| UniProt ID | IQCB1_HUMAN | |
|---|---|---|
| UniProt AC | Q15051 | |
| Protein Name | IQ calmodulin-binding motif-containing protein 1 | |
| Gene Name | IQCB1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 598 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localization to the centrosome depends on the interaction with CEP290/NPHP6. | |
| Protein Description | Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. [PubMed: 21565611] | |
| Protein Sequence | MKPTGTDPRILSIAAEVAKSPEQNVPVILLKLKEIINITPLGSSELKKIKQDIYCYDLIQYCLLVLSQDYSRIQGGWTTISQLTQILSHCCVGLEPGEDAEEFYNELLPSAAENFLVLGRQLQTCFINAAKAEEKDELLHFFQIVTDSLFWLLGGHVELIQNVLQSDHFLHLLQADNVQIGSAVMMMLQNILQINSGDLLRIGRKALYSILDEVIFKLFSTPSPVIRSTATKLLLLMAESHQEILILLRQSTCYKGLRRLLSKQETGTEFSQELRQLVGLLSPMVYQEVEEQKLHQAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRSKRSKMLLEINRQKEEEDLKLQLQLQRQRAMRLSRELQLSMLEIVHPGQVEKHYREMEEKSALIIQKHWRGYRERKNFHQQRQSLIEYKAAVTLQRAALKFLAKCRKKKKLFAPWRGLQELTDARRVELKKRVDDYVRRHLGSPMSDVVSRELHAQAQERLQHYFMGRALEERAQQHREALIAQISTNVEQLMKAPSLKEAEGKEPELFLSRSRPVAAKAKQAHLTTLKHIQAPWWKKLGEESGDEIDVPKDELSIELENLFIGGTKPP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MKPTGTDPRIL ----CCCCCCCHHHH | 47.39 | 20068231 | |
| 6 | Phosphorylation | --MKPTGTDPRILSI --CCCCCCCHHHHHH | 45.36 | 20068231 | |
| 12 | Phosphorylation | GTDPRILSIAAEVAK CCCHHHHHHHHHHHC | 14.07 | 20068231 | |
| 19 | Ubiquitination | SIAAEVAKSPEQNVP HHHHHHHCCCCCCCC | 72.26 | 29967540 | |
| 20 | Phosphorylation | IAAEVAKSPEQNVPV HHHHHHCCCCCCCCE | 24.75 | 25159151 | |
| 21 | Ubiquitination | AAEVAKSPEQNVPVI HHHHHCCCCCCCCEE | 46.62 | 21890473 | |
| 31 | Ubiquitination | NVPVILLKLKEIINI CCCEEEEEHHHHHCC | 54.81 | 29967540 | |
| 33 | Ubiquitination | PVILLKLKEIINITP CEEEEEHHHHHCCCC | 45.33 | 29967540 | |
| 47 | Ubiquitination | PLGSSELKKIKQDIY CCCCHHHHHHCHHCH | 48.69 | 29967540 | |
| 48 | Ubiquitination | LGSSELKKIKQDIYC CCCHHHHHHCHHCHH | 68.69 | - | |
| 79 | Ubiquitination | RIQGGWTTISQLTQI HCCCCCCHHHHHHHH | 16.48 | 22817900 | |
| 200 (in isoform 2) | Phosphorylation | - | 4.45 | 20068231 | |
| 205 | Ubiquitination | DLLRIGRKALYSILD CHHHHHHHHHHHHHH | 37.21 | 21890473 | |
| 205 (in isoform 3) | Ubiquitination | - | 37.21 | 21890473 | |
| 205 (in isoform 1) | Ubiquitination | - | 37.21 | 21890473 | |
| 205 | Ubiquitination | DLLRIGRKALYSILD CHHHHHHHHHHHHHH | 37.21 | 22817900 | |
| 240 | Phosphorylation | LLLLMAESHQEILIL HHHHHHHHHHHHHHH | 22.41 | 22468782 | |
| 251 | Phosphorylation | ILILLRQSTCYKGLR HHHHHHHCHHHHHHH | 17.63 | 22468782 | |
| 254 | Phosphorylation | LLRQSTCYKGLRRLL HHHHCHHHHHHHHHH | 14.26 | 22468782 | |
| 263 | Ubiquitination | GLRRLLSKQETGTEF HHHHHHHCCCCCCHH | 52.72 | 22817900 | |
| 263 (in isoform 1) | Ubiquitination | - | 52.72 | 21890473 | |
| 263 (in isoform 3) | Ubiquitination | - | 52.72 | 21890473 | |
| 319 | Phosphorylation | KRLKKLPSAVIALQR HHHHHCCHHHHHHHH | 45.67 | 28348404 | |
| 326 | Methylation | SAVIALQRSFRSKRS HHHHHHHHHHHHHHH | 38.32 | 115480399 | |
| 327 | Phosphorylation | AVIALQRSFRSKRSK HHHHHHHHHHHHHHH | 16.43 | 22817900 | |
| 331 | "N6,N6-dimethyllysine" | LQRSFRSKRSKMLLE HHHHHHHHHHHHHHH | 57.33 | - | |
| 331 | Methylation | LQRSFRSKRSKMLLE HHHHHHHHHHHHHHH | 57.33 | 23644510 | |
| 333 | Phosphorylation | RSFRSKRSKMLLEIN HHHHHHHHHHHHHHH | 26.59 | 20068231 | |
| 334 | Ubiquitination | SFRSKRSKMLLEINR HHHHHHHHHHHHHHH | 37.29 | - | |
| 363 | Phosphorylation | RQRAMRLSRELQLSM HHHHHHHHHHHHHHH | 17.22 | 24719451 | |
| 369 | Phosphorylation | LSRELQLSMLEIVHP HHHHHHHHHHHHCCH | 14.36 | 28555341 | |
| 395 | Ubiquitination | EKSALIIQKHWRGYR HHHHHHHHHHHCCHH | 25.27 | 29967540 | |
| 396 | Ubiquitination | KSALIIQKHWRGYRE HHHHHHHHHHCCHHH | 34.42 | - | |
| 417 | Ubiquitination | QRQSLIEYKAAVTLQ HHHHHHHHHHHHHHH | 10.03 | 29967540 | |
| 433 | Ubiquitination | AALKFLAKCRKKKKL HHHHHHHHHHHCCCC | 36.40 | 29967540 | |
| 472 | Phosphorylation | YVRRHLGSPMSDVVS HHHHHCCCCHHHHHH | 24.64 | 18691976 | |
| 475 | Phosphorylation | RHLGSPMSDVVSREL HHCCCCHHHHHHHHH | 30.55 | 23186163 | |
| 528 | Ubiquitination | LMKAPSLKEAEGKEP HHCCCCHHHHCCCCC | 60.25 | 29967540 | |
| 541 | Methylation | EPELFLSRSRPVAAK CCCHHHCCCCCHHHH | 38.54 | 115480393 | |
| 550 | Ubiquitination | RPVAAKAKQAHLTTL CCHHHHHHHHHHHHH | 47.51 | 29967540 | |
| 566 | Ubiquitination | HIQAPWWKKLGEESG HCCCHHHHHHCCCCC | 33.96 | 29967540 | |
| 572 | Phosphorylation | WKKLGEESGDEIDVP HHHHCCCCCCCCCCC | 47.44 | 28355574 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IQCB1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IQCB1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IQCB1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 609254 | Senior-Loken syndrome 5 (SLSN5) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-572, AND MASSSPECTROMETRY. | |
