| UniProt ID | UBE3A_HUMAN | |
|---|---|---|
| UniProt AC | Q05086 | |
| Protein Name | Ubiquitin-protein ligase E3A | |
| Gene Name | UBE3A {ECO:0000312|HGNC:HGNC:12496} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 875 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. [PubMed: 10373495] | |
| Protein Sequence | MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Ubiquitination | -MEKLHQCYWKSGEP -CCCCCCCCCCCCCC | 2.81 | 22053931 | |
| 19 (in isoform 3) | Phosphorylation | - | 5.98 | - | |
| 22 | Phosphorylation | QSDDIEASRMKRAAA CCCHHHHHHHHHHHH | 21.81 | - | |
| 27 (in isoform 3) | Ubiquitination | - | 13.27 | 21890473 | |
| 30 | Acetylation | RMKRAAAKHLIERYY HHHHHHHHHHHHHHH | 33.93 | 25953088 | |
| 30 | Ubiquitination | RMKRAAAKHLIERYY HHHHHHHHHHHHHHH | 33.93 | 21890473 | |
| 30 (in isoform 1) | Ubiquitination | - | 33.93 | 21890473 | |
| 48 | Ubiquitination | TEGCGNEACTNEFCA HCCCCCHHHCCHHHH | 14.94 | 22053931 | |
| 48 (in isoform 2) | Ubiquitination | - | 14.94 | 21890473 | |
| 54 (in isoform 2) | Ubiquitination | - | 1.91 | 21890473 | |
| 67 (in isoform 2) | Ubiquitination | - | 12.43 | 21890473 | |
| 68 (in isoform 3) | Ubiquitination | - | 16.31 | 21890473 | |
| 71 | Ubiquitination | DNNAAAIKALELYKI CCCHHHHHHHHHHHH | 42.04 | 21890473 | |
| 71 (in isoform 1) | Ubiquitination | - | 42.04 | 21890473 | |
| 74 (in isoform 3) | Ubiquitination | - | 55.71 | 21890473 | |
| 77 | Ubiquitination | IKALELYKINAKLCD HHHHHHHHHCCCCCC | 41.95 | 21890473 | |
| 77 (in isoform 1) | Ubiquitination | - | 41.95 | 21890473 | |
| 81 | Ubiquitination | ELYKINAKLCDPHPS HHHHHCCCCCCCCCC | 45.20 | - | |
| 87 (in isoform 3) | Ubiquitination | - | 53.91 | 21890473 | |
| 89 | Ubiquitination | LCDPHPSKKGASSAY CCCCCCCCCCCCHHH | 60.73 | - | |
| 90 | Ubiquitination | CDPHPSKKGASSAYL CCCCCCCCCCCHHHH | 65.14 | 90473 | |
| 90 (in isoform 1) | Ubiquitination | - | 65.14 | 21890473 | |
| 93 | Phosphorylation | HPSKKGASSAYLENS CCCCCCCCHHHHHCC | 24.95 | 23312004 | |
| 94 | Phosphorylation | PSKKGASSAYLENSK CCCCCCCHHHHHCCC | 22.02 | 28348404 | |
| 96 | Phosphorylation | KKGASSAYLENSKGA CCCCCHHHHHCCCCC | 19.25 | 27642862 | |
| 100 | Phosphorylation | SSAYLENSKGAPNNS CHHHHHCCCCCCCCC | 24.08 | 25159151 | |
| 100 (in isoform 2) | Ubiquitination | - | 24.08 | 21890473 | |
| 101 | Ubiquitination | SAYLENSKGAPNNSC HHHHHCCCCCCCCCC | 71.34 | - | |
| 107 | Phosphorylation | SKGAPNNSCSEIKMN CCCCCCCCCHHCCCC | 26.17 | 28348404 | |
| 109 | Phosphorylation | GAPNNSCSEIKMNKK CCCCCCCHHCCCCCC | 42.02 | 25627689 | |
| 109 | Ubiquitination | GAPNNSCSEIKMNKK CCCCCCCHHCCCCCC | 42.02 | 22053931 | |
| 112 | Ubiquitination | NNSCSEIKMNKKGAR CCCCHHCCCCCCCCC | 32.16 | - | |
| 120 (in isoform 3) | Ubiquitination | - | 7.87 | 21890473 | |
| 123 | Acetylation | KGARIDFKDVTYLTE CCCCCCCCCCEEECH | 47.76 | 25953088 | |
| 123 | Ubiquitination | KGARIDFKDVTYLTE CCCCCCCCCCEEECH | 47.76 | 21890473 | |
| 123 (in isoform 1) | Ubiquitination | - | 47.76 | 21890473 | |
| 126 | Phosphorylation | RIDFKDVTYLTEEKV CCCCCCCEEECHHHH | 23.97 | 28152594 | |
| 127 | Phosphorylation | IDFKDVTYLTEEKVY CCCCCCEEECHHHHH | 16.10 | 25884760 | |
| 129 | Phosphorylation | FKDVTYLTEEKVYEI CCCCEEECHHHHHHH | 31.52 | 28152594 | |
| 132 | Ubiquitination | VTYLTEEKVYEILEL CEEECHHHHHHHHHH | 43.83 | - | |
| 132 (in isoform 1) | Ubiquitination | - | 43.83 | 21890473 | |
| 147 | Phosphorylation | CREREDYSPLIRVIG HHCCCCCHHHHHHHH | 26.08 | 24719451 | |
| 158 | Phosphorylation | RVIGRVFSSAEALVQ HHHHHHHCCHHHHHH | 26.28 | - | |
| 159 | Phosphorylation | VIGRVFSSAEALVQS HHHHHHCCHHHHHHH | 20.75 | - | |
| 161 (in isoform 2) | Ubiquitination | - | 44.47 | 21890473 | |
| 179 | Ubiquitination | QHTKEELKSLQAKDE HHCHHHHHHCCCCCC | 53.02 | - | |
| 181 (in isoform 3) | Ubiquitination | - | 5.69 | 21890473 | |
| 184 | Ubiquitination | ELKSLQAKDEDKDED HHHHCCCCCCCCCHH | 49.00 | 21906983 | |
| 184 (in isoform 1) | Ubiquitination | - | 49.00 | 21890473 | |
| 195 (in isoform 2) | Phosphorylation | - | 52.96 | - | |
| 199 | Phosphorylation | EKEKAACSAAAMEED HHHHHHHHHHHHHHC | 19.06 | - | |
| 203 | Sulfoxidation | AACSAAAMEEDSEAS HHHHHHHHHHCCHHH | 5.06 | 21406390 | |
| 203 (in isoform 2) | Ubiquitination | - | 5.06 | 21890473 | |
| 207 | Phosphorylation | AAAMEEDSEASSSRI HHHHHHCCHHHHCCC | 38.04 | 30108239 | |
| 210 | Phosphorylation | MEEDSEASSSRIGDS HHHCCHHHHCCCCCC | 25.46 | 24719451 | |
| 211 | Phosphorylation | EEDSEASSSRIGDSS HHCCHHHHCCCCCCC | 30.59 | 30108239 | |
| 212 | Phosphorylation | EDSEASSSRIGDSSQ HCCHHHHCCCCCCCC | 25.97 | 30108239 | |
| 215 (in isoform 3) | Phosphorylation | - | 27.86 | - | |
| 217 | Phosphorylation | SSSRIGDSSQGDNNL HHCCCCCCCCCCCCH | 21.24 | 29255136 | |
| 218 | Phosphorylation | SSRIGDSSQGDNNLQ HCCCCCCCCCCCCHH | 42.81 | 17525332 | |
| 223 (in isoform 3) | Ubiquitination | - | 48.89 | 21890473 | |
| 226 | Ubiquitination | QGDNNLQKLGPDDVS CCCCCHHHHCCCCCE | 59.59 | 2266 | |
| 226 (in isoform 1) | Ubiquitination | - | 59.59 | 21890473 | |
| 288 (in isoform 2) | Ubiquitination | - | 2.33 | 21890473 | |
| 294 | Methylation | FIIVMENRNLHSPEY EEEEEECCCCCCHHH | 33.51 | 5169925 | |
| 300 (in isoform 2) | Ubiquitination | - | 66.81 | 21890473 | |
| 307 (in isoform 2) | Ubiquitination | - | 17.53 | 21890473 | |
| 308 (in isoform 3) | Ubiquitination | - | 9.06 | 21890473 | |
| 311 | Ubiquitination | MALPLFCKAMSKLPL HHHHHHHHHHHCCCH | 39.53 | 21890473 | |
| 311 (in isoform 1) | Ubiquitination | - | 39.53 | 21890473 | |
| 315 | Ubiquitination | LFCKAMSKLPLAAQG HHHHHHHCCCHHHHC | 40.83 | - | |
| 320 (in isoform 3) | Ubiquitination | - | 26.75 | 21890473 | |
| 323 | Ubiquitination | LPLAAQGKLIRLWSK CCHHHHCHHHHHHHH | 28.76 | 21890473 | |
| 323 (in isoform 1) | Ubiquitination | - | 28.76 | 21890473 | |
| 327 (in isoform 2) | Ubiquitination | - | 4.86 | 21890473 | |
| 327 (in isoform 3) | Ubiquitination | - | 4.86 | 21890473 | |
| 330 | Ubiquitination | KLIRLWSKYNADQIR HHHHHHHHCCHHHHH | 30.83 | 21890473 | |
| 330 (in isoform 1) | Ubiquitination | - | 30.83 | 21890473 | |
| 342 | Phosphorylation | QIRRMMETFQQLITY HHHHHHHHHHHHHHH | 14.62 | - | |
| 347 (in isoform 3) | Ubiquitination | - | 3.25 | 21890473 | |
| 349 | Phosphorylation | TFQQLITYKVISNEF HHHHHHHHHHHCCCC | 9.03 | - | |
| 350 | Ubiquitination | FQQLITYKVISNEFN HHHHHHHHHHCCCCC | 25.17 | 21890473 | |
| 350 (in isoform 1) | Ubiquitination | - | 25.17 | 21890473 | |
| 350 (in isoform 2) | Ubiquitination | - | 25.17 | 21890473 | |
| 370 (in isoform 3) | Ubiquitination | - | 10.41 | 21890473 | |
| 372 | O-linked_Glycosylation | DDAIVAASKCLKMVY HHHHHHHHHHHHHHH | 17.73 | 30379171 | |
| 372 | Phosphorylation | DDAIVAASKCLKMVY HHHHHHHHHHHHHHH | 17.73 | 27732954 | |
| 373 | Ubiquitination | DAIVAASKCLKMVYY HHHHHHHHHHHHHHH | 38.57 | 21890473 | |
| 373 (in isoform 1) | Ubiquitination | - | 38.57 | 21890473 | |
| 418 (in isoform 2) | Ubiquitination | - | 63.70 | - | |
| 420 | Ubiquitination | LGEERRNKKGPRVDP HCHHHHCCCCCCCCH | 58.24 | - | |
| 421 | Ubiquitination | GEERRNKKGPRVDPL CHHHHCCCCCCCCHH | 77.14 | - | |
| 435 | Ubiquitination | LETELGVKTLDCRKP HHHHCCCCCCCCCCC | 41.39 | - | |
| 441 | Ubiquitination | VKTLDCRKPLIPFEE CCCCCCCCCCCCHHH | 50.97 | - | |
| 445 (in isoform 2) | Ubiquitination | - | 37.98 | 21890473 | |
| 465 | Phosphorylation | LEMDKDYTFFKVETE HHCCCCCCEEEEEEC | 32.50 | - | |
| 465 (in isoform 3) | Ubiquitination | - | 32.50 | 21890473 | |
| 468 | Ubiquitination | DKDYTFFKVETENKF CCCCCEEEEEECCCE | 34.66 | 21890473 | |
| 468 (in isoform 1) | Ubiquitination | - | 34.66 | 21890473 | |
| 471 | Phosphorylation | YTFFKVETENKFSFM CCEEEEEECCCEEHH | 48.09 | - | |
| 474 | Ubiquitination | FKVETENKFSFMTCP EEEEECCCEEHHHHH | 35.83 | - | |
| 479 | Phosphorylation | ENKFSFMTCPFILNA CCCEEHHHHHHHHHH | 18.28 | - | |
| 485 (in isoform 2) | Phosphorylation | - | 27.78 | - | |
| 489 (in isoform 2) | Phosphorylation | - | 43.51 | - | |
| 494 | Phosphorylation | VTKNLGLYYDNRIRM HHHHCCCCCCCCCCC | 13.63 | 25147952 | |
| 503 | O-linked_Glycosylation | DNRIRMYSERRITVL CCCCCCCCHHHHHHH | 18.45 | 30379171 | |
| 508 | Phosphorylation | MYSERRITVLYSLVQ CCCHHHHHHHHHHHC | 11.57 | - | |
| 511 | Phosphorylation | ERRITVLYSLVQGQQ HHHHHHHHHHHCCCC | 8.81 | - | |
| 512 | Phosphorylation | RRITVLYSLVQGQQL HHHHHHHHHHCCCCC | 20.22 | - | |
| 529 (in isoform 2) | Ubiquitination | - | 42.73 | 21890473 | |
| 530 (in isoform 2) | Ubiquitination | - | 27.12 | 21890473 | |
| 542 | Sulfoxidation | DALVRLEMIAMENPA HHHHHHHHHHHCCHH | 2.54 | 21406390 | |
| 549 (in isoform 3) | Ubiquitination | - | 46.48 | 21890473 | |
| 550 (in isoform 3) | Ubiquitination | - | 61.35 | 21890473 | |
| 552 | Ubiquitination | MENPADLKKQLYVEF HCCHHHHHHHEEEEE | 38.73 | 21906983 | |
| 552 (in isoform 1) | Ubiquitination | - | 38.73 | 21890473 | |
| 553 | Ubiquitination | ENPADLKKQLYVEFE CCHHHHHHHEEEEEE | 53.48 | 21906983 | |
| 553 (in isoform 1) | Ubiquitination | - | 53.48 | 21890473 | |
| 636 (in isoform 2) | Phosphorylation | - | 3.31 | - | |
| 645 | Ubiquitination | YRKLMGKKGTFRDLG HHHHCCCCCCCCCCC | 58.41 | - | |
| 659 | Phosphorylation | GDSHPVLYQSLKDLL CCCCHHHHHHHHHHH | 9.04 | 9143503 | |
| 688 (in isoform 2) | Ubiquitination | - | 11.20 | 21890473 | |
| 697 | Acetylation | NPMMYDLKENGDKIP CCCEEEHHHCCCCCC | 46.35 | 25953088 | |
| 701 (in isoform 2) | Ubiquitination | - | 58.24 | 21890473 | |
| 702 | Ubiquitination | DLKENGDKIPITNEN EHHHCCCCCCCCCCC | 52.35 | - | |
| 705 (in isoform 2) | Ubiquitination | - | 8.01 | 21890473 | |
| 708 (in isoform 3) | Ubiquitination | - | 50.16 | 21890473 | |
| 711 | Ubiquitination | PITNENRKEFVNLYS CCCCCCHHHHHHHHH | 68.06 | 21890473 | |
| 711 (in isoform 1) | Ubiquitination | - | 68.06 | 21890473 | |
| 720 | Phosphorylation | FVNLYSDYILNKSVE HHHHHHHHHCCHHHH | 11.02 | 18083107 | |
| 721 (in isoform 3) | Ubiquitination | - | 4.03 | 21890473 | |
| 724 | Ubiquitination | YSDYILNKSVEKQFK HHHHHCCHHHHHHHH | 53.05 | 21890473 | |
| 724 (in isoform 1) | Ubiquitination | - | 53.05 | 21890473 | |
| 725 (in isoform 3) | Ubiquitination | - | 34.14 | 21890473 | |
| 728 | Ubiquitination | ILNKSVEKQFKAFRR HCCHHHHHHHHHHHH | 59.90 | 21890473 | |
| 728 (in isoform 1) | Ubiquitination | - | 59.90 | 21890473 | |
| 731 | Ubiquitination | KSVEKQFKAFRRGFH HHHHHHHHHHHHCCE | 44.09 | - | |
| 741 | Phosphorylation | RRGFHMVTNESPLKY HHCCEECCCCCCCHH | 26.20 | 28122231 | |
| 744 | Phosphorylation | FHMVTNESPLKYLFR CEECCCCCCCHHCCC | 37.29 | 24719451 | |
| 776 | Phosphorylation | ALEETTEYDGGYTRD HHHHCCCCCCCCCHH | 20.14 | 27642862 | |
| 779 (in isoform 2) | Ubiquitination | - | 20.10 | 21890473 | |
| 799 (in isoform 3) | Ubiquitination | - | 55.08 | 21890473 | |
| 802 | Ubiquitination | HSFTDEQKRLFLQFT HHCCHHHHHEEEEEC | 49.36 | 21906983 | |
| 802 (in isoform 1) | Ubiquitination | - | 49.36 | 21890473 | |
| 806 (in isoform 2) | Ubiquitination | - | 4.91 | 21890473 | |
| 822 | Acetylation | APVGGLGKLKMIIAK CCCCCHHHEEEEEEC | 50.40 | 25953088 | |
| 822 | Ubiquitination | APVGGLGKLKMIIAK CCCCCHHHEEEEEEC | 50.40 | - | |
| 824 | Ubiquitination | VGGLGKLKMIIAKNG CCCHHHEEEEEECCC | 31.38 | - | |
| 826 (in isoform 3) | Ubiquitination | - | 2.37 | 21890473 | |
| 829 | Ubiquitination | KLKMIIAKNGPDTER HEEEEEECCCCCCCC | 52.62 | 2190698 | |
| 829 (in isoform 1) | Ubiquitination | - | 52.62 | 21890473 | |
| 847 (in isoform 2) | Ubiquitination | - | 4.22 | - | |
| 855 | Ubiquitination | LLPEYSSKEKLKERL CCCCCCCHHHHHHHH | 53.58 | - | |
| 857 | Ubiquitination | PEYSSKEKLKERLLK CCCCCHHHHHHHHHH | 69.47 | - | |
| 864 | Ubiquitination | KLKERLLKAITYAKG HHHHHHHHHHHHHHC | 42.19 | - | |
| 870 | Ubiquitination | LKAITYAKGFGML-- HHHHHHHHCCCCC-- | 44.34 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 485 | T | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 636 | Y | Phosphorylation | Kinase | ABL1 | P00520 | GPS |
| 659 | Y | Phosphorylation | Kinase | ABL1 | P00519 | Uniprot |
| - | K | Ubiquitination | E3 ubiquitin ligase | UBE3A | Q05086 | PMID:10864652 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBE3A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBE3A_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 105830 | Angelman syndrome (AS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, AND MASSSPECTROMETRY. | |
| "ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, AND MASSSPECTROMETRY. | |
