EP300_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EP300_HUMAN
• UniProt AC: Q09472
• Protein Name: Histone acetyltransferase p300
• Gene Name: EP300
• Organism: Homo sapiens (Human).
• Sequence Length: 2414
• Subcellular Localization: Cytoplasm . Nucleus . Chromosome . Localizes to active chromatin: Colocalizes with histone H3 acetylated and/or crotonylated at 'Lys-18' (H3K18ac and H3K18cr, respectively) (PubMed:25818647). In the presence of ALX1 relocalizes from the cytoplasm to
• Protein Description: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. [PubMed: 23415232]
• Protein Sequence: MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAENVVEPG ------CCCCCCCCC	28.51	22223895
12	Phosphorylation	VVEPGPPSAKRPKLS CCCCCCCCCCCCCCC	49.94	29255136
14	Acetylation	EPGPPSAKRPKLSSP CCCCCCCCCCCCCCC	73.83	23954790
19	Phosphorylation	SAKRPKLSSPALSAS CCCCCCCCCCCHHCC	40.16	26074081
20	Phosphorylation	AKRPKLSSPALSASA CCCCCCCCCCHHCCC	25.32	26074081
24	Phosphorylation	KLSSPALSASASDGT CCCCCCHHCCCCCCC	23.45	26074081
26	Phosphorylation	SSPALSASASDGTDF CCCCHHCCCCCCCCC	25.57	26074081
28	Phosphorylation	PALSASASDGTDFGS CCHHCCCCCCCCCHH	33.79	26074081
31	Phosphorylation	SASASDGTDFGSLFD HCCCCCCCCCHHHHC	32.90	26074081
77	Acetylation	MVQDAASKHKQLSEL HHHHHHHHHHHHHHH	50.52	11991813
79	Acetylation	QDAASKHKQLSELLR HHHHHHHHHHHHHHH	57.58	26051181
79	Propionylation	QDAASKHKQLSELLR HHHHHHHHHHHHHHH	57.58	-
87	Phosphorylation	QLSELLRSGSSPNLN HHHHHHHHCCCCCCC	42.89	26657352
89	Phosphorylation	SELLRSGSSPNLNMG HHHHHHCCCCCCCCC	43.82	15006641
90	Phosphorylation	ELLRSGSSPNLNMGV HHHHHCCCCCCCCCC	22.72	26074081
106	Phosphorylation	GPGQVMASQAQQSSP CHHHHHHHHHHHCCC	14.14	21108945
111	Phosphorylation	MASQAQQSSPGLGLI HHHHHHHCCCCCHHH	26.81	27080861
112	Phosphorylation	ASQAQQSSPGLGLIN HHHHHHCCCCCHHHH	20.74	25954137
227	Phosphorylation	TEPLQQGSPQMGGQT CCCHHCCCCCCCCCC	13.97	28555341
237	Methylation	MGGQTGLRGPQPLKM CCCCCCCCCCCCCCC	56.97	97791037
243	Methylation	LRGPQPLKMGMMNNP CCCCCCCCCCCCCCC	39.84	115486165
255	Phosphorylation	NNPNPYGSPYTQNPG CCCCCCCCCCCCCCC	14.64	25159151
258	Phosphorylation	NPYGSPYTQNPGQQI CCCCCCCCCCCCCCC	25.84	28555341
281	Phosphorylation	IQTKTVLSNNLSPFA EECEEHHHCCCCCCC	21.24	29396449
285	Phosphorylation	TVLSNNLSPFAMDKK EHHHCCCCCCCCCCC	21.79	25159151
291	Acetylation	LSPFAMDKKAVPGGG CCCCCCCCCCCCCCC	29.55	26051181
291	Butyrylation	LSPFAMDKKAVPGGG CCCCCCCCCCCCCCC	29.55	-
291	Propionylation	LSPFAMDKKAVPGGG CCCCCCCCCCCCCCC	29.55	-
292	Acetylation	SPFAMDKKAVPGGGM CCCCCCCCCCCCCCC	50.80	11991817
317	Phosphorylation	VQQPGLVTPVAQGMG CCCCCCCCCCCCCCC	19.65	17623675
336	Acetylation	TADPEKRKLIQQQLV CCCHHHHHHHHHHHH	62.09	11991819
350	Acetylation	VLLLHAHKCQRREQA HHHHHHHHHHHHHHH	32.61	25953088
371	Phosphorylation	CNLPHCRTMKNVLNH CCCCHHHHHHHHHHH	37.58	22964224
373	Acetylation	LPHCRTMKNVLNHMT CCHHHHHHHHHHHHH	43.20	26051181
373	Propionylation	LPHCRTMKNVLNHMT CCHHHHHHHHHHHHH	43.20	-
373	Ubiquitination	LPHCRTMKNVLNHMT CCHHHHHHHHHHHHH	43.20	-
384	Phosphorylation	NHMTHCQSGKSCQVA HHHHHHCCCCCCEEE	54.29	22964224
386	Acetylation	MTHCQSGKSCQVAHC HHHHCCCCCCEEEEC	53.99	26051181
395	Phosphorylation	CQVAHCASSRQIISH CEEEECCCHHHHHHH	31.29	22964224
396	Phosphorylation	QVAHCASSRQIISHW EEEECCCHHHHHHHH	15.07	22964224
404	Acetylation	RQIISHWKNCTRHDC HHHHHHHHCCCCCCC	36.40	25953088
418	Acetylation	CPVCLPLKNAGDKRN CCEEEECCCCCCCCC	42.69	18995842
423	Acetylation	PLKNAGDKRNQQPIL ECCCCCCCCCCCCCC	52.94	18995842
489	Acetylation	TQPQVQAKNQQNQQP CCCCHHHCCCCCCCC	37.89	11991825
499	Phosphorylation	QNQQPGQSPQGMRPM CCCCCCCCCCCCCCC	25.71	25850435
529	Phosphorylation	VQTPSLLSDSMLHSA CCCHHHCCHHHHHHH	32.69	21601212
569	Acetylation	PSTTGIRKQWHEDIT CCCCCHHHHHHHHHH	56.68	11991827
569	Ubiquitination	PSTTGIRKQWHEDIT CCCCCHHHHHHHHHH	56.68	-
580	Methylation	EDITQDLRNHLVHKL HHHHHHHHHHHHHHH	36.49	11701890
586	Acetylation	LRNHLVHKLVQAIFP HHHHHHHHHHHHHCC	42.76	26051181
601	Acetylation	TPDPAALKDRRMENL CCCHHHHHHHHHHHH	44.45	23954790
601	Propionylation	TPDPAALKDRRMENL CCCHHHHHHHHHHHH	44.45	-
604	Methylation	PAALKDRRMENLVAY HHHHHHHHHHHHHHH	47.07	11701890
611	Phosphorylation	RMENLVAYARKVEGD HHHHHHHHHHHHCCC	10.24	22817900
614	Acetylation	NLVAYARKVEGDMYE HHHHHHHHHCCCHHH	36.14	11991829
614	Propionylation	NLVAYARKVEGDMYE HHHHHHHHHCCCHHH	36.14	-
614	Ubiquitination	NLVAYARKVEGDMYE HHHHHHHHHCCCHHH	36.14	-
620	Phosphorylation	RKVEGDMYESANNRA HHHCCCHHHHCCCHH	16.09	22817900
629	Phosphorylation	SANNRAEYYHLLAEK HCCCHHHHHHHHHHH	8.66	22817900
630	Phosphorylation	ANNRAEYYHLLAEKI CCCHHHHHHHHHHHH	4.22	22817900
636	Acetylation	YYHLLAEKIYKIQKE HHHHHHHHHHHHHHH	45.81	19608861
636	Ubiquitination	YYHLLAEKIYKIQKE HHHHHHHHHHHHHHH	45.81	19608861
638	Phosphorylation	HLLAEKIYKIQKELE HHHHHHHHHHHHHHH	17.07	12196545
642	Acetylation	EKIYKIQKELEEKRR HHHHHHHHHHHHHHH	68.67	26051181
668	Phosphorylation	AAGMVPVSMNPGPNM CCCCCEEECCCCCCC	13.53	24043423
683	Phosphorylation	GQPQPGMTSNGPLPD CCCCCCCCCCCCCCC	25.59	24043423
684	Phosphorylation	QPQPGMTSNGPLPDP CCCCCCCCCCCCCCH	30.78	24043423
692	Phosphorylation	NGPLPDPSMIRGSVP CCCCCCHHHCCCCCC	33.93	24043423
705	Methylation	VPNQMMPRITPQSGL CCCCCCCCCCCCCCC	27.76	115486157
728	Methylation	AQPPIVPRQTPPLQH CCCCCCCCCCCCCCC	41.95	82797559
831	Phosphorylation	QPALHQNSPSPVPSR CCCCCCCCCCCCCCC	21.86	22817900
833	Phosphorylation	ALHQNSPSPVPSRTP CCCCCCCCCCCCCCC	38.05	22817900
839	Phosphorylation	PSPVPSRTPTPHHTP CCCCCCCCCCCCCCC	35.53	22817900
841	Phosphorylation	PVPSRTPTPHHTPPS CCCCCCCCCCCCCCC	34.34	22817900
845	Phosphorylation	RTPTPHHTPPSIGAQ CCCCCCCCCCCCCCC	33.58	22817900
848	Phosphorylation	TPHHTPPSIGAQQPP CCCCCCCCCCCCCCC	34.55	27080861
857	Phosphorylation	GAQQPPATTIPAPVP CCCCCCCCCCCCCCC	30.91	27080861
858	Phosphorylation	AQQPPATTIPAPVPT CCCCCCCCCCCCCCC	27.37	27080861
865	Phosphorylation	TIPAPVPTPPAMPPG CCCCCCCCCCCCCCC	41.98	27080861
885	Phosphorylation	LHPPPRQTPTPPTTQ CCCCCCCCCCCCCCC	30.34	30266825
887	Phosphorylation	PPPRQTPTPPTTQLP CCCCCCCCCCCCCCC	45.33	30266825
890	Phosphorylation	RQTPTPPTTQLPQQV CCCCCCCCCCCCCCC	28.51	23401153
891	Phosphorylation	QTPTPPTTQLPQQVQ CCCCCCCCCCCCCCC	33.60	30266825
900	Phosphorylation	LPQQVQPSLPAAPSA CCCCCCCCCCCCCCC	29.87	30266825
906	Phosphorylation	PSLPAAPSADQPQQQ CCCCCCCCCCCCCCC	39.49	29255136
938	Phosphorylation	LLPPQPATPLSQPAV CCCCCCCCCCCCCCE	31.29	17623675
970	Acetylation	NSQAIAEKQPSQEVK HHHHHHHHCCCHHHH	59.49	11991833
977	Acetylation	KQPSQEVKMEAKMEV HCCCHHHHEEEEECC	30.21	19608861
981	Acetylation	QEVKMEAKMEVDQPE HHHHEEEEECCCCCC	23.45	23236377
992	Phosphorylation	DQPEPADTQPEDISE CCCCCCCCCCCCCCH	48.40	26714015
1001	Acetylation	PEDISESKVEDCKME CCCCCHHHHCCCCCC	45.66	23749302
1006	Acetylation	ESKVEDCKMESTETE HHHHCCCCCCCCCHH	59.01	25953088
1009	Phosphorylation	VEDCKMESTETEERS HCCCCCCCCCHHHHH	28.22	28450419
1010	Phosphorylation	EDCKMESTETEERST CCCCCCCCCHHHHHH	33.35	28450419
1012	Phosphorylation	CKMESTETEERSTEL CCCCCCCHHHHHHHH	43.14	28450419
1016	Phosphorylation	STETEERSTELKTEI CCCHHHHHHHHHHHH	29.52	30576142
1017	Phosphorylation	TETEERSTELKTEIK CCHHHHHHHHHHHHH	52.11	23312004
1020	Sumoylation	EERSTELKTEIKEEE HHHHHHHHHHHHHCC	37.57	-
1020	Acetylation	EERSTELKTEIKEEE HHHHHHHHHHHHHCC	37.57	15632193
1020	Sumoylation	EERSTELKTEIKEEE HHHHHHHHHHHHHCC	37.57	15632193
1021	Phosphorylation	ERSTELKTEIKEEED HHHHHHHHHHHHCCC	56.41	23403867
1024	Sumoylation	TELKTEIKEEEDQPS HHHHHHHHHCCCCCC	53.49	-
1024	Acetylation	TELKTEIKEEEDQPS HHHHHHHHHCCCCCC	53.49	15632193
1024	Sumoylation	TELKTEIKEEEDQPS HHHHHHHHHCCCCCC	53.49	15632193
1031	Phosphorylation	KEEEDQPSTSATQSS HHCCCCCCCCCCCCC	29.39	23927012
1032	Phosphorylation	EEEDQPSTSATQSSP HCCCCCCCCCCCCCC	29.12	23927012
1033	Phosphorylation	EEDQPSTSATQSSPA CCCCCCCCCCCCCCC	33.39	23927012
1035	Phosphorylation	DQPSTSATQSSPAPG CCCCCCCCCCCCCCC	28.84	30278072
1037	Phosphorylation	PSTSATQSSPAPGQS CCCCCCCCCCCCCCC	33.65	20201521
1038	Phosphorylation	STSATQSSPAPGQSK CCCCCCCCCCCCCCC	18.44	19664994
1044	Phosphorylation	SSPAPGQSKKKIFKP CCCCCCCCCCCCCCH	52.97	23927012
1045	Acetylation	SPAPGQSKKKIFKPE CCCCCCCCCCCCCHH	50.64	26051181
1045	Propionylation	SPAPGQSKKKIFKPE CCCCCCCCCCCCCHH	50.64	-
1046	Acetylation	PAPGQSKKKIFKPEE CCCCCCCCCCCCHHH	57.24	26051181
1046	Propionylation	PAPGQSKKKIFKPEE CCCCCCCCCCCCHHH	57.24	-
1047	Acetylation	APGQSKKKIFKPEEL CCCCCCCCCCCHHHH	58.05	11991837
1072	Phosphorylation	LYRQDPESLPFRQPV HHHCCCCCCCCCCCC	46.89	28509920
1089	Phosphorylation	QLLGIPDYFDIVKSP HHCCCCCHHHHHCCC	9.59	-
1094	Acetylation	PDYFDIVKSPMDLST CCHHHHHCCCCCHHH	49.53	11991843
1103	Acetylation	PMDLSTIKRKLDTGQ CCCHHHHHHHCCCCC	43.50	19608861
1105	Acetylation	DLSTIKRKLDTGQYQ CHHHHHHHCCCCCCC	45.79	11991841
1135	Phosphorylation	AWLYNRKTSRVYKYC EECCCCCHHHHHHHH	20.66	-
1140	Acetylation	RKTSRVYKYCSKLSE CCHHHHHHHHHHHHH	36.60	25953088
1144	Acetylation	RVYKYCSKLSEVFEQ HHHHHHHHHHHHHHH	53.09	11991839
1167	Acetylation	LGYCCGRKLEFSPQT HHCCCCCCCCCCCCC	37.34	26051181
1167	Ubiquitination	LGYCCGRKLEFSPQT HHCCCCCCCCCCCCC	37.34	-
1180	Acetylation	QTLCCYGKQLCTIPR CCEEECCCEEECCCC	17.39	23954790
1190	Phosphorylation	CTIPRDATYYSYQNR ECCCCCCHHCCCCCH	27.55	24043423
1191	Phosphorylation	TIPRDATYYSYQNRY CCCCCCHHCCCCCHH	7.67	24043423
1192	Phosphorylation	IPRDATYYSYQNRYH CCCCCHHCCCCCHHH	9.13	24043423
1193	Phosphorylation	PRDATYYSYQNRYHF CCCCHHCCCCCHHHH	15.16	24043423
1194	Phosphorylation	RDATYYSYQNRYHFC CCCHHCCCCCHHHHH	8.16	24043423
1203	Acetylation	NRYHFCEKCFNEIQG CHHHHHHHHHHHHCC	45.36	25953088
1220	Phosphorylation	VSLGDDPSQPQTTIN CCCCCCCCCCCCCCC	62.58	21406692
1224	Phosphorylation	DDPSQPQTTINKEQF CCCCCCCCCCCHHHH	36.00	21406692
1225	Phosphorylation	DPSQPQTTINKEQFS CCCCCCCCCCHHHHH	19.80	21406692
1228	Acetylation	QPQTTINKEQFSKRK CCCCCCCHHHHHHHC	49.38	11991873
1295	Phosphorylation	FSAKRLPSTRLGTFL CCCCCCCCCHHHHHH	30.65	20363803
1296	Phosphorylation	SAKRLPSTRLGTFLE CCCCCCCCHHHHHHH	28.15	20363803
1318	Phosphorylation	RRQNHPESGEVTVRV HHCCCCCCCCEEEEE	44.71	29496963
1331	Acetylation	RVVHASDKTVEVKPG EEEECCCCEEEECCC	52.56	11991845
1336	Acetylation	SDKTVEVKPGMKARF CCCEEEECCCCEEEE	23.50	17065153
1340	Acetylation	VEVKPGMKARFVDSG EEECCCCEEEECCCC	42.18	23749302
1340	Ubiquitination	VEVKPGMKARFVDSG EEECCCCEEEECCCC	42.18	-
1355	Phosphorylation	EMAESFPYRTKALFA CCHHHCCCCHHHHEE	28.98	-
1411	Phosphorylation	FRPKCLRTAVYHEIL CCHHHHHHHHHHHHH	13.92	20049867
1414	Phosphorylation	KCLRTAVYHEILIGY HHHHHHHHHHHHHHH	7.41	22817900
1421	Phosphorylation	YHEILIGYLEYVKKL HHHHHHHHHHHHHHH	6.86	22817900
1424	Phosphorylation	ILIGYLEYVKKLGYT HHHHHHHHHHHHCCC	18.25	22817900
1427	Acetylation	GYLEYVKKLGYTTGH HHHHHHHHHCCCCCC	36.78	11991847
1446	Phosphorylation	PPSEGDDYIFHCHPP CCCCCCCCEEECCCC	15.38	-
1473	Acetylation	WYKKMLDKAVSERIV HHHHHHHHHHHHHHH	46.88	15004546
1484	Acetylation	ERIVHDYKDIFKQAT HHHHCCHHHHHHHHH	50.86	26051181
1488	Ubiquitination	HDYKDIFKQATEDRL CCHHHHHHHHHHHHC	39.08	-
1499	Acetylation	EDRLTSAKELPYFEG HHHCCCCHHCCCCCC	60.60	15004546
1499	Ubiquitination	EDRLTSAKELPYFEG HHHCCCCHHCCCCCC	60.60	15004546
1518	Acetylation	NVLEESIKELEQEEE HHHHHHHHHHHHHHH	66.58	11991849
1528	Acetylation	EQEEEERKREENTSN HHHHHHHHHHHCCCC	68.40	19608861
1533	Phosphorylation	ERKREENTSNESTDV HHHHHHCCCCCCCCC	35.89	29449344
1534	Phosphorylation	RKREENTSNESTDVT HHHHHCCCCCCCCCC	50.62	29449344
1537	Phosphorylation	EENTSNESTDVTKGD HHCCCCCCCCCCCCC	33.87	29449344
1538	Phosphorylation	ENTSNESTDVTKGDS HCCCCCCCCCCCCCH	28.45	29449344
1542	Acetylation	NESTDVTKGDSKNAK CCCCCCCCCCHHCHH	61.64	18995842
1542	Propionylation	NESTDVTKGDSKNAK CCCCCCCCCCHHCHH	61.64	-
1546	Acetylation	DVTKGDSKNAKKKNN CCCCCCHHCHHHHCC	66.71	18995842
1546	Butyrylation	DVTKGDSKNAKKKNN CCCCCCHHCHHHHCC	66.71	-
1546	Propionylation	DVTKGDSKNAKKKNN CCCCCCHHCHHHHCC	66.71	-
1549	Acetylation	KGDSKNAKKKNNKKT CCCHHCHHHHCCCCC	73.92	18995842
1549	Butyrylation	KGDSKNAKKKNNKKT CCCHHCHHHHCCCCC	73.92	-
1549	Propionylation	KGDSKNAKKKNNKKT CCCHHCHHHHCCCCC	73.92	-
1550	Acetylation	GDSKNAKKKNNKKTS CCHHCHHHHCCCCCC	59.32	26051181
1550	Butyrylation	GDSKNAKKKNNKKTS CCHHCHHHHCCCCCC	59.32	-
1550	Propionylation	GDSKNAKKKNNKKTS CCHHCHHHHCCCCCC	59.32	-
1551	Acetylation	DSKNAKKKNNKKTSK CHHCHHHHCCCCCCC	66.11	15004546
1551	Butyrylation	DSKNAKKKNNKKTSK CHHCHHHHCCCCCCC	66.11	-
1551	Propionylation	DSKNAKKKNNKKTSK CHHCHHHHCCCCCCC	66.11	-
1554	Acetylation	NAKKKNNKKTSKNKS CHHHHCCCCCCCCHH	67.81	15004546
1554	Butyrylation	NAKKKNNKKTSKNKS CHHHHCCCCCCCCHH	67.81	-
1554	Propionylation	NAKKKNNKKTSKNKS CHHHHCCCCCCCCHH	67.81	-
1555	Acetylation	AKKKNNKKTSKNKSS HHHHCCCCCCCCHHH	61.22	15004546
1555	Butyrylation	AKKKNNKKTSKNKSS HHHHCCCCCCCCHHH	61.22	-
1555	Propionylation	AKKKNNKKTSKNKSS HHHHCCCCCCCCHHH	61.22	-
1558	Acetylation	KNNKKTSKNKSSLSR HCCCCCCCCHHHHCC	73.88	15004546
1558	Butyrylation	KNNKKTSKNKSSLSR HCCCCCCCCHHHHCC	73.88	-
1558	Propionylation	KNNKKTSKNKSSLSR HCCCCCCCCHHHHCC	73.88	-
1560	Acetylation	NKKTSKNKSSLSRGN CCCCCCCHHHHCCCC	45.20	15004546
1560	Butyrylation	NKKTSKNKSSLSRGN CCCCCCCHHHHCCCC	45.20	-
1560	Propionylation	NKKTSKNKSSLSRGN CCCCCCCHHHHCCCC	45.20	-
1568	Acetylation	SSLSRGNKKKPGMPN HHHCCCCCCCCCCCC	66.07	26051181
1568	Butyrylation	SSLSRGNKKKPGMPN HHHCCCCCCCCCCCC	66.07	-
1568	Propionylation	SSLSRGNKKKPGMPN HHHCCCCCCCCCCCC	66.07	-
1569	Acetylation	SLSRGNKKKPGMPNV HHCCCCCCCCCCCCC	69.10	26051181
1569	Propionylation	SLSRGNKKKPGMPNV HHCCCCCCCCCCCCC	69.10	-
1570	Acetylation	LSRGNKKKPGMPNVS HCCCCCCCCCCCCCC	48.70	23236377
1577	Phosphorylation	KPGMPNVSNDLSQKL CCCCCCCCHHHHHHH	31.13	20860994
1581	Phosphorylation	PNVSNDLSQKLYATM CCCCHHHHHHHHHHH	28.29	20860994
1583	Acetylation	VSNDLSQKLYATMEK CCHHHHHHHHHHHHH	39.84	19608861
1583	Ubiquitination	VSNDLSQKLYATMEK CCHHHHHHHHHHHHH	39.84	-
1585	Phosphorylation	NDLSQKLYATMEKHK HHHHHHHHHHHHHHH	13.68	-
1590	Acetylation	KLYATMEKHKEVFFV HHHHHHHHHHHEEEE	49.51	23954790
1590	Ubiquitination	KLYATMEKHKEVFFV HHHHHHHHHHHEEEE	49.51	-
1632	Phosphorylation	DGRDAFLTLARDKHL CCHHHHHHHHHHCCC	16.36	24719451
1637	Acetylation	FLTLARDKHLEFSSL HHHHHHHCCCCHHHH	44.53	15004546
1637	Ubiquitination	FLTLARDKHLEFSSL HHHHHHHCCCCHHHH	44.53	15004546
1643	Phosphorylation	DKHLEFSSLRRAQWS HCCCCHHHHHHHHHH	31.08	24719451
1674	Acetylation	VYTCNECKHHVETRW EEECCCCCCCCCCCE	30.48	21466224
1699	Acetylation	CITCYNTKNHDHKME EEEEEECCCCCCHHH	48.96	18995842
1704	Acetylation	NTKNHDHKMEKLGLG ECCCCCCHHHHCCCC	55.61	18995842
1707	Acetylation	NHDHKMEKLGLGLDD CCCCHHHHCCCCCCC	44.34	18995842
1707	Propionylation	NHDHKMEKLGLGLDD CCCCHHHHCCCCCCC	44.34	-
1716	Phosphorylation	GLGLDDESNNQQAAA CCCCCCCCCCCHHHH	48.34	26462736
1724	Phosphorylation	NNQQAAATQSPGDSR CCCHHHHHCCCCHHH	25.50	23401153
1726	Phosphorylation	QQAAATQSPGDSRRL CHHHHHCCCCHHHHH	26.88	29255136
1730	Phosphorylation	ATQSPGDSRRLSIQR HHCCCCHHHHHHHHH	25.80	29255136
1734	Phosphorylation	PGDSRRLSIQRCIQS CCHHHHHHHHHHHHH	18.18	20068231
1754	Phosphorylation	QCRNANCSLPSCQKM HHCCCCCCCCHHHHH	43.02	21712546
1760	Acetylation	CSLPSCQKMKRVVQH CCCCHHHHHHHHHHH	51.20	23749302
1762	Acetylation	LPSCQKMKRVVQHTK CCHHHHHHHHHHHCC	49.42	23749302
1769	Acetylation	KRVVQHTKGCKRKTN HHHHHHCCCCCCCCC	61.25	17267393
1769	Butyrylation	KRVVQHTKGCKRKTN HHHHHHCCCCCCCCC	61.25	-
1769	Propionylation	KRVVQHTKGCKRKTN HHHHHHCCCCCCCCC	61.25	-
1772	Acetylation	VQHTKGCKRKTNGGC HHHCCCCCCCCCCCC	66.65	17267393
1772	Propionylation	VQHTKGCKRKTNGGC HHHCCCCCCCCCCCC	66.65	-
1774	Acetylation	HTKGCKRKTNGGCPI HCCCCCCCCCCCCHH	31.66	11991867
1783	Acetylation	NGGCPICKQLIALCC CCCCHHHHHHHHHHH	49.19	25953088
1794	Acetylation	ALCCYHAKHCQENKC HHHHHHHHHHHHCCC	31.44	23749302
1800	Acetylation	AKHCQENKCPVPFCL HHHHHHCCCCCCCHH	38.88	23749302
1810	Acetylation	VPFCLNIKQKLRQQQ CCCHHHHHHHHHHHH	40.06	25953088
1812	Acetylation	FCLNIKQKLRQQQLQ CHHHHHHHHHHHHHH	40.41	11991859
1827	Sulfoxidation	HRLQQAQMLRRRMAS HHHHHHHHHHHHHHH	3.35	21406390
1834	Phosphorylation	MLRRRMASMQRTGVV HHHHHHHHHHHHCCC	13.20	16024795
1849	Phosphorylation	GQQQGLPSPTPATPT CCCCCCCCCCCCCCC	46.58	28348404
1851	Phosphorylation	QQGLPSPTPATPTTP CCCCCCCCCCCCCCC	29.87	28348404
1854	Phosphorylation	LPSPTPATPTTPTGQ CCCCCCCCCCCCCCC	23.52	28348404
1856	Phosphorylation	SPTPATPTTPTGQQP CCCCCCCCCCCCCCC	40.84	28348404
1857	Phosphorylation	PTPATPTTPTGQQPT CCCCCCCCCCCCCCC	21.76	19413330
1859	Phosphorylation	PATPTTPTGQQPTTP CCCCCCCCCCCCCCC	45.60	19413330
1864	Phosphorylation	TPTGQQPTTPQTPQP CCCCCCCCCCCCCCC	46.93	28348404
1865	Phosphorylation	PTGQQPTTPQTPQPT CCCCCCCCCCCCCCC	21.78	28348404
1897	Phosphorylation	TQAAGPVSQGKAAGQ CCCCCCCCCCCCCCC	36.03	23612710
1900	Acetylation	AGPVSQGKAAGQVTP CCCCCCCCCCCCCCC	27.68	21669532
1906	Phosphorylation	GKAAGQVTPPTPPQT CCCCCCCCCCCCCCC	18.70	30278072
1909	Phosphorylation	AGQVTPPTPPQTAQP CCCCCCCCCCCCCCC	49.13	30278072
1913	Phosphorylation	TPPTPPQTAQPPLPG CCCCCCCCCCCCCCC	32.79	29083192
1960	Phosphorylation	QHQMPPMTPMAPMGM HCCCCCCCCCCCCCC	18.71	17623675
2039	Phosphorylation	GLGQVGISPLKPGTV CCCCCCCCCCCCCCC	20.46	26074081
2045	Phosphorylation	ISPLKPGTVSQQALQ CCCCCCCCCCHHHHH	26.05	26074081
2059	Dimethylation	QNLLRTLRSPSSPLQ HHHHHHHCCCCCHHH	46.00	-
2059	Methylation	QNLLRTLRSPSSPLQ HHHHHHHCCCCCHHH	46.00	97812491
2086	Acetylation	QLLAAFIKQRAAKYA HHHHHHHHHHHHHHC	27.55	11991861
2091	Acetylation	FIKQRAAKYANSNPQ HHHHHHHHHCCCCCC	43.86	11991865
2142	Asymmetric dimethylarginine	PMQAGVQRAGLPQQQ HHHHHHHHCCCCCCC	28.37	-
2142	Citrullination	PMQAGVQRAGLPQQQ HHHHHHHHCCCCCCC	28.37	15731352
2142	Methylation	PMQAGVQRAGLPQQQ HHHHHHHHCCCCCCC	28.37	15731352
2219	Phosphorylation	QQPQGVGYPPQQQQR CCCCCCCCCHHHHHH	14.88	-
2226	Methylation	YPPQQQQRMQHHMQQ CCHHHHHHHHHHHHH	23.53	115486173
2256	Phosphorylation	LGAEAGASLQAYQQR HCCHHHHHHHHHHHH	21.79	24043423
2260	Phosphorylation	AGASLQAYQQRLLQQ HHHHHHHHHHHHHHH	7.69	24043423
2279	Phosphorylation	PVQPNPMSPQQHMLP CCCCCCCCHHHCCCC	22.33	17623675
2309	Phosphorylation	SLSNQVRSPQPVPSP CHHCCCCCCCCCCCC	29.09	30266825
2315	Phosphorylation	RSPQPVPSPRPQSQP CCCCCCCCCCCCCCC	33.50	26055452
2317	Methylation	PQPVPSPRPQSQPPH CCCCCCCCCCCCCCC	46.34	115486181
2320	Phosphorylation	VPSPRPQSQPPHSSP CCCCCCCCCCCCCCC	47.54	27362937
2325	O-linked_Glycosylation	PQSQPPHSSPSPRMQ CCCCCCCCCCCCCCC	50.12	30379171
2325	Phosphorylation	PQSQPPHSSPSPRMQ CCCCCCCCCCCCCCC	50.12	29255136
2326	Phosphorylation	QSQPPHSSPSPRMQP CCCCCCCCCCCCCCC	26.77	26503892
2328	Phosphorylation	QPPHSSPSPRMQPQP CCCCCCCCCCCCCCC	27.38	26503892
2330	Methylation	PHSSPSPRMQPQPSP CCCCCCCCCCCCCCC	40.48	115486189
2366	Phosphorylation	MEQGHFASPDQNSML CCCCCCCCCCHHHHH	28.24	17623675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
24	S	Phosphorylation	Kinase	KKCC1	Q8N5S9	PhosphoELM
24	S	Phosphorylation	Kinase	CAMK4	Q16566	GPS
89	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
89	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
89	S	Phosphorylation	Kinase	CAMK1-FAMILY	-	GPS
89	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
89	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
89	S	Phosphorylation	Kinase	AMPK_GROUP	-	PhosphoELM
89	S	Phosphorylation	Kinase	CAM-KI_GROUP	-	PhosphoELM
89	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
106	S	Phosphorylation	Kinase	ATM	Q13315	PSP
317	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
938	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
1038	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1038	S	Phosphorylation	Kinase	ERK2	P28482	PSP
1038	S	Phosphorylation	Kinase	ERK1	P27361	PSP
1834	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
1834	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
1834	S	Phosphorylation	Kinase	AKT1	P31749	PSP
1960	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
2039	S	Phosphorylation	Kinase	ERK1	P27361	PSP
2039	S	Phosphorylation	Kinase	ERK2	P28482	PSP
2039	S	Phosphorylation	Kinase	CDK1	P06493	PSP
2279	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
2279	S	Phosphorylation	Kinase	HIPK2	Q9H2X6	PSP
2315	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
2366	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:10207051
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO3	Q9UK99	PMID:18809579

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
89	S	Phosphorylation	Phosphorylation at Ser-89 by AMPK reduces interaction with nuclear receptors, such as PPARG.	11518699
418	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	9887100
423	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	18995842
580	R	Methylation	Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates apoptotic response.	11701890
604	R	Methylation	Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates apoptotic response.	11701890
1020	K	Acetylation	Deacetylated in the transcriptional repression domain (CRD1) by SIRT1, preferentially at Lys-1020.	12718889
1542	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	18995842
1546	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	18995842
1549	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	15004546
1699	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	18995842
1704	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	18995842
1707	K	Acetylation	Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.	18995842
2142	R	Citrullination	Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1.	15731352
2142	R	Methylation	Also methylated at Arg-2142 by CARM1, which impairs interaction with NCOA2/GRIP1.	15731352
2142	R	Methylation	Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1.	15731352

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EP300_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2A_HUMAN	TFAP2A	physical	12586840
EGR1_HUMAN	EGR1	physical	9806899
MAF_HUMAN	MAF	physical	11943779
CITE2_HUMAN	CITED2	physical	9887100
CITE2_HUMAN	CITED2	physical	12586840
JMY_HUMAN	JMY	physical	10518217
BRCA1_HUMAN	BRCA1	physical	10655477
PIAS3_HUMAN	PIAS3	physical	14691252
CLOCK_HUMAN	CLOCK	physical	14645221
BMAL1_HUMAN	ARNTL	physical	14645221
NPAS2_HUMAN	NPAS2	physical	14645221
ING4_HUMAN	ING4	physical	12750254
ING5_HUMAN	ING5	physical	12750254
N4BP2_HUMAN	N4BP2	physical	12730195
PPARG_HUMAN	PPARG	physical	12479814
ESR1_HUMAN	ESR1	physical	12479814
KAT2B_HUMAN	KAT2B	physical	12419806
TF65_HUMAN	RELA	physical	12419806
TYY1_HUMAN	YY1	physical	11486036
SMAD2_HUMAN	SMAD2	physical	10199400
ETS1_HUMAN	ETS1	genetic	10942770
ETS2_HUMAN	ETS2	genetic	10942770
TYY1_HUMAN	YY1	physical	7758944
SSXT_HUMAN	SS18	physical	11030627
CDX2_HUMAN	CDX2	physical	10506141
PAX6_HUMAN	PAX6	physical	10506141
USF2_HUMAN	USF2	physical	10434034
FEN1_HUMAN	FEN1	physical	11430825
EP300_HUMAN	EP300	physical	10567538
THA_HUMAN	THRA	physical	12371907
MEF2A_HUMAN	MEF2A	physical	12371907
RORA_HUMAN	RORA	physical	9862959
MYBB_HUMAN	MYBL2	physical	11733503
ING1_HUMAN	ING1	physical	12015309
SMAD1_HUMAN	SMAD1	physical	10673036
TWST1_HUMAN	TWIST1	physical	10025406
TWST1_HUMAN	TWIST1	genetic	10025406
NDF1_HUMAN	NEUROD1	physical	10545951
DTX1_HUMAN	DTX1	physical	11564735
ASCL1_HUMAN	ASCL1	physical	11564735
GPS2_HUMAN	GPS2	physical	10846067
HNRPU_HUMAN	HNRNPU	physical	11909954
SMAD7_HUMAN	SMAD7	physical	12408818
EID1_HUMAN	EID1	physical	11073989
EID1_HUMAN	EID1	physical	11073990
CITE4_HUMAN	CITED4	physical	11744733
CITE2_HUMAN	CITED2	physical	11744733
HIF1A_HUMAN	HIF1A	physical	11823643
HIF1A_HUMAN	HIF1A	physical	11959990
BCL3_HUMAN	BCL3	physical	10497212
TFE2_HUMAN	TCF3	physical	12435739
MGMT_HUMAN	MGMT	physical	11564893
DDX5_HUMAN	DDX5	physical	12527917
P53_HUMAN	TP53	physical	11782467
CITE1_HUMAN	CITED1	physical	10722728
PROX1_HUMAN	PROX1	physical	11943779
PELP1_HUMAN	PELP1	physical	11481323
SRBP2_HUMAN	SREBF2	physical	8918891
NFAC2_HUMAN	NFATC2	physical	9625762
TRIP4_HUMAN	TRIP4	physical	10454579
STAT3_MOUSE	Stat3	physical	10464260
STAT1_HUMAN	STAT1	physical	10464260
TDG_HUMAN	TDG	physical	11864601
TREF1_HUMAN	TRERF1	genetic	11349124
TREF1_HUMAN	TRERF1	physical	11349124
TGS1_HUMAN	TGS1	physical	11912212
SMAD4_HUMAN	SMAD4	physical	10887155
SNIP1_HUMAN	SNIP1	physical	10887155
IRF2_HUMAN	IRF2	physical	11304541
SMAD1_HUMAN	SMAD1	physical	10205054
STAT3_HUMAN	STAT3	physical	10205054
ESR1_HUMAN	ESR1	physical	11782371
HNF1A_HUMAN	HNF1A	physical	11978637
MYOD1_HUMAN	MYOD1	physical	9001254
TF65_HUMAN	RELA	physical	9096323
P53_HUMAN	TP53	physical	9809062
MDM2_HUMAN	MDM2	physical	9809062
CCND1_HUMAN	CCND1	physical	11788592
PCNA_HUMAN	PCNA	physical	11268218
XPA_HUMAN	XPA	physical	11268218
TAL1_HUMAN	TAL1	physical	10490830
PTMA_HUMAN	PTMA	physical	11967287
CEBPB_HUMAN	CEBPB	physical	9343424
RPB1_HUMAN	POLR2A	physical	9710619
CSN6_HUMAN	COPS6	physical	16169070
TCP4_HUMAN	SUB1	physical	11279157
ZBT17_HUMAN	ZBTB17	physical	11283613
H31T_HUMAN	HIST3H3	physical	11163245
P53_HUMAN	TP53	physical	18485870
P53_HUMAN	TP53	physical	17977830
TAF1B_HUMAN	TAF1B	physical	11073993
NP1L1_HUMAN	NAP1L1	physical	11073993
NP1L4_HUMAN	NAP1L4	physical	11073993
P53_HUMAN	TP53	physical	18612383
HDAC6_HUMAN	HDAC6	physical	19344692
RECQ4_HUMAN	RECQL4	physical	19299466
FBW1A_HUMAN	BTRC	physical	19297328
APC5_HUMAN	ANAPC5	physical	16319895
APC7_HUMAN	ANAPC7	physical	16319895
CADH1_HUMAN	CDH1	physical	16319895
CDC20_HUMAN	CDC20	physical	16319895
HDAC3_HUMAN	HDAC3	physical	19279113
TYY1_HUMAN	YY1	physical	19279113
CDT1_HUMAN	CDT1	physical	19276081
ATF4_HUMAN	ATF4	physical	16219772
DDX17_HUMAN	DDX17	physical	17226766
MAX_HUMAN	MAX	physical	17217336
POP1_CAEEL	pop-1	physical	12651889
HDAC3_HUMAN	HDAC3	physical	17158926
IKKA_HUMAN	CHUK	physical	19838210
NOTC1_HUMAN	NOTCH1	physical	19838210
ESR1_HUMAN	ESR1	physical	19838210
ESPB1_HUMAN	ELSPBP1	physical	19828133
SOX9_HUMAN	SOX9	physical	19828133
P53_HUMAN	TP53	physical	19805293
H31_HUMAN	HIST1H3A	physical	19801601
TBX21_HUMAN	TBX21	physical	17075044
PARP1_HUMAN	PARP1	physical	19622798
EP300_HUMAN	EP300	physical	17065153
HIPK2_HUMAN	HIPK2	physical	16917507
P53_HUMAN	TP53	physical	15542844
SMAD3_HUMAN	SMAD3	physical	16876108
PLAL1_HUMAN	PLAGL1	physical	16809786
SIR2_HUMAN	SIRT2	physical	18722353
HDAC1_HUMAN	HDAC1	physical	18722353
ING2_HUMAN	ING2	physical	16782091
SP1_HUMAN	SP1	physical	16734381
SP3_HUMAN	SP3	physical	16734381
RUNX2_HUMAN	RUNX2	physical	16728531
CACO1_HUMAN	CALCOCO1	physical	16717280
P53_HUMAN	TP53	physical	15337767
ESR1_HUMAN	ESR1	physical	16645043
P53_HUMAN	TP53	physical	15295102
TF3C1_HUMAN	GTF3C1	physical	18644873
TF3C3_HUMAN	GTF3C3	physical	18644873
TF3C2_HUMAN	GTF3C2	physical	18644873
TF3C5_HUMAN	GTF3C5	physical	18644873
RUNX2_HUMAN	RUNX2	physical	16613856
SMAD1_HUMAN	SMAD1	physical	16613856
SMAD5_HUMAN	SMAD5	physical	16613856
P53_HUMAN	TP53	physical	16537920
P53_HUMAN	TP53	physical	16678111
VHL_HUMAN	VHL	physical	16678111
RUNX3_HUMAN	RUNX3	physical	15138260
SP1_HUMAN	SP1	physical	16478997
NFKB1_HUMAN	NFKB1	physical	14662860
IRF1_HUMAN	IRF1	physical	14662860
H2A2C_HUMAN	HIST2H2AC	physical	16415179
H31_HUMAN	HIST1H3A	physical	16415179
FEN1_HUMAN	FEN1	physical	16326861
MYC_HUMAN	MYC	physical	16287840
H31_HUMAN	HIST1H3A	physical	16287840
MAX_HUMAN	MAX	physical	16287840
TYY1_HUMAN	YY1	physical	18542060
HDAC3_HUMAN	HDAC3	physical	18542060
PCNA_HUMAN	PCNA	physical	12937166
ETV1_HUMAN	ETV1	physical	12917345
KLF13_HUMAN	KLF13	physical	12758070
PARP1_HUMAN	PARP1	physical	16204234
SOX9_HUMAN	SOX9	physical	12732631
CREB1_HUMAN	CREB1	physical	12665587
MYOD1_HUMAN	MYOD1	physical	12665587
ESR1_HUMAN	ESR1	physical	12574227
PRGR_HUMAN	PGR	physical	12574227
H31_HUMAN	HIST1H3A	physical	12498683
PTMS_HUMAN	PTMS	physical	16150697
JUN_HUMAN	JUN	physical	12437352
STAT1_HUMAN	STAT1	physical	12403783
TF65_HUMAN	RELA	physical	12403783
BCL6_HUMAN	BCL6	physical	12402037
SP1_HUMAN	SP1	physical	12200149
SP3_HUMAN	SP3	physical	12200149
MYC_HUMAN	MYC	physical	16126174
MAX_HUMAN	MAX	physical	16126174
MTF1_HUMAN	MTF1	physical	18458062
NPM_HUMAN	NPM1	physical	16107701
CARM1_HUMAN	CARM1	physical	11997499
GRIP1_HUMAN	GRIP1	physical	11997499
JUN_HUMAN	JUN	physical	11980644
STAT3_HUMAN	STAT3	physical	11923478
STAT1_HUMAN	STAT1	physical	11923478
H2B1B_HUMAN	HIST1H2BB	physical	11884585
H31_HUMAN	HIST1H3A	physical	11884585
H2B1B_HUMAN	HIST1H2BB	physical	11830591
H31_HUMAN	HIST1H3A	physical	11830591
SRBP1_HUMAN	SREBF1	physical	14615581
P53_HUMAN	TP53	physical	16024799
DEK_HUMAN	DEK	physical	15987677
CTBP1_HUMAN	CTBP1	physical	15834423
H31_HUMAN	HIST1H3A	physical	15834423
NFKB1_HUMAN	NFKB1	physical	11739381
GRIP1_HUMAN	GRIP1	physical	15731352
H13_HUMAN	HIST1H1D	physical	11691934
H2A2B_HUMAN	HIST2H2AB	physical	11691934
H31_HUMAN	HIST1H3A	physical	11691934
TAT_HV1H2	tat	physical	11080476
STAT3_HUMAN	STAT3	physical	15653507
VDR_HUMAN	VDR	physical	15647825
SMAD2_HUMAN	SMAD2	physical	15623506
SMAD3_HUMAN	SMAD3	physical	15623506
SOX9_HUMAN	SOX9	physical	15623506
H2A2B_HUMAN	HIST2H2AB	physical	11689448
H31_HUMAN	HIST1H3A	physical	11689448
HNF1A_HUMAN	HNF1A	physical	15598887
CBP_HUMAN	CREBBP	physical	15598887
TF65_HUMAN	RELA	physical	11567019
CARM1_HUMAN	CARM1	physical	18280497
TF65_HUMAN	RELA	physical	18280497
PARP1_HUMAN	PARP1	physical	18280497
ANM1_HUMAN	PRMT1	physical	18280497
PCNA_HUMAN	PCNA	physical	18263614
GATA4_HUMAN	GATA4	physical	18252717
SMAD4_HUMAN	SMAD4	physical	18215124
NFYB_HUMAN	NFYB	physical	15454570
JUNB_HUMAN	JUNB	physical	15308641
SRY_HUMAN	SRY	physical	15297880
PRDM2_HUMAN	PRDM2	physical	15282304
IMA1_HUMAN	KPNA2	physical	10801418
SP1_HUMAN	SP1	physical	10651903
MDM2_HUMAN	MDM2	physical	15154850
HIF1A_HUMAN	HIF1A	physical	15154850
CITE2_HUMAN	CITED2	physical	15154850
STAT2_HUMAN	STAT2	physical	15154850
NCOA3_HUMAN	NCOA3	physical	15145939
ETS1_HUMAN	ETS1	physical	10358095
ETS2_HUMAN	ETS2	physical	10358095
GATA1_CHICK	GATA1	physical	9859997
XRCC6_HUMAN	XRCC6	physical	15023334
TAT_HV1H2	tat	physical	9811832
NFYB_HUMAN	NFYB	physical	9799238
GATA2_HUMAN	GATA2	physical	15001660
SNW1_HUMAN	SNW1	physical	14985122
HDAC1_HUMAN	HDAC1	physical	14968110
RARA_HUMAN	RARA	physical	17475621
P53_HUMAN	TP53	physical	17452980
KLF4_HUMAN	KLF4	physical	17908689
SP1_HUMAN	SP1	physical	17906698
EP300_HUMAN	EP300	physical	17510411
TYY1_HUMAN	YY1	physical	17510411
NFAC1_HUMAN	NFATC1	physical	21413932
KAT2B_HUMAN	KAT2B	physical	21413932
MK01_HUMAN	MAPK1	physical	17623675
PAX5_HUMAN	PAX5	physical	21357426
NR4A1_HUMAN	NR4A1	physical	20438716
ATR_HUMAN	ATR	physical	17272271
STAT6_HUMAN	STAT6	physical	17237818
ESR1_HUMAN	ESR1	physical	20388208
MEF2A_HUMAN	MEF2A	physical	20590529
KLF4_HUMAN	KLF4	physical	21252119
KLF8_HUMAN	KLF8	physical	20107328
NFKB1_HUMAN	NFKB1	physical	20065107
TGFR1_HUMAN	TGFBR1	physical	21629263
IRF5_HUMAN	IRF5	physical	20935208
ZBT7B_HUMAN	ZBTB7B	physical	20810990
KAT2B_HUMAN	KAT2B	physical	20870727
TAU_HUMAN	MAPT	physical	20869593
KS6B1_HUMAN	RPS6KB1	physical	19961954
KS6B2_HUMAN	RPS6KB2	physical	19961954
RUNX2_HUMAN	RUNX2	physical	20851880
SMAD1_HUMAN	SMAD1	physical	20851880
NR1H4_HUMAN	NR1H4	physical	19883617
FOXO3_HUMAN	FOXO3	physical	19592618
P53_HUMAN	TP53	physical	19234109
SOX4_HUMAN	SOX4	physical	19234109
HXD10_HUMAN	HOXD10	physical	11585930
HXD4_HUMAN	HOXD4	physical	11585930
MDC1_HUMAN	MDC1	physical	16051665
DDX24_HUMAN	DDX24	physical	16051665
ACTS_HUMAN	ACTA1	physical	16051665
ANXA2_HUMAN	ANXA2	physical	16051665
HERC1_HUMAN	HERC1	physical	16051665
TP53B_HUMAN	TP53BP1	physical	16051665
MSH6_HUMAN	MSH6	physical	16051665
RAD50_HUMAN	RAD50	physical	16051665
NBN_HUMAN	NBN	physical	16051665
MRE11_HUMAN	MRE11A	physical	16051665
NEDD1_HUMAN	NEDD1	physical	16051665
ACTA_HUMAN	ACTA2	physical	16051665
P73_HUMAN	TP73	physical	10648616
ESR1_HUMAN	ESR1	physical	19887647
ATF2_HUMAN	ATF2	physical	10327051
MYOD1_HUMAN	MYOD1	physical	8621548
TF2B_HUMAN	GTF2B	physical	10330164
CDK2_HUMAN	CDK2	physical	10330164
CRX_HUMAN	CRX	physical	10708567
HMGN1_HUMAN	HMGN1	physical	10753971
HMGN2_HUMAN	HMGN2	physical	10753971
AHR_HUMAN	AHR	physical	10999956
ARNT_HUMAN	ARNT	physical	10999956
IL8_HUMAN	CXCL8	physical	11940655
ESR1_HUMAN	ESR1	physical	14761960
PCKGC_HUMAN	PCK1	physical	21726808
BAG6_HUMAN	BAG6	physical	21726808
SPHK1_HUMAN	SPHK1	physical	22227192
ESR1_HUMAN	ESR1	physical	22227247
STAT3_HUMAN	STAT3	physical	22116549
KAT5_HUMAN	KAT5	physical	16001085
MK14_HUMAN	MAPK14	physical	21444723
H31_HUMAN	HIST1H3A	physical	20368990
MDM2_HUMAN	MDM2	physical	15013777
HBP1_HUMAN	HBP1	physical	21967847
TACC2_HUMAN	TACC2	physical	14767476
JUN_HUMAN	JUN	physical	21937452
FOS_HUMAN	FOS	physical	21937452
FOSB_HUMAN	FOSB	physical	21937452
FOSL1_HUMAN	FOSL1	physical	21937452
FOSL2_HUMAN	FOSL2	physical	21937452
JUNB_HUMAN	JUNB	physical	21937452
JUND_HUMAN	JUND	physical	21937452
BRCA1_HUMAN	BRCA1	physical	21212407
CREB1_HUMAN	CREB1	physical	21212407
RXRA_HUMAN	RXRA	physical	17761950
PPARG_HUMAN	PPARG	physical	17468099
P53_HUMAN	TP53	physical	17189186
CACO1_HUMAN	CALCOCO1	physical	16931570
CREB1_HUMAN	CREB1	physical	11313407
STA5A_HUMAN	STAT5A	physical	9773981
P53_HUMAN	TP53	physical	22266186
EP300_HUMAN	EP300	physical	22100894
NOTC1_HUMAN	NOTCH1	physical	22100894
DDB1_HUMAN	DDB1	physical	11425514
G3P_HUMAN	GAPDH	physical	18552833
P53_HUMAN	TP53	physical	20234175
MDM2_HUMAN	MDM2	physical	20234175
P53_HUMAN	TP53	physical	12690203
HIF1A_HUMAN	HIF1A	physical	21148070
FBX3_HUMAN	FBXO3	physical	18809579
ACK1_HUMAN	TNK2	physical	15964811
ZBT16_HUMAN	ZBTB16	physical	15964811
TF65_HUMAN	RELA	physical	20333651
AKT1_HUMAN	AKT1	physical	20333651
HIF1A_HUMAN	HIF1A	physical	19696166
SKP2_HUMAN	SKP2	physical	18243116
P53_HUMAN	TP53	physical	18243116
DDB1_HUMAN	DDB1	physical	12034848
DDB2_HUMAN	DDB2	physical	12034848
P53_HUMAN	TP53	physical	12162806
POL_HV1H2	gag-pol	physical	16096645
H2A2C_HUMAN	HIST2H2AC	physical	16096645
H2B2E_HUMAN	HIST2H2BE	physical	16096645
H32_HUMAN	HIST2H3C	physical	16096645
ZNF76_HUMAN	ZNF76	physical	16337145
HIF1A_HUMAN	HIF1A	physical	15261140
EPAS1_HUMAN	EPAS1	physical	15261140
ESR1_HUMAN	ESR1	physical	15308690
H11_HUMAN	HIST1H1A	physical	15308690
H2A2C_HUMAN	HIST2H2AC	physical	15308690
H2B2E_HUMAN	HIST2H2BE	physical	15308690
H31_HUMAN	HIST1H3A	physical	15308690
STAT3_HUMAN	STAT3	physical	15649887
P53_HUMAN	TP53	physical	11359905
MYB_HUMAN	MYB	physical	15691758
AKT1_HUMAN	AKT1	physical	21775285
P53_HUMAN	TP53	physical	15558054
P53_HUMAN	TP53	physical	19217391
KPYM_HUMAN	PKM	physical	21620138
SMAD3_HUMAN	SMAD3	physical	10497242
P53_HUMAN	TP53	physical	15509808
IRF1_HUMAN	IRF1	physical	15509808
IRF3_HUMAN	IRF3	physical	11940575
STAT3_HUMAN	STAT3	physical	15735682
STAT1_HUMAN	STAT1	physical	18566411
NCOA2_HUMAN	NCOA2	physical	9920895
APEX1_HUMAN	APEX1	physical	20856196
ASCL2_HUMAN	ASCL2	physical	20856196
YBOX1_HUMAN	YBX1	physical	20856196
SKP2_HUMAN	SKP2	physical	22770219
HIF1A_HUMAN	HIF1A	physical	20603618
HDAC6_HUMAN	HDAC6	physical	22778253
HDAC1_HUMAN	HDAC1	physical	22778253
VHL_HUMAN	VHL	physical	22071692
STRAP_HUMAN	STRAP	physical	18451878
IRF3_HUMAN	IRF3	physical	11314014
VIRF1_HHV8P	vIRF-1	physical	11314014
CTNB1_HUMAN	CTNNB1	physical	11050151
TCL1A_HUMAN	TCL1A	physical	19064921
KLF5_HUMAN	KLF5	physical	19419955
HIF1A_HUMAN	HIF1A	physical	16543236
EP300_HUMAN	EP300	physical	16543236
P53_HUMAN	TP53	physical	16543236
NBN_HUMAN	NBN	physical	21108945
ATG7_HUMAN	ATG7	physical	19124466
VIRF3_HHV8P	vIRF-3	physical	14668346
PPARG_HUMAN	PPARG	physical	14701856
P53_HUMAN	TP53	physical	11070080
P73_HUMAN	TP73	physical	11804596
TAL1_HUMAN	TAL1	physical	11118214
EP300_HUMAN	EP300	physical	11804596
P53_HUMAN	TP53	physical	11804596
MBB1A_HUMAN	MYBBP1A	physical	21471221
P53_HUMAN	TP53	physical	21471221
RS26_HUMAN	RPS26	physical	23728348
P53_HUMAN	TP53	physical	23728348
P53_HUMAN	TP53	physical	16611888
HIF1A_HUMAN	HIF1A	physical	23880760
P53_HUMAN	TP53	physical	23880760
ATF4_HUMAN	ATF4	physical	14630807
CEBPB_HUMAN	CEBPB	physical	14630807
JUN_HUMAN	JUN	physical	14630807
TNIP2_HUMAN	TNIP2	physical	21988832
GOGA2_HUMAN	GOLGA2	physical	21988832
PLMN_HUMAN	PLG	physical	21988832
MAGD1_HUMAN	MAGED1	physical	21988832
TINAL_HUMAN	TINAGL1	physical	21988832
K1C18_HUMAN	KRT18	physical	21988832
MIC60_HUMAN	IMMT	physical	21988832
MSTO1_HUMAN	MSTO1	physical	21988832
WDR59_HUMAN	WDR59	physical	21988832
EWS_HUMAN	EWSR1	physical	21988832
EPO_HUMAN	EPO	physical	21988832
LYAG_HUMAN	GAA	physical	21988832
ITIH3_HUMAN	ITIH3	physical	21988832
SMAD2_HUMAN	SMAD2	physical	21988832
PCKGM_HUMAN	PCK2	physical	21988832
PLS1_HUMAN	PLSCR1	physical	21988832
DPOD2_HUMAN	POLD2	physical	21988832
RL27_HUMAN	RPL27	physical	21988832
SEPP1_HUMAN	SEPP1	physical	21988832
TPO_HUMAN	THPO	physical	21988832
TRAF2_HUMAN	TRAF2	physical	21988832
GANP_HUMAN	MCM3AP	physical	21988832
NOXA1_HUMAN	NOXA1	physical	21988832
HNRL1_HUMAN	HNRNPUL1	physical	21988832
FBXL5_HUMAN	FBXL5	physical	21988832
SRTD1_HUMAN	SERTAD1	physical	21988832
UBQL1_HUMAN	UBQLN1	physical	21988832
KCTD5_HUMAN	KCTD5	physical	21988832
PLS2_HUMAN	PLSCR2	physical	21988832
VPS18_HUMAN	VPS18	physical	21988832
SAV1_HUMAN	SAV1	physical	21988832
HPS6_HUMAN	HPS6	physical	21988832
ZC12A_HUMAN	ZC3H12A	physical	21988832
PPARG_HUMAN	PPARG	physical	22787115
CREB1_HUMAN	CREB1	physical	22787115
BRCA1_HUMAN	BRCA1	physical	22787115
CREB1_HUMAN	CREB1	physical	21268077
JUN_HUMAN	JUN	physical	21268080
DDIT3_HUMAN	DDIT3	physical	24270407
P53_HUMAN	TP53	physical	24821727
ZBT16_HUMAN	ZBTB16	physical	24821727
CSN2_HUMAN	COPS2	physical	23441852
SIR1_HUMAN	SIRT1	physical	15632193
ZBT8A_HUMAN	ZBTB8A	physical	23329847
P53_HUMAN	TP53	physical	23329847
E2F1_HUMAN	E2F1	physical	24112038
VHL_HUMAN	VHL	physical	24112038
FOXO1_HUMAN	FOXO1	physical	18786403
TF65_HUMAN	RELA	physical	17692505
KLF2_HUMAN	KLF2	physical	21482710
KLF4_HUMAN	KLF4	physical	21482710
KLF2_HUMAN	KLF2	physical	15136591
SIR1_HUMAN	SIRT1	physical	19047049
GRP78_HUMAN	HSPA5	physical	25301734
UB2D1_HUMAN	UBE2D1	physical	19805293
EP300_HUMAN	EP300	physical	19805293
UB2D1_HUMAN	UBE2D1	physical	12690203
P53_HUMAN	TP53	physical	22731250
HDAC1_HUMAN	HDAC1	physical	22731250
ANDR_HUMAN	AR	physical	24480624
HIF1A_HUMAN	HIF1A	physical	16847340
HIF1A_HUMAN	HIF1A	physical	17906695
SENP3_HUMAN	SENP3	physical	22684029
P53_HUMAN	TP53	physical	22074660
SENP3_HUMAN	SENP3	physical	19680224
TERF2_HUMAN	TERF2	physical	23307557
P53_HUMAN	TP53	physical	23307557
CEBPD_HUMAN	CEBPD	physical	16397300
P53_HUMAN	TP53	physical	19339993
KAT2B_HUMAN	KAT2B	physical	12888487
HIF1A_HUMAN	HIF1A	physical	19589782
KAT2B_HUMAN	KAT2B	physical	8684459
DDX5_HUMAN	DDX5	physical	20663877
DDX17_HUMAN	DDX17	physical	20663877
TAT_HV1H2	tat	physical	10545121
EP300_HUMAN	EP300	physical	10545121
H31_HUMAN	HIST1H3A	physical	10545121
H31_HUMAN	HIST1H3A	physical	15611041
PAX8_HUMAN	PAX8	physical	10924503
WWTR1_MOUSE	Wwtr1	physical	16332960
ZEB1_HUMAN	ZEB1	physical	22384255
KAT2B_HUMAN	KAT2B	physical	22384255
ETV1_HUMAN	ETV1	physical	14747462
H2B1B_HUMAN	HIST1H2BB	physical	8945521
H31_HUMAN	HIST1H3A	physical	8945521
P53_HUMAN	TP53	physical	9891054
P53_HUMAN	TP53	physical	9744860
H11_HUMAN	HIST1H1A	physical	9744860
TAT_HV1H2	tat	physical	16135803
FOXP3_HUMAN	FOXP3	physical	19996091
P53_HUMAN	TP53	physical	12501250
STAT3_HUMAN	STAT3	physical	18782771
RUNX1_HUMAN	RUNX1	physical	14752096
H2B1B_HUMAN	HIST1H2BB	physical	14752096
H31_HUMAN	HIST1H3A	physical	14752096
E2F1_HUMAN	E2F1	physical	15123636
RB_HUMAN	RB1	physical	16878158
ANDR_HUMAN	AR	physical	10779504
EP300_HUMAN	EP300	physical	10779504
REL_HUMAN	REL	physical	24529102
SP1_HUMAN	SP1	physical	23714681
NANOG_HUMAN	NANOG	physical	23708658
TF65_HUMAN	RELA	physical	17982102
MK14_HUMAN	MAPK14	physical	17982102
P53_HUMAN	TP53	physical	9288740
GCR_HUMAN	NR3C1	physical	23125313
BRMS1_HUMAN	BRMS1	physical	23269275
TAT_HV1H2	tat	physical	9733868
CTNB1_MOUSE	Ctnnb1	physical	11973335
TCP4_HUMAN	SUB1	physical	19570987
H31_HUMAN	HIST1H3A	physical	16109717
SMAD3_HUMAN	SMAD3	physical	15345715
CEBPB_RAT	Cebpb	physical	20452968
CTNB1_HUMAN	CTNNB1	physical	15806138
P63_HUMAN	TP63	physical	23589370
FOXO1_HUMAN	FOXO1	physical	15890677
H2B1B_HUMAN	HIST1H2BB	physical	11983172
H31_HUMAN	HIST1H3A	physical	11983172
SATB1_HUMAN	SATB1	physical	14605447
FOXO1_HUMAN	FOXO1	physical	24419059
HIF1A_HUMAN	HIF1A	physical	23966271
EP300_HUMAN	EP300	physical	23934153
H2B1B_HUMAN	HIST1H2BB	physical	23934153
H31_HUMAN	HIST1H3A	physical	23934153
UBC_HUMAN	UBC	physical	23934153
H31_HUMAN	HIST1H3A	physical	23415232
P53_HUMAN	TP53	physical	17438265
H31_HUMAN	HIST1H3A	physical	19270680
P53_HUMAN	TP53	physical	17906639
AKT1_HUMAN	AKT1	physical	21901101
H31_HUMAN	HIST1H3A	physical	21875947
GABPA_HUMAN	GABPA	physical	16581781
MITF_HUMAN	MITF	physical	9660747
SMAD3_HUMAN	SMAD3	physical	9843571
SMAD4_HUMAN	SMAD4	physical	9843571
NFYB_HUMAN	NFYB	physical	10075648
NCOA1_HUMAN	NCOA1	physical	12208951
GCR_HUMAN	NR3C1	physical	12208951
SMAD4_HUMAN	SMAD4	physical	14612423
P53_HUMAN	TP53	physical	14612423
P63_HUMAN	TP63	physical	15965232
P53_HUMAN	TP53	physical	15965232
APEX1_HUMAN	APEX1	physical	14633989
HIF1A_HUMAN	HIF1A	physical	12588875
P53_HUMAN	TP53	physical	14759370
EID2_HUMAN	EID2	physical	14585496
H2B1B_HUMAN	HIST1H2BB	physical	14585496
H31_HUMAN	HIST1H3A	physical	14585496
HIF1A_HUMAN	HIF1A	physical	12914934
CREB1_HUMAN	CREB1	physical	7870179
PARP1_HUMAN	PARP1	physical	12960163
TF65_HUMAN	RELA	physical	12960163
NFKB1_HUMAN	NFKB1	physical	12960163
P53_HUMAN	TP53	physical	12724314
TAT_HV1H2	tat	physical	12904943
EGR1_HUMAN	EGR1	physical	20018936
H31T_HUMAN	HIST3H3	physical	10607594
TAT_HV1H2	tat	physical	10607594
HIF1A_HUMAN	HIF1A	physical	23618863
HIF1A_HUMAN	HIF1A	physical	21187066
TF65_HUMAN	RELA	physical	21187066
NFAC1_HUMAN	NFATC1	physical	15117818
PARP1_HUMAN	PARP1	physical	24636898
JUN_HUMAN	JUN	physical	24636898
CDK1_HUMAN	CDK1	physical	24530506
FBX3_HUMAN	FBXO3	physical	24530506
SP1_HUMAN	SP1	physical	24530506
NCOA3_HUMAN	NCOA3	physical	10490106
NCOA2_HUMAN	NCOA2	physical	10490106
P53_HUMAN	TP53	physical	10490106
EP300_HUMAN	EP300	physical	10490106
TFE2_HUMAN	TCF3	physical	22207202
AKT1_HUMAN	AKT1	physical	15224190
TF65_HUMAN	RELA	physical	12456660
SMAD3_HUMAN	SMAD3	physical	11134049
STAT1_HUMAN	STAT1	physical	11134049
ZEB1_HUMAN	ZEB1	physical	12743039
SMAD3_HUMAN	SMAD3	physical	12743039
JUN_HUMAN	JUN	physical	11689449
EP300_HUMAN	EP300	physical	11689449
CRTC1_HUMAN	CRTC1	physical	15961999
MAML2_HUMAN	MAML2	physical	15961999
STAT1_HUMAN	STAT1	physical	15824515
SMAD3_HUMAN	SMAD3	physical	15824515
CCND1_HUMAN	CCND1	physical	15951563
EP300_HUMAN	EP300	physical	15951563
H2B1B_HUMAN	HIST1H2BB	physical	15951563
H31_HUMAN	HIST1H3A	physical	15951563
IRF3_HUMAN	IRF3	physical	12473110
MYB_HUMAN	MYB	physical	10656693
HIF1A_HUMAN	HIF1A	physical	8917528
DPOLB_HUMAN	POLB	physical	12453427
CTNB1_HUMAN	CTNNB1	physical	12408825
ATF5_HUMAN	ATF5	physical	21791614
EP300_HUMAN	EP300	physical	21791614
2A5G_HUMAN	PPP2R5C	physical	15632055
PP2AA_HUMAN	PPP2CA	physical	15632055
DNA2_HUMAN	DNA2	physical	20019387
FEN1_HUMAN	FEN1	physical	20019387
CTNB1_HUMAN	CTNNB1	physical	15060161
ODPX_HUMAN	PDHX	physical	11756538
NDF1_HUMAN	NEUROD1	physical	11756538
SMAD2_HUMAN	SMAD2	physical	12237408
H31_HUMAN	HIST1H3A	physical	12237408
FOXP3_HUMAN	FOXP3	physical	16652169
FHL2_HUMAN	FHL2	physical	15572674
CTNB1_HUMAN	CTNNB1	physical	15572674
HIF1A_HUMAN	HIF1A	physical	19074848
GATA4_RAT	Gata4	physical	15220332
H31_HUMAN	HIST1H3A	physical	23870121
P53_HUMAN	TP53	physical	23870121
EP300_HUMAN	EP300	physical	23870121
ASH2L_HUMAN	ASH2L	physical	23870121
CXXC1_HUMAN	CXXC1	physical	23870121
SET1A_HUMAN	SETD1A	physical	23870121
WDR82_HUMAN	WDR82	physical	23870121
WDR5_HUMAN	WDR5	physical	23870121
RBBP5_HUMAN	RBBP5	physical	23870121
P53_HUMAN	TP53	physical	23796514
SMAD3_HUMAN	SMAD3	physical	21567395
EP300_HUMAN	EP300	physical	11433299
RB_HUMAN	RB1	physical	11433299
P53_HUMAN	TP53	physical	11433299
P53_HUMAN	TP53	physical	15664194
H2B2E_HUMAN	HIST2H2BE	physical	15664194
H31T_HUMAN	HIST3H3	physical	15664194
H2A2C_HUMAN	HIST2H2AC	physical	15664194
EP300_HUMAN	EP300	physical	15664194
NEIL2_HUMAN	NEIL2	physical	15175427
E2F5_MOUSE	E2f5	physical	10783242
FOXO3_HUMAN	FOXO3	physical	11896584
FOXO1_HUMAN	FOXO1	physical	11896584
HDAC6_HUMAN	HDAC6	physical	23133622
DC1I1_HUMAN	DYNC1I1	physical	23133622
UBC_HUMAN	UBC	physical	23133622
STAT2_HUMAN	STAT2	physical	18678383
APEX1_HUMAN	APEX1	physical	19934257
E2F1_HUMAN	E2F1	physical	23001041
SUMO2_HUMAN	SUMO2	physical	22578841
SRBP1_HUMAN	SREBF1	physical	20817729
H31_HUMAN	HIST1H3A	physical	16717280
CTNB1_HUMAN	CTNNB1	genetic	16990252
FLII_HUMAN	FLII	genetic	16990252
LRRF1_MOUSE	Lrrfip1	physical	16990252
EBNA6_EBVB9	EBNA3C	physical	11967287
H31_HUMAN	HIST1H3A	physical	23587423
CITE1_HUMAN	CITED1	physical	16864582
P53_HUMAN	TP53	physical	25753752
SMAD3_HUMAN	SMAD3	physical	15588252
HIF1A_HUMAN	HIF1A	physical	24421387
KAISO_HUMAN	ZBTB33	physical	25288747
P53_HUMAN	TP53	physical	25288747
STAT6_HUMAN	STAT6	physical	23461825
PCNA_HUMAN	PCNA	physical	24939902
TF65_HUMAN	RELA	physical	23999430
ZBT49_HUMAN	ZBTB49	physical	25245946
ORC2_HUMAN	ORC2	physical	20808282
MCM2_HUMAN	MCM2	physical	20808282
PRKDC_HUMAN	PRKDC	physical	20808282
RAD50_HUMAN	RAD50	physical	20808282
MCM4_HUMAN	MCM4	physical	20808282
MCM3_HUMAN	MCM3	physical	20808282
ILF3_HUMAN	ILF3	physical	20808282
MCM5_HUMAN	MCM5	physical	20808282
EF2_HUMAN	EEF2	physical	20808282
EF1A1_HUMAN	EEF1A1	physical	20808282
MO4L1_HUMAN	MORF4L1	physical	20808282
ILF2_HUMAN	ILF2	physical	20808282
RUVB2_HUMAN	RUVBL2	physical	20808282
APEX1_HUMAN	APEX1	physical	20808282
HDAC6_HUMAN	HDAC6	physical	12718889
H31_HUMAN	HIST1H3A	physical	18838386
CLH1_HUMAN	CLTC	physical	26496610
CITE2_HUMAN	CITED2	physical	26496610
COBL_HUMAN	COBL	physical	26496610
KLF5_HUMAN	KLF5	physical	16102021
PSD10_HUMAN	PSMD10	physical	25400040
SMC1A_HUMAN	SMC1A	physical	24945803
BRD4_HUMAN	BRD4	physical	24945803
HEMGN_HUMAN	HEMGN	physical	24740910
GATA1_HUMAN	GATA1	physical	24740910
GATA1_HUMAN	GATA1	physical	24255919
H31T_HUMAN	HIST3H3	physical	25818647
GCKR_HUMAN	GCKR	physical	26620281
1433Z_HUMAN	YWHAZ	physical	25770209
STAT1_HUMAN	STAT1	physical	26479788
P53_HUMAN	TP53	physical	16135789
TF65_HUMAN	RELA	physical	16135789
VE6_HPV16	E6	physical	10487758
NCOA3_HUMAN	NCOA3	physical	25728767
H31T_HUMAN	HIST3H3	physical	25728767
STAT1_HUMAN	STAT1	physical	26504087
STAT3_HUMAN	STAT3	physical	26504087
STA5A_HUMAN	STAT5A	physical	26504087
MYB_HUMAN	MYB	physical	25740244
MKL1_HUMAN	MKL1	physical	26476216
ZEB2_HUMAN	ZEB2	physical	22365546
SMAD1_HUMAN	SMAD1	physical	22365546
GLNA_HUMAN	GLUL	physical	26990986
CHD4_HUMAN	CHD4	physical	26546801
HSF1_HUMAN	HSF1	physical	28104499
DDX24_HUMAN	DDX24	physical	25867071
P53_HUMAN	TP53	physical	25867071
RORG_HUMAN	RORC	physical	26549310
P53_HUMAN	TP53	physical	26625199
P63_HUMAN	TP63	physical	25911675
SRC_HUMAN	SRC	physical	26695438
MDM2_HUMAN	MDM2	physical	28196907
ROA2_HUMAN	HNRNPA2B1	physical	26774881
AP2A_HUMAN	TFAP2A	physical	25669978
PLAK_HUMAN	JUP	physical	26657156
CTNB1_HUMAN	CTNNB1	physical	26657156
H31_HUMAN	HIST1H3A	physical	28465257
HSP7C_HUMAN	HSPA8	physical	28465257
LAMP2_HUMAN	LAMP2	physical	28465257
P53_HUMAN	TP53	physical	26302407
P53_HUMAN	TP53	physical	25651062
XRCC5_HUMAN	XRCC5	physical	29049411
LYRIC_HUMAN	MTDH	physical	27956703
JUN_HUMAN	JUN	physical	27956703
PIAS1_HUMAN	PIAS1	physical	27032383
GDIR1_HUMAN	ARHGDIA	physical	26719334
HIF1A_HUMAN	HIF1A	physical	22908229
PLAL1_HUMAN	PLAGL1	physical	28260048
CARM1_HUMAN	CARM1	physical	28844863
EP300_HUMAN	EP300	physical	28844863
H31_HUMAN	HIST1H3A	physical	28844863
H31_HUMAN	HIST1H3A	physical	29033323
EP300_HUMAN	EP300	physical	29033323

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• : Note=Defects in EP300 may play a role in epithelial cancer.
• 613684:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-285; THR-885; THR-887; SER-1038; THR-1857 ANDTHR-1859, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-636; LYS-977; LYS-981;LYS-1103; LYS-1499; LYS-1542; LYS-1546; LYS-1549; LYS-1554; LYS-1555;LYS-1558; LYS-1560; LYS-1583; LYS-1590 AND LYS-1674, AND MASSSPECTROMETRY.
PubMed: 19608861

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1554; LYS-1555; LYS-1558 ANDLYS-1560, AND MASS SPECTROMETRY.
PubMed: 16916647

"Kinetic and mass spectrometric analysis of p300 histoneacetyltransferase domain autoacetylation.";
Karanam B., Jiang L., Wang L., Kelleher N.L., Cole P.A.;
J. Biol. Chem. 281:40292-40301(2006).
Cited for: ACETYLATION AT LYS-1336 AND LYS-1473, AND MASS SPECTROMETRY.
PubMed: 17065153

"SIRT1 deacetylation and repression of p300 involves lysine residues1020/1024 within the cell cycle regulatory domain 1.";
Bouras T., Fu M., Sauve A.A., Wang F., Quong A.A., Perkins N.D.,Hay R.T., Gu W., Pestell R.G.;
J. Biol. Chem. 280:10264-10276(2005).
Cited for: DEACETYLATION BY SIRT1, ACETYLATION AT LYS-1020 AND LYS-1024, ANDMUTAGENESIS OF LYS-1020 AND LYS-1024.
PubMed: 15632193

Methylation

"Regulation of coactivator complex assembly and function by proteinarginine methylation and demethylimination.";
Lee Y.-H., Coonrod S.A., Kraus W.L., Jelinek M.A., Stallcup M.R.;
Proc. Natl. Acad. Sci. U.S.A. 102:3611-3616(2005).
Cited for: METHYLATION AT ARG-2142, CITRULLINATION AT ARG-2142, INTERACTION WITHNCOA2, AND MUTAGENESIS OF ARG-2056; ARG-2088 AND ARG-2142.
PubMed: 15731352

"A transcriptional switch mediated by cofactor methylation.";
Xu W., Chen H., Du K., Asahara H., Tini M., Emerson B.M., Montminy M.,Evans R.M.;
Science 294:2507-2511(2001).
Cited for: PARTIAL PROTEIN SEQUENCE, INTERACTION WITH CARM1, METHYLATION ATARG-580 AND ARG-604, AND FUNCTION.
PubMed: 11701890

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1734, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-285; THR-885; THR-887; SER-1038; THR-1857 ANDTHR-1859, AND MASS SPECTROMETRY.
PubMed: 19413330

"Regulation of transcription by AMP-activated protein kinase:phosphorylation of p300 blocks its interaction with nuclearreceptors.";
Yang W., Hong Y.H., Shen X.Q., Frankowski C., Camp H.S., Leff T.;
J. Biol. Chem. 276:38341-38344(2001).
Cited for: PHOSPHORYLATION AT SER-89, MUTAGENESIS OF SER-89, AND INTERACTION WITHPPARG.
PubMed: 11518699

Sumoylation

"P300 transcriptional repression is mediated by SUMO modification.";
Girdwood D., Bumpass D., Vaughan O.A., Thain A., Anderson L.A.,Snowden A.W., Garcia-Wilson E., Perkins N.D., Hay R.T.;
Mol. Cell 11:1043-1054(2003).
Cited for: SUMOYLATION AT LYS-1020 AND LYS-1024, AND MUTAGENESIS OF LYS-1020 ANDLYS-1024.
PubMed: 12718889