FAM3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAM3C_HUMAN
• UniProt AC: Q92520
• Protein Name: Protein FAM3C
• Gene Name: FAM3C
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Secreted. Cytoplasmic vesicle . Cytoplasmic in some cancer cells.
• Protein Description: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition..
• Protein Sequence: MRVAGAAKLVVAVAVFLLTFYVISQVFEIKMDASLGNLFARSALDTAARSTKPPRYKCGISKACPEKHFAFKMASGAANVVGPKICLEDNVLMSGVKNNVGRGINVALANGKTGEVLDTKYFDMWGGDVAPFIEFLKAIQDGTIVLMGTYDDGATKLNDEARRLIADLGSTSITNLGFRDNWVFCGGKGIKTKSPFEQHIKNNKDTNKYEGWPEVVEMEGCIPQKQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	LGNLFARSALDTAAR HHHHHHHHHHHHHHH	29.74	30576142
46	Phosphorylation	FARSALDTAARSTKP HHHHHHHHHHHCCCC	24.06	27251275
50	Phosphorylation	ALDTAARSTKPPRYK HHHHHHHCCCCCCCC	35.74	21964256
51	Phosphorylation	LDTAARSTKPPRYKC HHHHHHCCCCCCCCC	41.85	21964256
67	Acetylation	ISKACPEKHFAFKMA CCCCCCHHHHCHHHH	29.21	27178108
67	2-Hydroxyisobutyrylation	ISKACPEKHFAFKMA CCCCCCHHHHCHHHH	29.21	-
75	Phosphorylation	HFAFKMASGAANVVG HHCHHHHCCCCCCCC	26.01	22210691
86	Glutathionylation	NVVGPKICLEDNVLM CCCCCEEECCCCEEE	4.20	22555962
94	Phosphorylation	LEDNVLMSGVKNNVG CCCCEEECCCCCCCC	35.95	20071362
112	Ubiquitination	NVALANGKTGEVLDT EEEECCCCCCCEECC	53.84	22817900
156	Ubiquitination	TYDDGATKLNDEARR ECCCCCHHCCHHHHH	44.77	22817900
170	Phosphorylation	RLIADLGSTSITNLG HHHHHHCCCCCCCCC	26.69	17322306
171	Phosphorylation	LIADLGSTSITNLGF HHHHHCCCCCCCCCC	23.50	17322306
171	O-linked_Glycosylation	LIADLGSTSITNLGF HHHHHCCCCCCCCCC	23.50	OGP
174	Phosphorylation	DLGSTSITNLGFRDN HHCCCCCCCCCCCCC	24.94	17322306
185	Carbamidation	FRDNWVFCGGKGIKT CCCCEEEECCCCCCC	5.20	17322306
188	Ubiquitination	NWVFCGGKGIKTKSP CEEEECCCCCCCCCH	42.62	22817900
191	Ubiquitination	FCGGKGIKTKSPFEQ EECCCCCCCCCHHHH	59.58	22817900
192	O-linked_Glycosylation	CGGKGIKTKSPFEQH ECCCCCCCCCHHHHH	34.53	OGP
193	Ubiquitination	GGKGIKTKSPFEQHI CCCCCCCCCHHHHHH	51.64	22817900
201	Acetylation	SPFEQHIKNNKDTNK CHHHHHHHHCCCCCC	52.95	7380109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAM3C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAM3C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAM3C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RMD3_HUMAN	RMDN3	physical	22939629
SRSF3_HUMAN	SRSF3	physical	22939629
NDUS7_HUMAN	NDUFS7	physical	22939629
GALT2_HUMAN	GALNT2	physical	22939629
PTCD3_HUMAN	PTCD3	physical	22939629
TOM7_HUMAN	TOMM7	physical	22939629
MPV17_HUMAN	MPV17	physical	22939629
SNP23_HUMAN	SNAP23	physical	22939629
TOM22_HUMAN	TOMM22	physical	22939629
RM41_HUMAN	MRPL41	physical	22939629
RALA_HUMAN	RALA	physical	22939629
FLOT1_HUMAN	FLOT1	physical	22939629
MGST3_HUMAN	MGST3	physical	22939629
IR3IP_HUMAN	IER3IP1	physical	22939629
SFXN3_HUMAN	SFXN3	physical	22939629
CR3L1_HUMAN	CREB3L1	physical	25416956
CREB3_HUMAN	CREB3	physical	21516116
UBE4A_HUMAN	UBE4A	physical	27862841
UBE3C_HUMAN	UBE3C	physical	27862841

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.