| UniProt ID | UBQL1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UMX0 | |
| Protein Name | Ubiquilin-1 | |
| Gene Name | UBQLN1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 589 | |
| Subcellular Localization | Cytoplasm . Nucleus . Endoplasmic reticulum . Cytoplasmic vesicle, autophagosome . Cell membrane . Detected in neuronal processes and at synapses (By similarity). Recruited to the ER during ER-associated protein degradation (ERAD) (PubMed:19822669). | |
| Protein Description | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. [PubMed: 15147878 Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome] | |
| Protein Sequence | MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLLGSQPS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAESGESGG ------CCCCCCCCC | 21.47 | 20068231 | |
| 4 | Phosphorylation | ----MAESGESGGPP ----CCCCCCCCCCC | 38.02 | 28355574 | |
| 7 | Phosphorylation | -MAESGESGGPPGSQ -CCCCCCCCCCCCCC | 53.20 | 25159151 | |
| 13 | Phosphorylation | ESGGPPGSQDSAAGA CCCCCCCCCCCHHCC | 36.27 | 25159151 | |
| 13 (in isoform 2) | Phosphorylation | - | 36.27 | - | |
| 16 | Phosphorylation | GPPGSQDSAAGAEGA CCCCCCCCHHCCCCC | 16.63 | 25159151 | |
| 16 (in isoform 2) | Phosphorylation | - | 16.63 | 21406692 | |
| 31 | Phosphorylation | GAPAAAASAEPKIMK CCCHHHHHCCCCEEE | 28.56 | 25850435 | |
| 35 (in isoform 2) | Ubiquitination | - | 47.11 | 21890473 | |
| 35 (in isoform 1) | Ubiquitination | - | 47.11 | 21890473 | |
| 35 | Ubiquitination | AAASAEPKIMKVTVK HHHHCCCCEEEEEEC | 47.11 | 21890473 | |
| 38 | Ubiquitination | SAEPKIMKVTVKTPK HCCCCEEEEEECCCH | 37.92 | - | |
| 42 | Ubiquitination | KIMKVTVKTPKEKEE CEEEEEECCCHHHHC | 50.14 | - | |
| 43 | Phosphorylation | IMKVTVKTPKEKEEF EEEEEECCCHHHHCC | 34.94 | 20068231 | |
| 43 (in isoform 2) | Phosphorylation | - | 34.94 | - | |
| 45 | Ubiquitination | KVTVKTPKEKEEFAV EEEECCCHHHHCCCC | 83.25 | 21906983 | |
| 45 (in isoform 1) | Ubiquitination | - | 83.25 | 21890473 | |
| 45 (in isoform 2) | Ubiquitination | - | 83.25 | 21890473 | |
| 47 (in isoform 1) | Ubiquitination | - | 69.53 | 21890473 | |
| 47 (in isoform 2) | Ubiquitination | - | 69.53 | 21890473 | |
| 47 | Ubiquitination | TVKTPKEKEEFAVPE EECCCHHHHCCCCCC | 69.53 | 22053931 | |
| 62 (in isoform 1) | Ubiquitination | - | 50.53 | 21890473 | |
| 62 (in isoform 2) | Ubiquitination | - | 50.53 | 21890473 | |
| 62 | Ubiquitination | NSSVQQFKEEISKRF CCHHHHHHHHHHHHH | 50.53 | 21890473 | |
| 67 (in isoform 2) | Ubiquitination | - | 68.46 | 21890473 | |
| 67 (in isoform 1) | Ubiquitination | - | 68.46 | 21890473 | |
| 67 | Ubiquitination | QFKEEISKRFKSHTD HHHHHHHHHHHHHHH | 68.46 | 21906983 | |
| 70 | Ubiquitination | EEISKRFKSHTDQLV HHHHHHHHHHHHHEE | 45.41 | 21890473 | |
| 70 (in isoform 2) | Ubiquitination | - | 45.41 | 21890473 | |
| 70 (in isoform 1) | Ubiquitination | - | 45.41 | 21890473 | |
| 83 | Ubiquitination | LVLIFAGKILKDQDT EEEEEECCHHCCCCH | 41.24 | 21890473 | |
| 83 (in isoform 1) | Ubiquitination | - | 41.24 | 21890473 | |
| 83 (in isoform 2) | Ubiquitination | - | 41.24 | 21890473 | |
| 86 | Ubiquitination | IFAGKILKDQDTLSQ EEECCHHCCCCHHHH | 57.74 | - | |
| 210 | Sulfoxidation | DLMRQLIMANPQMQQ HHHHHHHHHCHHHHH | 3.92 | 28183972 | |
| 215 | Sulfoxidation | LIMANPQMQQLIQRN HHHHCHHHHHHHHHC | 2.64 | 28183972 | |
| 253 | Methylation | AMMQEMMRNQDRALS HHHHHHHHCHHHHHH | 36.03 | - | |
| 257 | Methylation | EMMRNQDRALSNLES HHHHCHHHHHHCHHH | 27.88 | - | |
| 260 | Phosphorylation | RNQDRALSNLESIPG HCHHHHHHCHHHCCC | 38.08 | 27050516 | |
| 264 | Phosphorylation | RALSNLESIPGGYNA HHHHCHHHCCCHHHH | 36.93 | 28152594 | |
| 269 | Phosphorylation | LESIPGGYNALRRMY HHHCCCHHHHHHHHH | 11.81 | 28796482 | |
| 269 (in isoform 2) | Phosphorylation | - | 11.81 | - | |
| 273 | Methylation | PGGYNALRRMYTDIQ CCHHHHHHHHHHHCH | 20.93 | - | |
| 276 | Phosphorylation | YNALRRMYTDIQEPM HHHHHHHHHHCHHHH | 10.23 | 27642862 | |
| 277 | Phosphorylation | NALRRMYTDIQEPML HHHHHHHHHCHHHHH | 19.79 | - | |
| 285 | Phosphorylation | DIQEPMLSAAQEQFG HCHHHHHHHHHHHHC | 18.46 | 25022875 | |
| 298 | Phosphorylation | FGGNPFASLVSNTSS HCCCCCHHHHCCCCC | 29.68 | 26074081 | |
| 301 | Phosphorylation | NPFASLVSNTSSGEG CCCHHHHCCCCCCCC | 39.42 | 26074081 | |
| 303 | Phosphorylation | FASLVSNTSSGEGSQ CHHHHCCCCCCCCCC | 19.43 | 26074081 | |
| 304 | Phosphorylation | ASLVSNTSSGEGSQP HHHHCCCCCCCCCCC | 40.36 | 26074081 | |
| 305 | Phosphorylation | SLVSNTSSGEGSQPS HHHCCCCCCCCCCCC | 38.53 | 26074081 | |
| 309 | Phosphorylation | NTSSGEGSQPSRTEN CCCCCCCCCCCCCCC | 34.32 | 26074081 | |
| 312 | Phosphorylation | SGEGSQPSRTENRDP CCCCCCCCCCCCCCC | 44.17 | 26074081 | |
| 314 | Phosphorylation | EGSQPSRTENRDPLP CCCCCCCCCCCCCCC | 41.78 | 26074081 | |
| 328 | O-linked_Glycosylation | PNPWAPQTSQSSSAS CCCCCCCCCCCCCCC | 27.89 | 23301498 | |
| 329 | O-linked_Glycosylation | NPWAPQTSQSSSASS CCCCCCCCCCCCCCC | 23.87 | 23301498 | |
| 335 | O-linked_Glycosylation | TSQSSSASSGTASTV CCCCCCCCCCCCEEC | 31.11 | 23301498 | |
| 349 | O-linked_Glycosylation | VGGTTGSTASGTSGQ CCCCCCCCCCCCCCC | 26.62 | 23301498 | |
| 402 (in isoform 2) | Phosphorylation | - | 11.32 | 21406692 | |
| 406 (in isoform 2) | Phosphorylation | - | 16.46 | 21406692 | |
| 408 (in isoform 2) | Phosphorylation | - | 32.91 | 21406692 | |
| 422 (in isoform 2) | Phosphorylation | - | 27.99 | 21406692 | |
| 424 (in isoform 2) | Phosphorylation | - | 9.61 | 21406692 | |
| 427 (in isoform 2) | Phosphorylation | - | 20.09 | 21406692 | |
| 518 | O-linked_Glycosylation | TSPTAGTTEPGHQQF CCCCCCCCCHHHHHH | 38.99 | 23301498 | |
| 557 | Sulfoxidation | QLEQLSAMGFLNREA HHHHHHHCCCCCHHH | 3.33 | 28183972 | |
| 586 | Phosphorylation | AIERLLGSQPS---- HHHHHHCCCCC---- | 38.60 | 28985074 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBQL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBQL1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
