dbPTM

RS15A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS15A_HUMAN
UniProt AC	P62244
Protein Name	40S ribosomal protein S15a
Gene Name	RPS15A
Organism	Homo sapiens (Human).
Sequence Length	130
Subcellular Localization
Protein Description
Protein Sequence	MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Sulfoxidation	----MVRMNVLADAL ----CCCHHHHHHHH	2.50	21406390
12	Acetylation	NVLADALKSINNAEK HHHHHHHHHCCHHHH	51.51	26051181
12	Ubiquitination	NVLADALKSINNAEK HHHHHHHHHCCHHHH	51.51	21890473
19	Acetylation	KSINNAEKRGKRQVL HHCCHHHHHCCCCEE	65.13	23749302
19	Ubiquitination	KSINNAEKRGKRQVL HHCCHHHHHCCCCEE	65.13	21890473
19	Succinylation	KSINNAEKRGKRQVL HHCCHHHHHCCCCEE	65.13	23954790
19	2-Hydroxyisobutyrylation	KSINNAEKRGKRQVL HHCCHHHHHCCCCEE	65.13	-
32	Ubiquitination	VLIRPCSKVIVRFLT EEEECCHHHHHHHHH	42.57	21890473
32	Acetylation	VLIRPCSKVIVRFLT EEEECCHHHHHHHHH	42.57	25953088
46	Phosphorylation	TVMMKHGYIGEFEII HHHHHCCCEEEEEEE	12.89	28152594
60	Ubiquitination	IDDHRAGKIVVNLTG ECCCCCCEEEEECCC	31.20	21890473
60	2-Hydroxyisobutyrylation	IDDHRAGKIVVNLTG ECCCCCCEEEEECCC	31.20	-
66	Phosphorylation	GKIVVNLTGRLNKCG CEEEEECCCCCCCCC	18.30	-
71	Acetylation	NLTGRLNKCGVISPR ECCCCCCCCCCCCCC	36.64	25953088
71	Ubiquitination	NLTGRLNKCGVISPR ECCCCCCCCCCCCCC	36.64	21890473
71	2-Hydroxyisobutyrylation	NLTGRLNKCGVISPR ECCCCCCCCCCCCCC	36.64	-
72	S-palmitoylation	LTGRLNKCGVISPRF CCCCCCCCCCCCCCC	5.25	29575903
84	2-Hydroxyisobutyrylation	PRFDVQLKDLEKWQN CCCCEEHHHHHHHHH	43.08	-
84	Ubiquitination	PRFDVQLKDLEKWQN CCCCEEHHHHHHHHH	43.08	21890473
84	Acetylation	PRFDVQLKDLEKWQN CCCCEEHHHHHHHHH	43.08	26822725
88	2-Hydroxyisobutyrylation	VQLKDLEKWQNNLLP EEHHHHHHHHHCCCC	62.47	-
88	Acetylation	VQLKDLEKWQNNLLP EEHHHHHHHHHCCCC	62.47	25825284
88	Succinylation	VQLKDLEKWQNNLLP EEHHHHHHHHHCCCC	62.47	21890473
88	Succinylation	VQLKDLEKWQNNLLP EEHHHHHHHHHCCCC	62.47	-
88	Ubiquitination	VQLKDLEKWQNNLLP EEHHHHHHHHHCCCC	62.47	21890473
96	Phosphorylation	WQNNLLPSRQFGFIV HHHCCCCHHHCCEEE	38.39	25278378
121	Phosphorylation	EEARRKHTGGKILGF HHHHHHHCCCCEEEE	51.14	-
124	2-Hydroxyisobutyrylation	RRKHTGGKILGFFF- HHHHCCCCEEEEEC-	35.78	-
124	Ubiquitination	RRKHTGGKILGFFF- HHHHCCCCEEEEEC-	35.78	21890473
124	Acetylation	RRKHTGGKILGFFF- HHHHCCCCEEEEEC-	35.78	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS15A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS15A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS15A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS19_HUMAN	RPS19	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RS27A_HUMAN	RPS27A	physical	22939629
RT14_HUMAN	MRPS14	physical	22939629
SAE2_HUMAN	UBA2	physical	22939629
PRS4_HUMAN	PSMC1	physical	22863883
PRS10_HUMAN	PSMC6	physical	22863883
PSD11_HUMAN	PSMD11	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
RS26_HUMAN	RPS26	physical	22863883
RS28_HUMAN	RPS28	physical	22863883
RS3_HUMAN	RPS3	physical	22863883
RS6_HUMAN	RPS6	physical	22863883
RS8_HUMAN	RPS8	physical	22863883
TSR1_HUMAN	TSR1	physical	22863883
DIM1_HUMAN	DIMT1	physical	26344197
IF6_HUMAN	EIF6	physical	26344197
UBIM_HUMAN	FAU	physical	26344197
GNL1_HUMAN	GNL1	physical	26344197
GNL3_HUMAN	GNL3	physical	26344197
IMP3_HUMAN	IMP3	physical	26344197
MPP10_HUMAN	MPHOSPH10	physical	26344197
RM14_HUMAN	MRPL14	physical	26344197
RM16_HUMAN	MRPL16	physical	26344197
RM22_HUMAN	MRPL22	physical	26344197
RT14_HUMAN	MRPS14	physical	26344197
RT07_HUMAN	MRPS7	physical	26344197
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL14_HUMAN	RPL14	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL18_HUMAN	RPL18	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL28_HUMAN	RPL28	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL32_HUMAN	RPL32	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL35_HUMAN	RPL35	physical	26344197
RL37_HUMAN	RPL37	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL38_HUMAN	RPL38	physical	26344197
RL6_HUMAN	RPL6	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RS11_HUMAN	RPS11	physical	26344197
RS13_HUMAN	RPS13	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS15_HUMAN	RPS15	physical	26344197
RS17_HUMAN	RPS17	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS19_HUMAN	RPS19	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
TBB5_HUMAN	TUBB	physical	26344197
TBB2B_HUMAN	TUBB2B	physical	26344197
TBB4B_HUMAN	TUBB4B	physical	26344197
RL40_HUMAN	UBA52	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS15A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-124, AND MASS SPECTROMETRY.	19608861 [Abstract]