ASPP1_HUMAN - dbPTM
ASPP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASPP1_HUMAN
UniProt AC Q96KQ4
Protein Name Apoptosis-stimulating of p53 protein 1
Gene Name PPP1R13B
Organism Homo sapiens (Human).
Sequence Length 1090
Subcellular Localization Cytoplasm . Nucleus . Predominantly cytoplasmic. Some fraction is nuclear.
Protein Description Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo..
Protein Sequence MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDHMMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36UbiquitinationRDVVEFCKEPGEGSC
HHHHHHHHCCCCCCE		72.7323503661
41UbiquitinationFCKEPGEGSCHLAEV
HHHCCCCCCEEEEEE		41.3023503661
113UbiquitinationVINVPGEKRTENGVG
CCCCCCCCCCCCCCC		71.2229967540
115PhosphorylationNVPGEKRTENGVGNP
CCCCCCCCCCCCCCC		44.8928787133
152UbiquitinationQQQMLVAKEQRLHFL
HHHHHHHHHHHHHHH		47.0732015554
160UbiquitinationEQRLHFLKQQERRQQ
HHHHHHHHHHHHHHH		49.3329967540
169PhosphorylationQERRQQQSISENEKL
HHHHHHHCCCHHHHH		24.6020068231
171PhosphorylationRRQQQSISENEKLQK
HHHHHCCCHHHHHHH		39.3520068231
211PhosphorylationKIMNGNLSAEIERFS
HHHCCCCHHHHHHHH		28.0530631047
218PhosphorylationSAEIERFSAMFQEKK
HHHHHHHHHHHHHHH		25.6624114839
230PhosphorylationEKKQEVQTAILRVDQ
HHHHHHHHHHHHHHH		22.3520068231
243UbiquitinationDQLSQQLEDLKKGKL
HHHHHHHHHHHCCCC		57.8923503661
244UbiquitinationQLSQQLEDLKKGKLN
HHHHHHHHHHCCCCC		72.8323503661
246UbiquitinationSQQLEDLKKGKLNGF
HHHHHHHHCCCCCCH		72.3323503661
247UbiquitinationQQLEDLKKGKLNGFQ
HHHHHHHCCCCCCHH		69.4523503661
249UbiquitinationLEDLKKGKLNGFQSY
HHHHHCCCCCCHHHC		47.8923503661
269UbiquitinationGPAAVELKRLYQELQ
CHHHHHHHHHHHHHH		27.1832015554
272PhosphorylationAVELKRLYQELQIRN
HHHHHHHHHHHHHHH		12.1827642862
285UbiquitinationRNQLNQEQNSKLQQQ
HHHCCHHHHHHHHHH		50.1323503661
288UbiquitinationLNQEQNSKLQQQKEL
CCHHHHHHHHHHHHH		58.8432015554
290UbiquitinationQEQNSKLQQQKELLN
HHHHHHHHHHHHHHH		47.6023503661
293UbiquitinationNSKLQQQKELLNKRN
HHHHHHHHHHHHHHH		46.0923503661
311PhosphorylationAMMDKRISELRERLY
HHHHHHHHHHHHHHH		34.3120068231
314UbiquitinationDKRISELRERLYGKK
HHHHHHHHHHHHCCC		23.9623503661
315UbiquitinationKRISELRERLYGKKI
HHHHHHHHHHHCCCC		60.7123503661
317UbiquitinationISELRERLYGKKIQL
HHHHHHHHHCCCCEE		5.9123503661
330PhosphorylationQLNRVNGTSSPQSPL
EEECCCCCCCCCCCC		22.3422199227
331PhosphorylationLNRVNGTSSPQSPLS
EECCCCCCCCCCCCC		41.2322199227
332PhosphorylationNRVNGTSSPQSPLST
ECCCCCCCCCCCCCC		27.1425159151
335PhosphorylationNGTSSPQSPLSTSGR
CCCCCCCCCCCCCCC		31.0625159151
338PhosphorylationSSPQSPLSTSGRVAA
CCCCCCCCCCCCEEE		24.7422199227
339PhosphorylationSPQSPLSTSGRVAAV
CCCCCCCCCCCEEEE		42.7720068231
340PhosphorylationPQSPLSTSGRVAAVG
CCCCCCCCCCEEEEC		22.6423090842
349PhosphorylationRVAAVGPYIQVPSAG
CEEEECCEEECCCCC		9.6922817900
356UbiquitinationYIQVPSAGSFPVLGD
EEECCCCCCCCCCCC		33.8723503661
361UbiquitinationSAGSFPVLGDPIKPQ
CCCCCCCCCCCCCCC		7.0123503661
382MethylationNAAHGRSKSANDGNW
CCCCCCCCCCCCCCC		52.83115975547
393MethylationDGNWPTLKQNSSSSV
CCCCCCCCCCCCCCC		50.33115975555
414PhosphorylationGADWKDPSVEGSVKQ
CCCCCCCCCCCCCCC		42.8220068231
418PhosphorylationKDPSVEGSVKQGTVS
CCCCCCCCCCCCCCC		16.7920068231
469PhosphorylationYGTYPSPTPLGPGST
CCCCCCCCCCCCCCC		35.1726852163
475PhosphorylationPTPLGPGSTSSLERR
CCCCCCCCCHHHHHH		28.4027732954
476PhosphorylationTPLGPGSTSSLERRK
CCCCCCCCHHHHHHH		28.4025159151
477PhosphorylationPLGPGSTSSLERRKE
CCCCCCCHHHHHHHC		34.3230624053
478PhosphorylationLGPGSTSSLERRKEG
CCCCCCHHHHHHHCC		34.0523403867
486PhosphorylationLERRKEGSLPRPSAG
HHHHHCCCCCCCCCC		35.9726657352
491PhosphorylationEGSLPRPSAGLPSRQ
CCCCCCCCCCCCCCC		35.9323403867
496PhosphorylationRPSAGLPSRQRPTLL
CCCCCCCCCCCCCCC		46.1923403867
499MethylationAGLPSRQRPTLLPAT
CCCCCCCCCCCCCCC		25.67115488443
509PhosphorylationLLPATGSTPQPGSSQ
CCCCCCCCCCCCCCH		27.5628555341
521MethylationSSQQIQQRISVPPSP
CCHHHHHHCCCCCCC		13.53115488451
523PhosphorylationQQIQQRISVPPSPTY
HHHHHHCCCCCCCCC		30.6628348404
527PhosphorylationQRISVPPSPTYPPAG
HHCCCCCCCCCCCCC		24.6528348404
529PhosphorylationISVPPSPTYPPAGPP
CCCCCCCCCCCCCCC		53.6628348404
554Asymmetric dimethylarginineLPLTVAIRPFLADKG
CCEEEEEHHHHCCCC		13.23-
554MethylationLPLTVAIRPFLADKG
CCEEEEEHHHHCCCC		13.23-
566PhosphorylationDKGSRPQSPRKGPQT
CCCCCCCCCCCCCCC		29.3833259812
583PhosphorylationSSSIYSMYLQQATPP
HHHHHHHHHHCCCCC		8.7428348404
588PhosphorylationSMYLQQATPPKNYQP
HHHHHCCCCCCCCCC		35.4724719451
593PhosphorylationQATPPKNYQPAAHSA
CCCCCCCCCCHHHHH		23.2327642862
620PhosphorylationVLPSGSTSPSPLPFL
CCCCCCCCCCCCCCC		25.69-
622PhosphorylationPSGSTSPSPLPFLHG
CCCCCCCCCCCCCCC		38.5427050516
630PhosphorylationPLPFLHGSLSTGTPQ
CCCCCCCCCCCCCCC		14.38-
635PhosphorylationHGSLSTGTPQPQPPS
CCCCCCCCCCCCCCC		20.88-
661PhosphorylationPAAPADGSTVESLPR
CCCCCCCCCCCCCCC		29.8130576142
662PhosphorylationAAPADGSTVESLPRP
CCCCCCCCCCCCCCC		33.5530576142
665PhosphorylationADGSTVESLPRPLSP
CCCCCCCCCCCCCCC		39.0630576142
671PhosphorylationESLPRPLSPTKLTPI
CCCCCCCCCCCCCCC		32.9528355574
673PhosphorylationLPRPLSPTKLTPIVH
CCCCCCCCCCCCCCC		35.0022496350
676PhosphorylationPLSPTKLTPIVHSPL
CCCCCCCCCCCCCCC		16.7223403867
681PhosphorylationKLTPIVHSPLRYQSD
CCCCCCCCCCCCCCH		18.0930266825
685PhosphorylationIVHSPLRYQSDADLE
CCCCCCCCCCHHHHH		21.7627642862
687PhosphorylationHSPLRYQSDADLEAL
CCCCCCCCHHHHHHH		26.3227251275
707MethylationNAPRPLKKRSSITEP
CCCCCCCCCCCCCCC		66.26115975563
709PhosphorylationPRPLKKRSSITEPEG
CCCCCCCCCCCCCCC		34.6623927012
710PhosphorylationRPLKKRSSITEPEGP
CCCCCCCCCCCCCCC		37.2523927012
712PhosphorylationLKKRSSITEPEGPGG
CCCCCCCCCCCCCCC		47.6523927012
727PhosphorylationPNIQKLLYQRFNTLA
CCHHHHHHHHHHHHC		14.21-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASPP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASPP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASPP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ERBB2_HUMANERBB2physical
17875712
LATS1_HUMANLATS1physical
21041411
LATS2_HUMANLATS2physical
21041411
LATS2_HUMANLATS2physical
21041410
SIAH2_HUMANSIAH2physical
23644657
MIPO1_HUMANMIPOL1physical
25416956
CC184_HUMANCCDC184physical
25416956
EP300_HUMANEP300physical
21513714
P53_HUMANTP53physical
21513714
BRCA1_HUMANBRCA1physical
25184681
CC85B_HUMANCCDC85Bphysical
24366813
CC85C_HUMANCCDC85Cphysical
24366813
CPVL_HUMANCPVLphysical
24366813
PP1A_HUMANPPP1CAphysical
24366813
PP1B_HUMANPPP1CBphysical
24366813
PP1G_HUMANPPP1CCphysical
24366813
PP1RA_HUMANPPP1R10physical
24366813
PP2BB_HUMANPPP3CBphysical
24366813
RASF9_HUMANRASSF9physical
24366813
STAM2_HUMANSTAM2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASPP1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-681, AND MASSSPECTROMETRY.

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