GSTM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTM1_HUMAN
• UniProt AC: P09488
• Protein Name: Glutathione S-transferase Mu 1
• Gene Name: GSTM1
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPMILGYWDIRGLA -CCCCCCEECHHHHH	9.10	24043423
23	Phosphorylation	AIRLLLEYTDSSYEE HHHHHHHHCCCCHHC	18.80	22817900
24	Phosphorylation	IRLLLEYTDSSYEEK HHHHHHHCCCCHHCC	21.74	22673903
26	Phosphorylation	LLLEYTDSSYEEKKY HHHHHCCCCHHCCCC	27.33	22673903
27	Phosphorylation	LLEYTDSSYEEKKYT HHHHCCCCHHCCCCC	39.10	25307156
28	Phosphorylation	LEYTDSSYEEKKYTM HHHCCCCHHCCCCCC	31.87	22673903
31 (in isoform 1)	Ubiquitination	-	38.86	21906983
31	Ubiquitination	TDSSYEEKKYTMGDA CCCCHHCCCCCCCCC	38.86	-
31 (in isoform 2)	Ubiquitination	-	38.86	21906983
32	Ubiquitination	DSSYEEKKYTMGDAP CCCHHCCCCCCCCCC	49.59	-
33	Phosphorylation	SSYEEKKYTMGDAPD CCHHCCCCCCCCCCC	17.02	21082442
34	Phosphorylation	SYEEKKYTMGDAPDY CHHCCCCCCCCCCCC	24.45	19060867
35	Sulfoxidation	YEEKKYTMGDAPDYD HHCCCCCCCCCCCCC	4.08	30846556
41	Phosphorylation	TMGDAPDYDRSQWLN CCCCCCCCCHHHHHH	16.52	28674419
43	Methylation	GDAPDYDRSQWLNEK CCCCCCCHHHHHHHH	25.23	-
50 (in isoform 2)	Ubiquitination	-	46.88	21906983
50 (in isoform 1)	Ubiquitination	-	46.88	21906983
50	Ubiquitination	RSQWLNEKFKLGLDF HHHHHHHHCCCCCCC	46.88	21906983
52 (in isoform 2)	Ubiquitination	-	53.35	21906983
52	Ubiquitination	QWLNEKFKLGLDFPN HHHHHHCCCCCCCCC	53.35	21906983
52 (in isoform 1)	Ubiquitination	-	53.35	21906983
62	Phosphorylation	LDFPNLPYLIDGAHK CCCCCCCEEECCCHH	21.32	-
71	Phosphorylation	IDGAHKITQSNAILC ECCCHHHHCHHHHHH	30.65	-
73	Phosphorylation	GAHKITQSNAILCYI CCHHHHCHHHHHHHH	21.41	-
79	Phosphorylation	QSNAILCYIARKHNL CHHHHHHHHHHHCCC	8.31	25159151
83	Ubiquitination	ILCYIARKHNLCGET HHHHHHHHCCCCCCC	28.02	-
94	Ubiquitination	CGETEEEKIRVDILE CCCCCCHHHHHHHHH	38.81	-
104	Phosphorylation	VDILENQTMDNHMQL HHHHHCCCCCCCCCE	37.77	-
116	Phosphorylation	MQLGMICYNPEFEKL CCEECEEECHHHHHC	23.87	-
126	Acetylation	EFEKLKPKYLEELPE HHHHCCHHHHHHHHH	61.96	19608861
126	Ubiquitination	EFEKLKPKYLEELPE HHHHCCHHHHHHHHH	61.96	19608861
134	Ubiquitination	YLEELPEKLKLYSEF HHHHHHHHHHHHHHH	49.32	-
136	Ubiquitination	EELPEKLKLYSEFLG HHHHHHHHHHHHHHC	57.35	-
144	Ubiquitination	LYSEFLGKRPWFAGN HHHHHHCCCCCCCCC	58.39	-
144	Acetylation	LYSEFLGKRPWFAGN HHHHHHCCCCCCCCC	58.39	25953088
162 (in isoform 2)	Ubiquitination	-	27.33	21906983
186	Phosphorylation	PNLKDFISRFEGLEK CCHHHHHHHHCCHHH	30.80	22673903
193	Ubiquitination	SRFEGLEKISAYMKS HHHCCHHHHHHHHHH	47.18	21906983
193 (in isoform 1)	Ubiquitination	-	47.18	21906983
199	Ubiquitination	EKISAYMKSSRFLPR HHHHHHHHHCCCCCC	32.38	2190698
199 (in isoform 1)	Ubiquitination	-	32.38	21906983
199	Acetylation	EKISAYMKSSRFLPR HHHHHHHHHCCCCCC	32.38	20167786
200	Phosphorylation	KISAYMKSSRFLPRP HHHHHHHHCCCCCCC	15.37	-
201	Phosphorylation	ISAYMKSSRFLPRPV HHHHHHHCCCCCCCC	22.87	-
210	Phosphorylation	FLPRPVFSKMAVWGN CCCCCCCCCCCCCCC	23.04	-
211	Ubiquitination	LPRPVFSKMAVWGNK CCCCCCCCCCCCCCC	21.29	-
218	Ubiquitination	KMAVWGNK------- CCCCCCCC-------	58.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K5_HUMAN	MAP3K5	physical	12077134
GSTM3_HUMAN	GSTM3	physical	24722188

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00993: Azathioprine
• DB01008: Busulfan
• DB00958: Carboplatin
• DB00515: Cisplatin
• DB00143: Glutathione
• DB00526: Oxaliplatin