IFRD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFRD1_HUMAN
• UniProt AC: O00458
• Protein Name: Interferon-related developmental regulator 1
• Gene Name: IFRD1
• Organism: Homo sapiens (Human).
• Sequence Length: 451
• Protein Description: Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity)..
• Protein Sequence: MPKNKKRNTPHRGSSAGGGGSGAAAATAATAGGQHRNVQPFSDEDASIETMSHCSGYSDPSSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALEGIKNALASKMLYEFILERRMTLTDSIERCLKKGKSDEQRAAAALASVLCIQLGPGIESEEILKTLGPILKKIICDGSASMQARQTCATCFGVCCFIATDDITELYSTLECLENIFTKSYLKEKDTTVICSTPNTVLHISSLLAWTLLLTICPINEVKKKLEMHFHKLPSLLSCDDVNMRIAAGESLALLFELARGIESDFFYEDMESLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERDFPTETIKFGPERMYIDCWVKKHTYDTFKEVLGSGMQYHLQSNEFLRNVFELGPPVMLDAATLKTMKISRFERHLYNSAAFKARTKARSKCRDKRADVGEFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	PKNKKRNTPHRGSSA CCCCCCCCCCCCCCC	25.22	29978859
14	Phosphorylation	RNTPHRGSSAGGGGS CCCCCCCCCCCCCHH	19.57	25159151
15	Phosphorylation	NTPHRGSSAGGGGSG CCCCCCCCCCCCHHH	33.48	25159151
21	Phosphorylation	SSAGGGGSGAAAATA CCCCCCHHHHHHHHH	28.65	25159151
27	Phosphorylation	GSGAAAATAATAGGQ HHHHHHHHHHHCCCC	16.46	26699800
30	Phosphorylation	AAAATAATAGGQHRN HHHHHHHHCCCCCCC	24.30	27080861
94	Ubiquitination	LIDLTLDKSAKTRQA HHHHHCCCCHHHHHH	56.26	-
107	Ubiquitination	QAALEGIKNALASKM HHHHHHHHHHHHHHH	47.20	-
116	Phosphorylation	ALASKMLYEFILERR HHHHHHHHHHHHHHC	12.80	19664994
162	Phosphorylation	QLGPGIESEEILKTL HHCCCCCHHHHHHHH	38.31	-
174	Ubiquitination	KTLGPILKKIICDGS HHHHHHHHHHHCCCC	42.52	21890473
174	Ubiquitination	KTLGPILKKIICDGS HHHHHHHHHHHCCCC	42.52	21890473
175	Ubiquitination	TLGPILKKIICDGSA HHHHHHHHHHCCCCH	33.58	21890473
175	Ubiquitination	TLGPILKKIICDGSA HHHHHHHHHHCCCCH	33.58	21890473
325	Ubiquitination	ALATDGNKHRAKVDK HHHHCCCCHHHHCCH	39.74	-
357	Ubiquitination	DFPTETIKFGPERMY CCCCCCEECCCCCEE	52.25	-
371	Ubiquitination	YIDCWVKKHTYDTFK EEEEEEEHHCHHHHH	31.40	-
416	Ubiquitination	AATLKTMKISRFERH HHHHHHHCCHHHHHH	42.64	-
425	Phosphorylation	SRFERHLYNSAAFKA HHHHHHHHHHHHHHH	10.84	23312004
427	Phosphorylation	FERHLYNSAAFKART HHHHHHHHHHHHHHH	13.86	22817900
431	Ubiquitination	LYNSAAFKARTKARS HHHHHHHHHHHHHHH	32.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFRD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFRD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFRD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	12198164
MEF2C_HUMAN	MEF2C	physical	15743821
IFRD1_HUMAN	IFRD1	physical	15743821
HDAC4_HUMAN	HDAC4	physical	15743821

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
PubMed: 18220336