GALT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALT2_HUMAN
• UniProt AC: Q10471
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 2
• Gene Name: GALNT2
• Organism: Homo sapiens (Human).
• Sequence Length: 571
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted . Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
• Protein Description: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region..
• Protein Sequence: MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	RMLLCFAFLWVLGIA HHHHHHHHHHHHHHH	2.50	-
21	Ubiquitination	LWVLGIAYYMYSGGG HHHHHHHHHHHCCCC	6.19	-
25	O-linked_Glycosylation	GIAYYMYSGGGSALA HHHHHHHCCCCCCCC	17.90	OGP
29	O-linked_Glycosylation	YMYSGGGSALAGGAG HHHCCCCCCCCCCCC	24.31	OGP
42	Ubiquitination	AGGGAGRKEDWNEID CCCCCCCCCCCCCCC	60.14	-
42	Sumoylation	AGGGAGRKEDWNEID CCCCCCCCCCCCCCC	60.14	-
52	Ubiquitination	WNEIDPIKKKDLHHS CCCCCCCCHHHCCCC	60.19	-
52	2-Hydroxyisobutyrylation	WNEIDPIKKKDLHHS CCCCCCCCHHHCCCC	60.19	-
53	Ubiquitination	NEIDPIKKKDLHHSN CCCCCCCHHHCCCCC	52.84	-
67	O-linked_Glycosylation	NGEEKAQSMETLPPG CHHHHHHHHCCCCCC	24.36	55829319
67	Phosphorylation	NGEEKAQSMETLPPG CHHHHHHHHCCCCCC	24.36	22210691
70	O-linked_Glycosylation	EKAQSMETLPPGKVR HHHHHHCCCCCCCCC	35.60	55829323
70	Phosphorylation	EKAQSMETLPPGKVR HHHHHHCCCCCCCCC	35.60	22210691
72	Ubiquitination	AQSMETLPPGKVRWP HHHHCCCCCCCCCCC	42.91	-
86	Phosphorylation	PDFNQEAYVGGTMVR CCCCCEEEECCEEEE	10.00	28102081
90	Phosphorylation	QEAYVGGTMVRSGQD CEEEECCEEEECCCC	13.43	28102081
94	O-linked_Glycosylation	VGGTMVRSGQDPYAR ECCEEEECCCCHHHH	29.42	OGP
94	Phosphorylation	VGGTMVRSGQDPYAR ECCEEEECCCCHHHH	29.42	27486199
99	Ubiquitination	VRSGQDPYARNKFNQ EECCCCHHHHHCCCH	26.87	-
99	Phosphorylation	VRSGQDPYARNKFNQ EECCCCHHHHHCCCH	26.87	28102081
103	Sumoylation	QDPYARNKFNQVESD CCHHHHHCCCHHHHH	39.89	-
103	Ubiquitination	QDPYARNKFNQVESD CCHHHHHCCCHHHHH	39.89	-
103	Sumoylation	QDPYARNKFNQVESD CCHHHHHCCCHHHHH	39.89	-
103	Acetylation	QDPYARNKFNQVESD CCHHHHHCCCHHHHH	39.89	26051181
109	Phosphorylation	NKFNQVESDKLRMDR HCCCHHHHHHHCCCC	40.98	20886841
109	Acetylation	NKFNQVESDKLRMDR HCCCHHHHHHHCCCC	40.98	45474409
111	2-Hydroxyisobutyrylation	FNQVESDKLRMDRAI CCHHHHHHHCCCCCC	47.47	-
111	Acetylation	FNQVESDKLRMDRAI CCHHHHHHHCCCCCC	47.47	26051181
111	Ubiquitination	FNQVESDKLRMDRAI CCHHHHHHHCCCCCC	47.47	-
128	Ubiquitination	TRHDQCQRKQWRVDL CCHHHHHCCCEECCC	40.53	-
162	Ubiquitination	TVVSVLKKSPPHLIK HHHHHHHHCCCHHEE	65.12	-
169	Ubiquitination	KSPPHLIKEIILVDD HCCCHHEEEEEEECC	49.58	-
189	Ubiquitination	EDGALLGKIEKVRVL HCCCCCCEEEEEEEE	47.89	21906983
218	Ubiquitination	GADAAQAKVLTFLDS CCHHHHHHHHHHHHH	26.20	-
250	Phosphorylation	EDRTRVVSPIIDVIN CCCCCCCCCEEEEEE	13.92	-
292	Phosphorylation	MTPEQRRSRQGNPVA CCHHHHHHCCCCCCC	31.01	21406692
302	Ubiquitination	GNPVAPIKTPMIAGG CCCCCCCCCCEECCC	45.58	-
302	Acetylation	GNPVAPIKTPMIAGG CCCCCCCCCCEECCC	45.58	30588867
303	Phosphorylation	NPVAPIKTPMIAGGL CCCCCCCCCEECCCE	20.86	24043423
317	Phosphorylation	LFVMDKFYFEELGKY EEEEEEHHHHHHCCC	18.80	-
363	Acetylation	RVGHVFRKQHPYTFP CCCEEEECCCCCCCC	41.30	21651894
363	Ubiquitination	RVGHVFRKQHPYTFP CCCEEEECCCCCCCC	41.30	-
367	Phosphorylation	VFRKQHPYTFPGGSG EEECCCCCCCCCCCC	20.91	24114839
368	O-linked_Glycosylation	FRKQHPYTFPGGSGT EECCCCCCCCCCCCC	28.01	55833067
368	Phosphorylation	FRKQHPYTFPGGSGT EECCCCCCCCCCCCC	28.01	20068231
373	Phosphorylation	PYTFPGGSGTVFARN CCCCCCCCCCEEECC	36.89	24114839
373	Acetylation	PYTFPGGSGTVFARN CCCCCCCCCCEEECC	36.89	50672827
375	Phosphorylation	TFPGGSGTVFARNTR CCCCCCCCEEECCCH	17.72	20068231
392	Phosphorylation	AEVWMDEYKNFYYAA HHHHHHHHCCEEEEE	13.63	-
393	Ubiquitination	EVWMDEYKNFYYAAV HHHHHHHCCEEEEEC	38.23	-
402	Phosphorylation	FYYAAVPSARNVPYG EEEEECCCCCCCCCC	33.01	-
402	O-linked_Glycosylation	FYYAAVPSARNVPYG EEEEECCCCCCCCCC	33.01	31492838
408	Phosphorylation	PSARNVPYGNIQSRL CCCCCCCCCCHHHHH	20.65	20068231
413	Phosphorylation	VPYGNIQSRLELRKK CCCCCHHHHHHHHHH	34.73	20068231
420	Methylation	SRLELRKKLSCKPFK HHHHHHHHHCCCCCH	38.92	-
434	Phosphorylation	KWYLENVYPELRVPD HHHHHHCCHHHCCCC	11.54	-
506	Phosphorylation	VVDRAPGSLIKLQGC EHHCCCCCEEEEECC	26.34	24719451
509	Ubiquitination	RAPGSLIKLQGCREN CCCCCEEEEECCCCC	39.80	-
509	Acetylation	RAPGSLIKLQGCREN CCCCCEEEEECCCCC	39.80	25953088
521	Acetylation	RENDSRQKWEQIEGN CCCCCHHHHHHHHCC	52.14	26051181
521	Ubiquitination	RENDSRQKWEQIEGN CCCCCHHHHHHHHCC	52.14	-
529	Acetylation	WEQIEGNSKLRHVGS HHHHHCCCCEEEECC	43.88	50672829
529	Phosphorylation	WEQIEGNSKLRHVGS HHHHHCCCCEEEECC	43.88	-
530	Ubiquitination	EQIEGNSKLRHVGSN HHHHCCCCEEEECCC	54.24	-
530	Sumoylation	EQIEGNSKLRHVGSN HHHHCCCCEEEECCC	54.24	-
530	Sumoylation	EQIEGNSKLRHVGSN HHHHCCCCEEEECCC	54.24	-
536	Phosphorylation	SKLRHVGSNLCLDSR CCEEEECCCCEECCC	26.07	30108239
546	Ubiquitination	CLDSRTAKSGGLSVE EECCCCCCCCCEEEE	49.36	-
551	Phosphorylation	TAKSGGLSVEVCGPA CCCCCCEEEEEECHH	21.36	30243723
560	Phosphorylation	EVCGPALSQQWKFTL EEECHHHHHEEEEEE	23.56	30243723

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS15A_HUMAN	RPS15A	physical	22939629
RT05_HUMAN	MRPS5	physical	22939629
PR40A_HUMAN	PRPF40A	physical	22939629
KASH5_HUMAN	CCDC155	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.