dbPTM

SMAD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMAD2_HUMAN
UniProt AC	Q15796
Protein Name	Mothers against decapentaplegic homolog 2
Gene Name	SMAD2
Organism	Homo sapiens (Human).
Sequence Length	467
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, a
Protein Description	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator..
Protein Sequence	MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSILPFTP ------CCCCCCCCH	26.53	20068231
2	Phosphorylation	------MSSILPFTP ------CCCCCCCCH	26.53	19413330
3	Phosphorylation	-----MSSILPFTPP -----CCCCCCCCHH	27.18	25159151
8	Phosphorylation	MSSILPFTPPVVKRL CCCCCCCCHHHHHHH	25.41	29255136
13	Ubiquitination	PFTPPVVKRLLGWKK CCCHHHHHHHHCCCC	37.25	-
19	Acetylation	VKRLLGWKKSAGGSG HHHHHCCCCCCCCCC	34.74	17074756
20	Acetylation	KRLLGWKKSAGGSGG HHHHCCCCCCCCCCC	38.74	17074756
21	Phosphorylation	RLLGWKKSAGGSGGA HHHCCCCCCCCCCCC	28.55	28985074
39	Acetylation	EQNGQEEKWCEKAVK CCCCCHHHHHHHHHH	57.29	150215
46	Sumoylation	KWCEKAVKSLVKKLK HHHHHHHHHHHHHHH	42.82	-
46	Sumoylation	KWCEKAVKSLVKKLK HHHHHHHHHHHHHHH	42.82	-
47	Phosphorylation	WCEKAVKSLVKKLKK HHHHHHHHHHHHHHH	31.62	24719451
54	Ubiquitination	SLVKKLKKTGRLDEL HHHHHHHHHCCHHHH	67.65	-
63	Ubiquitination	GRLDELEKAITTQNC CCHHHHHHHHHHCCC	58.68	-
102	Phosphorylation	QWDTTGLYSFSEQTR CCCCCCCEECCHHHC	14.71	22817900
110	Phosphorylation	SFSEQTRSLDGRLQV ECCHHHCCCCCCEEE	33.91	11027280
118	Phosphorylation	LDGRLQVSHRKGLPH CCCCEEEECCCCCCE	12.47	24719451
121	Ubiquitination	RLQVSHRKGLPHVIY CEEEECCCCCCEEEE	60.42	-
121	Malonylation	RLQVSHRKGLPHVIY CEEEECCCCCCEEEE	60.42	26320211
128	Phosphorylation	KGLPHVIYCRLWRWP CCCCEEEEEEECCCC	3.14	-
151	Phosphorylation	KAIENCEYAFNLKKD HHHHCCCEEEECCCC	20.77	27642862
156	Ubiquitination	CEYAFNLKKDEVCVN CCEEEECCCCCEEEC	60.32	-
156	Sumoylation	CEYAFNLKKDEVCVN CCEEEECCCCCEEEC	60.32	-
156	Sumoylation	CEYAFNLKKDEVCVN CCEEEECCCCCEEEC	60.32	-
156	Acetylation	CEYAFNLKKDEVCVN CCEEEECCCCCEEEC	60.32	25953088
157	Ubiquitination	EYAFNLKKDEVCVNP CEEEECCCCCEEECC	63.39	-
165	Phosphorylation	DEVCVNPYHYQRVET CCEEECCCCCCCCCC	14.14	27642862
167	Phosphorylation	VCVNPYHYQRVETPV EEECCCCCCCCCCCC	7.68	27642862
172	Phosphorylation	YHYQRVETPVLPPVL CCCCCCCCCCCCCCC	18.81	30266825
197	Phosphorylation	LPPLDDYTHSIPENT CCCCCCCCCCCCCCC	19.01	16121194
220	Phosphorylation	QSNYIPETPPPGYIS CCCCCCCCCCCCCCC	35.42	19917253
240	Phosphorylation	SDQQLNQSMDTGSPA CHHHHHHHCCCCCCC	19.97	11027280
243	Phosphorylation	QLNQSMDTGSPAELS HHHHHCCCCCCCCCC	30.80	26074081
245	Phosphorylation	NQSMDTGSPAELSPT HHHCCCCCCCCCCCC	24.03	11027280
250	Phosphorylation	TGSPAELSPTTLSPV CCCCCCCCCCCCCCC	16.23	11027280
252	Phosphorylation	SPAELSPTTLSPVNH CCCCCCCCCCCCCCC	36.67	26074081
253	Phosphorylation	PAELSPTTLSPVNHS CCCCCCCCCCCCCCC	28.73	26074081
255	Phosphorylation	ELSPTTLSPVNHSLD CCCCCCCCCCCCCCC	25.39	11027280
260	Phosphorylation	TLSPVNHSLDLQPVT CCCCCCCCCCCCCCC	20.55	11027280
317	Phosphorylation	RFCLGLLSNVNRNAT CHHHHHHHCCCCCCC	43.72	21712546
324	Phosphorylation	SNVNRNATVEMTRRH HCCCCCCCHHHHHHH	22.13	-
351	Phosphorylation	EVFAECLSDSAIFVQ HHHHHHHCCCEEEEE	40.97	-
417	Phosphorylation	RMCTIRMSFVKGWGA HHHHHHHHHHCCCCC	19.62	22393057
420	Malonylation	TIRMSFVKGWGAEYR HHHHHHHCCCCCCHH	47.11	26320211
420	Acetylation	TIRMSFVKGWGAEYR HHHHHHHCCCCCCHH	47.11	22634611
430	Phosphorylation	GAEYRRQTVTSTPCW CCCHHCEECCCCCEE	24.76	-
454	Phosphorylation	QWLDKVLTQMGSPSV HHHHHHHHHCCCCCC	21.35	28450419
458	Phosphorylation	KVLTQMGSPSVRCSS HHHHHCCCCCCCCCC	14.52	25159151
460	Phosphorylation	LTQMGSPSVRCSSMS HHHCCCCCCCCCCCC	24.72	22115753
464	Phosphorylation	GSPSVRCSSMS---- CCCCCCCCCCC----	20.64	9892009
465	Phosphorylation	SPSVRCSSMS----- CCCCCCCCCC-----	27.03	21996745
467	Phosphorylation	SVRCSSMS------- CCCCCCCC-------	38.73	21996745

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
8	T	Phosphorylation	Kinase	MK03	P27361	PhosphoELM
110	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
197	T	Phosphorylation	Kinase	GRK2	P25098	PSP
220	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
220	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
240	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
240	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
240	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
245	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
245	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
245	S	Phosphorylation	Kinase	MELK	Q61846	PSP
250	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
250	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
255	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
255	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
260	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
417	S	Phosphorylation	Kinase	PAK2	Q13177	PSP
464	S	Phosphorylation	Kinase	BMR1B	O00238	PhosphoELM
464	S	Phosphorylation	Kinase	TGFR1	P36897	PhosphoELM
464	S	Phosphorylation	Kinase	PAK2	Q13177	PSP
465	S	Phosphorylation	Kinase	PAK2	Q13177	PSP
465	S	Phosphorylation	Kinase	TGFR1	P36897	PhosphoELM
465	S	Phosphorylation	Kinase	BMR1B	O00238	PhosphoELM
467	S	Phosphorylation	Kinase	PAK2	Q13177	PSP
467	S	Phosphorylation	Kinase	TGFR1	P36897	PhosphoELM
467	S	Phosphorylation	Kinase	BMR1B	O00238	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF2	Q9HAU4	PMID:11016919
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:15496141
-	K	Ubiquitination	E3 ubiquitin ligase	WWP1	Q9H0M0	PMID:15359284
-	K	Ubiquitination	E3 ubiquitin ligase	RNF111	Q6ZNA4	PMID:18950738

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
19	K	Acetylation	17074756
Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity.
220	T	Phosphorylation	12193595
Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255.
240	S	Phosphorylation	11879191
In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2.
245	S	Phosphorylation	12193595
Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255.
250	S	Phosphorylation	12193595
Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255.
255	S	Phosphorylation	12193595
Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255.
465/467	S	Phosphorylation	8980228
Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation.
465/467	S	Phosphorylation	8980228
In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases.
465/467	S	Phosphorylation	8980228
TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMAD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHES_MOUSE	Rasd2	physical	15761153
RAB34_MOUSE	Rab34	physical	15761153
REBL1_MOUSE	Rhebl1	physical	15761153
RAB38_MOUSE	Rab38	physical	15761153
RHBT1_MOUSE	Rhobtb1	physical	15761153
ARHG7_MOUSE	Arhgef7	physical	15761153
RS27A_MOUSE	Rps27a	physical	15761153
FBX3_MOUSE	Fbxo3	physical	15761153
SQSTM_MOUSE	Sqstm1	physical	15761153
2ABD_MOUSE	Ppp2r2d	physical	15761153
MP2K3_MOUSE	Map2k3	physical	15761153
NUAK2_MOUSE	Nuak2	physical	15761153
UHMK1_MOUSE	Uhmk1	physical	15761153
ARHG6_MOUSE	Arhgef6	physical	15761153
RGS3_MOUSE	Rgs3	physical	15761153
LHX9_MOUSE	Lhx9	physical	15761153
TRI35_MOUSE	Trim35	physical	15761153
WWP2_MOUSE	Wwp2	physical	15761153
RHOJ_MOUSE	Rhoj	physical	15761153
RHOD_MOUSE	Rhod	physical	15761153
ARL4D_MOUSE	Arl4d	physical	15761153
ARHG1_MOUSE	Arhgef1	physical	15761153
PRP17_MOUSE	Cdc40	physical	15761153
IRAK2_MOUSE	Irak2	physical	15761153
RBTN2_MOUSE	Lmo2	physical	15761153
SMAD2_MOUSE	Smad2	physical	15761153
SMAD3_MOUSE	Smad3	physical	15761153
ZFYV9_HUMAN	ZFYVE9	physical	15356634
APC10_HUMAN	ANAPC10	physical	15144564
PIAS3_HUMAN	PIAS3	physical	14691252
EID2_HUMAN	EID2	physical	14612439
HIPK2_HUMAN	HIPK2	physical	12874272
SKI_HUMAN	SKI	physical	12874272
DVL1_HUMAN	DVL1	physical	12650946
ERBIN_HUMAN	ERBB2IP	physical	12650946
TGIF1_HUMAN	TGIF1	physical	10199400
SMAD4_HUMAN	SMAD4	physical	10199400
HDAC1_HUMAN	HDAC1	physical	10199400
SMAD4_HUMAN	SMAD4	physical	11264182
SNIP1_HUMAN	SNIP1	physical	10887155
EP300_HUMAN	EP300	physical	11371641
TGIF1_HUMAN	TGIF1	physical	11371641
JUN_HUMAN	JUN	physical	11371641
CDC27_HUMAN	CDC27	physical	11691834
CDC16_HUMAN	CDC16	physical	11691834
DAB2_HUMAN	DAB2	physical	11387212
SMAD4_HUMAN	SMAD4	physical	12419246
CTNB1_HUMAN	CTNNB1	physical	12000714
MEF2A_HUMAN	MEF2A	physical	11160896
MEF2C_HUMAN	MEF2C	physical	11160896
SKIL_HUMAN	SKIL	physical	10531062
SKI_HUMAN	SKI	physical	10485843
SMUF2_HUMAN	SMURF2	physical	11016919
AKT1_HUMAN	AKT1	physical	16362038
SMAD4_HUMAN	SMAD4	physical	9311995
NFYC_HUMAN	NFYC	physical	12023901
SMAD4_HUMAN	SMAD4	physical	11274206
INSR_HUMAN	INSR	physical	9092546
FOXH1_HUMAN	FOXH1	physical	10938097
RUNX1_HUMAN	RUNX1	physical	10531362
RUNX2_HUMAN	RUNX2	physical	10531362
RUNX3_HUMAN	RUNX3	physical	10531362
SNW1_HUMAN	SNW1	physical	11278756
STRAP_HUMAN	STRAP	physical	10757800
STRAP_HUMAN	STRAP	genetic	10757800
SMAD4_HUMAN	SMAD4	physical	9892009
SMAD3_HUMAN	SMAD3	genetic	9892009
SMAD7_HUMAN	SMAD7	genetic	9892009
CASL_HUMAN	NEDD9	physical	11118211
SMAD4_HUMAN	SMAD4	physical	11114293
SP1_HUMAN	SP1	physical	11114293
SMAD4_HUMAN	SMAD4	physical	11102446
LEF1_HUMAN	LEF1	physical	10890911
SMAD6_HUMAN	SMAD6	physical	9256479
PIN1_HUMAN	PIN1	physical	19122240
UCHL5_HUMAN	UCHL5	physical	16027725
BPTF_HUMAN	BPTF	physical	18974875
OBF1_HUMAN	POU2AF1	physical	20211142
NEDD4_HUMAN	NEDD4	physical	15496141
CITE2_HUMAN	CITED2	physical	16619037
WWP1_HUMAN	WWP1	physical	15221015
SMUF1_HUMAN	SMURF1	physical	15221015
SMUF2_HUMAN	SMURF2	physical	15221015
PIAS4_HUMAN	PIAS4	physical	12904571
MYCD_HUMAN	MYOCD	physical	16224064
TYY1_HUMAN	YY1	physical	12808092
SKI_HUMAN	SKI	physical	12732634
SMAD4_HUMAN	SMAD4	physical	12732634
MED15_HUMAN	MED15	physical	12167862
MED24_HUMAN	MED24	physical	12167862
MED6_HUMAN	MED6	physical	12167862
SMAD4_HUMAN	SMAD4	physical	12167862
GTF2I_HUMAN	GTF2I	physical	16055724
GT2D1_HUMAN	GTF2IRD1	physical	16055724
EVI1_HUMAN	MECOM	physical	15849193
SMAD2_HUMAN	SMAD2	physical	12700238
SMAD3_HUMAN	SMAD3	physical	12700238
SOX9_HUMAN	SOX9	physical	15623506
SKI_HUMAN	SKI	physical	10575014
KAT2A_HUMAN	KAT2A	physical	15009097
KAT2B_HUMAN	KAT2B	physical	15009097
CBP_HUMAN	CREBBP	physical	18003620
SMRC2_HUMAN	SMARCC2	physical	18003620
ARI1A_HUMAN	ARID1A	physical	18003620
SMRC1_HUMAN	SMARCC1	physical	18003620
SMCA4_HUMAN	SMARCA4	physical	18003620
ERBIN_HUMAN	ERBB2IP	physical	18003620
TRI33_HUMAN	TRIM33	physical	18003620
NCOA3_HUMAN	NCOA3	physical	18003620
SMAD7_HUMAN	SMAD7	physical	17438144
SKI_HUMAN	SKI	physical	14699069
HDAC1_HUMAN	HDAC1	physical	14699069
SMUF2_HUMAN	SMURF2	physical	11158580
SMAD4_HUMAN	SMAD4	physical	10781087
CTNB1_HUMAN	CTNNB1	physical	20571128
SMUF2_HUMAN	SMURF2	physical	19620243
ATF3_HUMAN	ATF3	physical	20930144
ESR1_HUMAN	ESR1	physical	20207742
SMUF1_HUMAN	SMURF1	physical	20207742
CBP_HUMAN	CREBBP	physical	16751102
ARI1B_HUMAN	ARID1B	physical	16751102
SMCA4_HUMAN	SMARCA4	physical	16751102
SMRC2_HUMAN	SMARCC2	physical	16751102
NCOA3_HUMAN	NCOA3	physical	16751102
SMRC1_HUMAN	SMARCC1	physical	16751102
TRI33_HUMAN	TRIM33	physical	16751102
SMAD4_HUMAN	SMAD4	physical	16751102
CHIP_HUMAN	STUB1	physical	14701756
WWP2_HUMAN	WWP2	physical	21258410
TGFR1_HUMAN	TGFBR1	physical	18511908
USP9X_HUMAN	USP9X	physical	19135894
SMAD4_HUMAN	SMAD4	physical	10085121
SMAD2_HUMAN	SMAD2	physical	10085121
SKIL_HUMAN	SKIL	physical	12426322
NU214_HUMAN	NUP214	physical	12917407
UBP15_HUMAN	USP15	physical	21947082
ITCH_HUMAN	ITCH	physical	15350225
TGFR1_HUMAN	TGFBR1	physical	15350225
SKI_HUMAN	SKI	physical	17283070
CBP_HUMAN	CREBBP	physical	17283070
SMAD4_HUMAN	SMAD4	physical	17283070
RGCC_HUMAN	RGCC	physical	21990365
ETV4_HUMAN	ETV4	physical	21613609
P53_HUMAN	TP53	physical	19580641
NED4L_HUMAN	NEDD4L	physical	19917253
SMAD4_HUMAN	SMAD4	physical	19917253
UBP15_HUMAN	USP15	physical	22344298
HGS_HUMAN	HGS	physical	11094085
ZFYV9_HUMAN	ZFYVE9	physical	11094085
SMAD4_HUMAN	SMAD4	physical	16916642
SMAD4_HUMAN	SMAD4	physical	18729074
SMAD3_HUMAN	SMAD3	physical	18729074
KC1D_HUMAN	CSNK1D	physical	18729074
DDX3Y_HUMAN	DDX3Y	physical	18729074
ERBIN_HUMAN	ERBB2IP	physical	18729074
HSP74_HUMAN	HSPA4	physical	18729074
MAN1_HUMAN	LEMD3	physical	18729074
ZFYV9_HUMAN	ZFYVE9	physical	18729074
SKI_HUMAN	SKI	physical	18729074
SNW1_HUMAN	SNW1	physical	18729074
SMUF2_HUMAN	SMURF2	physical	18729074
SKIL_HUMAN	SKIL	physical	18729074
WWP2_HUMAN	WWP2	physical	18729074
TYY1_HUMAN	YY1	physical	18729074
OPA1_HUMAN	OPA1	physical	18729074
DCAF7_HUMAN	DCAF7	physical	18729074
ADT2_HUMAN	SLC25A5	physical	18729074
ADT3_HUMAN	SLC25A6	physical	18729074
SQOR_HUMAN	SQRDL	physical	18729074
BUB3_HUMAN	BUB3	physical	18729074
RIN1_HUMAN	RIN1	physical	18729074
KLF5_HUMAN	KLF5	physical	18729074
SMAD5_HUMAN	SMAD5	physical	18729074
SMAD1_HUMAN	SMAD1	physical	18729074
MPCP_HUMAN	SLC25A3	physical	18729074
ITB4_HUMAN	ITGB4	physical	18729074
TCPZ_HUMAN	CCT6A	physical	18729074
SARG_HUMAN	C1orf116	physical	18729074
DHX8_HUMAN	DHX8	physical	18729074
U2AF2_HUMAN	U2AF2	physical	18729074
SIK3_HUMAN	SIK3	physical	18729074
DNJA2_HUMAN	DNAJA2	physical	18729074
ATD3B_HUMAN	ATAD3B	physical	18729074
PCID2_HUMAN	PCID2	physical	18729074
WRIP1_HUMAN	WRNIP1	physical	18729074
PSPC1_HUMAN	PSPC1	physical	18729074
DOCK9_HUMAN	DOCK9	physical	18729074
E41L5_HUMAN	EPB41L5	physical	18729074
PYR1_HUMAN	CAD	physical	18729074
DGKA_HUMAN	DGKA	physical	18729074
FA83G_HUMAN	FAM83G	physical	18729074
CPSF7_HUMAN	CPSF7	physical	18729074
SMAD4_HUMAN	SMAD4	physical	15922743
SMAD4_HUMAN	SMAD4	physical	15761153
ERBIN_HUMAN	ERBB2IP	physical	17591701
IKKA_HUMAN	CHUK	physical	18268325
SMAD4_HUMAN	SMAD4	physical	15350224
PIN1_HUMAN	PIN1	physical	19920136
RNZ2_HUMAN	ELAC2	physical	16636667
NOTC4_HUMAN	NOTCH4	physical	16007227
SMAD1_HUMAN	SMAD1	physical	9111321
SMAD2_HUMAN	SMAD2	physical	9111321
SMAD3_HUMAN	SMAD3	physical	9111321
SMAD4_HUMAN	SMAD4	physical	9111321
PSD11_HUMAN	PSMD11	physical	15231748
LAMA5_HUMAN	LAMA5	physical	15231748
ZEB2_HUMAN	ZEB2	physical	15231748
RNBP6_HUMAN	RANBP6	physical	15231748
PLIN3_HUMAN	PLIN3	physical	15231748
UBR5_HUMAN	UBR5	physical	15231748
SNAPN_HUMAN	SNAPIN	physical	15231748
CSH1_HUMAN	CSH1	physical	15231748
CSH2_HUMAN	CSH1	physical	15231748
CP11A_HUMAN	CYP11A1	physical	15231748
SAP_HUMAN	PSAP	physical	15231748
RU17_HUMAN	SNRNP70	physical	15231748
KAP0_HUMAN	PRKAR1A	physical	15231748
RARB_HUMAN	RARB	physical	15231748
SKIL_HUMAN	SKIL	physical	15231748
RXRA_HUMAN	RXRA	physical	15231748
TGM2_HUMAN	TGM2	physical	15231748
2AAA_HUMAN	PPP2R1A	physical	15231748
SORCN_HUMAN	SRI	physical	15231748
PEX19_HUMAN	PEX19	physical	15231748
PSMD8_HUMAN	PSMD8	physical	15231748
F10A1_HUMAN	ST13	physical	15231748
PAPOA_HUMAN	PAPOLA	physical	15231748
ZNF41_HUMAN	ZNF41	physical	15231748
AFAD_HUMAN	MLLT4	physical	15231748
ANTR2_HUMAN	ANTXR2	physical	15231748
RS14_HUMAN	RPS14	physical	15231748
RL40_HUMAN	UBA52	physical	15231748
EF1A1_HUMAN	EEF1A1	physical	15231748
ST5_HUMAN	ST5	physical	15231748
KHDR1_HUMAN	KHDRBS1	physical	15231748
PAPP1_HUMAN	PAPPA	physical	15231748
OS9_HUMAN	OS9	physical	15231748
ROCK1_HUMAN	ROCK1	physical	15231748
ANK3_HUMAN	ANK3	physical	15231748
NCOA6_HUMAN	NCOA6	physical	15231748
IMB1_HUMAN	KPNB1	physical	15231748
PSG9_HUMAN	PSG9	physical	15231748
ZMY11_HUMAN	ZMYND11	physical	15231748
WASC4_HUMAN	KIAA1033	physical	15231748
RS27A_HUMAN	RPS27A	physical	15231748
RN123_HUMAN	RNF123	physical	15231748
PAXI1_HUMAN	PAXIP1	physical	15231748
TBCD1_HUMAN	TBC1D1	physical	15231748
DOCK8_HUMAN	DOCK8	physical	15231748
P66B_HUMAN	GATAD2B	physical	15231748
CBP_HUMAN	CREBBP	physical	15231748
CSN5_HUMAN	COPS5	physical	15231748
CUL5_HUMAN	CUL5	physical	15231748
ABTB1_HUMAN	ABTB1	physical	15231748
DCNL1_HUMAN	DCUN1D1	physical	15231748
RBM40_HUMAN	RNPC3	physical	15231748
F161B_HUMAN	FAM161B	physical	15231748
NED4L_HUMAN	NEDD4L	physical	15231748
RANB9_HUMAN	RANBP9	physical	15231748
DNJC7_HUMAN	DNAJC7	physical	15231748
TRI62_HUMAN	TRIM62	physical	15231748
BTBD2_HUMAN	BTBD2	physical	15231748
CV046_HUMAN	C22orf46	physical	15231748
SMUF2_HUMAN	SMURF2	physical	15231748
SMUF1_HUMAN	SMURF1	physical	15231748
DYHC1_HUMAN	DYNC1H1	physical	15231748
BAZ1A_HUMAN	BAZ1A	physical	15231748
CISH_HUMAN	CISH	physical	15231748
BCD1_HUMAN	ZNHIT6	physical	15231748
NAGK_HUMAN	NAGK	physical	15231748
ANC2_HUMAN	ANAPC2	physical	15231748
EIF3L_HUMAN	EIF3L	physical	15231748
TGFR1_HUMAN	TGFBR1	physical	12543979
SMAD3_HUMAN	SMAD3	physical	12543979
SMAD4_HUMAN	SMAD4	physical	12543979
SH22A_HUMAN	SH2D2A	physical	16806069
MAN1_HUMAN	LEMD3	physical	15489854
IRF7_HUMAN	IRF7	physical	14729983
IRF3_HUMAN	IRF3	physical	14729983
TSC2_HUMAN	TSC2	physical	15066998
FHL1_HUMAN	FHL1	physical	19139564
SMAD4_HUMAN	SMAD4	physical	23788427
TRI33_HUMAN	TRIM33	physical	23788427
SMAD3_HUMAN	SMAD3	physical	21988832
SMAD4_HUMAN	SMAD4	physical	21988832
NFM_HUMAN	NEFM	physical	20195357
AN32E_HUMAN	ANP32E	physical	20195357
AN32B_HUMAN	ANP32B	physical	20195357
TBA1B_HUMAN	TUBA1B	physical	20195357
PTMS_HUMAN	PTMS	physical	20195357
SODC_HUMAN	SOD1	physical	20195357
SYT1_HUMAN	SYT1	physical	20195357
ATP5I_HUMAN	ATP5I	physical	20195357
JUN_HUMAN	JUN	physical	20195357
HDAC2_HUMAN	HDAC2	physical	20195357
SMAD4_HUMAN	SMAD4	physical	24157709
FOXH1_HUMAN	FOXH1	physical	15750622
CBP_HUMAN	CREBBP	physical	15750622
LEF1_HUMAN	LEF1	physical	15750622
DOK1_MOUSE	Dok1	physical	11927552
SMAD4_HUMAN	SMAD4	physical	11927552
NFIA_HUMAN	NFIA	physical	18215124
PARD3_HUMAN	PARD3	physical	12650946
SMAD4_HUMAN	SMAD4	physical	24584437
KAT2B_HUMAN	KAT2B	physical	22995475
SMAD4_HUMAN	SMAD4	physical	25514493
SMAD7_HUMAN	SMAD7	physical	26555259
SMAD4_HUMAN	SMAD4	physical	26555259
NED4L_HUMAN	NEDD4L	physical	26555259
SMUF2_HUMAN	SMURF2	physical	28881580
SMAD4_HUMAN	SMAD4	physical	28468752
SMUF2_HUMAN	SMURF2	physical	28468752

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMAD2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"The DNA binding activities of Smad2 and Smad3 are regulated bycoactivator-mediated acetylation."; Simonsson M., Kanduri M., Gronroos E., Heldin C.H., Ericsson J.; J. Biol. Chem. 281:39870-39880(2006). Cited for: ACETYLATION AT LYS-19, AND MUTAGENESIS OF LYS-19 AND LYS-20.	17074756 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8 AND SER-458, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Decorin suppresses transforming growth factor-beta-induced expressionof plasminogen activator inhibitor-1 in human mesangial cells througha mechanism that involves Ca2+-dependent phosphorylation of Smad2 atserine-240."; Abdel-Wahab N., Wicks S.J., Mason R.M., Chantry A.; Biochem. J. 362:643-649(2002). Cited for: PHOSPHORYLATION AT SER-240.	11879191 [Abstract]
"TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required forSmad2-Smad4 complex formation and signaling."; Abdollah S., Macias-Silva M., Tsukazaki T., Hayashi H., Attisano L.,Wrana J.L.; J. Biol. Chem. 272:27678-27685(1997). Cited for: PHOSPHORYLATION AT SER-465 AND SER-467 BY TGFBR1.	9346908 [Abstract]
"The TGF-beta family mediator Smad1 is phosphorylated directly andactivated functionally by the BMP receptor kinase."; Kretzschmar M., Liu F., Hata A., Doody J., Massague J.; Genes Dev. 11:984-995(1997). Cited for: PHOSPHORYLATION AT SER-465 AND SER-467.	9136927 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase."; Funaba M., Zimmerman C.M., Mathews L.S.; J. Biol. Chem. 277:41361-41368(2002). Cited for: PHOSPHORYLATION AT THR-8; THR-220; SER-245; SER-250 AND SER-255.	12193595 [Abstract]

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