ASPM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASPM_HUMAN
• UniProt AC: Q8IZT6
• Protein Name: Abnormal spindle-like microcephaly-associated protein
• Gene Name: ASPM
• Organism: Homo sapiens (Human).
• Sequence Length: 3477
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, spindle . Nucleus. The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule
• Protein Description: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. [PubMed: 28436967 May have a preferential role in regulating neurogenesis.]
• Protein Sequence: MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPLKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQRGENSKLSLTPNCSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSQPVHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDANVRVAITEHTEVREIKRIHFSPSEPKTSAVKKTKNVTTPISKRISNREKLNLKKKTDLSIFRTPISKTNKRTKPIIAVAQSSLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQRAFREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRSCVVIIQKRFRCFQAQKLYKRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEYIELRHAVLVLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRCRAYYQGKMQREKYLTILKAVKVLQASFRGVRVRRTLRKMQTAATLIQSNYRRYRQQTYFNKLKKITKTVQQRYWAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAILIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQSTFRMHRLHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLYQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMYRTYITFQTWKHASILIQQHYRTYRAAKLQRENYIRQWHSAVVIQAAYKGMKARQLLREKHKASIVIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKVFQHNELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYRMHRAKVDYETKKTAIVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFRGMKVRQKLKNVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAEYHSQSRAAVTIQKAFCRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNVRASAIIIQRKWRAILPAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKHERIKYIEFKKSTVILQALVRGWLVRKRFLEQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSIPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MANRRVGRGCWEVSP CCCCCCCCCCCCCCC	33.95	-
14	Phosphorylation	GRGCWEVSPTERRPP CCCCCCCCCCCCCCC	18.00	23401153
16	Phosphorylation	GCWEVSPTERRPPAG CCCCCCCCCCCCCCC	34.32	23927012
34	Phosphorylation	PAAEEEASSPPVLSL HHHHHHHCCCCCCCH	46.81	24732914
35	Phosphorylation	AAEEEASSPPVLSLS HHHHHHCCCCCCCHH	40.03	25159151
40	Phosphorylation	ASSPPVLSLSHFCRS HCCCCCCCHHHHCCC	28.23	24732914
42	Phosphorylation	SPPVLSLSHFCRSPF CCCCCCHHHHCCCCC	15.90	27080861
101	Ubiquitination	RCFVLQPKEKIVISV CEEEECCCCEEEEEE	59.69	-
111	Phosphorylation	IVISVNWTPLKEGRV EEEEEECCCCCCCCH	17.34	20860994
144	Sumoylation	LGNAEEQKKKKRSLW CCCHHHHHHHHHCHH	70.60	-
144	Sumoylation	LGNAEEQKKKKRSLW CCCHHHHHHHHHCHH	70.60	-
144	Ubiquitination	LGNAEEQKKKKRSLW CCCHHHHHHHHHCHH	70.60	-
149	Phosphorylation	EQKKKKRSLWDTIKK HHHHHHHCHHHHHHH	42.57	28555341
153	Phosphorylation	KKRSLWDTIKKKKIS HHHCHHHHHHHHCCC	24.10	20860994
156	Ubiquitination	SLWDTIKKKKISAST CHHHHHHHHCCCCCC	56.29	-
160	Phosphorylation	TIKKKKISASTSHNR HHHHHCCCCCCCCCC	25.66	21406692
162	Phosphorylation	KKKKISASTSHNRRV HHHCCCCCCCCCCCH	24.53	21406692
163	Phosphorylation	KKKISASTSHNRRVS HHCCCCCCCCCCCHH	33.45	21406692
164	Phosphorylation	KKISASTSHNRRVSN HCCCCCCCCCCCHHC	19.10	21406692
170	Phosphorylation	TSHNRRVSNIQNVNK CCCCCCHHCCCCCCC	26.80	25159151
177	Ubiquitination	SNIQNVNKTFSVSQK HCCCCCCCCEEHHHH	46.82	21890473
177	Ubiquitination	SNIQNVNKTFSVSQK HCCCCCCCCEEHHHH	46.82	21890473
177 (in isoform 1)	Ubiquitination	-	46.82	21890473
177 (in isoform 2)	Ubiquitination	-	46.82	21890473
178	Phosphorylation	NIQNVNKTFSVSQKV CCCCCCCCEEHHHHH	18.88	20860994
180	Phosphorylation	QNVNKTFSVSQKVDR CCCCCCEEHHHHHHC	26.54	20860994
182	Phosphorylation	VNKTFSVSQKVDRVR CCCCEEHHHHHHCCC	24.08	28555341
184	Sumoylation	KTFSVSQKVDRVRSP CCEEHHHHHHCCCCH	38.30	-
184	Sumoylation	KTFSVSQKVDRVRSP CCEEHHHHHHCCCCH	38.30	-
184	Ubiquitination	KTFSVSQKVDRVRSP CCEEHHHHHHCCCCH	38.30	-
190	Phosphorylation	QKVDRVRSPLQACEN HHHHCCCCHHHHHHH	27.40	25159151
207	Phosphorylation	MNEGGPPTENNSLIL CCCCCCCCCCCCEEE	55.25	25627689
211	Phosphorylation	GPPTENNSLILEENK CCCCCCCCEEECCCC	28.50	25159151
222	Phosphorylation	EENKIPISPISPAFN CCCCCCCCCCCHHHH	15.72	22199227
225	Phosphorylation	KIPISPISPAFNECH CCCCCCCCHHHHCCC	17.35	22199227
235	Phosphorylation	FNECHGATCLPLSVR HHCCCCCCCCEEEEC	21.11	25627689
240	Phosphorylation	GATCLPLSVRRSTTY CCCCCEEEECCCCCC	16.19	25627689
244	Phosphorylation	LPLSVRRSTTYSSLH CEEEECCCCCCCCCC	17.97	19691289
245	Phosphorylation	PLSVRRSTTYSSLHA EEEECCCCCCCCCCH	28.13	19691289
246	Phosphorylation	LSVRRSTTYSSLHAS EEECCCCCCCCCCHH	23.74	19691289
247	Phosphorylation	SVRRSTTYSSLHASE EECCCCCCCCCCHHH	9.06	19691289
248	Phosphorylation	VRRSTTYSSLHASEN ECCCCCCCCCCHHHC	25.08	19691289
249	Phosphorylation	RRSTTYSSLHASENR CCCCCCCCCCHHHCH	17.48	19691289
253	Phosphorylation	TYSSLHASENRELLN CCCCCCHHHCHHHCE	25.34	23186163
263	Phosphorylation	RELLNVHSANVSKVS HHHCEEECCCCEECC	19.77	25159151
267	Phosphorylation	NVHSANVSKVSFNEK EEECCCCEECCCCCC	27.44	26055452
270	Phosphorylation	SANVSKVSFNEKAVT CCCCEECCCCCCCCE	26.54	20860994
274	Ubiquitination	SKVSFNEKAVTETSF EECCCCCCCCEECCC	49.62	-
277	Phosphorylation	SFNEKAVTETSFNSV CCCCCCCEECCCCEE	38.10	29255136
279	Phosphorylation	NEKAVTETSFNSVNV CCCCCEECCCCEEEE	29.29	29255136
280	Phosphorylation	EKAVTETSFNSVNVN CCCCEECCCCEEEEC	19.05	29255136
283	Phosphorylation	VTETSFNSVNVNGQR CEECCCCEEEECCCC	17.04	25159151
294	Phosphorylation	NGQRGENSKLSLTPN CCCCCCCCCCEECCC	30.58	22199227
297	Phosphorylation	RGENSKLSLTPNCSS CCCCCCCEECCCCCC	33.65	-
348	Phosphorylation	DMFMKDNSQPVHLES CCCCCCCCCCCCCHH	46.09	25159151
355	Phosphorylation	SQPVHLESTIAHEIY CCCCCCHHHHHHHHH	31.32	29978859
356	Phosphorylation	QPVHLESTIAHEIYQ CCCCCHHHHHHHHHH	16.89	29978859
362	Phosphorylation	STIAHEIYQKILSPD HHHHHHHHHHHHCCC	10.77	25159151
364	Ubiquitination	IAHEIYQKILSPDSF HHHHHHHHHHCCCHH	28.74	-
367	Phosphorylation	EIYQKILSPDSFIKD HHHHHHHCCCHHCCC	30.08	30266825
370	Phosphorylation	QKILSPDSFIKDNYG HHHHCCCHHCCCCCC	32.05	30266825
373	Ubiquitination	LSPDSFIKDNYGLNQ HCCCHHCCCCCCCCC	37.60	-
376	Phosphorylation	DSFIKDNYGLNQDLE CHHCCCCCCCCCCCC	32.88	24732914
384	Phosphorylation	GLNQDLESESVNPIL CCCCCCCCCCCCCCC	42.33	24732914
386	Phosphorylation	NQDLESESVNPILSP CCCCCCCCCCCCCCH	36.15	24732914
392	Phosphorylation	ESVNPILSPNQFLKD CCCCCCCCHHHHHCC	23.64	30278072
398	Ubiquitination	LSPNQFLKDNMAYMC CCHHHHHCCCCCEEE	48.63	-
407	Phosphorylation	NMAYMCTSQQTCKVP CCCEEECCCCEEECC	18.50	21815630
416	Phosphorylation	QTCKVPLSNENSQVP CEEECCCCCCCCCCC	35.71	24732914
420	Phosphorylation	VPLSNENSQVPQSPE CCCCCCCCCCCCCHH	26.78	30266825
425	Phosphorylation	ENSQVPQSPEDWRKS CCCCCCCCHHHHHHH	24.96	22167270
431	Ubiquitination	QSPEDWRKSEVSPRI CCHHHHHHHCCCCCC	46.87	-
432	Phosphorylation	SPEDWRKSEVSPRIP CHHHHHHHCCCCCCC	34.36	20860994
435	Phosphorylation	DWRKSEVSPRIPECQ HHHHHCCCCCCCCCC	12.38	30576142
444	Phosphorylation	RIPECQGSKSPKAIF CCCCCCCCCCHHHHH	12.23	26552605
445	Ubiquitination	IPECQGSKSPKAIFE CCCCCCCCCHHHHHH	77.06	-
446	Phosphorylation	PECQGSKSPKAIFEE CCCCCCCCHHHHHHH	33.07	26055452
459	Phosphorylation	EELVEMKSNYYSFIK HHHHHHHHHHHHHHH	28.84	28555341
461	Phosphorylation	LVEMKSNYYSFIKQN HHHHHHHHHHHHHHC	13.94	28796482
462	Phosphorylation	VEMKSNYYSFIKQNN HHHHHHHHHHHHHCC	11.01	28796482
463	Phosphorylation	EMKSNYYSFIKQNNP HHHHHHHHHHHHCCC	15.33	21712546
466	Ubiquitination	SNYYSFIKQNNPKFS HHHHHHHHHCCCCCC	44.99	-
471	Ubiquitination	FIKQNNPKFSAVQDI HHHHCCCCCCCCCHH	54.82	-
473	Phosphorylation	KQNNPKFSAVQDISS HHCCCCCCCCCHHCC	33.39	28555341
479	Phosphorylation	FSAVQDISSHSHNKQ CCCCCHHCCCCCCCC	30.23	19691289
480	Phosphorylation	SAVQDISSHSHNKQP CCCCHHCCCCCCCCC	29.37	19691289
482	Phosphorylation	VQDISSHSHNKQPKR CCHHCCCCCCCCCCC	30.61	25159151
485	Ubiquitination	ISSHSHNKQPKRRPI HCCCCCCCCCCCCCC	63.65	-
494	Phosphorylation	PKRRPILSATVTKRK CCCCCCCEEEECCCC	23.71	20860994
496	Phosphorylation	RRPILSATVTKRKAT CCCCCEEEECCCCCC	25.90	20860994
498	Phosphorylation	PILSATVTKRKATCT CCCEEEECCCCCCCC	22.30	27174698
503	Phosphorylation	TVTKRKATCTRENQT EECCCCCCCCCCCCC	19.90	20068231
505	Phosphorylation	TKRKATCTRENQTEI CCCCCCCCCCCCCCC	36.34	20068231
510	Phosphorylation	TCTRENQTEINKPKA CCCCCCCCCCCCHHH	50.87	20068231
514	Ubiquitination	ENQTEINKPKAKRCL CCCCCCCCHHHHHHH	54.26	-
530	Acetylation	SAVGEHEKVINNQKE HHCCCHHHHHCCHHH	50.77	12430035
530	Ubiquitination	SAVGEHEKVINNQKE HHCCCHHHHHCCHHH	50.77	-
536	Ubiquitination	EKVINNQKEKEDFHS HHHHCCHHHHHCHHH	73.25	-
538	Ubiquitination	VINNQKEKEDFHSYL HHCCHHHHHCHHHHH	70.40	-
544	Phosphorylation	EKEDFHSYLPIIDPI HHHCHHHHHHHHHHH	14.13	27642862
553	Phosphorylation	PIIDPILSKSKSYKN HHHHHHHHCCCCCCC	35.29	25159151
554	Ubiquitination	IIDPILSKSKSYKNE HHHHHHHCCCCCCCC	59.46	-
556	Ubiquitination	DPILSKSKSYKNEVT HHHHHCCCCCCCCCC	62.63	-
559	Sumoylation	LSKSKSYKNEVTPSS HHCCCCCCCCCCCCC	54.44	-
559	Sumoylation	LSKSKSYKNEVTPSS HHCCCCCCCCCCCCC	54.44	-
559	Ubiquitination	LSKSKSYKNEVTPSS HHCCCCCCCCCCCCC	54.44	-
563	Phosphorylation	KSYKNEVTPSSTTAS CCCCCCCCCCCCHHH	15.98	29255136
565	Phosphorylation	YKNEVTPSSTTASVA CCCCCCCCCCHHHHH	30.83	29255136
566	Phosphorylation	KNEVTPSSTTASVAR CCCCCCCCCHHHHHH	30.86	29255136
567	Phosphorylation	NEVTPSSTTASVARK CCCCCCCCHHHHHHH	30.62	19691289
568	Phosphorylation	EVTPSSTTASVARKR CCCCCCCHHHHHHHC	20.91	19691289
570	Phosphorylation	TPSSTTASVARKRKS CCCCCHHHHHHHCCC	17.76	19691289
577	Phosphorylation	SVARKRKSDGSMEDA HHHHHCCCCCCCCCC	51.76	29255136
580	Phosphorylation	RKRKSDGSMEDANVR HHCCCCCCCCCCCEE	24.80	29255136
605	Phosphorylation	EIKRIHFSPSEPKTS EEEEEECCCCCCCCC	17.22	30266825
607	Phosphorylation	KRIHFSPSEPKTSAV EEEECCCCCCCCCCC	66.39	29255136
610	Ubiquitination	HFSPSEPKTSAVKKT ECCCCCCCCCCCCCC	51.57	-
611	Phosphorylation	FSPSEPKTSAVKKTK CCCCCCCCCCCCCCC	32.41	20873877
612	Phosphorylation	SPSEPKTSAVKKTKN CCCCCCCCCCCCCCC	36.87	20873877
615	Acetylation	EPKTSAVKKTKNVTT CCCCCCCCCCCCCCC	55.21	25825284
616	Acetylation	PKTSAVKKTKNVTTP CCCCCCCCCCCCCCC	59.12	25825284
618	Ubiquitination	TSAVKKTKNVTTPIS CCCCCCCCCCCCCHH	59.30	-
621	Phosphorylation	VKKTKNVTTPISKRI CCCCCCCCCCHHHHC	35.93	24732914
622	Phosphorylation	KKTKNVTTPISKRIS CCCCCCCCCHHHHCC	17.84	23911959
625	Phosphorylation	KNVTTPISKRISNRE CCCCCCHHHHCCCHH	19.65	24732914
626	Ubiquitination	NVTTPISKRISNREK CCCCCHHHHCCCHHH	55.24	-
639	Ubiquitination	EKLNLKKKTDLSIFR HHCCCCCCCCCCCCC	45.76	-
640	Phosphorylation	KLNLKKKTDLSIFRT HCCCCCCCCCCCCCC	51.56	20860994
643	Phosphorylation	LKKKTDLSIFRTPIS CCCCCCCCCCCCCCC	23.61	21815630
647	Phosphorylation	TDLSIFRTPISKTNK CCCCCCCCCCCCCCC	17.77	25159151
650	Phosphorylation	SIFRTPISKTNKRTK CCCCCCCCCCCCCCC	34.33	21712546
651	Ubiquitination	IFRTPISKTNKRTKP CCCCCCCCCCCCCCC	57.76	-
665	Phosphorylation	PIIAVAQSSLTFIKP CEEEEEEHHCCCCCC	19.99	20068231
666	Phosphorylation	IIAVAQSSLTFIKPL EEEEEEHHCCCCCCC	21.24	20068231
668	Phosphorylation	AVAQSSLTFIKPLKT EEEEHHCCCCCCCCC	25.84	20068231
674	Ubiquitination	LTFIKPLKTDIPRHP CCCCCCCCCCCCCCC	53.32	-
687	Ubiquitination	HPMPFAAKNMFYDER CCCCCHHHCCCCCHH	45.58	-
696	Ubiquitination	MFYDERWKEKQEQGF CCCCHHHHHHHHCCC	62.34	-
720	Phosphorylation	PDDFTVKTNISEVNA CCCCEECCCHHHHCH	33.19	21406692
723	Phosphorylation	FTVKTNISEVNAATL CEECCCHHHHCHHHH	37.25	21406692
729	Phosphorylation	ISEVNAATLLLGIEN HHHHCHHHHHHCCCC	18.61	20068231
739	Ubiquitination	LGIENQHKISVPRAP HCCCCCCCCCCCCCC	27.23	-
741	Phosphorylation	IENQHKISVPRAPTK CCCCCCCCCCCCCCC	30.76	24719451
747	Phosphorylation	ISVPRAPTKEEMSLR CCCCCCCCCHHHHHH	50.53	20860994
748	Ubiquitination	SVPRAPTKEEMSLRA CCCCCCCCHHHHHHH	51.09	-
752	Phosphorylation	APTKEEMSLRAYTAR CCCCHHHHHHHHHHH	20.27	20860994
756	Phosphorylation	EEMSLRAYTARCRLN HHHHHHHHHHHHHHH	8.42	22817900
777	Ubiquitination	CRLFTSEKMVKAIKK HHHHCCHHHHHHHHH	49.08	-
804	Ubiquitination	RKDRHLWKDVGERQK HCCHHHHCCHHHHHH	49.23	-
915	Ubiquitination	HDPCLFCKDAEFKAS CCCCCCCCCHHHCCC	53.27	-
920	Ubiquitination	FCKDAEFKASKEILL CCCCHHHCCCHHHHH	43.16	-
923	Ubiquitination	DAEFKASKEILLAFS CHHHCCCHHHHHHHH	54.34	-
994	Ubiquitination	QNWDLSKKLRIPAIS CCCCCCCCCCHHHHH	39.35	-
1017	Ubiquitination	DIVLQVLKSRGIELS HHHHHHHHHCCCCCC	38.97	-
1018	Phosphorylation	IVLQVLKSRGIELSD HHHHHHHHCCCCCCC	31.42	22115753
1024	Phosphorylation	KSRGIELSDEHGNTI HHCCCCCCCCCCCCE	28.32	22115753
1030	Phosphorylation	LSDEHGNTILSKDIV CCCCCCCCEECHHHH	28.08	22115753
1033	Phosphorylation	EHGNTILSKDIVDRH CCCCCEECHHHHHHH	25.16	22115753
1034	Ubiquitination	HGNTILSKDIVDRHR CCCCEECHHHHHHHH	48.29	-
1074	Ubiquitination	KEEIAFLKHTKSIKK HHHHHHHHHHHHHHH	42.65	-
1081	Ubiquitination	KHTKSIKKTISLLSC HHHHHHHHHHHHHHC	49.79	-
1082	Phosphorylation	HTKSIKKTISLLSCH HHHHHHHHHHHHHCC	15.70	23312004
1084	Phosphorylation	KSIKKTISLLSCHSD HHHHHHHHHHHCCCH	28.61	24114839
1087	Phosphorylation	KKTISLLSCHSDDLI HHHHHHHHCCCHHHC	18.31	23312004
1090	Phosphorylation	ISLLSCHSDDLINKK HHHHHCCCHHHCCCC	36.83	25159151
1096	Ubiquitination	HSDDLINKKKGKRDS CCHHHCCCCCCCCCC	49.20	-
1097	Ubiquitination	SDDLINKKKGKRDSG CHHHCCCCCCCCCCC	63.37	-
1101	Dimethylation	INKKKGKRDSGSFEQ CCCCCCCCCCCCHHH	52.58	-
1103	Phosphorylation	KKKGKRDSGSFEQYS CCCCCCCCCCHHHHH	40.13	25159151
1105	Phosphorylation	KGKRDSGSFEQYSEN CCCCCCCCHHHHHHH	29.57	23927012
1109	Phosphorylation	DSGSFEQYSENIKLL CCCCHHHHHHHHHHH	15.68	24732914
1110	Phosphorylation	SGSFEQYSENIKLLM CCCHHHHHHHHHHHH	24.70	23403867
1193	Phosphorylation	DDSSLDMSLKAFDHE CCCCCCHHHHHHCCC	26.78	24719451
1207	Ubiquitination	ENTSELYKELLENEK CCHHHHHHHHHHHHH	55.28	-
1215	Ubiquitination	ELLENEKKNFHLVRS HHHHHHHHHHHHHHH	59.68	-
1279	Acetylation	LIQTTWRKYKLKTDL HHHHHHHHHCCHHHH	37.99	19816873
1325	Phosphorylation	AALVIQKYWRRVLAQ HHHHHHHHHHHHHHH	6.43	-
1334	Ubiquitination	RRVLAQRKLLMLKKE HHHHHHHHHHHHCHH	33.61	-
1339	Acetylation	QRKLLMLKKEKLEKV HHHHHHHCHHHHHHH	44.94	18529881
1340	Acetylation	RKLLMLKKEKLEKVQ HHHHHHCHHHHHHHH	57.00	18529891
1345	Ubiquitination	LKKEKLEKVQNKAAS HCHHHHHHHHHHHHH	60.60	-
1349	Ubiquitination	KLEKVQNKAASLIQG HHHHHHHHHHHHHHH	28.39	21890473
1349 (in isoform 1)	Ubiquitination	-	28.39	21890473
1361	Phosphorylation	IQGYWRRYSTRQRFL HHHHHHHHHHHHHHH	13.06	-
1417	Phosphorylation	RKQDQQRYEMLKSST HHHHHHHHHHHHHHH	11.01	-
1421	Ubiquitination	QQRYEMLKSSTLIIQ HHHHHHHHHHHHHHH	40.84	-
1422	Phosphorylation	QRYEMLKSSTLIIQS HHHHHHHHHHHHHHH	25.29	27251275
1423	Phosphorylation	RYEMLKSSTLIIQSM HHHHHHHHHHHHHHH	26.16	27251275
1424	Phosphorylation	YEMLKSSTLIIQSMF HHHHHHHHHHHHHHH	29.12	27251275
1441	Phosphorylation	WKQRKMQSQVKATVI HHHHHHHHHHHHHHH	33.18	23684312
1444	Ubiquitination	RKMQSQVKATVILQR HHHHHHHHHHHHHHH	30.61	-
1476	Ubiquitination	IIIQSWYRMHKELRK HHHHHHHHHHHHHHH	17.93	21890473
1476 (in isoform 2)	Ubiquitination	-	17.93	21890473
1484	Phosphorylation	MHKELRKYIYIRSCV HHHHHHHHHHHHHHE	7.79	-
1505	Ubiquitination	FRCFQAQKLYKRRKE HHHHHHHHHHHHHHH	57.72	-
1511	Ubiquitination	QKLYKRRKESILTIQ HHHHHHHHHHHHHHH	60.90	-
1513	Phosphorylation	LYKRRKESILTIQKY HHHHHHHHHHHHHHH	26.40	20860994
1516	Phosphorylation	RRKESILTIQKYYKA HHHHHHHHHHHHHHH	21.49	29083192
1519	Ubiquitination	ESILTIQKYYKAYLK HHHHHHHHHHHHHHC	46.85	21890473
1519 (in isoform 1)	Ubiquitination	-	46.85	21890473
1520	Phosphorylation	SILTIQKYYKAYLKG HHHHHHHHHHHHHCC	8.20	29083192
1521	Phosphorylation	ILTIQKYYKAYLKGK HHHHHHHHHHHHCCC	9.00	29083192
1522	Ubiquitination	LTIQKYYKAYLKGKI HHHHHHHHHHHCCCH	27.71	-
1524	Phosphorylation	IQKYYKAYLKGKIER HHHHHHHHHCCCHHC	12.56	20049867
1537	Ubiquitination	ERTNYLQKRAAAIQL HCCCHHHHHHHHHHH	41.22	-
1552	Ubiquitination	QAAFRRLKAHNLCRQ HHHHHHHHHHHHHHH	45.87	-
1634	Phosphorylation	ASYQKTRSAVIVLQS HHCCHHHHHHHHHHH	31.92	28555341
1641	Phosphorylation	SAVIVLQSAYRGMQA HHHHHHHHHHCCHHH	24.09	20860994
1643	Phosphorylation	VIVLQSAYRGMQARK HHHHHHHHCCHHHHH	16.97	-
1652	Phosphorylation	GMQARKMYIHILTSV CHHHHHHHHHHHHHH	7.74	23663014
1657	Phosphorylation	KMYIHILTSVIKIQS HHHHHHHHHHHHHHH	21.98	23663014
1658	Phosphorylation	MYIHILTSVIKIQSY HHHHHHHHHHHHHHH	20.57	23663014
1664	Phosphorylation	TSVIKIQSYYRAYVS HHHHHHHHHHHHHCC	27.83	23663014
1665	Phosphorylation	SVIKIQSYYRAYVSK HHHHHHHHHHHHCCH	4.80	23663014
1666	Phosphorylation	VIKIQSYYRAYVSKK HHHHHHHHHHHCCHH	8.26	23663014
1679	Ubiquitination	KKEFLSLKNATIKLQ HHHHHHCCCCEEEEC	40.95	-
1684	Ubiquitination	SLKNATIKLQSTVKM HCCCCEEEECCCCCC	35.80	-
1690	Ubiquitination	IKLQSTVKMKQTRKQ EEECCCCCCHHHHHH	40.23	-
1696	Ubiquitination	VKMKQTRKQYLHLRA CCCHHHHHHHHHHHH	46.83	-
1770	Phosphorylation	RMRKARQYYLKMYKA HHHHHHHHHHHHHHH	12.76	-
1796	Ubiquitination	KAQVNQRKNFLQVKK HHHHHHCCCHHHHHH	42.14	-
1802	Ubiquitination	RKNFLQVKKAATCLQ CCCHHHHHHHHHHHH	24.59	-
1803	Ubiquitination	KNFLQVKKAATCLQA CCHHHHHHHHHHHHH	44.38	-
1806	Phosphorylation	LQVKKAATCLQAAYR HHHHHHHHHHHHHHC	20.71	20860994
1819	Ubiquitination	YRGYKVRQLIKQQSI HCCHHHHHHHHHHCH	50.99	21890473
1819 (in isoform 2)	Ubiquitination	-	50.99	21890473
1822	Ubiquitination	YKVRQLIKQQSIAAL HHHHHHHHHHCHHHH	51.37	-
1825	Phosphorylation	RQLIKQQSIAALKIQ HHHHHHHCHHHHHHH	16.23	20860994
1830	Ubiquitination	QQSIAALKIQSAFRG HHCHHHHHHHHHHCC	33.69	21890473
1830 (in isoform 1)	Ubiquitination	-	33.69	21890473
1833	Phosphorylation	IAALKIQSAFRGYNK HHHHHHHHHHCCCCC	32.61	21712546
1843	Ubiquitination	RGYNKRVKYQSVLQS CCCCCCCCHHHHHHH	41.42	21890473
1843 (in isoform 1)	Ubiquitination	-	41.42	21890473
1844	Phosphorylation	GYNKRVKYQSVLQSI CCCCCCCHHHHHHHH	11.81	20068231
1846	Phosphorylation	NKRVKYQSVLQSIIK CCCCCHHHHHHHHHH	23.00	-
1850	Phosphorylation	KYQSVLQSIIKIQRW CHHHHHHHHHHHHHH	23.32	24719451
1862	Ubiquitination	QRWYRAYKTLHDTRT HHHHHHHHHHHHHHC	43.56	-
1863	O-linked_Glycosylation	RWYRAYKTLHDTRTH HHHHHHHHHHHHHCH	19.35	30379171
1873	Ubiquitination	DTRTHFLKTKAAVIS HHHCHHHHHHHHHHH	47.22	-
1875	Ubiquitination	RTHFLKTKAAVISLQ HCHHHHHHHHHHHHH	32.53	-
1880	Phosphorylation	KTKAAVISLQSAYRG HHHHHHHHHHHHHHC	17.48	23403867
1883	Phosphorylation	AAVISLQSAYRGWKV HHHHHHHHHHHCHHH	32.34	23403867
1885	Phosphorylation	VISLQSAYRGWKVRK HHHHHHHHHCHHHHH	18.20	23403867
1903	Acetylation	REHQAALKIQSAFRM HHHHHHHHHHHHHHH	33.69	70941
1903	Ubiquitination	REHQAALKIQSAFRM HHHHHHHHHHHHHHH	33.69	-
1906	Phosphorylation	QAALKIQSAFRMAKA HHHHHHHHHHHHHHH	32.61	23532336
1912	Acetylation	QSAFRMAKAQKQFRL HHHHHHHHHHHHHHH	41.84	20167786
1915	Acetylation	FRMAKAQKQFRLFKT HHHHHHHHHHHHHHH	57.15	20167786
1921	Ubiquitination	QKQFRLFKTAALVIQ HHHHHHHHHHHHHHH	41.67	-
1922	Phosphorylation	KQFRLFKTAALVIQQ HHHHHHHHHHHHHHH	15.16	27732954
1939	Ubiquitination	RAWTAGRKQCMEYIE HHHHCCHHHHHHHHH	47.10	-
1944	Phosphorylation	GRKQCMEYIELRHAV CHHHHHHHHHHHHHH	3.47	-
1959	Ubiquitination	LVLQSMWKGKTLRRQ HHHHHHCCCHHHHHH	41.72	-
1972	Ubiquitination	RQLQRQHKCAIIIQS HHHHHHHCHHHEEHH	19.61	-
1995	Acetylation	KKWKIMKKAALLIQK HHHHHHHHHHHHHHH	22.85	25953088
1995	Ubiquitination	KKWKIMKKAALLIQK HHHHHHHHHHHHHHH	22.85	-
2002	Ubiquitination	KAALLIQKYYRAYSI HHHHHHHHHHHHHHC	36.94	-
2004	Phosphorylation	ALLIQKYYRAYSIGR HHHHHHHHHHHHCCC	8.87	22210691
2008	Phosphorylation	QKYYRAYSIGREQNH HHHHHHHHCCCCCCC	19.99	22210691
2019	Ubiquitination	EQNHLYLKTKAAVVT CCCCEECCCHHHHHH	34.13	-
2021	Ubiquitination	NHLYLKTKAAVVTLQ CCEECCCHHHHHHHH	32.53	-
2029	Phosphorylation	AAVVTLQSAYRGMKV HHHHHHHHHHHCCCH	30.31	20860994
2041	Ubiquitination	MKVRKRIKDCNKAAV CCHHHHHHCCCCHHH	61.33	-
2045	Ubiquitination	KRIKDCNKAAVTIQS HHHHCCCCHHHHHHH	44.01	-
2053	Acetylation	AAVTIQSKYRAYKTK HHHHHHHHHHHHHCC	23.52	30587079
2053	Ubiquitination	AAVTIQSKYRAYKTK HHHHHHHHHHHHHCC	23.52	-
2063	Phosphorylation	AYKTKKKYATYRASA HHHCCCCCCCHHHHH	17.04	-
2069	Phosphorylation	KYATYRASAIIIQRW CCCCHHHHHHHHHHH	15.82	19691289
2083	Phosphorylation	WYRGIKITNHQHKEY HHCCCCCCCCCCHHH	22.96	30576142
2088	Ubiquitination	KITNHQHKEYLNLKK CCCCCCCHHHHCCCH	41.29	-
2094	Ubiquitination	HKEYLNLKKTAIKIQ CHHHHCCCHHHHHHH	47.18	-
2096	Phosphorylation	EYLNLKKTAIKIQSV HHHCCCHHHHHHHHH	31.84	26074081
2099	Ubiquitination	NLKKTAIKIQSVYRG CCCHHHHHHHHHHHH	32.03	-
2102	Phosphorylation	KTAIKIQSVYRGIRV HHHHHHHHHHHHHHH	25.29	26074081
2104	Phosphorylation	AIKIQSVYRGIRVRR HHHHHHHHHHHHHHH	14.36	26074081
2121	Phosphorylation	QHMHRAATFIKAMFK HHHHHHHHHHHHHHH	25.55	-
2124	Ubiquitination	HRAATFIKAMFKMHQ HHHHHHHHHHHHHHH	29.61	-
2132	Phosphorylation	AMFKMHQSRISYHTM HHHHHHHHHCCHHHH	19.53	-
2135	Phosphorylation	KMHQSRISYHTMRKA HHHHHHCCHHHHHHE	15.11	-
2136	Phosphorylation	MHQSRISYHTMRKAA HHHHHCCHHHHHHEE	10.03	29116813
2138	Phosphorylation	QSRISYHTMRKAAIV HHHCCHHHHHHEEEE	15.50	17081983
2157	Ubiquitination	CRAYYQGKMQREKYL HHHHHCCCCCHHHHH	19.14	-
2162	Ubiquitination	QGKMQREKYLTILKA CCCCCHHHHHHHHHH	47.99	-
2168	Ubiquitination	EKYLTILKAVKVLQA HHHHHHHHHHHHHHH	47.48	-
2171	Ubiquitination	LTILKAVKVLQASFR HHHHHHHHHHHHHHC	41.93	-
2176	Phosphorylation	AVKVLQASFRGVRVR HHHHHHHHHCCHHHH	11.52	-
2188	Ubiquitination	RVRRTLRKMQTAATL HHHHHHHHHHHHHHH	38.17	-
2191	Phosphorylation	RTLRKMQTAATLIQS HHHHHHHHHHHHHHH	18.11	25072903
2194	Phosphorylation	RKMQTAATLIQSNYR HHHHHHHHHHHHHHH	23.17	25072903
2198	Phosphorylation	TAATLIQSNYRRYRQ HHHHHHHHHHHHHHH	28.92	25072903
2200	Phosphorylation	ATLIQSNYRRYRQQT HHHHHHHHHHHHHHH	11.17	25072903
2217	Ubiquitination	NKLKKITKTVQQRYW HHHHHHHHHHHHHHH	50.61	-
2227	Ubiquitination	QQRYWAMKERNIQFQ HHHHHHHHHCCCCHH	45.86	-
2236	Phosphorylation	RNIQFQRYNKLRHSV CCCCHHHHHHHHHHH	13.08	22817900
2245	Phosphorylation	KLRHSVIYIQAIFRG HHHHHHHHHHHHHCC	5.71	22817900
2260	"N6,N6-dimethyllysine"	KKARRHLKMMHIAAT HHHHHHHHHHHHHHH	28.22	-
2260	Methylation	KKARRHLKMMHIAAT HHHHHHHHHHHHHHH	28.22	23644510
2267	O-linked_Glycosylation	KMMHIAATLIQRRFR HHHHHHHHHHHHHHH	18.51	30379171
2287	Ubiquitination	RRFLSLKKTAILIQR HHHHHCHHHHHHHHH	48.78	-
2295	Acetylation	TAILIQRKYRAHLCT HHHHHHHHHHHHHCH	23.78	7926753
2303	Ubiquitination	YRAHLCTKHHLQFLQ HHHHHCHHHHHHHHH	28.20	-
2339	Phosphorylation	REMHRAATFIQSTFR HHHHHHHHHHHHHHH	21.93	26074081
2343	Phosphorylation	RAATFIQSTFRMHRL HHHHHHHHHHHHHHH	25.38	26074081
2344	Phosphorylation	AATFIQSTFRMHRLH HHHHHHHHHHHHHHH	10.01	26074081
2358	Ubiquitination	HMRYQALKQASVVIQ HHHHHHHHHHHHHHH	47.00	21906983
2358 (in isoform 1)	Ubiquitination	-	47.00	21890473
2387	Phosphorylation	HYLRQRHSAVILQAA HHHHHHHHHHHHHHH	26.81	28555341
2405	Ubiquitination	MKTRRHLKSMHSSAT HHHHHHHHHHHHHHH	39.34	-
2406	Phosphorylation	KTRRHLKSMHSSATL HHHHHHHHHHHHHHH	28.25	28555341
2409	Phosphorylation	RHLKSMHSSATLIQS HHHHHHHHHHHHHHH	17.02	29116813
2410	Phosphorylation	HLKSMHSSATLIQSR HHHHHHHHHHHHHHH	15.59	29116813
2412	Phosphorylation	KSMHSSATLIQSRFR HHHHHHHHHHHHHHH	26.75	29116813
2416	Phosphorylation	SSATLIQSRFRSLLV HHHHHHHHHHHHHHH	26.79	29116813
2429	Phosphorylation	LVRRRFISLKKATIF HHHHHHHCCCCEEEE	31.27	22817900
2432	Ubiquitination	RRFISLKKATIFVQR HHHHCCCCEEEEEEC	56.93	-
2434	Phosphorylation	FISLKKATIFVQRKY HHCCCCEEEEEECHH	24.67	30576142
2441	Phosphorylation	TIFVQRKYRATICAK EEEEECHHHHHHHHH	13.99	20068231
2444	Phosphorylation	VQRKYRATICAKHKL EECHHHHHHHHHHHH	13.95	20068231
2450	Acetylation	ATICAKHKLYQFLHL HHHHHHHHHHHHHHH	48.46	26051181
2459	Ubiquitination	YQFLHLRKAAITIQS HHHHHHHHHHHHHHH	48.83	-
2490	Phosphorylation	AAVLIQATFRMYRTY HHHHHHHHHHHHHHH	8.73	24719451
2494	Phosphorylation	IQATFRMYRTYITFQ HHHHHHHHHHHHHHC	8.78	27174698
2557	Phosphorylation	LREKHKASIVIQSTY HHHHHHHHHHHHHHH	23.38	27251275
2562	Phosphorylation	KASIVIQSTYRMYRQ HHHHHHHHHHHHHHH	19.11	27251275
2563	Phosphorylation	ASIVIQSTYRMYRQY HHHHHHHHHHHHHHH	9.96	27251275
2570	Phosphorylation	TYRMYRQYCFYQKLQ HHHHHHHHHHHHHHH	3.89	-
2573	Phosphorylation	MYRQYCFYQKLQWAT HHHHHHHHHHHHHHH	10.94	-
2581	Ubiquitination	QKLQWATKIIQEKYR HHHHHHHHHHHHHHH	30.02	-
2586	Ubiquitination	ATKIIQEKYRANKKK HHHHHHHHHHHCHHH	24.54	-
2595	Ubiquitination	RANKKKQKVFQHNEL HHCHHHHHHHHCHHH	54.63	-
2603	Ubiquitination	VFQHNELKKETCVQA HHHCHHHCHHHHHHH	42.24	-
2604	Ubiquitination	FQHNELKKETCVQAG HHCHHHCHHHHHHHC	71.52	-
2618	Ubiquitination	GFQDMNIKKQIQEQH CCCCCCHHHHHHHHH	33.35	-
2619	Ubiquitination	FQDMNIKKQIQEQHQ CCCCCHHHHHHHHHH	49.16	-
2633	Ubiquitination	QAAIIIQKHCKAFKI HHHHHHHHHHHHHHC	40.33	-
2675	Phosphorylation	AVICIQSYYRGFKVR HHHHHHHHHCCCCHH	4.84	-
2676	Phosphorylation	VICIQSYYRGFKVRK HHHHHHHHCCCCHHH	14.98	-
2730	Phosphorylation	RLYVRVKTERKNFLA EEEEEEECCCCCHHH	37.86	22496350
2733	Ubiquitination	VRVKTERKNFLAVQK EEEECCCCCHHHHHH	45.91	-
2740	Ubiquitination	KNFLAVQKSVRTIQA CCHHHHHHHHHHHHH	44.30	-
2759	Ubiquitination	MKVRQKLKNVSEEKM HHHHHHHCCCCHHHH	63.44	-
2765	Ubiquitination	LKNVSEEKMAAIVNQ HCCCCHHHHHHHHCH	29.77	-
2773	Phosphorylation	MAAIVNQSALCCYRS HHHHHCHHHHHCCCC	20.29	28555341
2781	Ubiquitination	ALCCYRSKTQYEAVQ HHHCCCCCCHHHHHH	30.56	-
2799	Ubiquitination	VMIQEWYKASGLACS CCCHHHHHHCCCCCC	36.83	-
2806	Phosphorylation	KASGLACSQEAEYHS HHCCCCCCHHHHHHC	26.00	25159151
2823	Ubiquitination	RAAVTIQKAFCRMVT CHHHHHHHHHHHHHH	39.31	-
2837	Ubiquitination	TRKLETQKCAALRIQ HHHHHHHHHHHHHHH	33.01	-
2877	Ubiquitination	FRTWQTRKQFLLYRK HHHHHHHHHHHHHHH	49.11	-
2884	Ubiquitination	KQFLLYRKAAVVLQN HHHHHHHHHHHHHHH	27.43	-
2900	Ubiquitination	YRAFLSAKHQRQVYL HHHHHCHHHHHHHHH	36.57	-
2906	Phosphorylation	AKHQRQVYLQIRSSV HHHHHHHHHEEECEE	5.64	27174698
2911	Phosphorylation	QVYLQIRSSVIIIQA HHHHEEECEEEEEEE	30.50	27174698
2912	Phosphorylation	VYLQIRSSVIIIQAR HHHEEECEEEEEEEC	13.90	27174698
2933	Ubiquitination	KRKFQEIKNSTIKIQ CCCHHHHHCCCHHHH	44.06	-
2960	Ubiquitination	CKVKAACKIQAWYRC HHHHHHHHHHHHHHH	32.88	-
2974	Phosphorylation	CWRAHKEYLAILKAV HHHHCHHHHHHHHHH	13.26	-
2991	Ubiquitination	IQGCFYTKLERTRFL HHCCCCCCCCCCCCC	36.65	-
3003	Phosphorylation	RFLNVRASAIIIQRK CCCCCCCEEEEEHHC	14.94	19691289
3010	Ubiquitination	SAIIIQRKWRAILPA EEEEEHHCHHHHHHH	25.34	-
3018	Ubiquitination	WRAILPAKIAHEHFL HHHHHHHHHHHHHHH	38.19	-
3028	Ubiquitination	HEHFLMIKRHRAACL HHHHHHHHHHHHHHH	28.34	-
3053	Ubiquitination	RQVFLRQKSAALIIQ CEEHHHHHHHHHHHH	35.31	-
3054	Phosphorylation	QVFLRQKSAALIIQK EEHHHHHHHHHHHHH	15.50	25159151
3061	Ubiquitination	SAALIIQKYIRAREA HHHHHHHHHHHHHHC	32.03	21890473
3061 (in isoform 1)	Ubiquitination	-	32.03	21890473
3082	Phosphorylation	KYIEFKKSTVILQAL EEEEECCHHHHHHHH	28.62	-
3135	Ubiquitination	YKLYLAVKNANKQVN HHHHHHHHCCCHHHC	44.74	-
3139	Ubiquitination	LAVKNANKQVNSVIC HHHHCCCHHHCCHHH	53.89	-
3163	Ubiquitination	QEKRFIQKYHSIKKI HHHHHHHHHHCHHCC	39.86	-
3169	Ubiquitination	QKYHSIKKIEHEGQE HHHHCHHCCHHCHHH	52.21	-
3186	Phosphorylation	SQRNRAASVIQKAVR HHHHHHHHHHHHHHH	20.83	20860994
3190	Ubiquitination	RAASVIQKAVRHFLL HHHHHHHHHHHHHHH	37.41	-
3203	Ubiquitination	LLRKKQEKFTSGIIK HHHHCHHHHCCCCHH	51.99	-
3235	Phosphorylation	KIKAIRLSLQVVNRE HHHHHHHHHHHHCHH	13.60	25159151
3309	Phosphorylation	LIRSCNRSIPCMEVI HHHHCCCCCCHHHHH	19.52	29038488
3364	Ubiquitination	PGNKVADKGGSIFTK CCCCCCCCCCCHHHH	56.27	-
3382	Phosphorylation	LLAILLKTTNRASDV HHHHHHHHCCCCHHH	29.31	20860994
3383	Phosphorylation	LAILLKTTNRASDVR HHHHHHHCCCCHHHH	22.56	20860994
3387	Phosphorylation	LKTTNRASDVRSRSK HHHCCCCHHHHCHHH	33.14	20860994
3400	Phosphorylation	SKVVDRIYSLYKLTA HHHHHHHHHHHHHHH	8.10	-
3404	Ubiquitination	DRIYSLYKLTAHKHK HHHHHHHHHHHHHHC	44.66	21890473
3404 (in isoform 1)	Ubiquitination	-	44.66	21890473
3406	Phosphorylation	IYSLYKLTAHKHKMN HHHHHHHHHHHHCCC	23.67	-
3420	Acetylation	NTERILYKQKKNSSI CHHHHHHCCCCCCCC	52.80	19666993
3422	Ubiquitination	ERILYKQKKNSSISI HHHHHCCCCCCCCCC	50.17	-
3423	Acetylation	RILYKQKKNSSISIP HHHHCCCCCCCCCCC	60.61	19667003
3423	Ubiquitination	RILYKQKKNSSISIP HHHHCCCCCCCCCCC	60.61	-
3425	Phosphorylation	LYKQKKNSSISIPFI HHCCCCCCCCCCCCC	37.62	29255136
3426	Phosphorylation	YKQKKNSSISIPFIP HCCCCCCCCCCCCCC	29.73	29255136
3428	Phosphorylation	QKKNSSISIPFIPET CCCCCCCCCCCCCCC	26.59	29255136
3435	Phosphorylation	SIPFIPETPVRTRIV CCCCCCCCCCCCCHH	23.02	29255136
3439	Phosphorylation	IPETPVRTRIVSRLK CCCCCCCCCHHHCCC	25.61	21712546
3443	Phosphorylation	PVRTRIVSRLKPDWV CCCCCHHHCCCCCEE	29.53	20860994
3446	Ubiquitination	TRIVSRLKPDWVLRR CCHHHCCCCCEEECC	39.56	-
3460	Phosphorylation	RDNMEEITNPLQAIQ CCCHHHHCCHHHHHH	33.78	23663014
3472	Phosphorylation	AIQMVMDTLGIPY-- HHHHHHHHHCCCC--	14.59	23663014
3477	Phosphorylation	MDTLGIPY------- HHHHCCCC-------	29.30	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASPM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASPM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASPM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE3A_HUMAN	UBE3A	physical	21633703
PSMD8_HUMAN	PSMD8	physical	26344197
CALU_HUMAN	CALU	physical	26496610
CENPB_HUMAN	CENPB	physical	26496610
QOR_HUMAN	CRYZ	physical	26496610
DIC_HUMAN	SLC25A10	physical	26496610
MTOR_HUMAN	MTOR	physical	26496610
LIMS1_HUMAN	LIMS1	physical	26496610
NP1L1_HUMAN	NAP1L1	physical	26496610
NP1L4_HUMAN	NAP1L4	physical	26496610
NUMA1_HUMAN	NUMA1	physical	26496610
AAPK1_HUMAN	PRKAA1	physical	26496610
RCN1_HUMAN	RCN1	physical	26496610
RCN2_HUMAN	RCN2	physical	26496610
SSRG_HUMAN	SSR3	physical	26496610
ELL_HUMAN	ELL	physical	26496610
TBA1B_HUMAN	TUBA1B	physical	26496610
IPO7_HUMAN	IPO7	physical	26496610
RPP38_HUMAN	RPP38	physical	26496610
SDCG3_HUMAN	SDCCAG3	physical	26496610
PACS2_HUMAN	PACS2	physical	26496610
ANO3_HUMAN	ANO3	physical	26496610
CEP78_HUMAN	CEP78	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608716: Microcephaly 5, primary, autosomal recessive (MCPH5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367 AND SER-392, ANDMASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-280; SER-283;SER-425 AND SER-1103, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-367; SER-392 ANDSER-605, AND MASS SPECTROMETRY.
PubMed: 18691976

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-35; SER-170;THR-178; SER-211; THR-246; SER-249; SER-270; THR-277; SER-280;SER-367; THR-563; SER-565; SER-566; SER-570; SER-577; SER-605;SER-1103; SER-1105 AND SER-3186, AND MASS SPECTROMETRY.
PubMed: 19007248

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-35; SER-222;SER-225; SER-263; SER-267; SER-270; SER-280; SER-283; SER-348;SER-367; SER-370; SER-392; SER-425; SER-463; THR-563; SER-605;THR-647; SER-1103 AND THR-3435, AND MASS SPECTROMETRY.
PubMed: 16565220

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425 AND SER-2429, ANDMASS SPECTROMETRY.
PubMed: 17081983