.74	21890473
252	Phosphorylation	GPPGTGKTLIARAVA CCCCCCHHHHHHHHH	25.41	28348404
276	Phosphorylation	INGPEIMSKLAGESE EECHHHHHHHCCCCH	30.13	22817900
277	Ubiquitination	NGPEIMSKLAGESES ECHHHHHHHCCCCHH	25.61	-
282	Phosphorylation	MSKLAGESESNLRKA HHHHCCCCHHHHHHH	45.46	25159151
284	Phosphorylation	KLAGESESNLRKAFE HHCCCCHHHHHHHHH	50.90	25159151
288	2-Hydroxyisobutyrylation	ESESNLRKAFEEAEK CCHHHHHHHHHHHHH	61.67	-
288	Ubiquitination	ESESNLRKAFEEAEK CCHHHHHHHHHHHHH	61.67	21906983
295	Ubiquitination	KAFEEAEKNAPAIIF HHHHHHHHCCCEEEE	66.51	21906983
312	Acetylation	ELDAIAPKREKTHGE CHHHHCCCCCCCCHH	65.25	134165
312	Ubiquitination	ELDAIAPKREKTHGE CHHHHCCCCCCCCHH	65.25	21890473
315	"N6,N6,N6-trimethyllysine"	AIAPKREKTHGEVER HHCCCCCCCCHHHHH	50.26	-
315	Acetylation	AIAPKREKTHGEVER HHCCCCCCCCHHHHH	50.26	19335618
315	Methylation	AIAPKREKTHGEVER HHCCCCCCCCHHHHH	50.26	23349634
316	Phosphorylation	IAPKREKTHGEVERR HCCCCCCCCHHHHHH	30.29	22817900
326	Phosphorylation	EVERRIVSQLLTLMD HHHHHHHHHHHHHHH	16.85	23403867
330	Phosphorylation	RIVSQLLTLMDGLKQ HHHHHHHHHHHHHHH	28.73	22817900
332	Sulfoxidation	VSQLLTLMDGLKQRA HHHHHHHHHHHHHCC	3.02	30846556
336	Acetylation	LTLMDGLKQRAHVIV HHHHHHHHHCCEEEE	43.18	19335618
336	Ubiquitination	LTLMDGLKQRAHVIV HHHHHHHHHCCEEEE	43.18	21890473
344	Sulfoxidation	QRAHVIVMAATNRPN HCCEEEEEEECCCCC	1.12	30846556
347	Phosphorylation	HVIVMAATNRPNSID EEEEEEECCCCCCCC	23.40	29214152
352	Phosphorylation	AATNRPNSIDPALRR EECCCCCCCCHHHHH	30.93	19335618
375	Phosphorylation	DIGIPDATGRLEILQ CCCCCCCCCCEEEEE	30.16	22817900
385	Phosphorylation	LEILQIHTKNMKLAD EEEEEEECCCCEECC	26.24	21406692
386	Acetylation	EILQIHTKNMKLADD EEEEEECCCCEECCC	40.66	19335618
386	Ubiquitination	EILQIHTKNMKLADD EEEEEECCCCEECCC	40.66	21890473
389	Ubiquitination	QIHTKNMKLADDVDL EEECCCCEECCCCCH	50.33	-
403	Phosphorylation	LEQVANETHGHVGAD HHHHHHHCCCCHHHH	32.72	-
425	Ubiquitination	AALQAIRKKMDLIDL HHHHHHHHHCCCCCC	46.46	-
436	Phosphorylation	LIDLEDETIDAEVMN CCCCCCCCCCHHHHH	36.16	17192257
457	Phosphorylation	DDFRWALSQSNPSAL HHHHHHHHCCCHHHH	24.66	22817900
459	Phosphorylation	FRWALSQSNPSALRE HHHHHHCCCHHHHHH	47.54	22817900
462	Phosphorylation	ALSQSNPSALRETVV HHHCCCHHHHHHHEE	44.16	21712546
486	2-Hydroxyisobutyrylation	IGGLEDVKRELQELV CCCHHHHHHHHHHHH	53.10	-
486	Ubiquitination	IGGLEDVKRELQELV CCCHHHHHHHHHHHH	53.10	20639865
495	Phosphorylation	ELQELVQYPVEHPDK HHHHHHCCCCCCCCC	11.19	28152594
502	2-Hydroxyisobutyrylation	YPVEHPDKFLKFGMT CCCCCCCCCCCCCCC	57.98	-
502	Acetylation	YPVEHPDKFLKFGMT CCCCCCCCCCCCCCC	57.98	25953088
502	Ubiquitination	YPVEHPDKFLKFGMT CCCCCCCCCCCCCCC	57.98	21890473
505	2-Hydroxyisobutyrylation	EHPDKFLKFGMTPSK CCCCCCCCCCCCCCC	42.90	-
505	Acetylation	EHPDKFLKFGMTPSK CCCCCCCCCCCCCCC	42.90	19335618
505	Ubiquitination	EHPDKFLKFGMTPSK CCCCCCCCCCCCCCC	42.90	21906983
509	Phosphorylation	KFLKFGMTPSKGVLF CCCCCCCCCCCCEEE	25.45	21712546
511	Phosphorylation	LKFGMTPSKGVLFYG CCCCCCCCCCEEEEC	32.64	21712546
512	Acetylation	KFGMTPSKGVLFYGP CCCCCCCCCEEEECC	55.00	19335618
512	Ubiquitination	KFGMTPSKGVLFYGP CCCCCCCCCEEEECC	55.00	21906983
517	Phosphorylation	PSKGVLFYGPPGCGK CCCCEEEECCCCCCH	25.26	28152594
522	S-nitrosylation	LFYGPPGCGKTLLAK EEECCCCCCHHHHHH	6.61	22178444
522	S-palmitoylation	LFYGPPGCGKTLLAK EEECCCCCCHHHHHH	6.61	29575903
524	2-Hydroxyisobutyrylation	YGPPGCGKTLLAKAI ECCCCCCHHHHHHHH	39.82	-
524	Acetylation	YGPPGCGKTLLAKAI ECCCCCCHHHHHHHH	39.82	19335618
524	Ubiquitination	YGPPGCGKTLLAKAI ECCCCCCHHHHHHHH	39.82	21890473
525	Phosphorylation	GPPGCGKTLLAKAIA CCCCCCHHHHHHHHH	16.58	23312004
529	Acetylation	CGKTLLAKAIANECQ CCHHHHHHHHHHHHH	40.05	19335618
529	Ubiquitination	CGKTLLAKAIANECQ CCHHHHHHHHHHHHH	40.05	21906983
535	S-nitrosocysteine	AKAIANECQANFISI HHHHHHHHHCCEEEE	4.67	-
535	S-nitrosylation	AKAIANECQANFISI HHHHHHHHHCCEEEE	4.67	19483679
541	Phosphorylation	ECQANFISIKGPELL HHHCCEEEEECHHHH	17.70	22817900
543	Ubiquitination	QANFISIKGPELLTM HCCEEEEECHHHHEE	62.72	-
555	Phosphorylation	LTMWFGESEANVREI HEEECCCCCHHHHHH	42.25	22817900
565	Ubiquitination	NVREIFDKARQAAPC HHHHHHHHHHHHCCE	34.42	21890473
572	S-nitrosocysteine	KARQAAPCVLFFDEL HHHHHCCEEEEECCH	3.40	-
572	Glutathionylation	KARQAAPCVLFFDEL HHHHHCCEEEEECCH	3.40	22555962
572	S-nitrosylation	KARQAAPCVLFFDEL HHHHHCCEEEEECCH	3.40	19483679
581	Phosphorylation	LFFDELDSIAKARGG EEECCHHHHHHHCCC	36.75	25338102
584	Ubiquitination	DELDSIAKARGGNIG CCHHHHHHHCCCCCC	36.63	21906983
586	Methylation	LDSIAKARGGNIGDG HHHHHHHCCCCCCCC	53.50	115919781
599	Methylation	DGGGAADRVINQILT CCCHHHHHHHHHHHH	26.87	115919785
606	Phosphorylation	RVINQILTEMDGMST HHHHHHHHHCCCCCC	30.78	21406692
608	Sulfoxidation	INQILTEMDGMSTKK HHHHHHHCCCCCCCC	4.55	21406390
612	Phosphorylation	LTEMDGMSTKKNVFI HHHCCCCCCCCCEEE	42.47	20068231
613	Phosphorylation	TEMDGMSTKKNVFII HHCCCCCCCCCEEEE	36.83	20068231
614	2-Hydroxyisobutyrylation	EMDGMSTKKNVFIIG HCCCCCCCCCEEEEE	34.74	-
614	Acetylation	EMDGMSTKKNVFIIG HCCCCCCCCCEEEEE	34.74	19335618
614	Ubiquitination	EMDGMSTKKNVFIIG HCCCCCCCCCEEEEE	34.74	21906983
615	Acetylation	MDGMSTKKNVFIIGA CCCCCCCCCEEEEEC	59.43	19335618
615	Ubiquitination	MDGMSTKKNVFIIGA CCCCCCCCCEEEEEC	59.43	-
623	Phosphorylation	NVFIIGATNRPDIID CEEEEECCCCCCCCC	26.92	22817900
644	Nitration	GRLDQLIYIPLPDEK CCCCEEEEEECCCHH	12.70	-
644	Phosphorylation	GRLDQLIYIPLPDEK CCCCEEEEEECCCHH	12.70	17360941
651	Acetylation	YIPLPDEKSRVAILK EEECCCHHHHEEHHH	51.44	23954790
651	Ubiquitination	YIPLPDEKSRVAILK EEECCCHHHHEEHHH	51.44	21890473
652	Phosphorylation	IPLPDEKSRVAILKA EECCCHHHHEEHHHH	29.91	22817900
658	2-Hydroxyisobutyrylation	KSRVAILKANLRKSP HHHEEHHHHHCCCCC	29.17	-
658	Acetylation	KSRVAILKANLRKSP HHHEEHHHHHCCCCC	29.17	27178108
658	Malonylation	KSRVAILKANLRKSP HHHEEHHHHHCCCCC	29.17	26320211
658	Ubiquitination	KSRVAILKANLRKSP HHHEEHHHHHCCCCC	29.17	21890473
663	Acetylation	ILKANLRKSPVAKDV HHHHHCCCCCCCCCC	63.38	19335618
663	Ubiquitination	ILKANLRKSPVAKDV HHHHHCCCCCCCCCC	63.38	21906983
664	Phosphorylation	LKANLRKSPVAKDVD HHHHCCCCCCCCCCC	20.41	22817900
668	Acetylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	23236377
668	Malonylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	26320211
668	Succinylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	-
668	Succinylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	-
668	Sumoylation	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	-
668	Ubiquitination	LRKSPVAKDVDLEFL CCCCCCCCCCCHHHH	59.52	21890473
677	Acetylation	VDLEFLAKMTNGFSG CCHHHHHHHCCCCCC	48.69	19335618
677	Ubiquitination	VDLEFLAKMTNGFSG CCHHHHHHHCCCCCC	48.69	-
679	Phosphorylation	LEFLAKMTNGFSGAD HHHHHHHCCCCCCCC	31.33	22817900
683	Phosphorylation	AKMTNGFSGADLTEI HHHCCCCCCCCHHHH	34.17	22817900
688	Phosphorylation	GFSGADLTEICQRAC CCCCCCHHHHHHHHH	24.69	22817900
691	S-palmitoylation	GADLTEICQRACKLA CCCHHHHHHHHHHHH	1.50	26865113
696	Acetylation	EICQRACKLAIRESI HHHHHHHHHHHHHHH	39.71	19335618
696	Ubiquitination	EICQRACKLAIRESI HHHHHHHHHHHHHHH	39.71	21890473
702	Phosphorylation	CKLAIRESIESEIRR HHHHHHHHHHHHHHH	23.08	30266825
705	Phosphorylation	AIRESIESEIRRERE HHHHHHHHHHHHHHH	36.33	22617229
708	Methylation	ESIESEIRRERERQT HHHHHHHHHHHHHCC	30.29	115919789
715	Phosphorylation	RRERERQTNPSAMEV HHHHHHCCCCCCCCC	56.15	29214152
718	Phosphorylation	RERQTNPSAMEVEED HHHCCCCCCCCCCCC	42.17	29507054
720	Sulfoxidation	RQTNPSAMEVEEDDP HCCCCCCCCCCCCCC	7.51	21406390
746	Phosphorylation	AMRFARRSVSDNDIR HHHHHHHCCCHHHHH	22.03	19335618
748	Phosphorylation	RFARRSVSDNDIRKY HHHHHCCCHHHHHHH	31.76	19335618
753	Methylation	SVSDNDIRKYEMFAQ CCCHHHHHHHHHHHH	38.06	115919793
754	2-Hydroxyisobutyrylation	VSDNDIRKYEMFAQT CCHHHHHHHHHHHHH	45.99	-
754	Acetylation	VSDNDIRKYEMFAQT CCHHHHHHHHHHHHH	45.99	19335618
754	Malonylation	VSDNDIRKYEMFAQT CCHHHHHHHHHHHHH	45.99	26320211
754	Ubiquitination	VSDNDIRKYEMFAQT CCHHHHHHHHHHHHH	45.99	21890473
755	Phosphorylation	SDNDIRKYEMFAQTL CHHHHHHHHHHHHHH	11.63	22817900
757	Sulfoxidation	NDIRKYEMFAQTLQQ HHHHHHHHHHHHHHH	2.83	28465586
761	Phosphorylation	KYEMFAQTLQQSRGF HHHHHHHHHHHHCCC	24.09	22817900
765	Phosphorylation	FAQTLQQSRGFGSFR HHHHHHHHCCCCCEE	22.78	30108239
770	Phosphorylation	QQSRGFGSFRFPSGN HHHCCCCCEECCCCC	15.81	28102081
775	Phosphorylation	FGSFRFPSGNQGGAG CCCEECCCCCCCCCC	47.89	24043423
784	Phosphorylation	NQGGAGPSQGSGGGT CCCCCCCCCCCCCCC	46.38	17525332
787	Phosphorylation	GAGPSQGSGGGTGGS CCCCCCCCCCCCCCC	26.99	24043423
791	Phosphorylation	SQGSGGGTGGSVYTE CCCCCCCCCCCCCCC	41.46	24043423
794	Phosphorylation	SGGGTGGSVYTEDND CCCCCCCCCCCCCCC	17.19	24043423
796	Phosphorylation	GGTGGSVYTEDNDDD CCCCCCCCCCCCCCC	13.20	28102081
797	Phosphorylation	GTGGSVYTEDNDDDL CCCCCCCCCCCCCCC	34.41	28796482
805	Phosphorylation	EDNDDDLYG------ CCCCCCCCC------	27.99	19605366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
326	S	Phosphorylation	Kinase	ATM	Q13315	PSP
352	S	Phosphorylation	Kinase	AKT1	P31749	PSP
352	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
509	T	Phosphorylation	Kinase	CDK4	P11802	PSP
664	S	Phosphorylation	Kinase	CDK4	P11802	PSP
746	S	Phosphorylation	Kinase	AKT1	P31749	PSP
746	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
748	S	Phosphorylation	Kinase	AKT1	P31749	PSP
748	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
784	S	Phosphorylation	Kinase	ATR	Q13535	PSP
784	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM13	O60858	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
315	K	Methylation	23349634
Lys-315 methylation may decrease ATPase activity.
315	K	Methylation	23349634
Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TERA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NSF1C_HUMAN	NSFL1C	physical	12810701
TERA_HUMAN	VCP	physical	12807884
TOM34_HUMAN	TOMM34	physical	11913976
BRCA1_HUMAN	BRCA1	physical	10855792
PRS4_HUMAN	PSMC1	physical	9452483
IKBA_HUMAN	NFKBIA	physical	9452483
TERA_HUMAN	VCP	physical	17525332
CHK2_HUMAN	CHEK2	physical	17525332
UFD1_HUMAN	UFD1L	physical	18199748
SELS_HUMAN	VIMP	physical	18199748
DERL1_HUMAN	DERL1	physical	18199748
ATX3_HUMAN	ATXN3	physical	18199748
SELS_HUMAN	VIMP	physical	17872946
SVIP_HUMAN	SVIP	physical	17872946
SYVN1_HUMAN	SYVN1	physical	17872946
AMFR_HUMAN	AMFR	physical	17872946
DERL1_HUMAN	DERL1	physical	17872946
UFD1_HUMAN	UFD1L	physical	17872946
NPL4_HUMAN	NPLOC4	physical	17872946
TERA_HUMAN	VCP	physical	16621797
CASR_HUMAN	CASR	physical	16513638
RN19A_HUMAN	RNF19A	physical	16513638
HERP1_HUMAN	HERPUD1	physical	16289116
SYVN1_HUMAN	SYVN1	physical	16289116
DERL1_HUMAN	DERL1	physical	16289116
DERL1_HUMAN	DERL1	physical	16186510
FBX2_HUMAN	FBXO2	physical	15723043
FBX6_HUMAN	FBXO6	physical	15723043
ITB1_HUMAN	ITGB1	physical	15723043
AMFR_HUMAN	AMFR	physical	15331598
UBE4B_HUMAN	UBE4B	physical	14749733
RN19A_HUMAN	RNF19A	physical	15456787
CSN5_HUMAN	COPS5	physical	19826004
AMFR_HUMAN	AMFR	physical	20126661
ANKZ1_HUMAN	ANKZF1	physical	21896481
UBXN6_HUMAN	UBXN6	physical	21896481
TADBP_HUMAN	TARDBP	physical	19237541
NSF1C_HUMAN	NSFL1C	physical	18775313
FAF2_HUMAN	FAF2	physical	18775313
UBX2B_HUMAN	UBXN2B	physical	18775313
UBXN7_HUMAN	UBXN7	physical	18775313
UBXN1_HUMAN	UBXN1	physical	18775313
UBX2A_HUMAN	UBXN2A	physical	18775313
ASPC1_HUMAN	ASPSCR1	physical	18775313
FAF1_HUMAN	FAF1	physical	18775313
HIF1A_HUMAN	HIF1A	physical	18775313
NPL4_HUMAN	NPLOC4	physical	18775313
UFD1_HUMAN	UFD1L	physical	18775313
CUL1_HUMAN	CUL1	physical	18775313
CUL2_HUMAN	CUL2	physical	18775313
DPYL1_HUMAN	CRMP1	physical	21900206
TM1L1_HUMAN	TOM1L1	physical	21900206
MLP3A_HUMAN	MAP1LC3A	physical	21909394
UFD1_HUMAN	UFD1L	physical	16822850
UBC_HUMAN	UBC	physical	16822850
NGLY1_HUMAN	NGLY1	physical	15362974
UBE4B_HUMAN	UBE4B	physical	19175675
AMFR_HUMAN	AMFR	physical	17311810
AMFR_HUMAN	AMFR	physical	21914798
ANKZ1_HUMAN	ANKZF1	physical	21914798
UBXN6_HUMAN	UBXN6	physical	21914798
SVIP_HUMAN	SVIP	physical	21914798
RHBL3_HUMAN	RHBDL3	physical	22795130
PTCRA_HUMAN	PTCRA	physical	22795130
WRN_HUMAN	WRN	physical	12937274
NSF1C_HUMAN	NSFL1C	physical	21949850
UBXN8_HUMAN	UBXN8	physical	21949850
FAF1_HUMAN	FAF1	physical	15743842
FAF1_HUMAN	FAF1	physical	20057067
UBXN1_HUMAN	UBXN1	physical	21135095
A1AT_HUMAN	SERPINA1	physical	21135095
CFTR_HUMAN	CFTR	physical	16954204
UBE4B_HUMAN	UBE4B	physical	20414249
NPL4_HUMAN	NPLOC4	physical	20414249
UFD1_HUMAN	UFD1L	physical	20414249
ATX3_HUMAN	ATXN3	physical	20414249
SYVN1_HUMAN	SYVN1	physical	20414249
NSF1C_HUMAN	NSFL1C	physical	20414249
UBXN6_HUMAN	UBXN6	physical	19275885
SPRTN_HUMAN	SPRTN	physical	22902628
NSF1C_HUMAN	NSFL1C	physical	16234241
NPL4_HUMAN	NPLOC4	physical	16234241
UFD1_HUMAN	UFD1L	physical	16234241
GRAK_HUMAN	GZMK	physical	20876349
UFD1_HUMAN	UFD1L	physical	15371428
NPL4_HUMAN	NPLOC4	physical	15371428
FAF1_HUMAN	FAF1	physical	22102026
NSF1C_HUMAN	NSFL1C	physical	12473691
TERA_HUMAN	VCP	physical	22270372
AKT1_HUMAN	AKT1	physical	16551632
UBC_HUMAN	UBC	physical	11483959
NF1_HUMAN	NF1	physical	22105171
2AAA_HUMAN	PPP2R1A	physical	20100830
PP2AA_HUMAN	PPP2CA	physical	20100830
PSPC_HUMAN	SFTPC	physical	19815549
ATX3_HUMAN	ATXN3	physical	22970133
DJC10_HUMAN	DNAJC10	physical	18400946
DNJB9_HUMAN	DNAJB9	physical	18400946
EEA1_HUMAN	EEA1	physical	21556036
TERA_HUMAN	VCP	physical	10350210
TXND5_HUMAN	TXNDC5	physical	22939629
THIOM_HUMAN	TXN2	physical	22939629
FAF1_HUMAN	FAF1	physical	23293021
NPL4_HUMAN	NPLOC4	physical	23293021
PSA1_HUMAN	PSMA1	physical	23393163
CH10_HUMAN	HSPE1	physical	23383273
1433B_HUMAN	YWHAB	physical	23383273
1433E_HUMAN	YWHAE	physical	23383273
1433F_HUMAN	YWHAH	physical	23383273
1433G_HUMAN	YWHAG	physical	23383273
1433T_HUMAN	YWHAQ	physical	23383273
1433Z_HUMAN	YWHAZ	physical	23383273
TB182_HUMAN	TNKS1BP1	physical	23383273
RS13_HUMAN	RPS13	physical	23383273
RS9_HUMAN	RPS9	physical	23383273
4F2_HUMAN	SLC3A2	physical	23383273
AAKG1_HUMAN	PRKAG1	physical	23383273
NMD3_HUMAN	NMD3	physical	23383273
RL6_HUMAN	RPL6	physical	23383273
GRP78_HUMAN	HSPA5	physical	23383273
ACACA_HUMAN	ACACA	physical	23383273
ACTB_HUMAN	ACTB	physical	23383273
ARPC2_HUMAN	ARPC2	physical	23383273
ARF6_HUMAN	ARF6	physical	23383273
ARFG2_HUMAN	ARFGAP2	physical	23383273
GGA1_HUMAN	GGA1	physical	23383273
GGA2_HUMAN	GGA2	physical	23383273
ACTN1_HUMAN	ACTN1	physical	23383273
ADDA_HUMAN	ADD1	physical	23383273
SNAA_HUMAN	NAPA	physical	23383273
ALS2_HUMAN	ALS2	physical	23383273
APC7_HUMAN	ANAPC7	physical	23383273
ANKH1_HUMAN	ANKHD1	physical	23383273
ANXA2_HUMAN	ANXA2	physical	23383273
ANXA5_HUMAN	ANXA5	physical	23383273
ANXA7_HUMAN	ANXA7	physical	23383273
AP1B1_HUMAN	AP1B1	physical	23383273
AP2A2_HUMAN	AP2A2	physical	23383273
BAX_HUMAN	BAX	physical	23383273
ATX10_HUMAN	ATXN10	physical	23383273
ATX3_HUMAN	ATXN3	physical	23383273
WRIP1_HUMAN	WRNIP1	physical	23383273
BAG2_HUMAN	BAG2	physical	23383273
BZW2_HUMAN	BZW2	physical	23383273
BASI_HUMAN	BSG	physical	23383273
BCLF1_HUMAN	BCLAF1	physical	23383273
CTBL1_HUMAN	CTNNBL1	physical	23383273
BID_HUMAN	BID	physical	23383273
BI2L1_HUMAN	BAIAP2L1	physical	23383273
BRAT1_HUMAN	BRAT1	physical	23383273
BCCIP_HUMAN	BCCIP	physical	23383273
BIG2_HUMAN	ARFGEF2	physical	23383273
CAB39_HUMAN	CAB39	physical	23383273
CALX_HUMAN	CANX	physical	23383273
KAP2_HUMAN	PRKAR2A	physical	23383273
CSK2B_HUMAN	CSNK2B	physical	23383273
CAAP1_HUMAN	CAAP1	physical	23383273
CASP7_HUMAN	CASP7	physical	23383273
COMT_HUMAN	COMT	physical	23383273
CTNA1_HUMAN	CTNNA1	physical	23383273
CTND1_HUMAN	CTNND1	physical	23383273
CNO10_HUMAN	CNOT10	physical	23383273
CNOT2_HUMAN	CNOT2	physical	23383273
CNOT8_HUMAN	CNOT8	physical	23383273
BORG5_HUMAN	CDC42EP1	physical	23383273
BORG4_HUMAN	CDC42EP4	physical	23383273
CARF_HUMAN	CDKN2AIP	physical	23383273
CIDEC_HUMAN	CIDEC	physical	23383273
CNOT9_HUMAN	RQCD1	physical	23383273
CDC27_HUMAN	CDC27	physical	23383273
LYAR_HUMAN	LYAR	physical	23383273
P53_HUMAN	TP53	physical	23383273
CENPH_HUMAN	CENPH	physical	23383273
CEP55_HUMAN	CEP55	physical	23383273
COQ8A_HUMAN	ADCK3	physical	23383273
CLAP1_HUMAN	CLASP1	physical	23383273
COPE_HUMAN	COPE	physical	23383273
STAG2_HUMAN	STAG2	physical	23383273
VPS50_HUMAN	CCDC132	physical	23383273
CC134_HUMAN	CCDC134	physical	23383273
COIL_HUMAN	COIL	physical	23383273
COMD1_HUMAN	COMMD1	physical	23383273
COMD6_HUMAN	COMMD6	physical	23383273
CND2_HUMAN	NCAPH	physical	23383273
COG4_HUMAN	COG4	physical	23383273
COG5_HUMAN	COG5	physical	23383273
CSN3_HUMAN	COPS3	physical	23383273
CSN7A_HUMAN	COPS7A	physical	23383273
CUL5_HUMAN	CUL5	physical	23383273
CUL7_HUMAN	CUL7	physical	23383273
CDK1_HUMAN	CDK1	physical	23383273
CDKA1_HUMAN	CDK2AP1	physical	23383273
CDK4_HUMAN	CDK4	physical	23383273
DC1I2_HUMAN	DYNC1I2	physical	23383273
DC1L1_HUMAN	DYNC1LI1	physical	23383273
ZN326_HUMAN	ZNF326	physical	23383273
DP13A_HUMAN	APPL1	physical	23383273
DOCK7_HUMAN	DOCK7	physical	23383273
P5CS_HUMAN	ALDH18A1	physical	23383273
DESP_HUMAN	DSP	physical	23383273
LRIG1_HUMAN	LRIG1	physical	23383273
TOP1_HUMAN	TOP1	physical	23383273
RPB2_HUMAN	POLR2B	physical	23383273
RPC3_HUMAN	POLR3C	physical	23383273
RPN1_HUMAN	RPN1	physical	23383273
MP2K1_HUMAN	MAP2K1	physical	23383273
TTK_HUMAN	TTK	physical	23383273
DUS9_HUMAN	DUSP9	physical	23383273
DYN3_HUMAN	DNM3	physical	23383273
TRI25_HUMAN	TRIM25	physical	23383273
AMFR_HUMAN	AMFR	physical	23383273
ARI1_HUMAN	ARIH1	physical	23383273
ARI2_HUMAN	ARIH2	physical	23383273
HUWE1_HUMAN	HUWE1	physical	23383273
KCMF1_HUMAN	KCMF1	physical	23383273
MDM2_HUMAN	MDM2	physical	23383273
RING2_HUMAN	RNF2	physical	23383273
RO52_HUMAN	TRIM21	physical	23383273
UBR4_HUMAN	UBR4	physical	23383273
UBR5_HUMAN	UBR5	physical	23383273
MK03_HUMAN	MAPK3	physical	23383273
MK01_HUMAN	MAPK1	physical	23383273
IF4A2_HUMAN	EIF4A2	physical	23383273
IF5A1_HUMAN	EIF5A	physical	23383273
SP16H_HUMAN	SUPT16H	physical	23383273
FANCI_HUMAN	FANCI	physical	23383273
FAF1_HUMAN	FAF1	physical	23383273
FERM2_HUMAN	FERMT2	physical	23383273
FHOD1_HUMAN	FHOD1	physical	23383273
FKB15_HUMAN	FKBP15	physical	23383273
CCNB1_HUMAN	CCNB1	physical	23383273
GCP2_HUMAN	TUBGCP2	physical	23383273
TF3C1_HUMAN	GTF3C1	physical	23383273
TF3C3_HUMAN	GTF3C3	physical	23383273
TF3C5_HUMAN	GTF3C5	physical	23383273
GLP3L_HUMAN	GOLPH3L	physical	23383273
GET4_HUMAN	GET4	physical	23383273
GBF1_HUMAN	GBF1	physical	23383273
HAUS1_HUMAN	HAUS1	physical	23383273
H1BP3_HUMAN	HS1BP3	physical	23383273
HEAT1_HUMAN	HEATR1	physical	23383273
HSP74_HUMAN	HSPA4	physical	23383273
HSP7C_HUMAN	HSPA8	physical	23383273
HSBP1_HUMAN	HSBP1	physical	23383273
HSPB1_HUMAN	HSPB1	physical	23383273
HS90A_HUMAN	HSP90AA1	physical	23383273
HS90B_HUMAN	HSP90AB1	physical	23383273
ROA1_HUMAN	HNRNPA1	physical	23383273
HNRH2_HUMAN	HNRNPH2	physical	23383273
HNRH3_HUMAN	HNRNPH3	physical	23383273
SAP18_HUMAN	SAP18	physical	23383273
H2AJ_HUMAN	H2AFJ	physical	23383273
F10A1_HUMAN	ST13	physical	23383273
CDC37_HUMAN	CDC37	physical	23383273
HD_HUMAN	HTT	physical	23383273
HIP1R_HUMAN	HIP1R	physical	23383273
INF2_HUMAN	INF2	physical	23383273
IQCB1_HUMAN	IQCB1	physical	23383273
KBP_HUMAN	KIAA1279	physical	23383273
SPC24_HUMAN	SPC24	physical	23383273
LMNB2_HUMAN	LMNB2	physical	23383273
BAG6_HUMAN	BAG6	physical	23383273
K1468_HUMAN	KIAA1468	physical	23383273
HELLS_HUMAN	HELLS	physical	23383273
KDM3B_HUMAN	KDM3B	physical	23383273
MA7D3_HUMAN	MAP7D3	physical	23383273
MDN1_HUMAN	MDN1	physical	23383273
MK13_HUMAN	MAPK13	physical	23383273
UBC12_HUMAN	UBE2M	physical	23383273
NBEA_HUMAN	NBEA	physical	23383273
NCDN_HUMAN	NCDN	physical	23383273
DDIAS_HUMAN	DDIAS	physical	23383273
NFKB2_HUMAN	NFKB2	physical	23383273
NUMA1_HUMAN	NUMA1	physical	23383273
NU107_HUMAN	NUP107	physical	23383273
NU205_HUMAN	NUP205	physical	23383273
NUP62_HUMAN	NUP62	physical	23383273
NUP58_HUMAN	NUPL1	physical	23383273
NDKB_HUMAN	NME2	physical	23383273
P85B_HUMAN	PIK3R2	physical	23383273
P3C2B_HUMAN	PIK3C2B	physical	23383273
PLEC_HUMAN	PLEC	physical	23383273
LMNA_HUMAN	LMNA	physical	23383273
TRIPC_HUMAN	TRIP12	physical	23383273
RBM23_HUMAN	RBM23	physical	23383273
PDC10_HUMAN	PDCD10	physical	23383273
PDCD4_HUMAN	PDCD4	physical	23383273
PDCD6_HUMAN	PDCD6	physical	23383273
CIP2A_HUMAN	KIAA1524	physical	23383273
DIAP3_HUMAN	DIAPH3	physical	23383273
HOOK1_HUMAN	HOOK1	physical	23383273
SON_HUMAN	SON	physical	23383273
SC16A_HUMAN	SEC16A	physical	23383273
KPYM_HUMAN	PKM	physical	23383273
PDXD1_HUMAN	PDXDC1	physical	23383273
RBGP1_HUMAN	RABGAP1	physical	23383273
RB3GP_HUMAN	RAB3GAP1	physical	23383273
RBGPR_HUMAN	RAB3GAP2	physical	23383273
AKT1_HUMAN	AKT1	physical	23383273
RAF1_HUMAN	RAF1	physical	23383273
G3BP2_HUMAN	G3BP2	physical	23383273
RSU1_HUMAN	RSU1	physical	23383273
RAB10_HUMAN	RAB10	physical	23383273
RB11B_HUMAN	RAB11B	physical	23383273
RAB14_HUMAN	RAB14	physical	23383273
RAB7A_HUMAN	RAB7A	physical	23383273
RFC3_HUMAN	RFC3	physical	23383273
RFC5_HUMAN	RFC5	physical	23383273
RHG17_HUMAN	ARHGAP17	physical	23383273
ARHG2_HUMAN	ARHGEF2	physical	23383273
RN126_HUMAN	RNF126	physical	23383273
RBX2_HUMAN	RNF7	physical	23383273
RFOX2_HUMAN	RBFOX2	physical	23383273
PNO1_HUMAN	PNO1	physical	23383273
RRP12_HUMAN	RRP12	physical	23383273
SCFD1_HUMAN	SCFD1	physical	23383273
ESPL1_HUMAN	ESPL1	physical	23383273
SRS11_HUMAN	SRSF11	physical	23383273
SRSF3_HUMAN	SRSF3	physical	23383273
CHK1_HUMAN	CHEK1	physical	23383273
ICK_HUMAN	ICK	physical	23383273
MARK2_HUMAN	MARK2	physical	23383273
MTOR_HUMAN	MTOR	physical	23383273
PKN2_HUMAN	PKN2	physical	23383273
NEK2_HUMAN	NEK2	physical	23383273
PLK1_HUMAN	PLK1	physical	23383273
ULK3_HUMAN	ULK3	physical	23383273
WNK1_HUMAN	WNK1	physical	23383273
PP2AB_HUMAN	PPP2CB	physical	23383273
PPP6_HUMAN	PPP6C	physical	23383273
SDCG3_HUMAN	SDCCAG3	physical	23383273
SESN2_HUMAN	SESN2	physical	23383273
STAT1_HUMAN	STAT1	physical	23383273
SUMO1_HUMAN	SUMO1	physical	23383273
SUMO2_HUMAN	SUMO2	physical	23383273
SNX3_HUMAN	SNX3	physical	23383273
SPAST_HUMAN	SPAST	physical	23383273
SKP1_HUMAN	SKP1	physical	23383273
STMN1_HUMAN	STMN1	physical	23383273
SMRC1_HUMAN	SMARCC1	physical	23383273
SMCA5_HUMAN	SMARCA5	physical	23383273
TAF6L_HUMAN	TAF6L	physical	23383273
TOM1_HUMAN	TOM1	physical	23383273
TAXB1_HUMAN	TAX1BP1	physical	23383273
TB10B_HUMAN	TBC1D10B	physical	23383273
TBC9B_HUMAN	TBC1D9B	physical	23383273
TCPA_HUMAN	TCP1	physical	23383273
TCPB_HUMAN	CCT2	physical	23383273
TCPD_HUMAN	CCT4	physical	23383273
TCPE_HUMAN	CCT5	physical	23383273
TCPH_HUMAN	CCT7	physical	23383273
TCPG_HUMAN	CCT3	physical	23383273
TCPQ_HUMAN	CCT8	physical	23383273
TCPZ_HUMAN	CCT6A	physical	23383273
TELO2_HUMAN	TELO2	physical	23383273
RIF1_HUMAN	RIF1	physical	23383273
TERF2_HUMAN	TERF2	physical	23383273
ASPC1_HUMAN	ASPSCR1	physical	23383273
TTC4_HUMAN	TTC4	physical	23383273
TERA_HUMAN	VCP	physical	23383273
TMEDA_HUMAN	TMED10	physical	23383273
TMM33_HUMAN	TMEM33	physical	23383273
TNPO3_HUMAN	TNPO3	physical	23383273
TP53B_HUMAN	TP53BP1	physical	23383273
TS101_HUMAN	TSG101	physical	23383273
CSK_HUMAN	CSK	physical	23383273
PTN23_HUMAN	PTPN23	physical	23383273
PTN9_HUMAN	PTPN9	physical	23383273
UBQL1_HUMAN	UBQLN1	physical	23383273
UBP10_HUMAN	USP10	physical	23383273
UBB_HUMAN	UBB	physical	23383273
UBE2S_HUMAN	UBE2S	physical	23383273
UBA5_HUMAN	UBA5	physical	23383273
UBXN6_HUMAN	UBXN6	physical	23383273
NEPRO_HUMAN	C3orf17	physical	23383273
VPS53_HUMAN	VPS53	physical	23383273
SC22B_HUMAN	SEC22B	physical	23383273
VIGLN_HUMAN	HDLBP	physical	23383273
VILI_HUMAN	VIL1	physical	23383273
VIME_HUMAN	VIM	physical	23383273
VINC_HUMAN	VCL	physical	23383273
WDR43_HUMAN	WDR43	physical	23383273
WDR82_HUMAN	WDR82	physical	23383273
WAPL_HUMAN	WAPAL	physical	23383273
ZFR_HUMAN	ZFR	physical	23383273
CDN1B_HUMAN	CDKN1B	physical	23383273
CDN1A_HUMAN	CDKN1A	physical	23383273
BAD_HUMAN	BAD	physical	23383273
CASP9_HUMAN	CASP9	physical	23383273
IKBA_HUMAN	NFKBIA	physical	23383273
TERA_HUMAN	VCP	physical	20512113
TADBP_MOUSE	Tardbp	physical	23747512
PFD3_HUMAN	VBP1	physical	23964080
BUD23_HUMAN	WBSCR22	physical	21988832
1433Z_HUMAN	YWHAZ	physical	21988832
UFD1_HUMAN	UFD1L	physical	23333620
NPL4_HUMAN	NPLOC4	physical	23333620
AMFR_HUMAN	AMFR	physical	23333620
IKBA_HUMAN	NFKBIA	physical	24248593
FBW1A_HUMAN	BTRC	physical	24248593
FBW1B_HUMAN	FBXW11	physical	24248593
IOD2_HUMAN	DIO2	physical	24196352
PSMD4_HUMAN	PSMD4	physical	24196352
ACTN4_HUMAN	ACTN4	physical	22863883
ANM5_HUMAN	PRMT5	physical	22863883
OTU1_YEAST	OTU1	physical	24610782
SYVN1_HUMAN	SYVN1	physical	24100225
ATX3_HUMAN	ATXN3	physical	24100225
SVIP_HUMAN	SVIP	physical	24100225
AMFR_HUMAN	AMFR	physical	24100225
TERA_HUMAN	VCP	physical	18044963
1A02_HUMAN	HLA-A	physical	20702414
1A03_HUMAN	HLA-A	physical	20702414
1A01_HUMAN	HLA-A	physical	20702414
1A26_HUMAN	HLA-A	physical	20702414
BRSK2_HUMAN	BRSK2	physical	23907667
OTU1_HUMAN	YOD1	physical	24417208
OTUL_HUMAN	OTULIN	physical	24726323
PEX19_HUMAN	PEX19	physical	23457492
PP2AA_HUMAN	PPP2CA	physical	23108140
2AAA_HUMAN	PPP2R1A	physical	23108140
HD_HUMAN	HTT	physical	23652004
ATX7_HUMAN	ATXN7	physical	23652004
ATX1_HUMAN	ATXN1	physical	23652004
ANDR_HUMAN	AR	physical	23652004
ACTB_HUMAN	ACTB	physical	23443559
ANKL2_HUMAN	ANKLE2	physical	23443559
ASPC1_HUMAN	ASPSCR1	physical	23443559
SLIRP_HUMAN	SLIRP	physical	23443559
CCNB1_HUMAN	CCNB1	physical	23443559
CDK2_HUMAN	CDK2	physical	23443559
CEP55_HUMAN	CEP55	physical	23443559
TBB5_HUMAN	TUBB	physical	23443559
DDX54_HUMAN	DDX54	physical	23443559
DGC14_HUMAN	DGCR14	physical	23443559
DJB11_HUMAN	DNAJB11	physical	23443559
DESP_HUMAN	DSP	physical	23443559
EF1A2_HUMAN	EEF1A2	physical	23443559
EPIPL_HUMAN	EPPK1	physical	23443559
RT18B_HUMAN	MRPS18B	physical	23443559
RL24_HUMAN	RPL24	physical	23443559
RT29_HUMAN	DAP3	physical	23443559
RL23_HUMAN	RPL23	physical	23443559
FA7_HUMAN	F7	physical	23443559
F104A_HUMAN	FAM104A	physical	23443559
FBF1_HUMAN	FBF1	physical	23443559
NIPS2_HUMAN	GBAS	physical	23443559
GGYF2_HUMAN	GIGYF2	physical	23443559
BGAL_HUMAN	GLB1	physical	23443559
NMDE4_HUMAN	GRIN2D	physical	23443559
GRWD1_HUMAN	GRWD1	physical	23443559
TF3C5_HUMAN	GTF3C5	physical	23443559
H2AV_HUMAN	H2AFV	physical	23443559
HNRH1_HUMAN	HNRNPH1	physical	23443559
CH60_HUMAN	HSPD1	physical	23443559
IQGA1_HUMAN	IQGAP1	physical	23443559
IRS4_HUMAN	IRS4	physical	23443559
RT23_HUMAN	MRPS23	physical	23443559
NIPS1_HUMAN	NIPSNAP1	physical	23443559
NSF1C_HUMAN	NSFL1C	physical	23443559
NUP54_HUMAN	NUP54	physical	23443559
RL13_HUMAN	RPL13	physical	23443559
PHKG2_HUMAN	PHKG2	physical	23443559
LIPB1_HUMAN	PPFIBP1	physical	23443559
PPM1B_HUMAN	PPM1B	physical	23443559
PP2BA_HUMAN	PPP3CA	physical	23443559
PRP19_HUMAN	PRPF19	physical	23443559
PRP31_HUMAN	PRPF31	physical	23443559
PRP4_HUMAN	PRPF4	physical	23443559
PRS6B_HUMAN	PSMC4	physical	23443559
RL18A_HUMAN	RPL18A	physical	23443559
RL22_HUMAN	RPL22	physical	23443559
RL30_HUMAN	RPL30	physical	23443559
RS11_HUMAN	RPS11	physical	23443559
RS25_HUMAN	RPS25	physical	23443559
RS3_HUMAN	RPS3	physical	23443559
RS3A_HUMAN	RPS3A	physical	23443559
RS4X_HUMAN	RPS4X	physical	23443559
RS6_HUMAN	RPS6	physical	23443559
RS8_HUMAN	RPS8	physical	23443559
RS9_HUMAN	RPS9	physical	23443559
RRBP1_HUMAN	RRBP1	physical	23443559
RUVB2_HUMAN	RUVBL2	physical	23443559
SKP1_HUMAN	SKP1	physical	23443559
SPTN1_HUMAN	SPTAN1	physical	23443559
SPT6H_HUMAN	SUPT6H	physical	23443559
SYMPK_HUMAN	SYMPK	physical	23443559
TIM44_HUMAN	TIMM44	physical	23443559
TMPSD_HUMAN	TMPRSS13	physical	23443559
TPD54_HUMAN	TPD52L2	physical	23443559
TBA1C_HUMAN	TUBA1C	physical	23443559
TBB4B_HUMAN	TUBB4B	physical	23443559
UBB_HUMAN	UBB	physical	23443559
UBR4_HUMAN	UBR4	physical	23443559
UBX2A_HUMAN	UBXN2A	physical	23443559
UFD1_HUMAN	UFD1L	physical	23443559
DCAF7_HUMAN	DCAF7	physical	23443559
OTU1_YEAST	OTU1	physical	25084388
AMFR_HUMAN	AMFR	physical	16275660
NSF1C_HUMAN	NSFL1C	physical	16275660
TERA_HUMAN	VCP	physical	25416956
RNF8_HUMAN	RNF8	physical	25416956
PLAP_HUMAN	PLAA	physical	25416956
ATG5_HUMAN	ATG5	physical	25416956
RNF37_HUMAN	UBOX5	physical	25416956
UBXN1_HUMAN	UBXN1	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
NSF1C_HUMAN	NSFL1C	physical	25416956
ASPC1_HUMAN	ASPSCR1	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
F104A_HUMAN	FAM104A	physical	25416956
CEP19_HUMAN	CEP19	physical	25416956
UBX2B_HUMAN	UBXN2B	physical	25416956
ELAV1_HUMAN	ELAVL1	physical	23618873
UBQL1_HUMAN	UBQLN1	physical	19822669
UBXN4_HUMAN	UBXN4	physical	19822669
PSA6_HUMAN	PSMA6	physical	19822669
NSF1C_HUMAN	NSFL1C	physical	25078495
ASPC1_HUMAN	ASPSCR1	physical	25078495
UBXN6_HUMAN	UBXN6	physical	25078495
UBXN4_HUMAN	UBXN4	physical	25078495
FAF2_HUMAN	FAF2	physical	25078495
UBXN8_HUMAN	UBXN8	physical	25078495
NSF1C_HUMAN	NSFL1C	physical	25775548
UBX2B_HUMAN	UBXN2B	physical	25775548
MRP1_HUMAN	ABCC1	physical	26344197
MRP3_HUMAN	ABCC3	physical	26344197
CALR_HUMAN	CALR	physical	26344197
CALU_HUMAN	CALU	physical	26344197
ENPL_HUMAN	HSP90B1	physical	26344197
INO1_HUMAN	ISYNA1	physical	26344197
NACA2_HUMAN	NACA2	physical	26344197
NSF_HUMAN	NSF	physical	26344197
PHB_HUMAN	PHB	physical	26344197
TEBP_HUMAN	PTGES3	physical	26344197
RB11B_HUMAN	RAB11B	physical	26344197
RCN1_HUMAN	RCN1	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
TBB5_HUMAN	TUBB	physical	26344197
TBB2B_HUMAN	TUBB2B	physical	26344197
TBB3_HUMAN	TUBB3	physical	26344197
TBB4B_HUMAN	TUBB4B	physical	26344197
GRB2_HUMAN	GRB2	physical	25814554
ITB4_HUMAN	ITGB4	physical	26496610
SYF2_HUMAN	SYF2	physical	26496610
NSF1C_HUMAN	NSFL1C	physical	26496610
ASPC1_HUMAN	ASPSCR1	physical	26496610
F104A_HUMAN	FAM104A	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
PPR18_HUMAN	PPP1R18	physical	26496610
ZN778_HUMAN	ZNF778	physical	26496610
UFD1_HUMAN	UFD1L	physical	26712280
FBW1A_HUMAN	BTRC	physical	26112410
CUL1_HUMAN	CUL1	physical	26112410
IKBA_HUMAN	NFKBIA	physical	26463447
ERCC6_HUMAN	ERCC6	physical	26826127
AN13A_HUMAN	ANKRD13A	physical	26797118
AN13D_HUMAN	ANKRD13D	physical	26797118
CLUA1_HUMAN	CLUAP1	physical	26389662
NSF1C_HUMAN	NSFL1C	physical	26389662
UBXN6_HUMAN	UBXN6	physical	26389662
ASPC1_HUMAN	ASPSCR1	physical	26389662
NPL4_HUMAN	NPLOC4	physical	26389662
VCIP1_HUMAN	VCPIP1	physical	26389662
UFD1_HUMAN	UFD1L	physical	26389662
UBX2B_HUMAN	UBXN2B	physical	26389662
UBX2A_HUMAN	UBXN2A	physical	26389662
UBE4B_HUMAN	UBE4B	physical	26389662
UFD1_HUMAN	UFD1L	physical	26549226
NPL4_HUMAN	NPLOC4	physical	26549226
PLPP3_HUMAN	PPAP2B	physical	26549226
SELS_HUMAN	VIMP	physical	26549226
UFD1_HUMAN	UFD1L	physical	27226613
NPL4_HUMAN	NPLOC4	physical	27226613
NSF1C_HUMAN	NSFL1C	physical	27226613
UBE4B_HUMAN	UBE4B	physical	27226613
UBXN6_HUMAN	UBXN6	physical	27913212
UFD1_HUMAN	UFD1L	physical	27913212
NSF1C_HUMAN	NSFL1C	physical	27913212
NPL4_HUMAN	NPLOC4	physical	27913212
RHBL4_HUMAN	RHBDD1	physical	27407164
UBC_HUMAN	UBC	physical	27407164
RPB1_HUMAN	POLR2A	physical	28036256
ASPC1_HUMAN	ASPSCR1	physical	28514442
UBE4B_HUMAN	UBE4B	physical	28514442
F104A_HUMAN	FAM104A	physical	28514442
MT21D_HUMAN	VCPKMT	physical	28514442
UBXN7_HUMAN	UBXN7	physical	28274878
IQGA1_HUMAN	IQGAP1	physical	28970065

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
167320	Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1 (IBMPFD1)
613954	Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia (ALS14)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TERA_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-770 AND SER-775, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-37; SER-282;SER-284; SER-457; SER-746 AND SER-748, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; THR-436; THR-509 ANDSER-787, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-702 AND SER-705, ANDMASS SPECTROMETRY.	18187866 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-805, AND MASSSPECTROMETRY.	15592455 [Abstract]
"Phosphoproteome analysis of HeLa cells using stable isotope labelingwith amino acids in cell culture (SILAC)."; Amanchy R., Kalume D.E., Iwahori A., Zhong J., Pandey A.; J. Proteome Res. 4:1661-1671(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-805, AND MASSSPECTROMETRY.	16212419 [Abstract]

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