dbPTM

UBXN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBXN4_HUMAN
UniProt AC	Q92575
Protein Name	UBX domain-containing protein 4
Gene Name	UBXN4
Organism	Homo sapiens (Human).
Sequence Length	508
Subcellular Localization	Endoplasmic reticulum membrane Peripheral membrane protein . Nucleus envelope . Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.
Protein Description	Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. [PubMed: 19822669]
Protein Sequence	MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	AIPAAIATAKRSGAV CHHHHHHHHHHCCCE	26.97	-
16	Ubiquitination	PAAIATAKRSGAVFV HHHHHHHHHCCCEEE	42.62	-
18	Phosphorylation	AIATAKRSGAVFVVF HHHHHHHCCCEEEEE	30.33	28111955
33	Phosphorylation	VAGDDEQSTQMAASW EECCCHHHHCCCHHC	20.68	28111955
34	Phosphorylation	AGDDEQSTQMAASWE ECCCHHHHCCCHHCC	23.27	28111955
39	Phosphorylation	QSTQMAASWEDDKVT HHHCCCHHCCCCCCE	22.81	28111955
46	Phosphorylation	SWEDDKVTEASSNSF HCCCCCCEECCCCCE	31.41	-
57	Ubiquitination	SNSFVAIKIDTKSEA CCCEEEEEEECCCHH	25.45	32015554
62	Phosphorylation	AIKIDTKSEACLQFS EEEEECCCHHHHHHH	32.30	29978859
69	Phosphorylation	SEACLQFSQIYPVVC CHHHHHHHHCCCEEE	11.60	29978859
72	Phosphorylation	CLQFSQIYPVVCVPS HHHHHHCCCEEEECC	5.15	29978859
79	Phosphorylation	YPVVCVPSSFFIGDS CCEEEECCCCCCCCC	21.27	29978859
80	Phosphorylation	PVVCVPSSFFIGDSG CEEEECCCCCCCCCC	20.36	29978859
129	Phosphorylation	ANGSQSESSVSTPSA CCCCCCCCCCCCCCC	41.09	27251275
130	Phosphorylation	NGSQSESSVSTPSAS CCCCCCCCCCCCCCC	18.94	27251275
132	Phosphorylation	SQSESSVSTPSASFE CCCCCCCCCCCCCCC	36.23	25627689
133	Phosphorylation	QSESSVSTPSASFEP CCCCCCCCCCCCCCC	21.07	25159151
143	Phosphorylation	ASFEPNNTCENSQSR CCCCCCCCCCCCCCC	28.03	27251275
147	Phosphorylation	PNNTCENSQSRNAEL CCCCCCCCCCCCCCC	13.77	27251275
149	Phosphorylation	NTCENSQSRNAELCE CCCCCCCCCCCCCCC	27.59	24275569
165	Phosphorylation	PPTSDTKSDTATGGE CCCCCCCCCCCCCCC	42.14	23663014
167	Phosphorylation	TSDTKSDTATGGESA CCCCCCCCCCCCCCC	32.96	23663014
169	Phosphorylation	DTKSDTATGGESAGH CCCCCCCCCCCCCCC	48.05	23663014
173	Phosphorylation	DTATGGESAGHATSS CCCCCCCCCCCCCCC	42.71	23663014
178	Phosphorylation	GESAGHATSSQEPSG CCCCCCCCCCCCCCC	24.20	23663014
179	Phosphorylation	ESAGHATSSQEPSGC CCCCCCCCCCCCCCC	30.70	23663014
180	Phosphorylation	SAGHATSSQEPSGCS CCCCCCCCCCCCCCC	33.92	23663014
184	Phosphorylation	ATSSQEPSGCSDQRP CCCCCCCCCCCCCCC	52.24	21406692
187	Phosphorylation	SQEPSGCSDQRPAED CCCCCCCCCCCCHHH	40.06	21406692
204	Ubiquitination	IRVERLTKKLEERRE HHHHHHHHHHHHHHH	61.01	29967540
205	Ubiquitination	RVERLTKKLEERREE HHHHHHHHHHHHHHH	56.76	24816145
233	Ubiquitination	IERRKTGKEMLDYKR HHHHHHHHHHHHHHH	45.22	32015554
238	Phosphorylation	TGKEMLDYKRKQEEE HHHHHHHHHHHHHHH	14.55	-
239	2-Hydroxyisobutyrylation	GKEMLDYKRKQEEEL HHHHHHHHHHHHHHH	53.43	-
239	Ubiquitination	GKEMLDYKRKQEEEL HHHHHHHHHHHHHHH	53.43	32015554
239	Methylation	GKEMLDYKRKQEEEL HHHHHHHHHHHHHHH	53.43	115978963
241	Ubiquitination	EMLDYKRKQEEELTK HHHHHHHHHHHHHHH	58.89	29967540
248	Ubiquitination	KQEEELTKRMLEERN HHHHHHHHHHHHHHH	48.73	29967540
248	2-Hydroxyisobutyrylation	KQEEELTKRMLEERN HHHHHHHHHHHHHHH	48.73	-
269	Ubiquitination	RAARERIKQQIALDR HHHHHHHHHHHHHHH	42.23	33845483
269	2-Hydroxyisobutyrylation	RAARERIKQQIALDR HHHHHHHHHHHHHHH	42.23	-
285	Ubiquitination	ERAARFAKTKEEVEA HHHHHHHCCHHHHHH	58.37	-
287	Ubiquitination	AARFAKTKEEVEAAK HHHHHCCHHHHHHHH	51.69	33845483
294	Ubiquitination	KEEVEAAKAAALLAK HHHHHHHHHHHHHHH	45.68	32015554
301	Methylation	KAAALLAKQAEMEVK HHHHHHHHHHHHHHH	50.43	23644510
301	Ubiquitination	KAAALLAKQAEMEVK HHHHHHHHHHHHHHH	50.43	21906983
301	Trimethylation	KAAALLAKQAEMEVK HHHHHHHHHHHHHHH	50.43	-
308	Ubiquitination	KQAEMEVKRESYARE HHHHHHHHHHHHHHH	36.82	33845483
311	Phosphorylation	EMEVKRESYARERST HHHHHHHHHHHHHHH	28.29	20068231
312	Phosphorylation	MEVKRESYARERSTV HHHHHHHHHHHHHHE	12.62	20068231
318	Phosphorylation	SYARERSTVARIQFR HHHHHHHHEEEEEEE	25.14	-
330	Phosphorylation	QFRLPDGSSFTNQFP EEECCCCCCCCCCCC	29.65	28857561
331	Phosphorylation	FRLPDGSSFTNQFPS EECCCCCCCCCCCCC	41.44	28857561
333	Phosphorylation	LPDGSSFTNQFPSDA CCCCCCCCCCCCCCC	30.02	28857561
373	Ubiquitination	FPRREFTKEDYKKKL CCCCCCCHHHHHHHH	54.64	27667366
377	Ubiquitination	EFTKEDYKKKLLDLE CCCHHHHHHHHHCCC	56.61	23503661
378	Ubiquitination	FTKEDYKKKLLDLEL CCHHHHHHHHHCCCC	42.28	23503661
379	Ubiquitination	TKEDYKKKLLDLELA CHHHHHHHHHCCCCC	50.56	23503661
388	Phosphorylation	LDLELAPSASVVLLP HCCCCCCCCEEEEEE	27.80	25693802
390	Phosphorylation	LELAPSASVVLLPAG CCCCCCCEEEEEECC	19.66	25693802
413	Phosphorylation	SSSGDIWTLLGTVLY CCCHHHHHHHHHHHH	16.67	26074081
440	Phosphorylation	LFSNPPPTQTSVRVT HHCCCCCCCCEEEEE	50.70	28857561
442	Phosphorylation	SNPPPTQTSVRVTSS CCCCCCCCEEEEECC	31.50	28857561
443	Phosphorylation	NPPPTQTSVRVTSSE CCCCCCCEEEEECCC	9.71	28857561
447	Phosphorylation	TQTSVRVTSSEPPNP CCCEEEEECCCCCCC	18.90	29396449
448	Phosphorylation	QTSVRVTSSEPPNPA CCEEEEECCCCCCCC	29.82	29396449
449	Phosphorylation	TSVRVTSSEPPNPAS CEEEEECCCCCCCCC	44.77	29396449
456	Phosphorylation	SEPPNPASSSKSEKR CCCCCCCCCCCCCCC	36.08	30266825
457	Phosphorylation	EPPNPASSSKSEKRE CCCCCCCCCCCCCCH	43.84	30266825
458	Phosphorylation	PPNPASSSKSEKREP CCCCCCCCCCCCCHH	37.39	30266825
459	Ubiquitination	PNPASSSKSEKREPV CCCCCCCCCCCCHHH	65.66	27667366
460	Phosphorylation	NPASSSKSEKREPVR CCCCCCCCCCCHHHH	50.74	29214152
462	Ubiquitination	ASSSKSEKREPVRKR CCCCCCCCCHHHHHH	69.97	22817900
479	Ubiquitination	EKRGDDFKKEGKIYR HHHCCCHHHCCCEEE	57.84	24816145
485	Phosphorylation	FKKEGKIYRLRTQDD HHHCCCEEEEEECCC	13.69	-
489	Phosphorylation	GKIYRLRTQDDGEDE CCEEEEEECCCCCCC	40.73	17525332
499	Phosphorylation	DGEDENNTWNGNSTQ CCCCCCCCCCCCCCC	31.71	22617229
504	Phosphorylation	NNTWNGNSTQQM--- CCCCCCCCCCCC---	29.05	23186163
505	Phosphorylation	NTWNGNSTQQM---- CCCCCCCCCCC----	27.16	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBXN4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBXN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBXN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM1L1_HUMAN	TOM1L1	physical	16169070
TERA_HUMAN	VCP	physical	18775313
TERA_HUMAN	VCP	physical	19822669
UBQL1_HUMAN	UBQLN1	physical	19822669
CALX_HUMAN	CANX	physical	16968747
TERA_HUMAN	VCP	physical	16968747
AMFR_HUMAN	AMFR	physical	16968747
DERL1_HUMAN	DERL1	physical	16968747
UBQL1_HUMAN	UBQLN1	physical	25416956
UBE4A_HUMAN	UBE4A	physical	22119785
PSA6_HUMAN	PSMA6	physical	19822669
ACTA_HUMAN	ACTA2	physical	26186194
VP13A_HUMAN	VPS13A	physical	26186194
VP13C_HUMAN	VPS13C	physical	26186194
IP6K1_HUMAN	IP6K1	physical	26186194
FBX11_HUMAN	FBXO11	physical	26186194
UBE4A_HUMAN	UBE4A	physical	26186194
BC11A_HUMAN	BCL11A	physical	26186194
DPP8_HUMAN	DPP8	physical	26186194
PP1R7_HUMAN	PPP1R7	physical	26389662
TERA_HUMAN	VCP	physical	26389662
UBE4A_HUMAN	UBE4A	physical	26389662
ODR4_HUMAN	C1orf27	physical	26389662
IP6K1_HUMAN	IP6K1	physical	26389662
S27A4_HUMAN	SLC27A4	physical	26389662
VP13A_HUMAN	VPS13A	physical	26389662
VP13C_HUMAN	VPS13C	physical	26389662
UBXN6_HUMAN	UBXN6	physical	26389662
BC11A_HUMAN	BCL11A	physical	28514442
IP6K1_HUMAN	IP6K1	physical	28514442
UBE4A_HUMAN	UBE4A	physical	28514442
VP13C_HUMAN	VPS13C	physical	28514442
VP13A_HUMAN	VPS13A	physical	28514442
DPP8_HUMAN	DPP8	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBXN4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-489, AND MASSSPECTROMETRY.	17525332 [Abstract]