GPN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPN3_HUMAN
• UniProt AC: Q9UHW5
• Protein Name: GPN-loop GTPase 3 {ECO:0000303|Ref.2}
• Gene Name: GPN3 {ECO:0000303|Ref.2, ECO:0000312|HGNC:HGNC:30186}
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Protein Description: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import..
• Protein Sequence: MPRYAQLVMGPAGSGKSTYCATMVQHCEALNRSVQVVNLDPAAEHFNYSVMADIRELIEVDDVMEDDSLRFGPNGGLVFCMEYFANNFDWLENCLGHVEDDYILFDCPGQIELYTHLPVMKQLVQQLEQWEFRVCGVFLVDSQFMVESFKFISGILAALSAMISLEIPQVNIMTKMDLLSKKAKKEIEKFLDPDMYSLLEDSTSDLRSKKFKKLTKAICGLIDDYSMVRFLPYDQSDEESMNIVLQHIDFAIQYGEDLEFKEPKEREDESSSMFDEYFQECQDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPRYAQLVMGP ----CCCEEEEEECC	7.88	28122231
14	Phosphorylation	LVMGPAGSGKSTYCA EEECCCCCCCCHHHH	45.19	28122231
16	Ubiquitination	MGPAGSGKSTYCATM ECCCCCCCCHHHHHH	41.12	-
17	Phosphorylation	GPAGSGKSTYCATMV CCCCCCCCHHHHHHH	28.30	28122231
18	Phosphorylation	PAGSGKSTYCATMVQ CCCCCCCHHHHHHHH	26.55	28122231
19	Phosphorylation	AGSGKSTYCATMVQH CCCCCCHHHHHHHHH	6.28	28122231
22	Phosphorylation	GKSTYCATMVQHCEA CCCHHHHHHHHHHHH	17.83	28122231
48	Phosphorylation	PAAEHFNYSVMADIR HHHHHCCCCHHHHHH	11.16	21712546
49	Phosphorylation	AAEHFNYSVMADIRE HHHHCCCCHHHHHHH	13.40	25159151
162	Ubiquitination	ILAALSAMISLEIPQ HHHHHHHHHCCCCCC	1.60	22817900
163	Ubiquitination	LAALSAMISLEIPQV HHHHHHHHCCCCCCC	4.20	22817900
167	Ubiquitination	SAMISLEIPQVNIMT HHHHCCCCCCCCHHC	3.33	22817900
181	Ubiquitination	TKMDLLSKKAKKEIE CHHHHHCHHHHHHHH	57.63	29967540
184	Ubiquitination	DLLSKKAKKEIEKFL HHHCHHHHHHHHHHC	60.87	22817900
185	Ubiquitination	LLSKKAKKEIEKFLD HHCHHHHHHHHHHCC	69.64	22817900
189 (in isoform 1)	Ubiquitination	-	57.81	21906983
189	Ubiquitination	KAKKEIEKFLDPDMY HHHHHHHHHCCHHHH	57.81	21906983
190	Ubiquitination	AKKEIEKFLDPDMYS HHHHHHHHCCHHHHH	6.41	22817900
191	Ubiquitination	KKEIEKFLDPDMYSL HHHHHHHCCHHHHHH	16.11	22817900
194	Ubiquitination	IEKFLDPDMYSLLED HHHHCCHHHHHHHCC	48.60	21963094
195	Ubiquitination	EKFLDPDMYSLLEDS HHHCCHHHHHHHCCC	2.73	22817900
199 (in isoform 2)	Ubiquitination	-	5.89	21906983
199	Ubiquitination	DPDMYSLLEDSTSDL CHHHHHHHCCCCHHH	5.89	22817900
212	Ubiquitination	DLRSKKFKKLTKAIC HHHHHHHHHHHHHHH	56.61	22817900
213	Ubiquitination	LRSKKFKKLTKAICG HHHHHHHHHHHHHHH	65.60	22817900
216	Ubiquitination	KKFKKLTKAICGLID HHHHHHHHHHHHHCC	46.30	21963094
220	Ubiquitination	KLTKAICGLIDDYSM HHHHHHHHHCCCCCE	21.39	29967540
222	Ubiquitination	TKAICGLIDDYSMVR HHHHHHHCCCCCEEE	1.99	22817900
223	Ubiquitination	KAICGLIDDYSMVRF HHHHHHCCCCCEEEE	54.56	22817900
224	Ubiquitination	AICGLIDDYSMVRFL HHHHHCCCCCEEEEC	30.34	22817900
226	Ubiquitination	CGLIDDYSMVRFLPY HHHCCCCCEEEECCC	20.14	21963094
228	Ubiquitination	LIDDYSMVRFLPYDQ HCCCCCEEEECCCCC	3.00	22817900
251	Ubiquitination	VLQHIDFAIQYGEDL HHHHHHHHHHHCCCC	5.57	22817900
252	Ubiquitination	LQHIDFAIQYGEDLE HHHHHHHHHHCCCCC	3.07	22817900
255	Ubiquitination	IDFAIQYGEDLEFKE HHHHHHHCCCCCCCC	12.93	21963094
270	Phosphorylation	PKEREDESSSMFDEY CCCCCCCCCHHHHHH	39.78	21712546
271	Phosphorylation	KEREDESSSMFDEYF CCCCCCCCHHHHHHH	24.63	21712546
272	Phosphorylation	EREDESSSMFDEYFQ CCCCCCCHHHHHHHH	32.52	27134283
277	Phosphorylation	SSSMFDEYFQECQDE CCHHHHHHHHHHCCC	16.65	28796482
357	Ubiquitination	-------------------------------------------------------------------------------- --------------------------------------------------------------------------------		22817900
358	Ubiquitination	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		22817900
362	Ubiquitination	------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------		22817900
385	Ubiquitination	------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------		22817900
386	Ubiquitination	------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------		22817900
389	Ubiquitination	---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------		21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPR1A_HUMAN	RPRD1A	physical	26186194
RPC10_HUMAN	POLR3K	physical	26186194
PIHD1_HUMAN	PIH1D1	physical	26186194
RPB7_HUMAN	POLR2G	physical	26186194
RPC8_HUMAN	POLR3H	physical	26186194
RPA49_HUMAN	POLR1E	physical	26186194
RPA2_HUMAN	POLR1B	physical	26186194
ASPM_HUMAN	ASPM	physical	26186194
RPA1_HUMAN	POLR1A	physical	26186194
RPC1_HUMAN	POLR3A	physical	26186194
RPAP2_HUMAN	RPAP2	physical	26186194
RPC5_HUMAN	POLR3E	physical	26186194
RPB1_HUMAN	POLR2A	physical	26186194
RPB4_HUMAN	POLR2D	physical	26186194
RPC2_HUMAN	POLR3B	physical	26186194
DAAM1_HUMAN	DAAM1	physical	26186194
GPN1_HUMAN	GPN1	physical	26186194
RPAC1_HUMAN	POLR1C	physical	26186194
RPC4_HUMAN	POLR3D	physical	26186194
RPB9_HUMAN	POLR2I	physical	26186194
CRNN_HUMAN	CRNN	physical	26186194
RPB3_HUMAN	POLR2C	physical	26186194
EPHA4_HUMAN	EPHA4	physical	26186194
MYZAP_HUMAN	POLR2M	physical	26186194
GRL1A_HUMAN	POLR2M	physical	26186194
GL1AD_HUMAN	POLR2M	physical	26186194
PP1A_HUMAN	PPP1CA	physical	26186194
RPAB5_HUMAN	POLR2L	physical	26186194
RPA34_HUMAN	CD3EAP	physical	26186194
RPAB2_HUMAN	POLR2F	physical	26186194
MYZAP_HUMAN	POLR2M	physical	28514442
GRL1A_HUMAN	POLR2M	physical	28514442
GL1AD_HUMAN	POLR2M	physical	28514442
RPC5_HUMAN	POLR3E	physical	28514442
RPC4_HUMAN	POLR3D	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
RPC10_HUMAN	POLR3K	physical	28514442
RPB7_HUMAN	POLR2G	physical	28514442
RPC8_HUMAN	POLR3H	physical	28514442
RPA49_HUMAN	POLR1E	physical	28514442
RPC2_HUMAN	POLR3B	physical	28514442
RPA34_HUMAN	CD3EAP	physical	28514442
RPAC1_HUMAN	POLR1C	physical	28514442
RPC1_HUMAN	POLR3A	physical	28514442
GPN1_HUMAN	GPN1	physical	28514442
PIHD1_HUMAN	PIH1D1	physical	28514442
CRNN_HUMAN	CRNN	physical	28514442
RPA1_HUMAN	POLR1A	physical	28514442
RPB9_HUMAN	POLR2I	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442
RPA2_HUMAN	POLR1B	physical	28514442
PP1A_HUMAN	PPP1CA	physical	28514442
RPB3_HUMAN	POLR2C	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
RPR1A_HUMAN	RPRD1A	physical	28514442
EPHA4_HUMAN	EPHA4	physical	28514442
RPB2_HUMAN	POLR2B	physical	28514442
DAAM1_HUMAN	DAAM1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.