ITA11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITA11_HUMAN
• UniProt AC: Q9UKX5
• Protein Name: Integrin alpha-11
• Gene Name: ITGA11
• Organism: Homo sapiens (Human).
• Sequence Length: 1188
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Integrin alpha-11/beta-1 is a receptor for collagen..
• Protein Sequence: MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGAPLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKNHGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATGLQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCKRSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAVLLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	N-linked_Glycosylation	KCPVIHGNCTKLNLG ECCEEECCCCEEECC	19.00	UniProtKB CARBOHYD
92	Phosphorylation	KLNLGRVTLSNVSER EEECCEEEECCHHHC	24.10	22210691
94	Phosphorylation	NLGRVTLSNVSERKD ECCEEEECCHHHCCC	26.31	29396449
95	N-linked_Glycosylation	LGRVTLSNVSERKDN CCEEEECCHHHCCCC	44.43	UniProtKB CARBOHYD
97	Phosphorylation	RVTLSNVSERKDNMR EEEECCHHHCCCCEE	35.61	29396449
150	Acetylation	NSNFRFSKTVAPALQ CCCCCCCCCHHHHHH	44.28	7480079
291	N-linked_Glycosylation	IQQSERDNVTRYAVA HHHHHHHCHHHHHHH	43.19	UniProtKB CARBOHYD
331	N-linked_Glycosylation	PDDKHFFNVTDEAAL CCCCCCCCCCCHHHH	34.53	19159218
351	Phosphorylation	ALGDRIFSLEGTNKN HHHCEEEEEECCCCC	24.12	23403867
358	N-linked_Glycosylation	SLEGTNKNETSFGLE EEECCCCCCCCEEEE	60.90	UniProtKB CARBOHYD
409	Phosphorylation	KVIPLRESYLKEFPE CEEECCHHHHHHCCH	29.36	24719451
430	Phosphorylation	AYLGYTVTSVVSSRQ CCCCEEEEEEEECCC	14.17	22210691
431	Phosphorylation	YLGYTVTSVVSSRQG CCCEEEEEEEECCCC	19.04	-
434	Phosphorylation	YTVTSVVSSRQGRVY EEEEEEEECCCCCEE	20.04	22210691
449	N-linked_Glycosylation	VAGAPRFNHTGKVIL EEECCCCCCCCCEEE	32.84	UniProtKB CARBOHYD
462	N-linked_Glycosylation	ILFTMHNNRSLTIHQ EEEEEECCCEEEEEH	21.90	UniProtKB CARBOHYD
479	Phosphorylation	RGQQIGSYFGSEITS CCCCCHHHCCCEEEE	13.52	22210691
485	Phosphorylation	SYFGSEITSVDIDGD HHCCCEEEEEECCCC	20.74	23403867
486	Phosphorylation	YFGSEITSVDIDGDG HCCCEEEEEECCCCC	24.37	23403867
528	N-linked_Glycosylation	RQNLFVYNGTLKDSH CCCEEEEECCCCCCC	31.50	UniProtKB CARBOHYD
583	Phosphorylation	IFHGFRGSILKTPKQ EEECCCCCCCCCHHH	22.08	24719451
642	N-linked_Glycosylation	SRPVVQINASLHFEP CCCEEEEEEEECCCH	13.34	UniProtKB CARBOHYD
686	Phosphorylation	FLAPHFQTTTVGIRY HHCCCCCCCEEEEEE	24.40	-
693	Phosphorylation	TTTVGIRYNATMDER CCEEEEEEECCCCCC	13.76	25262027
694	N-linked_Glycosylation	TTVGIRYNATMDERR CEEEEEEECCCCCCC	21.06	UniProtKB CARBOHYD
696	Phosphorylation	VGIRYNATMDERRYT EEEEEECCCCCCCCC	22.86	25262027
703	Phosphorylation	TMDERRYTPRAHLDE CCCCCCCCCCCCCCC	12.42	30631047
769	Phosphorylation	MLDDGWPTTLRVSVP CCCCCCCCEEEEEEE	31.77	20363803
770	Phosphorylation	LDDGWPTTLRVSVPF CCCCCCCEEEEEEEE	14.42	20363803
857	N-linked_Glycosylation	NAYSTVLNISQSANL CHHHHHEEHHHCCCC	27.77	UniProtKB CARBOHYD
894	N-linked_Glycosylation	RLQKQVCNVSYPFFR HHHHHHHCCCCHHHH	27.24	UniProtKB CARBOHYD
953	Phosphorylation	PLRFHLKYEADVLFT CCEEEEEEEEEEEEE	23.78	24719451
960	Phosphorylation	YEADVLFTRSSSLSH EEEEEEEECCCCCCC	26.02	24719451
973	N-linked_Glycosylation	SHYEVKPNSSLERYD CCCEECCCCCCCCCC	38.21	UniProtKB CARBOHYD
1031	N-linked_Glycosylation	DFLTDEANTSCNIWG HHHCCCCCCCCCCCC	30.40	UniProtKB CARBOHYD
1039	N-linked_Glycosylation	TSCNIWGNSTEYRPT CCCCCCCCCCCCCCC	30.66	UniProtKB CARBOHYD
1059	N-linked_Glycosylation	LRRAPQLNHSNSDVV HHHCCCCCCCCCCCE	31.15	UniProtKB CARBOHYD
1098	Phosphorylation	RSLKALKYKSMKIMV HHHHHHHHCHHHHHH	14.78	18083107
1100	Phosphorylation	LKALKYKSMKIMVNA HHHHHHCHHHHHHHH	23.40	-
1183	Phosphorylation	REPGLDPTPKVLE-- CCCCCCCCCCCCC--	35.09	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITA11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITA11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ITA11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-331, AND MASSSPECTROMETRY.
PubMed: 19159218