MICU1_HUMAN - dbPTM
MICU1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MICU1_HUMAN
UniProt AC Q9BPX6
Protein Name Calcium uptake protein 1, mitochondrial
Gene Name MICU1
Organism Homo sapiens (Human).
Sequence Length 476
Subcellular Localization Mitochondrion inner membrane
Single-pass membrane protein . Mitochondrion intermembrane space .
Protein Description Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. [PubMed: 20693986]
Protein Sequence MFRLNSLSALAELAVGSRWYHGGSQPIQIRRRLMMVAFLGASAVTASTGLLWKRAHAESPPCVDNLKSDIGDKGKNKDEGDVCNHEKKTADLAPHPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNEKQPEHLGLDQYIIKRFDGKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MFRLNSLSALAEL
--CCCCCHHHHHHHH		28.4427251275
6 (in isoform 3)Phosphorylation-28.4427251275
8PhosphorylationMFRLNSLSALAELAV
CCCCCHHHHHHHHHC		22.5127251275
66UbiquitinationSPPCVDNLKSDIGDK
CCCCHHHHHCCCCCC		4.9321890473
96UbiquitinationTADLAPHPEEKKKKR
CCCCCCCHHHHHHHC		50.8421890473
96UbiquitinationTADLAPHPEEKKKKR
CCCCCCCHHHHHHHC		50.8421890473
96UbiquitinationTADLAPHPEEKKKKR
CCCCCCCHHHHHHHC		50.8421890473
992-HydroxyisobutyrylationLAPHPEEKKKKRSGF
CCCCHHHHHHHCCCC		69.13-
100UbiquitinationAPHPEEKKKKRSGFR
CCCHHHHHHHCCCCC		67.80-
101UbiquitinationPHPEEKKKKRSGFRD
CCHHHHHHHCCCCCC		65.57-
102UbiquitinationHPEEKKKKRSGFRDR
CHHHHHHHCCCCCCH		61.75-
104UbiquitinationEEKKKKRSGFRDRKV
HHHHHHCCCCCCHHH		51.6829967540
110UbiquitinationRSGFRDRKVMEYENR
CCCCCCHHHHHHHHH		50.6624816145
111UbiquitinationSGFRDRKVMEYENRI
CCCCCHHHHHHHHHH		3.5229967540
114PhosphorylationRDRKVMEYENRIRAY
CCHHHHHHHHHHHHH		10.6229496907
126UbiquitinationRAYSTPDKIFRYFAT
HHHCCHHHHHHHHEE		44.97-
138PhosphorylationFATLKVISEPGEAEV
HEEEEEECCCCCCEE		40.50-
143UbiquitinationVISEPGEAEVFMTPE
EECCCCCCEEEECHH		24.9429967540
161UbiquitinationRSITPNEKQPEHLGL
HHCCCCCCCCCCCCC		77.2129967540
171PhosphorylationEHLGLDQYIIKRFDG
CCCCCCHHHHHHCCC		12.32-
174UbiquitinationGLDQYIIKRFDGKKI
CCCHHHHHHCCCCCC		37.1429967540
248PhosphorylationEEFEQVQSIIRSQTS
HHHHHHHHHHHHCCC		22.5624719451
251UbiquitinationEQVQSIIRSQTSMGM
HHHHHHHHHCCCCCC		22.5033845483
265PhosphorylationMRHRDRPTTGNTLKS
CCCCCCCCCCCHHHH		48.5121406692
266PhosphorylationRHRDRPTTGNTLKSG
CCCCCCCCCCHHHHH		30.9921406692
269PhosphorylationDRPTTGNTLKSGLCS
CCCCCCCHHHHHHHH		36.5921406692
292PhosphorylationADLKGKLTIKNFLEF
CCCCCCEEHHHHHHH		33.1324719451
294UbiquitinationLKGKLTIKNFLEFQR
CCCCEEHHHHHHHHH		36.0921890473
294 (in isoform 1)Ubiquitination-36.0921890473
294 (in isoform 2)Ubiquitination-36.0921890473
294UbiquitinationLKGKLTIKNFLEFQR
CCCCEEHHHHHHHHH		36.0921890473
296 (in isoform 3)Ubiquitination-6.1721890473
296UbiquitinationGKLTIKNFLEFQRKL
CCEEHHHHHHHHHHH		6.1721890473
296UbiquitinationGKLTIKNFLEFQRKL
CCEEHHHHHHHHHHH		6.1721890473
296UbiquitinationGKLTIKNFLEFQRKL
CCEEHHHHHHHHHHH		6.1721890473
300UbiquitinationIKNFLEFQRKLQHDV
HHHHHHHHHHHHCCH		32.0221890473
302UbiquitinationNFLEFQRKLQHDVLK
HHHHHHHHHHCCHHH		41.5429967540
304UbiquitinationLEFQRKLQHDVLKLE
HHHHHHHHCCHHHHH		33.5029967540
309UbiquitinationKLQHDVLKLEFERHD
HHHCCHHHHHHHCCC		45.9129967540
311UbiquitinationQHDVLKLEFERHDPV
HCCHHHHHHHCCCCC		43.8229967540
334PhosphorylationFGGMLLAYSGVQSKK
HHHEEEECCCCCHHH		13.1120068231
335PhosphorylationGGMLLAYSGVQSKKL
HHEEEECCCCCHHHH		27.2120068231
339PhosphorylationLAYSGVQSKKLTAMQ
EECCCCCHHHHHHHH		29.3820068231
341UbiquitinationYSGVQSKKLTAMQRQ
CCCCCHHHHHHHHHH		57.2129967540
343UbiquitinationGVQSKKLTAMQRQLK
CCCHHHHHHHHHHHH		29.0329967540
350UbiquitinationTAMQRQLKKHFKEGK
HHHHHHHHHHHHCCC		35.5421890473
357UbiquitinationKKHFKEGKGLTFQEV
HHHHHCCCCCCHHHH		52.41-
384PhosphorylationVDTALSFYHMAGASL
HHHHHHHHHHHCCCC		6.31-
438AcetylationKEFVSIMKQRLMRGL
HHHHHHHHHHHHCCC		30.517664623
449UbiquitinationMRGLEKPKDMGFTRL
HCCCCCCCCCCHHHH		71.9933845483
451UbiquitinationGLEKPKDMGFTRLMQ
CCCCCCCCCHHHHHH		6.2533845483
475UbiquitinationAWDFALPKQ------
HHHHHCCCC------		70.28-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MICU1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MICU1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MICU1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
MICU3_HUMANMICU3physical
28514442
GPN3_HUMANGPN3physical
28514442
ARL10_HUMANARL10physical
28514442
ANGE1_HUMANANGEL1physical
28514442
SYAC_HUMANAARSphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615673Myopathy with extrapyramidal signs (MPXPS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MICU1_HUMAN

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Related Literatures of Post-Translational Modification

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