dbPTM

MYOD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYOD1_HUMAN
UniProt AC	P15172
Protein Name	Myoblast determination protein 1
Gene Name	MYOD1
Organism	Homo sapiens (Human).
Sequence Length	320
Subcellular Localization	Nucleus.
Protein Description	Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity)..
Protein Sequence	MELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRFFEDLDPRLMHVGALLKPEEHSHFPAAVHPAPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAAFYAPGPLPPGRGGEHYSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGESSGDPTQSPDAAPQCPAGANPNPIYQVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MELLSPPLRDVD ---CCCCCCCCCCCC	36.78	14749395
30	Phosphorylation	FATTDDFYDDPCFDS EECCCCCCCCCCCCC	26.82	-
58	Acetylation	MHVGALLKPEEHSHF HCHHEECCHHHHCCC	51.76	60833
99	Acetylation	RCLLWACKACKRKTT HHHHHHHHHHCCCCC	49.42	10619020
102	Acetylation	LWACKACKRKTTNAD HHHHHHHCCCCCCHH	62.89	10619020
104	Acetylation	ACKACKRKTTNADRR HHHHHCCCCCCHHHH	45.24	10619020
104	Methylation	ACKACKRKTTNADRR HHHHHCCCCCCHHHH	45.24	10619020
106	Phosphorylation	KACKRKTTNADRRKA HHHCCCCCCHHHHHH	31.29	27134283
115	Phosphorylation	ADRRKAATMRERRRL HHHHHHHHHHHHHHH	22.94	9751114
200	Phosphorylation	YSGDSDASSPRSNCS CCCCCCCCCCCCCCC	45.96	14749395
201	Phosphorylation	SGDSDASSPRSNCSD CCCCCCCCCCCCCCC	26.50	14749395
204	Phosphorylation	SDASSPRSNCSDGMM CCCCCCCCCCCCCCC	45.64	24114839
207	Phosphorylation	SSPRSNCSDGMMDYS CCCCCCCCCCCCCCC	41.26	24114839
213	Phosphorylation	CSDGMMDYSGPPSGA CCCCCCCCCCCCCCH	9.53	24114839
214	Phosphorylation	SDGMMDYSGPPSGAR CCCCCCCCCCCCCHH	40.33	24114839
278	Phosphorylation	LADVPSESPPRRQEA HCCCCCCCCCCHHCC	44.54	-
294	Phosphorylation	APSEGESSGDPTQSP CCCCCCCCCCCCCCC	42.80	23879269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	CDK1	P06493	PhosphoELM
115	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
115	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
200	S	Phosphorylation	Kinase	CDK1	P06493	PhosphoELM
200	S	Phosphorylation	Kinase	P38G	P53778	PSP
200	S	Phosphorylation	Kinase	P38G	O08911	PSP
200	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
201	S	Phosphorylation	Kinase	CDK1	P06493	GPS
201	S	Phosphorylation	Kinase	P38G	P53778	PSP
201	S	Phosphorylation	Kinase	P38G	O08911	PSP
201	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	HUWE1	Q7Z6Z7	PMID:22277673
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO32	Q969P5	PMID:15531760
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO34	Q9NWN3	PMID:19319192

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
104	K	Methylation		22215600
Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYOD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT3_HUMAN	STAT3	physical	12947115
HDAC1_HUMAN	HDAC1	physical	11684023
HDAC1_HUMAN	HDAC1	physical	11285237
RB_HUMAN	RB1	physical	11285237
RORA_HUMAN	RORA	physical	9862959
EP300_HUMAN	EP300	physical	9862959
EP300_HUMAN	EP300	genetic	9001254
CBP_HUMAN	CREBBP	genetic	9001254
EP300_HUMAN	EP300	physical	9001254
CBP_HUMAN	CREBBP	physical	9001254
RXRA_HUMAN	RXRA	physical	9692544
TWST1_MOUSE	Twist1	physical	9343420
CDN1C_HUMAN	CDKN1C	physical	10764802
NCOR1_HUMAN	NCOR1	physical	10406466
RB_HUMAN	RB1	physical	8381715
MYOD1_HUMAN	MYOD1	physical	9184158
TFE2_HUMAN	TCF3	physical	9184158
ID1_HUMAN	ID1	physical	9242638
ID2_HUMAN	ID2	physical	9242638
ID3_HUMAN	ID3	physical	9242638
MEF2C_HUMAN	MEF2C	physical	9418854
CSRP3_HUMAN	CSRP3	physical	9234731
COT2_HUMAN	NR2F2	physical	9826778
SNW1_HUMAN	SNW1	physical	11371506
PABP2_HUMAN	PABPN1	physical	11371506
CDK4_HUMAN	CDK4	physical	10601020
CDK4_HUMAN	CDK4	physical	10022835
ID1_HUMAN	ID1	physical	18674781
PBX1_HUMAN	PBX1	physical	20195544
IFRD1_HUMAN	IFRD1	physical	20195544
ID1_HUMAN	ID1	physical	20195544
ESPB1_HUMAN	ELSPBP1	physical	20195544
SMCA4_HUMAN	SMARCA4	physical	20195544
PHB_HUMAN	PHB	physical	20195544
CBX1_HUMAN	CBX1	physical	20195544
ANM5_HUMAN	PRMT5	physical	20195544
PEBB_HUMAN	CBFB	physical	20195544
RUNX1_HUMAN	RUNX1	physical	20195544
DDX5_HUMAN	DDX5	physical	17011493
ESR2_HUMAN	ESR2	physical	18765668
ESR1_HUMAN	ESR1	physical	18765668
H31_HUMAN	HIST1H3A	physical	16858404
SUV91_HUMAN	SUV39H1	physical	16858404
CREB1_HUMAN	CREB1	physical	12665587
MEF2C_HUMAN	MEF2C	physical	15743821
IFRD1_HUMAN	IFRD1	physical	15743821
BHE41_HUMAN	BHLHE41	physical	17487425
BHE40_HUMAN	BHLHE40	physical	17487425
EP300_HUMAN	EP300	physical	17964260
KAT2B_HUMAN	KAT2B	physical	17964260
EP300_HUMAN	EP300	physical	20364308
KAT2B_HUMAN	KAT2B	physical	20364308
HDAC1_HUMAN	HDAC1	physical	20124407
T22D3_HUMAN	TSC22D3	physical	20124407
EP300_HUMAN	EP300	physical	8621548
PSMD4_HUMAN	PSMD4	physical	9235903
SMCA4_HUMAN	SMARCA4	physical	22068056
SMRD3_HUMAN	SMARCD3	physical	22068056
RPB7_HUMAN	POLR2G	physical	21988832
PSME2_HUMAN	PSME2	physical	21988832
TRI27_HUMAN	TRIM27	physical	25025573
PAX7_HUMAN	PAX7	physical	25025573
HUWE1_HUMAN	HUWE1	physical	22277673
ID2_HUMAN	ID2	physical	21209940
FBX32_HUMAN	FBXO32	physical	15531760
KAT2B_HUMAN	KAT2B	physical	27453350

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYOD1_HUMAN

Related Literatures of Post-Translational Modification

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