GSTM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTM3_HUMAN
• UniProt AC: P21266
• Protein Name: Glutathione S-transferase Mu 3
• Gene Name: GSTM3
• Organism: Homo sapiens (Human).
• Sequence Length: 225
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers..
• Protein Sequence: MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLDFPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCYSSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLDEFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSCESSMVL ------CCCCCCCCC	26.96	28857561
5	Phosphorylation	---MSCESSMVLGYW ---CCCCCCCCCCHH	28.23	28857561
6	Phosphorylation	--MSCESSMVLGYWD --CCCCCCCCCCHHH	7.21	28857561
28	Phosphorylation	IRLLLEFTDTSYEEK HHHHHHCCCCCHHHH	29.06	-
30	Phosphorylation	LLLEFTDTSYEEKRY HHHHCCCCCHHHHCC	30.10	-
31	Phosphorylation	LLEFTDTSYEEKRYT HHHCCCCCHHHHCCC	33.10	21712546
35	Ubiquitination	TDTSYEEKRYTCGEA CCCCHHHHCCCCCCC	38.47	-
37	Phosphorylation	TSYEEKRYTCGEAPD CCHHHHCCCCCCCCC	19.90	30622161
38	Phosphorylation	SYEEKRYTCGEAPDY CHHHHCCCCCCCCCC	20.33	30622161
39	S-nitrosocysteine	YEEKRYTCGEAPDYD HHHHCCCCCCCCCCC	3.25	-
39	S-nitrosylation	YEEKRYTCGEAPDYD HHHHCCCCCCCCCCC	3.25	19483679
45	Phosphorylation	TCGEAPDYDRSQWLD CCCCCCCCCHHHCCE	16.52	30622161
47	Methylation	GEAPDYDRSQWLDVK CCCCCCCHHHCCEEE	25.23	-
48	Phosphorylation	EAPDYDRSQWLDVKF CCCCCCHHHCCEEEE	23.86	30622161
54	Sumoylation	RSQWLDVKFKLDLDF HHHCCEEEEEEECCC	36.13	28112733
54	Ubiquitination	RSQWLDVKFKLDLDF HHHCCEEEEEEECCC	36.13	21890473
56	Ubiquitination	QWLDVKFKLDLDFPN HCCEEEEEEECCCCC	35.06	-
66	Phosphorylation	LDFPNLPYLLDGKNK CCCCCCCEEECCCCC	24.06	-
71	Acetylation	LPYLLDGKNKITQSN CCEEECCCCCCCCHH	55.52	25038526
71	Ubiquitination	LPYLLDGKNKITQSN CCEEECCCCCCCCHH	55.52	-
73	Sumoylation	YLLDGKNKITQSNAI EEECCCCCCCCHHHH	51.09	28112733
73	Ubiquitination	YLLDGKNKITQSNAI EEECCCCCCCCHHHH	51.09	-
73	2-Hydroxyisobutyrylation	YLLDGKNKITQSNAI EEECCCCCCCCHHHH	51.09	-
75	Phosphorylation	LDGKNKITQSNAILR ECCCCCCCCHHHHHH	27.79	20068231
77	Phosphorylation	GKNKITQSNAILRYI CCCCCCCHHHHHHHH	21.41	28857561
82	Methylation	TQSNAILRYIARKHN CCHHHHHHHHHHHCC	18.07	-
87	Acetylation	ILRYIARKHNMCGET HHHHHHHHCCCCCCC	30.24	26210075
87	Ubiquitination	ILRYIARKHNMCGET HHHHHHHHCCCCCCC	30.24	-
90	Sulfoxidation	YIARKHNMCGETEEE HHHHHCCCCCCCCCH	2.88	30846556
109	Sulfoxidation	DIIENQVMDFRTQLI HHHHHHHHHHHHHHH	2.65	28183972
121	Phosphorylation	QLIRLCYSSDHEKLK HHHHHHHCCCHHHHC	28.44	27732954
122	Phosphorylation	LIRLCYSSDHEKLKP HHHHHHCCCHHHHCH	19.26	27732954
128	Ubiquitination	SSDHEKLKPQYLEEL CCCHHHHCHHHHHHC	40.94	21890473
128	Sumoylation	SSDHEKLKPQYLEEL CCCHHHHCHHHHHHC	40.94	-
128	Sumoylation	SSDHEKLKPQYLEEL CCCHHHHCHHHHHHC	40.94	-
131	Phosphorylation	HEKLKPQYLEELPGQ HHHHCHHHHHHCCCH	25.30	30622161
140	Ubiquitination	EELPGQLKQFSMFLG HHCCCHHHHHHHHHH	41.22	-
143	Phosphorylation	PGQLKQFSMFLGKFS CCHHHHHHHHHHHCC	13.21	21712546
158	Phosphorylation	WFAGEKLTFVDFLTY CCCCCCCEEEEECCH	32.45	25693802
164	Phosphorylation	LTFVDFLTYDILDQN CEEEEECCHHCCCCC	21.10	30622161
165	Phosphorylation	TFVDFLTYDILDQNR EEEEECCHHCCCCCC	11.79	30622161
177	Ubiquitination	QNRIFDPKCLDEFPN CCCCCCHHHHHCCCC	49.64	-
177	Acetylation	QNRIFDPKCLDEFPN CCCCCCHHHHHCCCC	49.64	27452117
186	Acetylation	LDEFPNLKAFMCRFE HHCCCCHHHHHHHHH	46.33	26051181
186	Ubiquitination	LDEFPNLKAFMCRFE HHCCCCHHHHHHHHH	46.33	-
197	Ubiquitination	CRFEALEKIAAYLQS HHHHHHHHHHHHHHC	38.20	-
201	Phosphorylation	ALEKIAAYLQSDQFC HHHHHHHHHHCCCCC	9.03	30622161
204	Phosphorylation	KIAAYLQSDQFCKMP HHHHHHHCCCCCCCC	30.68	21712546
208	S-nitrosocysteine	YLQSDQFCKMPINNK HHHCCCCCCCCCCCC	2.83	-
208	S-nitrosylation	YLQSDQFCKMPINNK HHHCCCCCCCCCCCC	2.83	19483679
208	Glutathionylation	YLQSDQFCKMPINNK HHHCCCCCCCCCCCC	2.83	22555962
209	Ubiquitination	LQSDQFCKMPINNKM HHCCCCCCCCCCCCC	49.34	-
215	Ubiquitination	CKMPINNKMAQWGNK CCCCCCCCCCCCCCC	30.99	-
222	Ubiquitination	KMAQWGNKPVC---- CCCCCCCCCCC----	34.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTM3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTM3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSTM3_HUMAN	GSTM3	physical	16189514
GSTM3_HUMAN	GSTM3	physical	19060904
GSTM3_HUMAN	GSTM3	physical	25416956
GSTM4_HUMAN	GSTM4	physical	25416956
GSTM5_HUMAN	GSTM5	physical	25416956
GSTM4_HUMAN	GSTM4	physical	26186194
PLSI_HUMAN	PLS1	physical	26186194
LANC2_HUMAN	LANCL2	physical	26186194
GNB1L_HUMAN	GNB1L	physical	26186194
TPX2_HUMAN	TPX2	physical	26186194
HNRLL_HUMAN	HNRNPLL	physical	26186194
KLH42_HUMAN	KLHL42	physical	26186194
ASPP1_HUMAN	PPP1R13B	physical	26186194
ECT2L_HUMAN	ECT2L	physical	26186194
F120B_HUMAN	FAM120B	physical	26186194
SLBP_HUMAN	SLBP	physical	26186194
GSTM3_HUMAN	GSTM3	physical	21516116
GSTM4_HUMAN	GSTM4	physical	28514442
ASPP1_HUMAN	PPP1R13B	physical	28514442
HNRLL_HUMAN	HNRNPLL	physical	28514442
SLBP_HUMAN	SLBP	physical	28514442
TPX2_HUMAN	TPX2	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
F120B_HUMAN	FAM120B	physical	28514442
LANC2_HUMAN	LANCL2	physical	28514442
GNB1L_HUMAN	GNB1L	physical	28514442
ECT2L_HUMAN	ECT2L	physical	28514442
SPB5_HUMAN	SERPINB5	physical	16049007

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione
• DB00163: Vitamin E