PDE1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE1B_HUMAN
• UniProt AC: Q01064
• Protein Name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
• Gene Name: PDE1B
• Organism: Homo sapiens (Human).
• Sequence Length: 536
• Subcellular Localization: Cytoplasm.
• Protein Description: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate..
• Protein Sequence: MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MELSPRSPPEM ----CCCCCCCCHHH	12.64	24719451
7	Phosphorylation	-MELSPRSPPEMLEE -CCCCCCCCHHHHCC	48.46	24076635
10 (in isoform 2)	Phosphorylation	-	60.84	24043423
15	Phosphorylation	PPEMLEESDCPSPLE CHHHHCCCCCCCCCC	34.83	24076635
19	Phosphorylation	LEESDCPSPLELKSA HCCCCCCCCCCCCCC	48.74	24043423
41	Phosphorylation	KLRSLLRYMVKQLEN HHHHHHHHHHHHHHC	13.26	22817900
62	Phosphorylation	ELKKNLEYTASLLEA HHHHHHHHHHHHHHH	15.69	-
71	Phosphorylation	ASLLEAVYIDETRQI HHHHHHHHHHCHHHC	15.09	-
144	Phosphorylation	RMFRRTYTSVGPTYS HHHHCCCCCCCCCHH	19.14	-
152	Phosphorylation	SVGPTYSTAVLNCLK CCCCCHHHHHHHHHH	15.46	-
201	Phosphorylation	ISRFKIPTVFLMSFL HHHCCCCHHHHHHHH	27.62	-
242	Phosphorylation	VHCFLLRTGMVHCLS HHHHHHHCCHHHHHH	29.60	24043423
249	Phosphorylation	TGMVHCLSEIELLAI CCHHHHHHHHHHHHH	41.75	24043423
265	Phosphorylation	FAAAIHDYEHTGTTN HHHHHCCCCCCCCCC	8.75	24043423
268	Phosphorylation	AIHDYEHTGTTNSFH HHCCCCCCCCCCEEE	25.04	24043423
270	Phosphorylation	HDYEHTGTTNSFHIQ CCCCCCCCCCEEEEE	24.78	24043423
271	Phosphorylation	DYEHTGTTNSFHIQT CCCCCCCCCEEEEEE	30.15	24043423
273	Phosphorylation	EHTGTTNSFHIQTKS CCCCCCCEEEEEECC	18.99	24043423
278	Phosphorylation	TNSFHIQTKSECAIV CCEEEEEECCCEEEE	35.61	24043423
363	Phosphorylation	IDKPKALSLLLHAAD CCHHHHHHHHHHHHH	23.10	-
372	Phosphorylation	LLHAADISHPTKQWL HHHHHHCCCCCHHHH	24.78	-
375	Phosphorylation	AADISHPTKQWLVHS HHHCCCCCHHHHHHH	30.37	-
382	Phosphorylation	TKQWLVHSRWTKALM CHHHHHHHHHHHHHH	23.25	-
443	Phosphorylation	LTDVAEKSVQPLADE HHHHHHHHCCCCCCC	19.93	-
452	Phosphorylation	QPLADEDSKSKNQPS CCCCCCCCCCCCCCC	36.46	-
454	Phosphorylation	LADEDSKSKNQPSFQ CCCCCCCCCCCCCCC	40.57	-
466	Phosphorylation	SFQWRQPSLDVEVGD CCCCCCCCCCEECCC	28.94	15345747
514	Phosphorylation	QMSIDELSPCEEEAP CCCHHHCCCCCCCCC	26.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDE1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE1B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PDE1B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01244: Bepridil
• DB00201: Caffeine
• DB01023: Felodipine
• DB00622: Nicardipine