dbPTM

HDAC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HDAC1_HUMAN
UniProt AC	Q13547
Protein Name	Histone deacetylase 1
Gene Name	HDAC1
Organism	Homo sapiens (Human).
Sequence Length	482
Subcellular Localization	Nucleus .
Protein Description	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation..
Protein Sequence	MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAQTQGTRRKV ----CCCCCCCCEEE	21.30	27470641
10	Ubiquitination	QTQGTRRKVCYYYDG CCCCCCEEEEEEECC	33.11	21890473
31	Acetylation	YGQGHPMKPHRIRMT ECCCCCCCCCEECCH	41.97	25953088
31	Ubiquitination	YGQGHPMKPHRIRMT ECCCCCCCCCEECCH	41.97	-
36	Methylation	PMKPHRIRMTHNLLL CCCCCEECCHHHHHH	24.73	-
38	Phosphorylation	KPHRIRMTHNLLLNY CCCEECCHHHHHHHH	9.58	24719451
45	Phosphorylation	THNLLLNYGLYRKME HHHHHHHHHHHHCCE	14.42	28258704
48	Phosphorylation	LLLNYGLYRKMEIYR HHHHHHHHHCCEEEC	12.11	24719451
50	Ubiquitination	LNYGLYRKMEIYRPH HHHHHHHCCEEECCC	27.59	-
54	Phosphorylation	LYRKMEIYRPHKANA HHHCCEEECCCCCCH	12.56	28258704
58	Ubiquitination	MEIYRPHKANAEEMT CEEECCCCCCHHHHH	46.12	-
66	Acetylation	ANAEEMTKYHSDDYI CCHHHHHHHCCHHHH	39.39	23236377
66	Ubiquitination	ANAEEMTKYHSDDYI CCHHHHHHHCCHHHH	39.39	21906983
72	Phosphorylation	TKYHSDDYIKFLRSI HHHCCHHHHHHHHHH	15.82	-
74	Acetylation	YHSDDYIKFLRSIRP HCCHHHHHHHHHHCC	31.92	19608861
74	Ubiquitination	YHSDDYIKFLRSIRP HCCHHHHHHHHHHCC	31.92	21890473
84	Sulfoxidation	RSIRPDNMSEYSKQM HHHCCCCHHHHHHHH	4.14	21406390
85	Phosphorylation	SIRPDNMSEYSKQMQ HHCCCCHHHHHHHHH	39.37	28450419
87	Phosphorylation	RPDNMSEYSKQMQRF CCCCHHHHHHHHHHC	17.54	-
87	Nitration	RPDNMSEYSKQMQRF CCCCHHHHHHHHHHC	17.54	-
88	Phosphorylation	PDNMSEYSKQMQRFN CCCHHHHHHHHHHCC	16.62	20860994
89	Sumoylation	DNMSEYSKQMQRFNV CCHHHHHHHHHHCCC	49.22	-
89	Sumoylation	DNMSEYSKQMQRFNV CCHHHHHHHHHHCCC	49.22	19608861
89	Acetylation	DNMSEYSKQMQRFNV CCHHHHHHHHHHCCC	49.22	23749302
89	Ubiquitination	DNMSEYSKQMQRFNV CCHHHHHHHHHHCCC	49.22	21890473
89	Methylation	DNMSEYSKQMQRFNV CCHHHHHHHHHHCCC	49.22	19608861
89	Malonylation	DNMSEYSKQMQRFNV CCHHHHHHHHHHCCC	49.22	26320211
114	O-linked_Glycosylation	FEFCQLSTGGSVASA HHHHHCCCCCCHHHH	54.90	23301498
126	Ubiquitination	ASAVKLNKQQTDIAV HHHHHCCCCCCCEEE	54.97	21890473
143	Ubiquitination	AGGLHHAKKSEASGF CCCCCCCCCCCCCCC	53.10	-
144	Ubiquitination	GGLHHAKKSEASGFC CCCCCCCCCCCCCCH	55.07	-
195	Phosphorylation	YTTDRVMTVSFHKYG EECCCEEEEEEECCC	15.33	20068231
197	Phosphorylation	TDRVMTVSFHKYGEY CCCEEEEEEECCCCC	16.68	20068231
200	Acetylation	VMTVSFHKYGEYFPG EEEEEEECCCCCCCC	53.60	25953088
200	Ubiquitination	VMTVSFHKYGEYFPG EEEEEEECCCCCCCC	53.60	21890473
201	Phosphorylation	MTVSFHKYGEYFPGT EEEEEECCCCCCCCC	13.45	28152594
204	Phosphorylation	SFHKYGEYFPGTGDL EEECCCCCCCCCCCC	15.65	28152594
218	Ubiquitination	LRDIGAGKGKYYAVN CEECCCCCCCEEEEE	52.26	-
218	Acetylation	LRDIGAGKGKYYAVN CEECCCCCCCEEEEE	52.26	8439433
220	Acetylation	DIGAGKGKYYAVNYP ECCCCCCCEEEEECC	38.28	19608861
220	Ubiquitination	DIGAGKGKYYAVNYP ECCCCCCCEEEEECC	38.28	19608861
220	Malonylation	DIGAGKGKYYAVNYP ECCCCCCCEEEEECC	38.28	26320211
221	Phosphorylation	IGAGKGKYYAVNYPL CCCCCCCEEEEECCC	12.82	20068231
222	Phosphorylation	GAGKGKYYAVNYPLR CCCCCCEEEEECCCC	13.94	20068231
226	Phosphorylation	GKYYAVNYPLRDGID CCEEEEECCCCCCCC	9.31	20068231
236	Phosphorylation	RDGIDDESYEAIFKP CCCCCCHHHHHHHHH	34.96	20068231
237	Phosphorylation	DGIDDESYEAIFKPV CCCCCHHHHHHHHHH	13.82	20068231
242	Ubiquitination	ESYEAIFKPVMSKVM HHHHHHHHHHHHHHH	30.50	21906983
261	Glutathionylation	PSAVVLQCGSDSLSG CCEEEEECCCCCCCC	5.01	22555962
261	S-nitrosylation	PSAVVLQCGSDSLSG CCEEEEECCCCCCCC	5.01	-
261	S-nitrosocysteine	PSAVVLQCGSDSLSG CCEEEEECCCCCCCC	5.01	-
263	O-linked_Glycosylation	AVVLQCGSDSLSGDR EEEEECCCCCCCCCC	31.49	23301498
273	S-nitrosylation	LSGDRLGCFNLTIKG CCCCCEECEEEEECC	2.12	-
273	S-nitrosocysteine	LSGDRLGCFNLTIKG CCCCCEECEEEEECC	2.12	-
279	Ubiquitination	GCFNLTIKGHAKCVE ECEEEEECCCHHHHH	39.13	-
283	Ubiquitination	LTIKGHAKCVEFVKS EEECCCHHHHHHHHH	32.89	-
290	Phosphorylation	KCVEFVKSFNLPMLM HHHHHHHHCCCCEEE	17.67	-
303	Phosphorylation	LMLGGGGYTIRNVAR EEECCCCCHHHCHHH	11.41	17081983
304	Phosphorylation	MLGGGGYTIRNVARC EECCCCCHHHCHHHC	19.41	20068231
333	Phosphorylation	NELPYNDYFEYFGPD CCCCCCCCHHHHCCC	8.48	-
336	Phosphorylation	PYNDYFEYFGPDFKL CCCCCHHHHCCCCEE	12.16	-
342	Sumoylation	EYFGPDFKLHISPSN HHHCCCCEEEECCCC	46.68	-
346	Phosphorylation	PDFKLHISPSNMTNQ CCCEEEECCCCCCCC	16.13	28450419
348	Phosphorylation	FKLHISPSNMTNQNT CEEEECCCCCCCCCH	32.23	21406692
350	Sulfoxidation	LHISPSNMTNQNTNE EEECCCCCCCCCHHH	4.34	28183972
351	Phosphorylation	HISPSNMTNQNTNEY EECCCCCCCCCHHHH	37.59	21406692
355	Phosphorylation	SNMTNQNTNEYLEKI CCCCCCCHHHHHHHH	21.47	21406692
358	Phosphorylation	TNQNTNEYLEKIKQR CCCCHHHHHHHHHHH	23.41	21406692
361	Ubiquitination	NTNEYLEKIKQRLFE CHHHHHHHHHHHHHH	53.24	21890473
361	Acetylation	NTNEYLEKIKQRLFE CHHHHHHHHHHHHHH	53.24	19608861
363	Ubiquitination	NEYLEKIKQRLFENL HHHHHHHHHHHHHHH	40.20	-
365	Methylation	YLEKIKQRLFENLRM HHHHHHHHHHHHHCC	36.02	-
393	Phosphorylation	EDAIPEESGDEDEDD CCCCCCCCCCCCCCC	50.29	29255136
406	Phosphorylation	DDPDKRISICSSDKR CCCCCCEEEECCCCE	22.90	30266825
409	Phosphorylation	DKRISICSSDKRIAC CCCEEEECCCCEEEE	39.64	23927012
410	Phosphorylation	KRISICSSDKRIACE CCEEEECCCCEEEEE	42.62	30266825
412	Ubiquitination	ISICSSDKRIACEEE EEEECCCCEEEEECC	47.88	-
412	Acetylation	ISICSSDKRIACEEE EEEECCCCEEEEECC	47.88	23749302
421	Phosphorylation	IACEEEFSDSEEEGE EEEECCCCCCHHCCC	43.43	29255136
423	Phosphorylation	CEEEFSDSEEEGEGG EECCCCCCHHCCCCC	45.79	29255136
432	Methylation	EEGEGGRKNSSNFKK HCCCCCCCCCHHHHH	65.54	18438403
432	Acetylation	EEGEGGRKNSSNFKK HCCCCCCCCCHHHHH	65.54	8439421
434	Phosphorylation	GEGGRKNSSNFKKAK CCCCCCCCHHHHHHH	29.69	23927012
435	Phosphorylation	EGGRKNSSNFKKAKR CCCCCCCHHHHHHHC	56.53	23927012
438	Ubiquitination	RKNSSNFKKAKRVKT CCCCHHHHHHHCCCC	56.95	-
438	Acetylation	RKNSSNFKKAKRVKT CCCCHHHHHHHCCCC	56.95	25953088
438	Sumoylation	RKNSSNFKKAKRVKT CCCCHHHHHHHCCCC	56.95	28112733
439	Acetylation	KNSSNFKKAKRVKTE CCCHHHHHHHCCCCH	55.81	8439409
441	Acetylation	SSNFKKAKRVKTEDE CHHHHHHHCCCCHHH	67.61	8439427
444	Sumoylation	FKKAKRVKTEDEKEK HHHHHCCCCHHHHCC	50.67	11960997
444	Sumoylation	FKKAKRVKTEDEKEK HHHHHCCCCHHHHCC	50.67	-
445	Phosphorylation	KKAKRVKTEDEKEKD HHHHCCCCHHHHCCC	45.90	30576142
457	Sumoylation	EKDPEEKKEVTEEEK CCCHHHHHCCCHHHH	61.77	25218447
457	Sumoylation	EKDPEEKKEVTEEEK CCCHHHHHCCCHHHH	61.77	-
460	Phosphorylation	PEEKKEVTEEEKTKE HHHHHCCCHHHHHHH	38.48	28122231
476	Sumoylation	KPEAKGVKEEVKLA- CCCCCCCCHHHCCC-	57.75	11960997
476	Sumoylation	KPEAKGVKEEVKLA- CCCCCCCCHHHCCC-	57.75	-
480	Sumoylation	KGVKEEVKLA----- CCCCHHHCCC-----	41.81	28112733
480	Ubiquitination	KGVKEEVKLA----- CCCCHHHCCC-----	41.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
421	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
421	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
421	S	Phosphorylation	Kinase	CK2	-	Uniprot
421	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
423	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
423	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
423	S	Phosphorylation	Kinase	CK2	-	Uniprot
423	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	KCTD11	Q693B1	PMID:20081843
-	K	Ubiquitination	E3 ubiquitin ligase	CHFR	Q96EP1	PMID:19182791
-	K	Ubiquitination	E3 ubiquitin ligase	RCHY1	Q96PM5	PMID:18344599

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
421	S	Phosphorylation	11602581
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.
423	S	Phosphorylation	11602581
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.
444	K	Sumoylation	11960997
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity.
476	K	Sumoylation	11960997
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HDAC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	12032298
HM20B_HUMAN	HMG20B	physical	12032298
HDAC2_HUMAN	HDAC2	physical	12032298
CTBP1_HUMAN	CTBP1	physical	11022042
CTBP1_HUMAN	CTBP1	physical	10995736
TGIF1_HUMAN	TGIF1	physical	10995736
PF21A_HUMAN	PHF21A	physical	15325272
DDX5_HUMAN	DDX5	physical	15298701
DDX17_HUMAN	DDX17	physical	15298701
GATA1_HUMAN	GATA1	physical	14668799
CDYL_HUMAN	CDYL	physical	12947414
SIN3A_HUMAN	SIN3A	physical	12943729
MTA1_HUMAN	MTA1	physical	12920132
MTA2_HUMAN	MTA2	physical	12920132
HDAC1_HUMAN	HDAC1	physical	12920132
HDAC2_HUMAN	HDAC2	physical	12920132
CHD4_HUMAN	CHD4	physical	12920132
SIN3A_HUMAN	SIN3A	physical	12920132
RBBP4_HUMAN	RBBP4	physical	12920132
RBBP7_HUMAN	RBBP7	physical	12920132
CHD1_HUMAN	CHD1	physical	12890497
ANDR_HUMAN	AR	physical	11994312
TYY1_HUMAN	YY1	physical	9346952
GTF2I_HUMAN	GTF2I	physical	12393887
RBBP4_HUMAN	RBBP4	physical	11470869
CHD4_HUMAN	CHD4	physical	10220385
RBBP4_HUMAN	RBBP4	physical	10220385
SIN3A_HUMAN	SIN3A	physical	10220385
HDAC2_HUMAN	HDAC2	physical	11804585
CH60_HUMAN	HSPD1	physical	11777905
HSP74_HUMAN	HSPA4	physical	11777905
HDAC2_HUMAN	HDAC2	physical	11466315
SIN3A_HUMAN	SIN3A	physical	11931768
TOP2B_HUMAN	TOP2B	physical	11062478
TOP2A_HUMAN	TOP2A	physical	11062478
HDAC2_HUMAN	HDAC2	physical	11739383
NCOR2_HUMAN	NCOR2	physical	11739383
RCOR1_HUMAN	RCOR1	physical	11171972
RBBP4_HUMAN	RBBP4	physical	11171972
MTA2_HUMAN	MTA2	physical	11171972
SIN3A_HUMAN	SIN3A	physical	11171972
KDM1A_HUMAN	KDM1A	physical	11171972
PML_HUMAN	PML	physical	11430826
PML_HUMAN	PML	physical	11259576
DNMT1_MOUSE	Dnmt1	physical	10615135
TOP2A_HUMAN	TOP2A	physical	11136718
RB_HUMAN	RB1	physical	11684023
MYOD1_HUMAN	MYOD1	physical	11684023
TF65_HUMAN	RELA	physical	11931769
NFKB1_HUMAN	NFKB1	physical	11931769
HDAC2_HUMAN	HDAC2	physical	11564889
TF65_HUMAN	RELA	physical	11564889
MDM2_HUMAN	MDM2	physical	12426395
FOXG1_MOUSE	Foxg1	physical	11238932
PHB_HUMAN	PHB	physical	12466959
RB_HUMAN	RB1	physical	12466959
PCNA_HUMAN	PCNA	physical	11929879
RB_HUMAN	RB1	physical	9491888
RB_HUMAN	RB1	physical	10490602
RBL1_HUMAN	RBL1	physical	10490602
FKBP3_HUMAN	FKBP3	physical	11532945
RBBP4_HUMAN	RBBP4	physical	9150133
PPARD_HUMAN	PPARD	physical	11867749
MBD2_HUMAN	MBD2	physical	10471499
RBBP4_HUMAN	RBBP4	physical	10471499
RBBP7_HUMAN	RBBP7	physical	10471499
MTA1_HUMAN	MTA1	physical	11146623
MIER1_HUMAN	MIER1	physical	12482978
TGIF1_HUMAN	TGIF1	physical	11427533
TGIF2_HUMAN	TGIF2	physical	11427533
DAXX_HUMAN	DAXX	physical	10669754
SAP30_HUMAN	SAP30	physical	9651585
MBD3_HUMAN	MBD3	physical	10444591
MTA2_HUMAN	MTA2	physical	10444591
HDAC2_HUMAN	HDAC2	physical	10444591
RBBP4_HUMAN	RBBP4	physical	10444591
RBBP7_HUMAN	RBBP7	physical	10444591
SAP30_HUMAN	SAP30	physical	10444591
MBD2_HUMAN	MBD2	physical	10444591
SIN3A_HUMAN	SIN3A	physical	10444591
SIN3B_HUMAN	SIN3B	physical	10444591
HBP1_HUMAN	HBP1	physical	15235594
SIN3A_HUMAN	SIN3A	physical	12091390
IKZF1_HUMAN	IKZF1	physical	10357820
CHD3_HUMAN	CHD3	physical	9804427
CHD4_HUMAN	CHD4	physical	9804427
SMAD2_HUMAN	SMAD2	physical	10199400
DNM3L_HUMAN	DNMT3L	physical	12177302
DNM3L_HUMAN	DNMT3L	physical	12202768
ZBT16_HUMAN	ZBTB16	physical	9627120
BCL6_HUMAN	BCL6	physical	9627120
CABIN_HUMAN	CABIN1	physical	10933397
HDAC2_HUMAN	HDAC2	physical	9520398
RBBP4_HUMAN	RBBP4	physical	9520398
SIN3A_HUMAN	SIN3A	physical	9520398
VHL_HUMAN	VHL	physical	11641274
HIF1N_HUMAN	HIF1AN	physical	11641274
HIF1A_HUMAN	HIF1A	physical	11641274
DNM3A_HUMAN	DNMT3A	physical	11350943
SIN3A_HUMAN	SIN3A	physical	12374985
SATB1_HUMAN	SATB1	physical	12374985
MTA2_HUMAN	MTA2	physical	12374985
HDAC2_HUMAN	HDAC2	physical	9150135
RBBP4_HUMAN	RBBP4	physical	9150135
RBBP7_HUMAN	RBBP7	physical	9150135
HUS1_HUMAN	HUS1	physical	10846170
RAD9A_HUMAN	RAD9A	physical	10846170
ING1_HUMAN	ING1	physical	12015309
IKZF1_HUMAN	IKZF1	physical	12015313
MTG8_HUMAN	RUNX1T1	physical	11533236
MTG16_HUMAN	CBFA2T3	physical	11533236
SIN3A_HUMAN	SIN3A	physical	10640275
EVI1_HUMAN	MECOM	physical	11568182
EED_HUMAN	EED	physical	10581039
EZH2_HUMAN	EZH2	physical	10581039
HDAC2_HUMAN	HDAC2	physical	10581039
RBL2_HUMAN	RBL2	physical	10969803
SIN3A_HUMAN	SIN3A	physical	11784859
SAP30_HUMAN	SAP30	physical	11784859
CHD3_HUMAN	CHD3	physical	11784859
COT2_HUMAN	NR2F2	physical	10704340
HAIR_HUMAN	HR	physical	11641275
IFRD1_HUMAN	IFRD1	physical	12198164
ZBT16_HUMAN	ZBTB16	physical	9765306
DZIP3_HUMAN	DZIP3	physical	18206970
UHRF1_HUMAN	UHRF1	physical	17934516
DNMT1_HUMAN	DNMT1	physical	17934516
PADI4_HUMAN	PADI4	physical	19581286
MECP2_HUMAN	MECP2	physical	14593184
SIN3A_HUMAN	SIN3A	physical	14593184
SPI1_HUMAN	SPI1	physical	14647463
MECP2_HUMAN	MECP2	physical	14647463
SIN3A_HUMAN	SIN3A	physical	14647463
MBD4_HUMAN	MBD4	physical	15899845
NSD2_HUMAN	WHSC1	physical	16197452
SPI1_HUMAN	SPI1	physical	16331260
SIN3A_HUMAN	SIN3A	physical	16331260
DNM3B_HUMAN	DNMT3B	physical	16331260
MECP2_HUMAN	MECP2	physical	16331260
ZMY11_HUMAN	ZMYND11	physical	16565076
NSD2_HUMAN	WHSC1	physical	18156491
ETHE1_HUMAN	ETHE1	physical	17353187
REST_HUMAN	REST	physical	18806873
PRDM1_HUMAN	PRDM1	physical	19124609
CDN1A_HUMAN	CDKN1A	physical	20154723
GLI1_HUMAN	GLI1	physical	20081843
GLI2_HUMAN	GLI2	physical	20081843
CHFR_HUMAN	CHFR	physical	19182791
TF65_HUMAN	RELA	physical	20001970
CD5R1_HUMAN	CDK5R1	physical	19081376
SMCA4_HUMAN	SMARCA4	physical	19081374
RB_HUMAN	RB1	physical	19081374
PP1G_HUMAN	PPP1CC	physical	19070599
HSF1_HUMAN	HSF1	physical	19793920
HDAC2_HUMAN	HDAC2	physical	19041848
MBD3_HUMAN	MBD3	physical	19041848
MTA2_HUMAN	MTA2	physical	19686092
RBBP4_HUMAN	RBBP4	physical	19686092
RBBP7_HUMAN	RBBP7	physical	19686092
PO2F1_HUMAN	POU2F1	physical	19617623
CREM_HUMAN	CREM	physical	17056544
SMAD7_HUMAN	SMAD7	physical	15831498
HELLS_HUMAN	HELLS	physical	19561196
SP1_HUMAN	SP1	physical	18948152
NKX25_HUMAN	NKX2-5	physical	18851995
BRMS1_HUMAN	BRMS1	physical	17000776
SPB5_HUMAN	SERPINB5	physical	16982778
PHB_HUMAN	PHB	physical	16964284
ANDR_HUMAN	AR	physical	15640443
MDM2_HUMAN	MDM2	physical	15640443
FOSL1_HUMAN	FOSL1	physical	15615716
PAX3_HUMAN	PAX3	physical	16787918
EP300_HUMAN	EP300	physical	16787918
CBP_HUMAN	CREBBP	physical	16787918
P66A_HUMAN	GATAD2A	physical	16738318
P66B_HUMAN	GATAD2B	physical	16738318
SP1_HUMAN	SP1	physical	16734381
SP3_HUMAN	SP3	physical	16734381
NKX31_HUMAN	NKX3-1	physical	16697957
P53_HUMAN	TP53	physical	16697957
RUNX1_HUMAN	RUNX1	physical	16652147
NUP98_HUMAN	NUP98	physical	16651408
NUP54_HUMAN	NUP54	physical	16651408
SATB1_HUMAN	SATB1	physical	16630892
PLAL1_HUMAN	PLAGL1	physical	18644983
PML_HUMAN	PML	physical	18644863
HDAC9_HUMAN	HDAC9	physical	16611996
MK08_HUMAN	MAPK8	physical	16611996
MK09_HUMAN	MAPK9	physical	16611996
MK10_HUMAN	MAPK10	physical	16611996
GCM1_HUMAN	GCM1	physical	16528103
CBP_HUMAN	CREBBP	physical	16528103
TRI27_HUMAN	TRIM27	physical	19351825
SNAI1_HUMAN	SNAI1	physical	14673164
SNAI2_HUMAN	SNAI2	physical	14673164
SNAI3_HUMAN	SNAI3	physical	14673164
NKX32_HUMAN	NKX3-2	physical	14612411
ESR1_HUMAN	ESR1	physical	14506733
NFKB1_HUMAN	NFKB1	physical	12972430
NFKB1_HUMAN	NFKB1	physical	16319923
KSYK_HUMAN	SYK	physical	16288017
GFI1_HUMAN	GFI1	physical	16287849
CRYAB_HUMAN	CRYAB	physical	18552382
ESCO2_HUMAN	ESCO2	physical	18501190
E4F1_HUMAN	E4F1	physical	12730668
C2TA_HUMAN	CIITA	physical	12697811
HES1_HUMAN	HES1	physical	16195230
CREB1_HUMAN	CREB1	physical	12567184
PP1G_HUMAN	PPP1CC	physical	12567184
GLI3_HUMAN	GLI3	physical	12435627
SP1_HUMAN	SP1	physical	12200149
SP3_HUMAN	SP3	physical	12200149
DHI2_HUMAN	HSD11B2	physical	12082639
BC11B_HUMAN	BCL11B	physical	16091750
TYY1_HUMAN	YY1	physical	11940654
HDAC2_HUMAN	HDAC2	physical	11919195
ZBT16_HUMAN	ZBTB16	physical	11865059
RB_HUMAN	RB1	physical	11839806
ZBT16_HUMAN	ZBTB16	physical	16024608
HDAC2_HUMAN	HDAC2	physical	15987735
MYT1_HUMAN	MYT1	physical	15935060
SIN3B_HUMAN	SIN3B	physical	15935060
SMAD7_HUMAN	SMAD7	physical	15831516
GCR_HUMAN	NR3C1	physical	15826950
SP1_HUMAN	SP1	physical	15722551
CCND1_HUMAN	CCND1	physical	15713663
SATB1_HUMAN	SATB1	physical	15713622
SIN3A_HUMAN	SIN3A	physical	15695521
NKX22_HUMAN	NKX2-2	physical	15695521
KLF5_HUMAN	KLF5	physical	15668237
RBBP4_HUMAN	RBBP4	physical	11602581
MTA2_HUMAN	MTA2	physical	11602581
SIN3A_HUMAN	SIN3A	physical	11602581
RCOR1_HUMAN	RCOR1	physical	11602581
SPI1_HUMAN	SPI1	physical	11593411
ESR1_HUMAN	ESR1	physical	15557281
SP1_HUMAN	SP1	physical	15557281
IKBA_HUMAN	NFKBIA	physical	15536134
SP1_HUMAN	SP1	physical	11517158
SP3_HUMAN	SP3	physical	11517158
MYC_HUMAN	MYC	physical	18271930
MNT_HUMAN	MNT	physical	18271930
RB_HUMAN	RB1	physical	15485920
P53_HUMAN	TP53	physical	11313951
TBP_HUMAN	TBP	physical	11313951
SAP30_HUMAN	SAP30	physical	18193082
ING2_HUMAN	ING2	physical	18193082
ING1_HUMAN	ING1	physical	18193082
KLF1_HUMAN	KLF1	physical	11287616
ING1_HUMAN	ING1	physical	11118440
SIN3A_HUMAN	SIN3A	physical	11118440
SAP30_HUMAN	SAP30	physical	11118440
RBBP4_HUMAN	RBBP4	physical	11118440
P73_HUMAN	TP73	physical	15454570
BCL6_HUMAN	BCL6	physical	15454082
UHRF1_HUMAN	UHRF1	physical	15361834
UHRF2_HUMAN	UHRF2	physical	15361834
HDAC2_HUMAN	HDAC2	physical	11102443
CHD4_HUMAN	CHD4	physical	11102443
KDM1A_HUMAN	KDM1A	physical	11102443
MTA2_HUMAN	MTA2	physical	11102443
RCOR1_HUMAN	RCOR1	physical	11102443
RBBP4_HUMAN	RBBP4	physical	11102443
RBBP7_HUMAN	RBBP7	physical	11102443
MBD2_HUMAN	MBD2	physical	11102443
ACTS_HUMAN	ACTA1	physical	11102443
MBD3_HUMAN	MBD3	physical	11102443
SIN3A_HUMAN	SIN3A	physical	11102443
SIN3B_HUMAN	SIN3B	physical	11102443
HDAC2_HUMAN	HDAC2	physical	15297431
PBX1_HUMAN	PBX1	physical	11046157
SENP1_HUMAN	SENP1	physical	15199155
P53_HUMAN	TP53	physical	10777477
ATM_HUMAN	ATM	physical	10531300
TF65_HUMAN	RELA	physical	15192014
HDAC9_HUMAN	HDAC9	physical	10487760
SP1_HUMAN	SP1	physical	10409740
PHB2_HUMAN	PHB2	physical	15140878
TAF1B_HUMAN	TAF1B	physical	15136563
HDAC2_HUMAN	HDAC2	physical	18059533
RBL2_HUMAN	RBL2	physical	9858615
E2F4_HUMAN	E2F4	physical	9858615
CHD4_HUMAN	CHD4	physical	9790534
SIN3A_HUMAN	SIN3A	physical	9790534
UBS3B_HUMAN	UBASH3B	physical	9790534
SAP30_HUMAN	SAP30	physical	9790534
HDAC2_HUMAN	HDAC2	physical	9790534
RBBP4_HUMAN	RBBP4	physical	9790534
RBBP7_HUMAN	RBBP7	physical	9790534
MTA2_HUMAN	MTA2	physical	9790534
BCL6_HUMAN	BCL6	physical	9753732
EP300_HUMAN	EP300	physical	14968110
MYC_HUMAN	MYC	physical	18003922
SP1_HUMAN	SP1	physical	18003922
NR1D2_HUMAN	NR1D2	physical	17996965
RB_HUMAN	RB1	physical	9468140
RB_HUMAN	RB1	physical	9468139
BHE41_HUMAN	BHLHE41	physical	17487425
E2F1_HUMAN	E2F1	physical	17980157
HELLS_HUMAN	HELLS	physical	17967891
DNMT1_HUMAN	DNMT1	physical	17967891
NONO_HUMAN	NONO	physical	17452459
ESR1_HUMAN	ESR1	physical	14722073
MTA1_HUMAN	MTA1	physical	14722073
CEBPD_HUMAN	CEBPD	physical	17910034
RCOR1_HUMAN	RCOR1	physical	17938259
RBBP4_HUMAN	RBBP4	physical	17827154
MTG8_HUMAN	RUNX1T1	physical	17389244
ZN148_HUMAN	ZNF148	physical	17663720
SIN3A_HUMAN	SIN3A	physical	17643391
RBBP4_HUMAN	RBBP4	physical	17643391
PRDM5_HUMAN	PRDM5	physical	17636019
KDM1A_HUMAN	KDM1A	physical	17634443
RFX1_HUMAN	RFX1	physical	17630394
ESR1_HUMAN	ESR1	physical	17312152
OVOL1_HUMAN	OVOL1	physical	17311813
SAMN1_HUMAN	SAMSN1	physical	20478393
SP3_HUMAN	SP3	physical	17548428
HIF1A_HUMAN	HIF1A	physical	17273746
DMAP1_HUMAN	DMAP1	physical	17371848
SP1_HUMAN	SP1	physical	20385359
PPARG_HUMAN	PPARG	physical	16407282
RUVB2_HUMAN	RUVBL2	physical	20603076
PARP1_HUMAN	PARP1	physical	20596014
SMCA4_HUMAN	SMARCA4	physical	20596014
CHD3_HUMAN	CHD3	physical	20585571
CHD4_HUMAN	CHD4	physical	20585571
SMC4_HUMAN	SMC4	physical	20585571
SIN3A_HUMAN	SIN3A	physical	20585571
SIN3B_HUMAN	SIN3B	physical	20585571
KDM1A_HUMAN	KDM1A	physical	20585571
MTA1_HUMAN	MTA1	physical	20585571
MTA2_HUMAN	MTA2	physical	20585571
TCPQ_HUMAN	CCT8	physical	20585571
TCPA_HUMAN	TCP1	physical	20585571
VIME_HUMAN	VIM	physical	20585571
RO52_HUMAN	TRIM21	physical	20585571
RBBP4_HUMAN	RBBP4	physical	20585571
TRM1_HHV11	UL28	physical	20585571
DNBI_HHV11	UL29	physical	20585571
TRX1_HHV11	UL38	physical	20585571
ESCO1_HUMAN	ESCO1	physical	20331966
PARK7_HUMAN	PARK7	physical	20127688
MTA2_HUMAN	MTA2	physical	20127688
P53_HUMAN	TP53	physical	20075864
SP1_HUMAN	SP1	physical	20072153
IRF5_HUMAN	IRF5	physical	20935208
KDM1A_HUMAN	KDM1A	physical	20856864
PPARG_HUMAN	PPARG	physical	21151932
H2AY_HUMAN	H2AFY	physical	16107708
H2AY_HUMAN	H2AFY	physical	17474147
CHD4_HUMAN	CHD4	physical	9885572
CHD3_HUMAN	CHD3	physical	9885572
HDAC2_HUMAN	HDAC2	physical	9885572
RBBP4_HUMAN	RBBP4	physical	9885572
MTA1_HUMAN	MTA1	physical	9885572
PP6R3_HUMAN	PPP6R3	physical	9885572
SP130_HUMAN	SAP130	physical	9885572
SIN3A_HUMAN	SIN3A	physical	9885572
RBBP7_HUMAN	RBBP7	physical	9885572
SAP30_HUMAN	SAP30	physical	9885572
RUNX1_HUMAN	RUNX1	physical	21059642
BRNP1_HUMAN	BRINP1	physical	21030595
H31T_HUMAN	HIST3H3	physical	12700765
BCL3_HUMAN	BCL3	physical	15469820
SMAD2_HUMAN	SMAD2	physical	11226163
TGIF1_HUMAN	TGIF1	physical	11226163
NR0B2_HUMAN	NR0B2	physical	21566081
SMRCD_HUMAN	SMARCAD1	physical	21549307
FOXP3_HUMAN	FOXP3	physical	21974802
KDM5B_HUMAN	KDM5B	physical	21937684
KDM5B_HUMAN	KDM5B	physical	17373667
TF65_HUMAN	RELA	physical	21983014
KBZIP_HHV8P	K8	physical	22416134
HDAC2_HUMAN	HDAC2	physical	22416134
UBF1_HUMAN	UBTF	physical	22393235
RUNX2_HUMAN	RUNX2	physical	22393235
RUNX2_HUMAN	RUNX2	genetic	22393235
VHL_HUMAN	VHL	physical	22286234
MYC_HUMAN	MYC	physical	22286234
CDN2A_HUMAN	CDKN2A	physical	21846774
ARF_HUMAN	CDKN2A	physical	21846774
EZH2_HUMAN	EZH2	physical	21685935
SNAI1_HUMAN	SNAI1	physical	21685935
NR2C2_HUMAN	NR2C2	physical	21670149
NR2C1_HUMAN	NR2C1	physical	21670149
DNMT1_HUMAN	DNMT1	physical	21670149
KDM1A_HUMAN	KDM1A	physical	21670149
HDAC2_HUMAN	HDAC2	physical	21670149
MTA2_HUMAN	MTA2	physical	21670149
MTA1_HUMAN	MTA1	physical	21670149
CHD4_HUMAN	CHD4	physical	21670149
RBBP4_HUMAN	RBBP4	physical	21670149
MBD3_HUMAN	MBD3	physical	21670149
DPOD3_HUMAN	POLD3	physical	21670149
TIF1B_HUMAN	TRIM28	physical	21669397
T7L1A_DANRE	tcf7l1a	physical	21666599
STAT3_HUMAN	STAT3	physical	22750444
NFAC1_HUMAN	NFATC1	physical	19218564
HIF1A_HUMAN	HIF1A	physical	21148070
DCAF1_HUMAN	VPRBP	physical	22184063
ZBT16_HUMAN	ZBTB16	physical	19648967
JDP2_HUMAN	JDP2	physical	22989952
ATF3_HUMAN	ATF3	physical	22989952
DNMT1_HUMAN	DNMT1	physical	20613874
SFPQ_HUMAN	SFPQ	physical	16731528
ZNF76_HUMAN	ZNF76	physical	16337145
HDAC2_HUMAN	HDAC2	physical	22939629
MBD3_HUMAN	MBD3	physical	22939629
RBBP4_HUMAN	RBBP4	physical	22939629
RBBP7_HUMAN	RBBP7	physical	22939629
MTA1_HUMAN	MTA1	physical	22939629
MTA2_HUMAN	MTA2	physical	22939629
P66A_HUMAN	GATAD2A	physical	22939629
SMRC1_HUMAN	SMARCC1	physical	22939629
SMCA5_HUMAN	SMARCA5	physical	22939629
SMRD1_HUMAN	SMARCD1	physical	22939629
CTNB1_HUMAN	CTNNB1	physical	19166851
TLE1_HUMAN	TLE1	physical	22439931
EZH2_HUMAN	EZH2	physical	22439931
GSE1_HUMAN	GSE1	physical	21258344
HM20B_HUMAN	HMG20B	physical	21258344
HM20A_HUMAN	HMG20A	physical	21258344
KDM1A_HUMAN	KDM1A	physical	21258344
RCOR3_HUMAN	RCOR3	physical	21258344
RCOR1_HUMAN	RCOR1	physical	21258344
TDIF1_HUMAN	DNTTIP1	physical	21258344
EMSA1_HUMAN	ELMSAN1	physical	21258344
MIER1_HUMAN	MIER1	physical	21258344
HDAC2_HUMAN	HDAC2	physical	21258344
HDAC1_HUMAN	HDAC1	physical	21258344
RBBP7_HUMAN	RBBP7	physical	21258344
RBBP4_HUMAN	RBBP4	physical	21258344
CDKA1_HUMAN	CDK2AP1	physical	21258344
P66B_HUMAN	GATAD2B	physical	21258344
P66A_HUMAN	GATAD2A	physical	21258344
MTA3_HUMAN	MTA3	physical	21258344
MTA1_HUMAN	MTA1	physical	21258344
CHD4_HUMAN	CHD4	physical	21258344
MTA2_HUMAN	MTA2	physical	21258344
MBD3_HUMAN	MBD3	physical	21258344
MBD2_HUMAN	MBD2	physical	21258344
BRMS1_HUMAN	BRMS1	physical	21258344
SAP30_HUMAN	SAP30	physical	21258344
SIN3A_HUMAN	SIN3A	physical	21258344
E2F3_HUMAN	E2F3	physical	23060449
E2F4_HUMAN	E2F4	physical	23060449
TIF1B_HUMAN	TRIM28	physical	23060449
TMM54_HUMAN	TMEM54	physical	22982681
EID3_HUMAN	EID3	physical	15970276
STAT1_HUMAN	STAT1	physical	16481475
ADNP_HUMAN	ADNP	physical	23752268
ADHX_HUMAN	ADH5	physical	23752268
RERE_HUMAN	RERE	physical	23752268
ARI4A_HUMAN	ARID4A	physical	23752268
ARI4B_HUMAN	ARID4B	physical	23752268
ARI5B_HUMAN	ARID5B	physical	23752268
BC11A_HUMAN	BCL11A	physical	23752268
BC11B_HUMAN	BCL11B	physical	23752268
BEND3_HUMAN	BEND3	physical	23752268
BRMS1_HUMAN	BRMS1	physical	23752268
BRM1L_HUMAN	BRMS1L	physical	23752268
CSK21_HUMAN	CSNK2A1	physical	23752268
CSK2B_HUMAN	CSNK2B	physical	23752268
CDYL_HUMAN	CDYL	physical	23752268
CHD3_HUMAN	CHD3	physical	23752268
CHD4_HUMAN	CHD4	physical	23752268
CTBP1_HUMAN	CTBP1	physical	23752268
CDKA1_HUMAN	CDK2AP1	physical	23752268
TDIF1_HUMAN	DNTTIP1	physical	23752268
IKZF1_HUMAN	IKZF1	physical	23752268
TBL1R_HUMAN	TBL1XR1	physical	23752268
GATD1_HUMAN	GATAD1	physical	23752268
GSE1_HUMAN	GSE1	physical	23752268
HM20A_HUMAN	HMG20A	physical	23752268
HDAC1_HUMAN	HDAC1	physical	23752268
HDAC2_HUMAN	HDAC2	physical	23752268
SP130_HUMAN	SAP130	physical	23752268
SAP30_HUMAN	SAP30	physical	23752268
SP30L_HUMAN	SAP30L	physical	23752268
RBBP4_HUMAN	RBBP4	physical	23752268
RBBP7_HUMAN	RBBP7	physical	23752268
EHMT2_HUMAN	EHMT2	physical	23752268
BBX_HUMAN	BBX	physical	23752268
IMA5_HUMAN	KPNA1	physical	23752268
IMA4_HUMAN	KPNA3	physical	23752268
IMA3_HUMAN	KPNA4	physical	23752268
IMA7_HUMAN	KPNA6	physical	23752268
ING1_HUMAN	ING1	physical	23752268
ING2_HUMAN	ING2	physical	23752268
IDHP_HUMAN	IDH2	physical	23752268
KDM5A_HUMAN	KDM5A	physical	23752268
KDM1A_HUMAN	KDM1A	physical	23752268
ACADM_HUMAN	ACADM	physical	23752268
MIER1_HUMAN	MIER1	physical	23752268
MIER2_HUMAN	MIER2	physical	23752268
MIER3_HUMAN	MIER3	physical	23752268
MTA1_HUMAN	MTA1	physical	23752268
MTA2_HUMAN	MTA2	physical	23752268
MTA3_HUMAN	MTA3	physical	23752268
MBD2_HUMAN	MBD2	physical	23752268
MBD3_HUMAN	MBD3	physical	23752268
SIN3A_HUMAN	SIN3A	physical	23752268
SIN3B_HUMAN	SIN3B	physical	23752268
PHF12_HUMAN	PHF12	physical	23752268
PF21A_HUMAN	PHF21A	physical	23752268
PFD2_HUMAN	PFDN2	physical	23752268
PFD3_HUMAN	VBP1	physical	23752268
PFD5_HUMAN	PFDN5	physical	23752268
PFD6_HUMAN	PFDN6	physical	23752268
EMSY_HUMAN	C11orf30	physical	23752268
FA60A_HUMAN	FAM60A	physical	23752268
PKCB1_HUMAN	ZMYND8	physical	23752268
PWP2A_HUMAN	PWWP2A	physical	23752268
RREB1_HUMAN	RREB1	physical	23752268
RCOR1_HUMAN	RCOR1	physical	23752268
RCOR2_HUMAN	RCOR2	physical	23752268
RCOR3_HUMAN	RCOR3	physical	23752268
RB_HUMAN	RB1	physical	23752268
ESTD_HUMAN	ESD	physical	23752268
SDS3_HUMAN	SUDS3	physical	23752268
HM20B_HUMAN	HMG20B	physical	23752268
P66A_HUMAN	GATAD2A	physical	23752268
P66B_HUMAN	GATAD2B	physical	23752268
TREF1_HUMAN	TRERF1	physical	23752268
TNC18_HUMAN	TNRC18	physical	23752268
TRM61_HUMAN	TRMT61A	physical	23752268
EMSA1_HUMAN	ELMSAN1	physical	23752268
CP087_HUMAN	C16orf87	physical	23752268
WDR5_HUMAN	WDR5	physical	23752268
ZBTB2_HUMAN	ZBTB2	physical	23752268
ZMYM2_HUMAN	ZMYM2	physical	23752268
ZMYM3_HUMAN	ZMYM3	physical	23752268
ZN217_HUMAN	ZNF217	physical	23752268
Z512B_HUMAN	ZNF512B	physical	23752268
ZN516_HUMAN	ZNF516	physical	23752268
ZN521_HUMAN	ZNF521	physical	23752268
ZN592_HUMAN	ZNF592	physical	23752268
ZN609_HUMAN	ZNF609	physical	23752268
ZN687_HUMAN	ZNF687	physical	23752268
ZN827_HUMAN	ZNF827	physical	23752268
IKZF2_HUMAN	IKZF2	physical	23752268
HDAC2_HUMAN	HDAC2	physical	17894944
SP1_HUMAN	SP1	physical	17894944
TMG4_HUMAN	PRRG4	physical	21988832
HIF1A_HUMAN	HIF1A	physical	24015760
BHE41_HUMAN	BHLHE41	physical	22355045
BRCC3_HUMAN	BRCC3	physical	22863883
HNRPR_HUMAN	HNRNPR	physical	22863883
LARP7_HUMAN	LARP7	physical	22863883
MTA2_HUMAN	MTA2	physical	22863883
PAAF1_HUMAN	PAAF1	physical	22863883
RABE2_HUMAN	RABEP2	physical	22863883
TIF1B_HUMAN	TRIM28	physical	22863883
NACC2_HUMAN	NACC2	physical	22926524
RARA_HUMAN	RARA	physical	23898169
ZBT16_HUMAN	ZBTB16	physical	23898169
DNMT1_HUMAN	DNMT1	physical	23708667
FEZF2_HUMAN	FEZF2	physical	23677067
CUL4B_HUMAN	CUL4B	physical	25189618
DDB1_HUMAN	DDB1	physical	25189618
SIN3A_HUMAN	SIN3A	physical	19182791
HDAC2_HUMAN	HDAC2	physical	19182791
DDIT3_HUMAN	DDIT3	physical	17872950
DDX5_HUMAN	DDX5	physical	20663877
DDX17_HUMAN	DDX17	physical	20663877
PARP1_HUMAN	PARP1	physical	19470756
BRMS1_HUMAN	BRMS1	physical	14581478
APEX1_HUMAN	APEX1	physical	14633989
PHF6_HUMAN	PHF6	physical	22720776
LOXL2_HUMAN	LOXL2	physical	22483618
P53_HUMAN	TP53	physical	19303885
P53_HUMAN	TP53	physical	11099047
MLP3B_HUMAN	MAP1LC3B	genetic	22496786
CBX5_MOUSE	Cbx5	physical	12242305
DDB1_HUMAN	DDB1	physical	24249678
EP400_HUMAN	EP400	physical	26344197
HDAC2_HUMAN	HDAC2	physical	26344197
MO4L1_HUMAN	MORF4L1	physical	26344197
MTA1_HUMAN	MTA1	physical	26344197
MTA2_HUMAN	MTA2	physical	26344197
MTA3_HUMAN	MTA3	physical	26344197
PIN1_HUMAN	PIN1	physical	26344197
RBBP4_HUMAN	RBBP4	physical	26344197
SIN3A_HUMAN	SIN3A	physical	26344197
SIN3B_HUMAN	SIN3B	physical	26344197
SMCA5_HUMAN	SMARCA5	physical	26344197
SUZ12_HUMAN	SUZ12	physical	26344197
TLE3_HUMAN	TLE3	physical	26344197
PP1A_HUMAN	PPP1CA	physical	17008050
NRIP1_HUMAN	NRIP1	physical	15060175
AL1B1_HUMAN	ALDH1B1	physical	26496610
RERE_HUMAN	RERE	physical	26496610
TCPZ_HUMAN	CCT6A	physical	26496610
CHD3_HUMAN	CHD3	physical	26496610
CHD4_HUMAN	CHD4	physical	26496610
E2F6_HUMAN	E2F6	physical	26496610
ERCC6_HUMAN	ERCC6	physical	26496610
H33_HUMAN	H3F3A	physical	26496610
HDAC2_HUMAN	HDAC2	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
ING1_HUMAN	ING1	physical	26496610
IMA3_HUMAN	KPNA4	physical	26496610
IPO5_HUMAN	IPO5	physical	26496610
AFF1_HUMAN	AFF1	physical	26496610
PEX10_HUMAN	PEX10	physical	26496610
PK3CA_HUMAN	PIK3CA	physical	26496610
ARI4A_HUMAN	ARID4A	physical	26496610
KDM5A_HUMAN	KDM5A	physical	26496610
RBBP4_HUMAN	RBBP4	physical	26496610
RBBP7_HUMAN	RBBP7	physical	26496610
RING1_HUMAN	RING1	physical	26496610
RREB1_HUMAN	RREB1	physical	26496610
SMCA2_HUMAN	SMARCA2	physical	26496610
SRPRA_HUMAN	SRPR	physical	26496610
TCF20_HUMAN	TCF20	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
TRPS1_HUMAN	TRPS1	physical	26496610
ZMYM2_HUMAN	ZMYM2	physical	26496610
ZN217_HUMAN	ZNF217	physical	26496610
CDKA1_HUMAN	CDK2AP1	physical	26496610
H31_HUMAN	HIST1H3A	physical	26496610
MRCKA_HUMAN	CDC42BPA	physical	26496610
EED_HUMAN	EED	physical	26496610
SAP30_HUMAN	SAP30	physical	26496610
MBD2_HUMAN	MBD2	physical	26496610
MTA1_HUMAN	MTA1	physical	26496610
ZMYM3_HUMAN	ZMYM3	physical	26496610
MTA2_HUMAN	MTA2	physical	26496610
NOLC1_HUMAN	NOLC1	physical	26496610
CDYL_HUMAN	CDYL	physical	26496610
ZN592_HUMAN	ZNF592	physical	26496610
PHF14_HUMAN	PHF14	physical	26496610
AUXI_HUMAN	DNAJC6	physical	26496610
PARP2_HUMAN	PARP2	physical	26496610
HM20B_HUMAN	HMG20B	physical	26496610
HM20A_HUMAN	HMG20A	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
ZN273_HUMAN	ZNF273	physical	26496610
EHMT2_HUMAN	EHMT2	physical	26496610
RBP1_HUMAN	RALBP1	physical	26496610
BAZ2A_HUMAN	BAZ2A	physical	26496610
TRAK1_HUMAN	TRAK1	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
EXOS7_HUMAN	EXOSC7	physical	26496610
KDM1A_HUMAN	KDM1A	physical	26496610
ZN609_HUMAN	ZNF609	physical	26496610
RCOR1_HUMAN	RCOR1	physical	26496610
GSE1_HUMAN	GSE1	physical	26496610
PHLP1_HUMAN	PHLPP1	physical	26496610
MGAP_HUMAN	MGA	physical	26496610
SIN3B_HUMAN	SIN3B	physical	26496610
ADNP_HUMAN	ADNP	physical	26496610
PKCB1_HUMAN	ZMYND8	physical	26496610
COG4_HUMAN	COG4	physical	26496610
BRMS1_HUMAN	BRMS1	physical	26496610
SIN3A_HUMAN	SIN3A	physical	26496610
TIM13_HUMAN	TIMM13	physical	26496610
DESI1_HUMAN	DESI1	physical	26496610
PF21A_HUMAN	PHF21A	physical	26496610
SNX9_HUMAN	SNX9	physical	26496610
ARI4B_HUMAN	ARID4B	physical	26496610
MBD3_HUMAN	MBD3	physical	26496610
P66A_HUMAN	GATAD2A	physical	26496610
TRPM7_HUMAN	TRPM7	physical	26496610
BCAS3_HUMAN	BCAS3	physical	26496610
ZF64A_HUMAN	ZFP64	physical	26496610
ZF64B_HUMAN	ZFP64	physical	26496610
RCOR3_HUMAN	RCOR3	physical	26496610
TREF1_HUMAN	TRERF1	physical	26496610
EMSY_HUMAN	C11orf30	physical	26496610
P66B_HUMAN	GATAD2B	physical	26496610
MTA3_HUMAN	MTA3	physical	26496610
ZN687_HUMAN	ZNF687	physical	26496610
BAHC1_HUMAN	BAHCC1	physical	26496610
ZBTB2_HUMAN	ZBTB2	physical	26496610
PHF12_HUMAN	PHF12	physical	26496610
GPAT1_HUMAN	GPAM	physical	26496610
MIER1_HUMAN	MIER1	physical	26496610
FA60A_HUMAN	FAM60A	physical	26496610
SDS3_HUMAN	SUDS3	physical	26496610
SP130_HUMAN	SAP130	physical	26496610
EHMT1_HUMAN	EHMT1	physical	26496610
CCNL2_HUMAN	CCNL2	physical	26496610
ARI5B_HUMAN	ARID5B	physical	26496610
ASCC2_HUMAN	ASCC2	physical	26496610
HSDL2_HUMAN	HSDL2	physical	26496610
BRM1L_HUMAN	BRMS1L	physical	26496610
TNC18_HUMAN	TNRC18	physical	26496610
EMSA1_HUMAN	ELMSAN1	physical	26496610
PWP2A_HUMAN	PWWP2A	physical	26496610
TDIF1_HUMAN	DNTTIP1	physical	26496610
AN13B_HUMAN	ANKRD13B	physical	26496610
CB069_HUMAN	C2orf69	physical	26496610
FOXK1_HUMAN	FOXK1	physical	26496610
PGBD3_HUMAN	PGBD3	physical	26496610
RUNX1_HUMAN	RUNX1	physical	26598521
DCAF1_HUMAN	VPRBP	physical	26679995
DDB1_HUMAN	DDB1	physical	26679995
STRAP_HUMAN	STRAP	physical	25483064
RBBP7_HUMAN	RBBP7	physical	25885317
MAGB2_HUMAN	MAGEB2	physical	26468294
E2F1_HUMAN	E2F1	physical	26468294
ANDR_HUMAN	AR	physical	26468294
P53_HUMAN	TP53	physical	26539911
GCR_HUMAN	NR3C1	physical	21127047
CHD4_HUMAN	CHD4	physical	27616479
UBP19_HUMAN	USP19	physical	27517492
UHRF2_HUMAN	UHRF2	physical	27743347
RORG_HUMAN	RORC	physical	26549310
KDM1A_HUMAN	KDM1A	physical	27183383
MIER2_HUMAN	MIER2	physical	28514442
EMSA1_HUMAN	ELMSAN1	physical	28514442
TDIF1_HUMAN	DNTTIP1	physical	28514442
ZN217_HUMAN	ZNF217	physical	28514442
RREB1_HUMAN	RREB1	physical	28514442
RERE_HUMAN	RERE	physical	28514442
PHF12_HUMAN	PHF12	physical	28514442
TREF1_HUMAN	TRERF1	physical	28514442
SDS3_HUMAN	SUDS3	physical	28514442
MIER3_HUMAN	MIER3	physical	28514442
LMBL2_HUMAN	L3MBTL2	physical	28514442
KDM5A_HUMAN	KDM5A	physical	28514442
C8AP2_HUMAN	CASP8AP2	physical	28514442
MBD2_HUMAN	MBD2	physical	28514442
ARI5B_HUMAN	ARID5B	physical	28514442
MBD3_HUMAN	MBD3	physical	28514442
SMBT1_HUMAN	SFMBT1	physical	28514442
CHD5_HUMAN	CHD5	physical	28514442
CCD71_HUMAN	CCDC71	physical	28514442
GSE1_HUMAN	GSE1	physical	28514442
RCOR2_HUMAN	RCOR2	physical	28514442
MIER1_HUMAN	MIER1	physical	28514442
ARI4B_HUMAN	ARID4B	physical	28514442
SP130_HUMAN	SAP130	physical	28514442
TNC18_HUMAN	TNRC18	physical	28514442
MTA3_HUMAN	MTA3	physical	28514442
EMSY_HUMAN	C11orf30	physical	28514442
PF21A_HUMAN	PHF21A	physical	28514442
PWP2A_HUMAN	PWWP2A	physical	28514442
ARI4A_HUMAN	ARID4A	physical	28514442
BRM1L_HUMAN	BRMS1L	physical	28514442
MTA1_HUMAN	MTA1	physical	28514442
ZN516_HUMAN	ZNF516	physical	28514442
GATD1_HUMAN	GATAD1	physical	28514442
BAHC1_HUMAN	BAHCC1	physical	28514442
SP30L_HUMAN	SAP30L	physical	28514442
BC11A_HUMAN	BCL11A	physical	28514442
SIN3A_HUMAN	SIN3A	physical	28514442
SIN3B_HUMAN	SIN3B	physical	28514442
SAP30_HUMAN	SAP30	physical	28514442
CHD4_HUMAN	CHD4	physical	28514442
CHD3_HUMAN	CHD3	physical	28514442
ZMYM2_HUMAN	ZMYM2	physical	28514442
MTA2_HUMAN	MTA2	physical	28514442
ZN521_HUMAN	ZNF521	physical	28514442
ZBTB2_HUMAN	ZBTB2	physical	28514442
PF21B_HUMAN	PHF21B	physical	28514442
CDKA1_HUMAN	CDK2AP1	physical	28514442
TFDP1_HUMAN	TFDP1	physical	28514442
MGAP_HUMAN	MGA	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
BAHD1_HUMAN	BAHD1	physical	28514442
PWP2B_HUMAN	PWWP2B	physical	28514442
ZN608_HUMAN	ZNF608	physical	28514442
ZMYM3_HUMAN	ZMYM3	physical	28514442
KDM1A_HUMAN	KDM1A	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
RBBP4_HUMAN	RBBP4	physical	28514442
ZN800_HUMAN	ZNF800	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
EHMT1_HUMAN	EHMT1	physical	28514442
Z512B_HUMAN	ZNF512B	physical	28514442
ZN639_HUMAN	ZNF639	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
EHMT2_HUMAN	EHMT2	physical	28514442
FOXK2_HUMAN	FOXK2	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
WIZ_HUMAN	WIZ	physical	28514442
SNAI1_HUMAN	SNAI1	physical	26794444
DNMT1_HUMAN	DNMT1	physical	26794444
MTA2_HUMAN	MTA2	physical	27173435
TAF6L_HUMAN	TAF6L	physical	27173435
FOXJ1_HUMAN	FOXJ1	physical	27173435
BTG2_RAT	Btg2	physical	27333946
BTG2_RAT	Btg2	physical	17371797
RB_HUMAN	RB1	physical	10891495

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB02546	Vorinostat

Regulatory Network of HDAC1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-74 AND LYS-220, AND MASSSPECTROMETRY.	19608861 [Abstract]
Methylation
Reference	PubMed
"Protein lysine methyltransferase G9a acts on non-histone targets."; Rathert P., Dhayalan A., Murakami M., Zhang X., Tamas R.,Jurkowska R., Komatsu Y., Shinkai Y., Cheng X., Jeltsch A.; Nat. Chem. Biol. 4:344-346(2008). Cited for: METHYLATION AT LYS-432.	18438403 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393; SER-421 ANDSER-423, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393; SER-421 ANDSER-423, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421 AND SER-423, ANDMASS SPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393; SER-421 ANDSER-423, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421 AND SER-423, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline."; Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.; Electrophoresis 28:2027-2034(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393, AND MASSSPECTROMETRY.	17487921 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393; SER-421 ANDSER-423, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Histone deacetylase 1 phosphorylation promotes enzymatic activity andcomplex formation."; Pflum M.K.H., Tong J.K., Lane W.S., Schreiber S.L.; J. Biol. Chem. 276:47733-47741(2001). Cited for: PHOSPHORYLATION AT SER-421 AND SER-423, MUTAGENESIS OF SER-421 ANDSER-423, AND MASS SPECTROMETRY.	11602581 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-221, AND MASSSPECTROMETRY.	15592455 [Abstract]
Sumoylation
Reference	PubMed
"SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates itsbiological activities."; David G., Neptune M.A., DePinho R.A.; J. Biol. Chem. 277:23658-23663(2002). Cited for: SUMOYLATION AT LYS-444 AND LYS-476.	11960997 [Abstract]

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