dbPTM

TBA1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBA1B_HUMAN
UniProt AC	P68363
Protein Name	Tubulin alpha-1B chain
Gene Name	TUBA1B
Organism	Homo sapiens (Human).
Sequence Length	451
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
Protein Sequence	MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRECISIHVGQAG --CCCEEEEEECCHH	20.50	-
6	O-linked_Glycosylation	--MRECISIHVGQAG --CCCEEEEEECCHH	20.50	31373491
24	Phosphorylation	GNACWELYCLEHGIQ CHHHHHCHHHHCCCC	5.40	-
38	Phosphorylation	QPDGQMPSDKTIGGG CCCCCCCCCCCCCCC	46.53	26074081
40	Acetylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
40	Ubiquitination	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
40	Methylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
41	Phosphorylation	GQMPSDKTIGGGDDS CCCCCCCCCCCCCCC	29.82	25463755
41	O-linked_Glycosylation	GQMPSDKTIGGGDDS CCCCCCCCCCCCCCC	29.82	31373491
48	Phosphorylation	TIGGGDDSFNTFFSE CCCCCCCCHHHCCCC	25.74	19664994
51	Phosphorylation	GGDDSFNTFFSETGA CCCCCHHHCCCCCCC	24.85	29255136
54	Phosphorylation	DSFNTFFSETGAGKH CCHHHCCCCCCCCCC	30.02	25159151
54	O-linked_Glycosylation	DSFNTFFSETGAGKH CCHHHCCCCCCCCCC	30.02	31373491
56	Phosphorylation	FNTFFSETGAGKHVP HHHCCCCCCCCCCCC	31.00	23927012
56	O-linked_Glycosylation	FNTFFSETGAGKHVP HHHCCCCCCCCCCCC	31.00	31373491
60	Acetylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	23954790
60	Sumoylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Ubiquitination	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	27667366
60	Sumoylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Neddylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	32015554
60	2-Hydroxyisobutyrylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Methylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	12692561
60	Ubiquitination	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	21890473
73	Phosphorylation	VFVDLEPTVIDEVRT EEECCCCEEEHHCCC	22.25	30108239
73	O-linked_Glycosylation	VFVDLEPTVIDEVRT EEECCCCEEEHHCCC	22.25	31373491
80	Phosphorylation	TVIDEVRTGTYRQLF EEEHHCCCCCCHHCC	38.77	28857561
80	O-linked_Glycosylation	TVIDEVRTGTYRQLF EEEHHCCCCCCHHCC	38.77	31373491
82	Phosphorylation	IDEVRTGTYRQLFHP EHHCCCCCCHHCCCH	18.21	28857561
83	Phosphorylation	DEVRTGTYRQLFHPE HHCCCCCCHHCCCHH	9.56	28857561
94	Phosphorylation	FHPEQLITGKEDAAN CCHHHHCCCCHHHHH	51.28	28152594
94	O-linked_Glycosylation	FHPEQLITGKEDAAN CCHHHHCCCCHHHHH	51.28	31373491
96	Acetylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	23749302
96	Sumoylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	21906983
96	Sumoylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	21890473
103	Phosphorylation	KEDAANNYARGHYTI CHHHHHHCCCCCCCC	9.48	27155012
108	Phosphorylation	NNYARGHYTIGKEII HHCCCCCCCCCHHHH	11.68	25884760
109	Phosphorylation	NYARGHYTIGKEIID HCCCCCCCCCHHHHH	19.99	28796482
109	O-linked_Glycosylation	NYARGHYTIGKEIID HCCCCCCCCCHHHHH	19.99	31373491
112	Acetylation	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	23954790
112	Sumoylation	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	-
112	Ubiquitination	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	21963094
112	Sumoylation	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	-
112	2-Hydroxyisobutyrylation	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	-
124	Acetylation	LVLDRIRKLADQCTG HHHHHHHHHHHHCCC	45.73	21466224
124	Ubiquitination	LVLDRIRKLADQCTG HHHHHHHHHHHHCCC	45.73	21906983
145	O-linked_Glycosylation	FHSFGGGTGSGFTSL EEECCCCCCCCHHHH	31.30	31373491
147	O-linked_Glycosylation	SFGGGTGSGFTSLLM ECCCCCCCCHHHHHH	30.48	31373491
151	Phosphorylation	GTGSGFTSLLMERLS CCCCCHHHHHHHHHC	19.76	-
154	Sulfoxidation	SGFTSLLMERLSVDY CCHHHHHHHHHCCCC	3.23	30846556
158	Phosphorylation	SLLMERLSVDYGKKS HHHHHHHCCCCCCCC	21.11	28355574
161	Phosphorylation	MERLSVDYGKKSKLE HHHHCCCCCCCCCEE	28.79	23911959
161	Nitration	MERLSVDYGKKSKLE HHHHCCCCCCCCCEE	28.79	-
163	Methylation	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	129187
163	Acetylation	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	23749302
163	Ubiquitination	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	27667366
164	Ubiquitination	LSVDYGKKSKLEFSI HCCCCCCCCCEEEEE	48.75	21906983
164	Ubiquitination	LSVDYGKKSKLEFSI HCCCCCCCCCEEEEE	48.75	21890473
165	Phosphorylation	SVDYGKKSKLEFSIY CCCCCCCCCEEEEEE	46.06	22817900
166	Ubiquitination	VDYGKKSKLEFSIYP CCCCCCCCEEEEEEE	62.00	22817900
170	Phosphorylation	KKSKLEFSIYPAPQV CCCCEEEEEEECCCC	16.31	23663014
172	Phosphorylation	SKLEFSIYPAPQVST CCEEEEEEECCCCCE	7.67	23663014
178	Phosphorylation	IYPAPQVSTAVVEPY EEECCCCCEEEEECC	12.85	23663014
179	Phosphorylation	YPAPQVSTAVVEPYN EECCCCCEEEEECCC	25.31	23663014
185	Phosphorylation	STAVVEPYNSILTTH CEEEEECCCCCCCCC	14.18	23663014
187	Phosphorylation	AVVEPYNSILTTHTT EEEECCCCCCCCCCC	17.09	23663014
188	Ubiquitination	VVEPYNSILTTHTTL EEECCCCCCCCCCCC	3.36	21890473
190	Phosphorylation	EPYNSILTTHTTLEH ECCCCCCCCCCCCCC	18.18	23663014
191	Phosphorylation	PYNSILTTHTTLEHS CCCCCCCCCCCCCCC	17.49	23663014
193	Phosphorylation	NSILTTHTTLEHSDC CCCCCCCCCCCCCCE	30.86	23663014
194	Phosphorylation	SILTTHTTLEHSDCA CCCCCCCCCCCCCEE	23.65	23663014
195	Ubiquitination	ILTTHTTLEHSDCAF CCCCCCCCCCCCEEE	6.15	21890473
198	Phosphorylation	THTTLEHSDCAFMVD CCCCCCCCCEEEEEC	25.63	26356563
210	Phosphorylation	MVDNEAIYDICRRNL EECHHHHHHHHHCCC	13.30	25884760
210	Ubiquitination	MVDNEAIYDICRRNL EECHHHHHHHHHCCC	13.30	21890473
220	Ubiquitination	CRRNLDIERPTYTNL HHCCCCCCCCCHHCH	52.88	21890473
222	Ubiquitination	RNLDIERPTYTNLNR CCCCCCCCCHHCHHH	19.57	21890473
223	Phosphorylation	NLDIERPTYTNLNRL CCCCCCCCHHCHHHH	49.55	28796482
224	Phosphorylation	LDIERPTYTNLNRLI CCCCCCCHHCHHHHH	9.05	19605366
225	Phosphorylation	DIERPTYTNLNRLIS CCCCCCHHCHHHHHH	35.39	28555341
225	O-linked_Glycosylation	DIERPTYTNLNRLIS CCCCCCHHCHHHHHH	35.39	31373491
232	Phosphorylation	TNLNRLISQIVSSIT HCHHHHHHHHHHHHH	20.60	21712546
236	Phosphorylation	RLISQIVSSITASLR HHHHHHHHHHHHHCC	20.04	23403867
236	Ubiquitination	RLISQIVSSITASLR HHHHHHHHHHHHHCC	20.04	21890473
237	Phosphorylation	LISQIVSSITASLRF HHHHHHHHHHHHCCC	17.05	23403867
239	Phosphorylation	SQIVSSITASLRFDG HHHHHHHHHHCCCCC	16.49	23403867
241	Phosphorylation	IVSSITASLRFDGAL HHHHHHHHCCCCCCC	16.07	23403867
253	Phosphorylation	GALNVDLTEFQTNLV CCCCCCCCEEECCCC	30.23	21712546
254	Ubiquitination	ALNVDLTEFQTNLVP CCCCCCCEEECCCCC	42.95	21890473
257	Phosphorylation	VDLTEFQTNLVPYPR CCCCEEECCCCCCCC	35.52	21712546
257	O-linked_Glycosylation	VDLTEFQTNLVPYPR CCCCEEECCCCCCCC	35.52	31373491
262	Phosphorylation	FQTNLVPYPRIHFPL EECCCCCCCCCCCCC	9.54	22817901
271	Phosphorylation	RIHFPLATYAPVISA CCCCCCCCCCCCCCH	28.09	21945579
271	O-linked_Glycosylation	RIHFPLATYAPVISA CCCCCCCCCCCCCCH	28.09	31373491
272	Phosphorylation	IHFPLATYAPVISAE CCCCCCCCCCCCCHH	11.87	21945579
277	Phosphorylation	ATYAPVISAEKAYHE CCCCCCCCHHHHHHH	30.52	21945579
277	O-linked_Glycosylation	ATYAPVISAEKAYHE CCCCCCCCHHHHHHH	30.52	31373491
278	Ubiquitination	TYAPVISAEKAYHEQ CCCCCCCHHHHHHHH	15.93	21890473
280	Acetylation	APVISAEKAYHEQLS CCCCCHHHHHHHHCC	54.70	88221
280	Ubiquitination	APVISAEKAYHEQLS CCCCCHHHHHHHHCC	54.70	21906983
282	Nitrated tyrosine	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
282	Phosphorylation	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	25159151
282	Nitration	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
285	Ubiquitination	AEKAYHEQLSVAEIT HHHHHHHHCCHHHHH	26.23	21890473
287	Phosphorylation	KAYHEQLSVAEITNA HHHHHHCCHHHHHHH	20.98	22322096
292	Phosphorylation	QLSVAEITNACFEPA HCCHHHHHHHHCCCH	14.31	30576142
295	Glutathionylation	VAEITNACFEPANQM HHHHHHHHCCCHHHC	4.27	22555962
295	S-nitrosylation	VAEITNACFEPANQM HHHHHHHHCCCHHHC	4.27	25040305
302	Sulfoxidation	CFEPANQMVKCDPRH HCCCHHHCCCCCCCC	2.89	30846556
304	Ubiquitination	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	21963094
304	Neddylation	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	32015554
304	2-Hydroxyisobutyrylation	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	-
304	Acetylation	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	26051181
311	Acetylation	KCDPRHGKYMACCLL CCCCCCCCEEEEHHH	26.23	23954790
311	Ubiquitination	KCDPRHGKYMACCLL CCCCCCCCEEEEHHH	26.23	21906983
312	Phosphorylation	CDPRHGKYMACCLLY CCCCCCCEEEEHHHC	8.44	28152594
314	Ubiquitination	PRHGKYMACCLLYRG CCCCCEEEEHHHCCC	4.27	21890473
315	Glutathionylation	RHGKYMACCLLYRGD CCCCEEEEHHHCCCC	0.67	22555962
316	S-nitrosylation	HGKYMACCLLYRGDV CCCEEEEHHHCCCCC	1.81	25040305
319	Phosphorylation	YMACCLLYRGDVVPK EEEEHHHCCCCCCCC	10.29	23917254
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCHHHHHH	63.80	21466224
326	Sumoylation	YRGDVVPKDVNAAIA CCCCCCCCCHHHHHH	63.80	-
326	Ubiquitination	YRGDVVPKDVNAAIA CCCCCCCCCHHHHHH	63.80	27667366
326	Sumoylation	YRGDVVPKDVNAAIA CCCCCCCCCHHHHHH	63.80	-
326	2-Hydroxyisobutyrylation	YRGDVVPKDVNAAIA CCCCCCCCCHHHHHH	63.80	-
334	Phosphorylation	DVNAAIATIKTKRSI CHHHHHHHCCCCCEE	19.52	23401153
334	O-linked_Glycosylation	DVNAAIATIKTKRSI CHHHHHHHCCCCCEE	19.52	31373491
336	Acetylation	NAAIATIKTKRSIQF HHHHHHCCCCCEEEE	43.57	26051181
336	Sumoylation	NAAIATIKTKRSIQF HHHHHHCCCCCEEEE	43.57	-
336	Ubiquitination	NAAIATIKTKRSIQF HHHHHHCCCCCEEEE	43.57	21906983
336	Sumoylation	NAAIATIKTKRSIQF HHHHHHCCCCCEEEE	43.57	-
336	Neddylation	NAAIATIKTKRSIQF HHHHHHCCCCCEEEE	43.57	32015554
336	2-Hydroxyisobutyrylation	NAAIATIKTKRSIQF HHHHHHCCCCCEEEE	43.57	-
337	Phosphorylation	AAIATIKTKRSIQFV HHHHHCCCCCEEEEE	28.04	30266825
338	Methylation	AIATIKTKRSIQFVD HHHHCCCCCEEEEEE	38.86	184615
338	Ubiquitination	AIATIKTKRSIQFVD HHHHCCCCCEEEEEE	38.86	21987572
339	Methylation	IATIKTKRSIQFVDW HHHCCCCCEEEEEEE	44.20	-
340	Phosphorylation	ATIKTKRSIQFVDWC HHCCCCCEEEEEEEC	23.46	26846344
340	O-linked_Glycosylation	ATIKTKRSIQFVDWC HHCCCCCEEEEEEEC	23.46	31373491
347	Glutathionylation	SIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	22555962
347	S-nitrosylation	SIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	25040305
347	S-palmitoylation	SIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	29575903
349	Phosphorylation	QFVDWCPTGFKVGIN EEEEECCCCEEEEEE	52.71	30266825
352	Acetylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	26051181
352	Ubiquitination	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	21906983
352	Sumoylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	-
352	Neddylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	32015554
357	Phosphorylation	GFKVGINYQPPTVVP CEEEEEECCCCEECC	22.07	27273156
361	Phosphorylation	GINYQPPTVVPGGDL EEECCCCEECCCCCH	40.60	28152594
370	Acetylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	23749302
370	Sumoylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
370	Ubiquitination	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	27667366
370	Sumoylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
370	Neddylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	32015554
370	2-Hydroxyisobutyrylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
376	Glutathionylation	AKVQRAVCMLSNTTA HHHHHHHHHHCCHHH	1.90	22555962
376	S-nitrosylation	AKVQRAVCMLSNTTA HHHHHHHHHHCCHHH	1.90	25040305
376	S-palmitoylation	AKVQRAVCMLSNTTA HHHHHHHHHHCCHHH	1.90	26865113
377	Sulfoxidation	KVQRAVCMLSNTTAI HHHHHHHHHCCHHHH	3.55	30846556
379	Phosphorylation	QRAVCMLSNTTAIAE HHHHHHHCCHHHHHH	12.78	19664995
381	O-linked_Glycosylation	AVCMLSNTTAIAEAW HHHHHCCHHHHHHHH	17.77	31373491
381	Phosphorylation	AVCMLSNTTAIAEAW HHHHHCCHHHHHHHH	17.77	30108239
382	O-linked_Glycosylation	VCMLSNTTAIAEAWA HHHHCCHHHHHHHHH	21.95	31373491
382	Phosphorylation	VCMLSNTTAIAEAWA HHHHCCHHHHHHHHH	21.95	30108239
394	Methylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	Acetylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	23954790
394	Sumoylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	Ubiquitination	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	32142685
394	Sumoylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	2-Hydroxyisobutyrylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
399	Phosphorylation	DHKFDLMYAKRAFVH CCCCCHHHEEEHHHH	19.10	28674151
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	27178108
401	Sumoylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
401	Ubiquitination	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	21963094
401	Sumoylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
401	2-Hydroxyisobutyrylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
408	Phosphorylation	KRAFVHWYVGEGMEE EEHHHHHHCCCCCCC	5.45	28796482
413	Sulfoxidation	HWYVGEGMEEGEFSE HHHCCCCCCCCCHHH	3.54	30846556
419	Phosphorylation	GMEEGEFSEAREDMA CCCCCCHHHHHHHHH	26.50	28270605
419	O-linked_Glycosylation	GMEEGEFSEAREDMA CCCCCCHHHHHHHHH	26.50	31373491
425	Sulfoxidation	FSEAREDMAALEKDY HHHHHHHHHHHHHCH	1.69	30846556
430	Ubiquitination	EDMAALEKDYEEVGV HHHHHHHHCHHHHCC	67.47	21906983
430	Acetylation	EDMAALEKDYEEVGV HHHHHHHHCHHHHCC	67.47	26051181
432	Phosphorylation	MAALEKDYEEVGVDS HHHHHHCHHHHCCCC	25.67	28796482
439	Phosphorylation	YEEVGVDSVEGEGEE HHHHCCCCCCCCCCC	21.47	20201521
445	5-glutamyl polyglutamate	DSVEGEGEEEGEEY- CCCCCCCCCCCCCC-	48.88	-
445	Formation of an isopeptide bond	DSVEGEGEEEGEEY- CCCCCCCCCCCCCC-	48.88	-
451	Phosphorylation	GEEEGEEY------- CCCCCCCC-------	21.39	28674151
451	Nitration	GEEEGEEY------- CCCCCCCC-------	21.39	10339593

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
253	T	Phosphorylation	Kinase	PKCB	P68403	PSP
334	T	Phosphorylation	Kinase	MAP3K7	O43318	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:18195004

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
40	K	Acetylation	24906155
Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen.
40	K	Methylation	24906155
Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBA1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD3Z_HUMAN	CD247	physical	15084271
ZAP70_HUMAN	ZAP70	physical	15084271
TM1L1_HUMAN	TOM1L1	physical	21900206
SYUA_HUMAN	SNCA	physical	11698390
SYUA_HUMAN	SNCA	physical	16216085
SC6A3_HUMAN	SLC6A3	physical	16216085
TBB1_HUMAN	TUBB1	physical	16216085
TBA1C_HUMAN	TUBA1C	physical	22939629
TBB2A_HUMAN	TUBB2A	physical	22939629
TCPZ_HUMAN	CCT6A	physical	22939629
TBB4B_HUMAN	TUBB4B	physical	22939629
TBB6_HUMAN	TUBB6	physical	22939629
TBB3_HUMAN	TUBB3	physical	22939629
TBB2B_HUMAN	TUBB2B	physical	22939629
TBB5_HUMAN	TUBB	physical	22939629
U520_HUMAN	SNRNP200	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
VDAC1_HUMAN	VDAC1	physical	12087096
HDAC6_HUMAN	HDAC6	physical	23798680
ATRAP_HUMAN	AGTRAP	physical	25416956
MTCL1_HUMAN	MTCL1	physical	23902687
RANB9_HUMAN	RANBP9	physical	25659156
PIWL1_HUMAN	PIWIL1	physical	26317901
TBB3_HUMAN	TUBB3	physical	26317901
STMN1_HUMAN	STMN1	physical	26317901
T11L2_HUMAN	TCP11L2	physical	28514442
TXND9_HUMAN	TXNDC9	physical	28514442
DLGP5_HUMAN	DLGAP5	physical	28514442
TBA1C_HUMAN	TUBA1C	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
MICU1_HUMAN	MICU1	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBA1B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340; TYR-432; SER-439AND TYR-451, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232 AND SER-340, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-41; SER-48; THR-334 ANDSER-439, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-272, AND MASSSPECTROMETRY.	15592455 [Abstract]
Ubiquitylation
Reference	PubMed
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-326 AND LYS-370, AND MASSSPECTROMETRY.	18781797 [Abstract]

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