UBE4A_HUMAN - dbPTM
UBE4A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBE4A_HUMAN
UniProt AC Q14139
Protein Name Ubiquitin conjugation factor E4 A {ECO:0000305}
Gene Name UBE4A {ECO:0000312|HGNC:HGNC:12499}
Organism Homo sapiens (Human).
Sequence Length 1066
Subcellular Localization Cytoplasm .
Protein Description Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates..
Protein Sequence MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVAEISRSFRSQQEICEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQALFARLLLQDPGNHLINMTSSTTLNLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALILDEEVRTFPEVMIPVFDILLGRIKDLELCQILLYAYLDILLYFTRQKDMAKVFVEYIQPKDPTNGQMYQKTLLGVILSISCLLKTPGVVENHGYFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILSWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCALKELNDEERKIKNVHMRGLDKETCLIPAVQEPKFPQNYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELTFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFADDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPNPLVSSVFHRKRVFCNFQYAPQLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDTYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFLLDEAIQYLSKIKIQQIEKDRGEWDSLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLAFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIMAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQLE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTDQENNNN
------CCCCCCCCC		58.6626846344
11PhosphorylationQENNNNISSNPFAAL
CCCCCCCCCCHHHHH		26.6226846344
12PhosphorylationENNNNISSNPFAALF
CCCCCCCCCHHHHHH		44.7328464451
33UbiquitinationKQFAAIQKEQLKQQS
HHHHHHHHHHHHHHC		41.1229967540
33 (in isoform 2)Ubiquitination-41.12-
40PhosphorylationKEQLKQQSDELPASP
HHHHHHHCCCCCCCC		30.4728634120
46PhosphorylationQSDELPASPDDSDNS
HCCCCCCCCCCCCCC		27.2422798277
50PhosphorylationLPASPDDSDNSVSES
CCCCCCCCCCCHHHH		46.1828634120
50 (in isoform 2)Phosphorylation-46.1827251275
53PhosphorylationSPDDSDNSVSESLDE
CCCCCCCCHHHHHHH		31.8226657352
55PhosphorylationDDSDNSVSESLDEFD
CCCCCCHHHHHHHHC		22.6828634120
57PhosphorylationSDNSVSESLDEFDYS
CCCCHHHHHHHHCCH		33.3530177828
63PhosphorylationESLDEFDYSVAEISR
HHHHHHCCHHHHHHH		15.4630177828
63 (in isoform 2)Phosphorylation-15.4627642862
71PhosphorylationSVAEISRSFRSQQEI
HHHHHHHHHHHHHHH		20.4425693802
74PhosphorylationEISRSFRSQQEICEQ
HHHHHHHHHHHHHHH		33.9225693802
104UbiquitinationDNSDPSLKSGNGIPS
CCCCCCCCCCCCCCC		61.7321906983
104 (in isoform 1)Ubiquitination-61.7321890473
104 (in isoform 2)Ubiquitination-61.7321890473
155PhosphorylationGNHLINMTSSTTLNL
CCCEEECCCCCEEEE		18.2925693802
156PhosphorylationNHLINMTSSTTLNLS
CCEEECCCCCEEEEE		18.2125693802
157PhosphorylationHLINMTSSTTLNLSA
CEEECCCCCEEEEEC		19.0825693802
158PhosphorylationLINMTSSTTLNLSAD
EEECCCCCEEEEECC		34.7625693802
159PhosphorylationINMTSSTTLNLSADR
EECCCCCEEEEECCC		18.6525693802
185UbiquitinationYSCFQRAKEEITKVP
HHHHHHHHHHHHCCC		59.05-
185 (in isoform 2)Ubiquitination-59.05-
190UbiquitinationRAKEEITKVPENLLP
HHHHHHHCCCCHHHH		62.5524816145
190 (in isoform 2)Ubiquitination-62.55-
313PhosphorylationMAKVFVEYIQPKDPT
HHHHHHHHHCCCCCC		10.27-
317UbiquitinationFVEYIQPKDPTNGQM
HHHHHCCCCCCCCHH		61.0222817900
317 (in isoform 1)Ubiquitination-61.0221890473
324UbiquitinationKDPTNGQMYQKTLLG
CCCCCCHHHHHHHHH		3.9722817900
324 (in isoform 2)Ubiquitination-3.9721890473
325PhosphorylationDPTNGQMYQKTLLGV
CCCCCHHHHHHHHHH		10.0430387612
327NeddylationTNGQMYQKTLLGVIL
CCCHHHHHHHHHHHH		24.5332015554
334NeddylationKTLLGVILSISCLLK
HHHHHHHHHHHHHHC		3.2732015554
386AcetylationEKIYQMLKNLLQLSP
HHHHHHHHHHHHCCH		39.9619608861
393AcetylationKNLLQLSPETKHCIL
HHHHHCCHHHHHHHH		62.9719608861
451AcetylationKLCQPFCKPRSSRLL
HHHHHHCCCCCCCCH		43.7925953088
451MalonylationKLCQPFCKPRSSRLL
HHHHHHCCCCCCCCH		43.7926320211
451UbiquitinationKLCQPFCKPRSSRLL
HHHHHHCCCCCCCCH		43.79-
458 (in isoform 2)Ubiquitination-5.09-
459PhosphorylationPRSSRLLTFNPTYCA
CCCCCCHHCCHHHHH		26.4228857561
463PhosphorylationRLLTFNPTYCALKEL
CCHHCCHHHHHHHHC		32.1328857561
464PhosphorylationLLTFNPTYCALKELN
CHHCCHHHHHHHHCC		4.1328796482
465S-nitrosocysteineLTFNPTYCALKELND
HHCCHHHHHHHHCCH		3.83-
465S-nitrosylationLTFNPTYCALKELND
HHCCHHHHHHHHCCH		3.8319483679
468UbiquitinationNPTYCALKELNDEER
CHHHHHHHHCCHHHH		41.4521963094
471 (in isoform 2)Phosphorylation-56.6027642862
475UbiquitinationKELNDEERKIKNVHM
HHCCHHHHHHHCCHH		43.9121963094
475 (in isoform 2)Ubiquitination-43.91-
478UbiquitinationNDEERKIKNVHMRGL
CHHHHHHHCCHHCCC		56.8229967540
485UbiquitinationKNVHMRGLDKETCLI
HCCHHCCCCCCCCEE		6.3229967540
485 (in isoform 2)Ubiquitination-6.32-
487UbiquitinationVHMRGLDKETCLIPA
CHHCCCCCCCCEECC		61.0229967540
494UbiquitinationKETCLIPAVQEPKFP
CCCCEECCCCCCCCC		14.5029967540
494 (in isoform 2)Ubiquitination-14.50-
531AcetylationRLHDQMVKINQNLHR
HHHHHHHHHHHCHHH		30.517670957
531UbiquitinationRLHDQMVKINQNLHR
HHHHHHHHHHHCHHH		30.5121906983
531 (in isoform 1)Ubiquitination-30.5121890473
538UbiquitinationKINQNLHRLQVAWRD
HHHHCHHHHHHHHHH		29.9521963094
538 (in isoform 2)Ubiquitination-29.9521890473
549PhosphorylationAWRDAQQSSSPAADN
HHHHHHHCCCHHHHH		22.2429214152
550PhosphorylationWRDAQQSSSPAADNL
HHHHHHCCCHHHHHH		35.6821815630
551PhosphorylationRDAQQSSSPAADNLR
HHHHHCCCHHHHHHH		24.6521815630
566PhosphorylationEQFERLMTIYLSTKT
HHHHHHHHHHHCCCC		15.8620068231
568PhosphorylationFERLMTIYLSTKTAM
HHHHHHHHHCCCCCC		5.8520068231
570PhosphorylationRLMTIYLSTKTAMTE
HHHHHHHCCCCCCCC		15.7520068231
571PhosphorylationLMTIYLSTKTAMTEP
HHHHHHCCCCCCCCH		29.8020068231
749PhosphorylationFNYRRPMYPILRYMW
HCCCCCCHHHHHHHH		6.9818083107
754PhosphorylationPMYPILRYMWGTDTY
CCHHHHHHHHCCHHH		8.1824043423
758PhosphorylationILRYMWGTDTYRESI
HHHHHHCCHHHHHHH		15.0624043423
760PhosphorylationRYMWGTDTYRESIKD
HHHHCCHHHHHHHHH		25.0624043423
761PhosphorylationYMWGTDTYRESIKDL
HHHCCHHHHHHHHHH		18.3924043423
766UbiquitinationDTYRESIKDLADYAS
HHHHHHHHHHHHHHH		56.8427667366
766 (in isoform 1)Ubiquitination-56.8421890473
773UbiquitinationKDLADYASKNLEAMN
HHHHHHHHHCHHHHC		18.8221890473
773 (in isoform 2)Ubiquitination-18.8221890473
774UbiquitinationDLADYASKNLEAMNP
HHHHHHHHCHHHHCH		58.3322817900
774 (in isoform 1)Ubiquitination-58.3321890473
779SulfoxidationASKNLEAMNPPLFLR
HHHCHHHHCHHHHHH		5.8921406390
781UbiquitinationKNLEAMNPPLFLRFL
HCHHHHCHHHHHHHH		17.5621890473
781 (in isoform 2)Ubiquitination-17.5621890473
808UbiquitinationEAIQYLSKIKIQQIE
HHHHHHHCCCCHHHH		45.4822817900
810UbiquitinationIQYLSKIKIQQIEKD
HHHHHCCCCHHHHCC		37.8922817900
810 (in isoform 1)Ubiquitination-37.8921890473
815UbiquitinationKIKIQQIEKDRGEWD
CCCCHHHHCCCCCHH		44.5622817900
816UbiquitinationIKIQQIEKDRGEWDS
CCCHHHHCCCCCHHH		55.1229967540
817UbiquitinationKIQQIEKDRGEWDSL
CCHHHHCCCCCHHHC		51.5322817900
817 (in isoform 2)Ubiquitination-51.5321890473
823UbiquitinationKDRGEWDSLTPEARR
CCCCCHHHCCHHHHH		34.9029967540
832UbiquitinationTPEARREKEAGLQMF
CHHHHHHHHHHHHHH		51.56-
838SulfoxidationEKEAGLQMFGQLARF
HHHHHHHHHHHHHHH		4.9821406390
839 (in isoform 2)Ubiquitination-3.48-
938PhosphorylationTVPKDGRSYSPTLFA
ECCCCCCCCCCCHHH		35.1826434776
939PhosphorylationVPKDGRSYSPTLFAQ
CCCCCCCCCCCHHHH		19.8023186163
940PhosphorylationPKDGRSYSPTLFAQT
CCCCCCCCCCHHHHH		16.8028857561
942PhosphorylationDGRSYSPTLFAQTVR
CCCCCCCCHHHHHHH		28.6826434776
947PhosphorylationSPTLFAQTVRVLKKI
CCCHHHHHHHHHHHC		13.5728857561
947 (in isoform 2)Phosphorylation-13.5724719451
1017PhosphorylationSRVTVDRSTIARHLL
CCEEECHHHHHHHHH		21.5028857561
1034PhosphorylationQTDPFNRSPLTMDQI
CCCCCCCCCCCHHHC		25.9328348404
1059UbiquitinationQRWLAERKQQKEQLE
HHHHHHHHHHHHHHC		48.8924816145
1066UbiquitinationKQQKEQLE-------
HHHHHHHC-------		59.2724816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBE4A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBE4A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBE4A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTTG1_HUMANPTTG1physical
15611659
UB2D3_HUMANUBE2D3physical
15611659
SLAP1_HUMANSLAphysical
24457997
EPHA2_HUMANEPHA2physical
24457997
UBXN4_HUMANUBXN4physical
26389662
FAM3C_HUMANFAM3Cphysical
27862841
PCBP1_HUMANPCBP1physical
28963376
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBE4A_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-386, AND MASS SPECTROMETRY.

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